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Items: 1 to 50 of 213

1.

Immunization of BLT Humanized Mice Redirects T Cell Responses to Gag and Reduces Acute HIV-1 Viremia.

Claiborne DT, Dudek TE, Maldini CR, Power KA, Ghebremichael M, Seung E, Mellors EF, Vrbanac VD, Krupp K, Bisesi A, Tager AM, Knipe DM, Boutwell CL, Allen TM.

J Virol. 2019 Aug 2. pii: JVI.00814-19. doi: 10.1128/JVI.00814-19. [Epub ahead of print]

PMID:
31375576
2.

Maternal immunization confers protection against neonatal herpes simplex mortality and behavioral morbidity.

Patel CD, Backes IM, Taylor SA, Jiang Y, Marchant A, Pesola JM, Coen DM, Knipe DM, Ackerman ME, Leib DA.

Sci Transl Med. 2019 Apr 10;11(487). pii: eaau6039. doi: 10.1126/scitranslmed.aau6039.

3.

Herpes Simplex Virus 1 Lytic Infection Blocks MicroRNA (miRNA) Biogenesis at the Stage of Nuclear Export of Pre-miRNAs.

Pan D, Li G, Morris-Love J, Qi S, Feng L, Mertens ME, Jurak I, Knipe DM, Coen DM.

MBio. 2019 Feb 12;10(1). pii: e02856-18. doi: 10.1128/mBio.02856-18.

4.

Generation of an Oncolytic Herpes Simplex Virus 1 Expressing Human MelanA.

Boscheinen JB, Thomann S, Knipe DM, DeLuca N, Schuler-Thurner B, Gross S, Dörrie J, Schaft N, Bach C, Rohrhofer A, Werner-Klein M, Schmidt B, Schuster P.

Front Immunol. 2019 Jan 22;10:2. doi: 10.3389/fimmu.2019.00002. eCollection 2019.

5.

Role for a Filamentous Nuclear Assembly of IFI16, DNA, and Host Factors in Restriction of Herpesviral Infection.

Merkl PE, Knipe DM.

MBio. 2019 Jan 22;10(1). pii: e02621-18. doi: 10.1128/mBio.02621-18.

6.

Classification of human Herpesviridae proteins using Domain-architecture Aware Inference of Orthologs (DAIO).

Zmasek CM, Knipe DM, Pellett PE, Scheuermann RH.

Virology. 2019 Mar;529:29-42. doi: 10.1016/j.virol.2019.01.005. Epub 2019 Jan 6.

7.

ATRX promotes maintenance of herpes simplex virus heterochromatin during chromatin stress.

Cabral JM, Oh HS, Knipe DM.

Elife. 2018 Nov 22;7. pii: e40228. doi: 10.7554/eLife.40228.

8.

CNBP controls IL-12 gene transcription and Th1 immunity.

Chen Y, Sharma S, Assis PA, Jiang Z, Elling R, Olive AJ, Hang S, Bernier J, Huh JR, Sassetti CM, Knipe DM, Gazzinelli RT, Fitzgerald KA.

J Exp Med. 2018 Dec 3;215(12):3136-3150. doi: 10.1084/jem.20181031. Epub 2018 Nov 15.

9.

ABIN-1 heterozygosity sensitizes to innate immune response in both RIPK1-dependent and RIPK1-independent manner.

Su Z, Dziedzic SA, Hu D, Barrett VJ, Broekema N, Li W, Qian L, Jia N, Ofengeim D, Najafov A, Zhu H, Knipe DM, Yuan J.

Cell Death Differ. 2019 Jun;26(6):1077-1088. doi: 10.1038/s41418-018-0215-3. Epub 2018 Oct 19.

PMID:
30341420
10.

Mechanisms of Host IFI16, PML, and Daxx Protein Restriction of Herpes Simplex Virus 1 Replication.

Merkl PE, Orzalli MH, Knipe DM.

J Virol. 2018 Apr 27;92(10). pii: e00057-18. doi: 10.1128/JVI.00057-18. Print 2018 May 15.

11.

CCCTC-Binding Factor Acts as a Heterochromatin Barrier on Herpes Simplex Viral Latent Chromatin and Contributes to Poised Latent Infection.

Lee JS, Raja P, Pan D, Pesola JM, Coen DM, Knipe DM.

MBio. 2018 Feb 6;9(1). pii: e02372-17. doi: 10.1128/mBio.02372-17.

12.

A digenic human immunodeficiency characterized by IFNAR1 and IFNGR2 mutations.

Hoyos-Bachiloglu R, Chou J, Sodroski CN, Beano A, Bainter W, Angelova M, Al Idrissi E, Habazi MK, Alghamdi HA, Almanjomi F, Al Shehri M, Elsidig N, Alaa Eldin M, Knipe DM, AlZahrani M, Geha RS.

J Clin Invest. 2017 Dec 1;127(12):4415-4420. doi: 10.1172/JCI93486. Epub 2017 Nov 6.

13.

Intramuscular delivery of replication-defective herpes simplex virus gives antigen expression in muscle syncytia and improved protection against pathogenic HSV-2 strains.

Diaz F, Gregory S, Nakashima H, Viapiano MS, Knipe DM.

Virology. 2018 Jan 1;513:129-135. doi: 10.1016/j.virol.2017.10.011. Epub 2017 Oct 22.

14.

Role of Herpes Simplex Virus 1 γ34.5 in the Regulation of IRF3 Signaling.

Manivanh R, Mehrbach J, Knipe DM, Leib DA.

J Virol. 2017 Nov 14;91(23). pii: e01156-17. doi: 10.1128/JVI.01156-17. Print 2017 Dec 1.

15.

Keratinocytes produce IL-17c to protect peripheral nervous systems during human HSV-2 reactivation.

Peng T, Chanthaphavong RS, Sun S, Trigilio JA, Phasouk K, Jin L, Layton ED, Li AZ, Correnti CE, De van der Schueren W, Vazquez J, O'Day DR, Glass IA, Knipe DM, Wald A, Corey L, Zhu J.

J Exp Med. 2017 Aug 7;214(8):2315-2329. doi: 10.1084/jem.20160581. Epub 2017 Jun 29.

16.

Innate Immune Mechanisms and Herpes Simplex Virus Infection and Disease.

Kurt-Jones EA, Orzalli MH, Knipe DM.

Adv Anat Embryol Cell Biol. 2017;223:49-75. doi: 10.1007/978-3-319-53168-7_3. Review.

PMID:
28528439
17.

Viral gene products actively promote latent infection by epigenetic silencing mechanisms.

Knipe DM, Raja P, Lee J.

Curr Opin Virol. 2017 Apr;23:68-74. doi: 10.1016/j.coviro.2017.03.010. Epub 2017 Apr 14. Review.

18.

Relative Contributions of Herpes Simplex Virus 1 ICP0 and vhs to Loss of Cellular IFI16 Vary in Different Human Cell Types.

Orzalli MH, Broekema NM, Knipe DM.

J Virol. 2016 Aug 26;90(18):8351-9. doi: 10.1128/JVI.00939-16. Print 2016 Sep 15.

19.

Production of immunogenic West Nile virus-like particles using a herpes simplex virus 1 recombinant vector.

Taylor TJ, Diaz F, Colgrove RC, Bernard KA, DeLuca NA, Whelan SPJ, Knipe DM.

Virology. 2016 Sep;496:186-193. doi: 10.1016/j.virol.2016.06.006. Epub 2016 Jun 20.

20.

HSV-1 ICP27 targets the TBK1-activated STING signalsome to inhibit virus-induced type I IFN expression.

Christensen MH, Jensen SB, Miettinen JJ, Luecke S, Prabakaran T, Reinert LS, Mettenleiter T, Chen ZJ, Knipe DM, Sandri-Goldin RM, Enquist LW, Hartmann R, Mogensen TH, Rice SA, Nyman TA, Matikainen S, Paludan SR.

EMBO J. 2016 Jul 1;35(13):1385-99. doi: 10.15252/embj.201593458. Epub 2016 May 27.

21.

A Herpesviral Lytic Protein Regulates the Structure of Latent Viral Chromatin.

Raja P, Lee JS, Pan D, Pesola JM, Coen DM, Knipe DM.

MBio. 2016 May 17;7(3). pii: e00633-16. doi: 10.1128/mBio.00633-16.

22.

Herpesviral ICP0 Protein Promotes Two Waves of Heterochromatin Removal on an Early Viral Promoter during Lytic Infection.

Lee JS, Raja P, Knipe DM.

MBio. 2016 Jan 12;7(1):e02007-15. doi: 10.1128/mBio.02007-15.

24.

History and genomic sequence analysis of the herpes simplex virus 1 KOS and KOS1.1 sub-strains.

Colgrove RC, Liu X, Griffiths A, Raja P, Deluca NA, Newman RM, Coen DM, Knipe DM.

Virology. 2016 Jan;487:215-21. doi: 10.1016/j.virol.2015.09.026. Epub 2015 Nov 5. Review.

25.

Clues to mechanisms of herpesviral latent infection and potential cures.

Knipe DM, Raja P, Lee JS.

Proc Natl Acad Sci U S A. 2015 Sep 29;112(39):11993-4. doi: 10.1073/pnas.1516224112. Epub 2015 Sep 21. No abstract available.

26.

Combined cytotoxic activity of an infectious, but non-replicative herpes simplex virus type 1 and plasmacytoid dendritic cells against tumour cells.

Thomann S, Boscheinen JB, Vogel K, Knipe DM, DeLuca N, Gross S, Schuler-Thurner B, Schuster P, Schmidt B.

Immunology. 2015 Oct;146(2):327-38. doi: 10.1111/imm.12509.

27.

Inhibition of O-Linked N-Acetylglucosamine Transferase Reduces Replication of Herpes Simplex Virus and Human Cytomegalovirus.

Angelova M, Ortiz-Meoz RF, Walker S, Knipe DM.

J Virol. 2015 Aug;89(16):8474-83. doi: 10.1128/JVI.01002-15. Epub 2015 Jun 3.

28.

Genome Sequencing and Analysis of Geographically Diverse Clinical Isolates of Herpes Simplex Virus 2.

Newman RM, Lamers SL, Weiner B, Ray SC, Colgrove RC, Diaz F, Jing L, Wang K, Saif S, Young S, Henn M, Laeyendecker O, Tobian AA, Cohen JI, Koelle DM, Quinn TC, Knipe DM.

J Virol. 2015 Aug;89(16):8219-32. doi: 10.1128/JVI.01303-15. Epub 2015 May 27.

29.

Global Diversity within and between Human Herpesvirus 1 and 2 Glycoproteins.

Lamers SL, Newman RM, Laeyendecker O, Tobian AA, Colgrove RC, Ray SC, Koelle DM, Cohen J, Knipe DM, Quinn TC.

J Virol. 2015 Aug;89(16):8206-18. doi: 10.1128/JVI.01302-15. Epub 2015 May 27.

31.

Rethinking the Response to Emerging Microbes: Vaccines and Therapeutics in the Ebola Era--a Conference at Harvard Medical School.

Knipe DM, Whelan SP.

J Virol. 2015 Aug;89(15):7446-8. doi: 10.1128/JVI.01251-15. Epub 2015 May 20.

32.

cGAS-mediated stabilization of IFI16 promotes innate signaling during herpes simplex virus infection.

Orzalli MH, Broekema NM, Diner BA, Hancks DC, Elde NC, Cristea IM, Knipe DM.

Proc Natl Acad Sci U S A. 2015 Apr 7;112(14):E1773-81. doi: 10.1073/pnas.1424637112. Epub 2015 Mar 23.

33.

Proteomic analysis of the herpes simplex virus 1 virion protein 16 transactivator protein in infected cells.

Suk H, Knipe DM.

Proteomics. 2015 Jun;15(12):1957-67. doi: 10.1002/pmic.201500020. Epub 2015 Apr 29.

34.

Nuclear sensing of viral DNA, epigenetic regulation of herpes simplex virus infection, and innate immunity.

Knipe DM.

Virology. 2015 May;479-480:153-9. doi: 10.1016/j.virol.2015.02.009. Epub 2015 Mar 3. Review.

35.

Heparin octasaccharide decoy liposomes inhibit replication of multiple viruses.

Hendricks GL, Velazquez L, Pham S, Qaisar N, Delaney JC, Viswanathan K, Albers L, Comolli JC, Shriver Z, Knipe DM, Kurt-Jones EA, Fygenson DK, Trevejo JM, Wang JP, Finberg RW.

Antiviral Res. 2015 Apr;116:34-44. doi: 10.1016/j.antiviral.2015.01.008. Epub 2015 Jan 28.

36.

HSV-1 remodels host telomeres to facilitate viral replication.

Deng Z, Kim ET, Vladimirova O, Dheekollu J, Wang Z, Newhart A, Liu D, Myers JL, Hensley SE, Moffat J, Janicki SM, Fraser NW, Knipe DM, Weitzman MD, Lieberman PM.

Cell Rep. 2014 Dec 24;9(6):2263-78. doi: 10.1016/j.celrep.2014.11.019. Epub 2014 Dec 11.

37.

Inhibition of LSD1 reduces herpesvirus infection, shedding, and recurrence by promoting epigenetic suppression of viral genomes.

Hill JM, Quenelle DC, Cardin RD, Vogel JL, Clement C, Bravo FJ, Foster TP, Bosch-Marce M, Raja P, Lee JS, Bernstein DI, Krause PR, Knipe DM, Kristie TM.

Sci Transl Med. 2014 Dec 3;6(265):265ra169. doi: 10.1126/scitranslmed.3010643.

38.

Identification of TRIM27 as a novel degradation target of herpes simplex virus 1 ICP0.

Conwell SE, White AE, Harper JW, Knipe DM.

J Virol. 2015 Jan;89(1):220-9. doi: 10.1128/JVI.02635-14. Epub 2014 Oct 15.

39.

Interferon γ-inducible protein (IFI) 16 transcriptionally regulates type i interferons and other interferon-stimulated genes and controls the interferon response to both DNA and RNA viruses.

Thompson MR, Sharma S, Atianand M, Jensen SB, Carpenter S, Knipe DM, Fitzgerald KA, Kurt-Jones EA.

J Biol Chem. 2014 Aug 22;289(34):23568-81. doi: 10.1074/jbc.M114.554147. Epub 2014 Jul 7.

40.

Cellular sensing of viral DNA and viral evasion mechanisms.

Orzalli MH, Knipe DM.

Annu Rev Microbiol. 2014;68:477-92. doi: 10.1146/annurev-micro-091313-103409. Epub 2014 Jun 16. Review.

41.

HIV integrase inhibitors block replication of alpha-, beta-, and gammaherpesviruses.

Yan Z, Bryant KF, Gregory SM, Angelova M, Dreyfus DH, Zhao XZ, Coen DM, Burke TR Jr, Knipe DM.

MBio. 2014 Jul 1;5(4):e01318-14. doi: 10.1128/mBio.01318-14.

42.

A promiscuous lipid-binding protein diversifies the subcellular sites of toll-like receptor signal transduction.

Bonham KS, Orzalli MH, Hayashi K, Wolf AI, Glanemann C, Weninger W, Iwasaki A, Knipe DM, Kagan JC.

Cell. 2014 Feb 13;156(4):705-16. doi: 10.1016/j.cell.2014.01.019.

43.

Genomic sequences of a low passage herpes simplex virus 2 clinical isolate and its plaque-purified derivative strain.

Colgrove R, Diaz F, Newman R, Saif S, Shea T, Young S, Henn M, Knipe DM.

Virology. 2014 Feb;450-451:140-5. doi: 10.1016/j.virol.2013.12.014. Epub 2013 Dec 31.

44.

A targeted RNA interference screen reveals novel epigenetic factors that regulate herpesviral gene expression.

Oh HS, Bryant KF, Nieland TJ, Mazumder A, Bagul M, Bathe M, Root DE, Knipe DM.

MBio. 2014 Feb 4;5(1):e01086-13. doi: 10.1128/mBio.01086-13.

45.

Summary and recommendations from a National Institute of Allergy and Infectious Diseases (NIAID) workshop on "Next Generation Herpes Simplex Virus Vaccines".

Knipe DM, Corey L, Cohen JI, Deal CD.

Vaccine. 2014 Mar 20;32(14):1561-2. doi: 10.1016/j.vaccine.2014.01.052. Epub 2014 Jan 28. No abstract available.

46.

Nuclear interferon-inducible protein 16 promotes silencing of herpesviral and transfected DNA.

Orzalli MH, Conwell SE, Berrios C, DeCaprio JA, Knipe DM.

Proc Natl Acad Sci U S A. 2013 Nov 19;110(47):E4492-501. doi: 10.1073/pnas.1316194110. Epub 2013 Nov 6.

47.

Herpes simplex virus US3 tegument protein inhibits Toll-like receptor 2 signaling at or before TRAF6 ubiquitination.

Sen J, Liu X, Roller R, Knipe DM.

Virology. 2013 May 10;439(2):65-73. doi: 10.1016/j.virol.2013.01.026. Epub 2013 Mar 7.

48.
49.

Identification of regulators of the innate immune response to cytosolic DNA and retroviral infection by an integrative approach.

Lee MN, Roy M, Ong SE, Mertins P, Villani AC, Li W, Dotiwala F, Sen J, Doench JG, Orzalli MH, Kramnik I, Knipe DM, Lieberman J, Carr SA, Hacohen N.

Nat Immunol. 2013 Feb;14(2):179-85. doi: 10.1038/ni.2509. Epub 2012 Dec 23.

50.

Snapshots: chromatin control of viral infection.

Knipe DM, Lieberman PM, Jung JU, McBride AA, Morris KV, Ott M, Margolis D, Nieto A, Nevels M, Parks RJ, Kristie TM.

Virology. 2013 Jan 5;435(1):141-56. doi: 10.1016/j.virol.2012.09.023. Review.

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