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Items: 1 to 50 of 626

1.

No Association Between Ljungan Virus Seropositivity and the Beta-Cell Damaging Process in the Finnish Type 1 Diabetes Prediction and Prevention Study Cohort.

Jääskeläinen AJ, Nurminen N, Kolehmainen P, Smura T, Tauriainen S, Toppari J, Ilonen J, Veijola R, Knip M, Hyöty H, Vapalahti O, Kallio-Kokko H.

Pediatr Infect Dis J. 2018 Oct 19. doi: 10.1097/INF.0000000000002201. [Epub ahead of print]

PMID:
30346370
2.

Early childhood CMV infection may decelerate the progression to clinical type 1 diabetes.

Ekman I, Vuorinen T, Knip M, Veijola R, Toppari J, Hyöty H, Kinnunen T, Ilonen J, Lempainen J.

Pediatr Diabetes. 2018 Oct 18. doi: 10.1111/pedi.12788. [Epub ahead of print]

PMID:
30338642
3.

Carotenoid Intake and Serum Concentration in Young Finnish Children and Their Relation with Fruit and Vegetable Consumption.

Prasad M, Takkinen HM, Uusitalo L, Tapanainen H, Ovaskainen ML, Alfthan G, Erlund I, Ahonen S, Åkerlund M, Toppari J, Ilonen J, Knip M, Veijola R, Virtanen SM.

Nutrients. 2018 Oct 17;10(10). pii: E1533. doi: 10.3390/nu10101533.

4.

Probiotic intervention in infancy is not associated with development of beta cell autoimmunity and type 1 diabetes.

Savilahti E, Härkönen T, Savilahti EM, Kukkonen K, Kuitunen M, Knip M.

Diabetologia. 2018 Sep 20. doi: 10.1007/s00125-018-4738-4. [Epub ahead of print] No abstract available.

PMID:
30238182
5.

Enterovirus infection during pregnancy is inversely associated with atopic disease in the offspring.

Korhonen L, Seiskari T, Lehtonen J, Puustinen L, Surcel HM, Haapala AM, Niemelä O, Virtanen SM, Honkanen H, Karjalainen M, Ilonen J, Veijola R, Knip M, Lönnrot M, Hyöty H.

Clin Exp Allergy. 2018 Sep 19. doi: 10.1111/cea.13280. [Epub ahead of print]

PMID:
30230072
6.

Prospects for primary prevention of type 1 diabetes by restoring a disappearing microbe.

Insel R, Knip M.

Pediatr Diabetes. 2018 Aug 22. doi: 10.1111/pedi.12756. [Epub ahead of print] Review.

PMID:
30136344
7.

Serum, plasma and erythrocyte membrane lipidomes in infants fed formula supplemented with bovine milk fat globule membranes.

Grip T, Dyrlund TS, Ahonen L, Domellöf M, Hernell O, Hyötyläinen T, Knip M, Lönnerdal B, Orešič M, Timby N.

Pediatr Res. 2018 Aug 4. doi: 10.1038/s41390-018-0130-9. [Epub ahead of print]

PMID:
30120403
8.

ISPAD Clinical Practice Consensus Guidelines 2018: Other complications and associated conditions in children and adolescents with type 1 diabetes.

Mahmud FH, Elbarbary NS, Fröhlich-Reiterer E, Holl RW, Kordonouri O, Knip M, Simmons K, Craig ME.

Pediatr Diabetes. 2018 Oct;19 Suppl 27:275-286. doi: 10.1111/pedi.12740. No abstract available.

PMID:
30066458
9.

ISPAD Clinical Practice Consensus Guidelines 2018: Stages of type 1 diabetes in children and adolescents.

Couper JJ, Haller MJ, Greenbaum CJ, Ziegler AG, Wherrett DK, Knip M, Craig ME.

Pediatr Diabetes. 2018 Oct;19 Suppl 27:20-27. doi: 10.1111/pedi.12734. No abstract available.

PMID:
30051639
10.

Dynamics of Plasma Lipidome in Progression to Islet Autoimmunity and Type 1 Diabetes - Type 1 Diabetes Prediction and Prevention Study (DIPP).

Lamichhane S, Ahonen L, Dyrlund TS, Kemppainen E, Siljander H, Hyöty H, Ilonen J, Toppari J, Veijola R, Hyötyläinen T, Knip M, Oresic M.

Sci Rep. 2018 Jul 13;8(1):10635. doi: 10.1038/s41598-018-28907-8.

11.

Effector T Cell Resistance to Suppression and STAT3 Signaling during the Development of Human Type 1 Diabetes.

Ihantola EL, Viisanen T, Gazali AM, Näntö-Salonen K, Juutilainen A, Moilanen L, Rintamäki R, Pihlajamäki J, Veijola R, Toppari J, Knip M, Ilonen J, Kinnunen T.

J Immunol. 2018 Aug 15;201(4):1144-1153. doi: 10.4049/jimmunol.1701199. Epub 2018 Jul 13.

PMID:
30006377
12.

Strain-Level Analysis of Mother-to-Child Bacterial Transmission during the First Few Months of Life.

Yassour M, Jason E, Hogstrom LJ, Arthur TD, Tripathi S, Siljander H, Selvenius J, Oikarinen S, Hyöty H, Virtanen SM, Ilonen J, Ferretti P, Pasolli E, Tett A, Asnicar F, Segata N, Vlamakis H, Lander ES, Huttenhower C, Knip M, Xavier RJ.

Cell Host Microbe. 2018 Jul 11;24(1):146-154.e4. doi: 10.1016/j.chom.2018.06.007.

PMID:
30001517
13.

Sex as a determinant of type 1 diabetes at diagnosis.

Turtinen M, Härkönen T, Parkkola A, Ilonen J, Knip M; Finnish Pediatric Diabetes Register.

Pediatr Diabetes. 2018 Nov;19(7):1221-1228. doi: 10.1111/pedi.12697. Epub 2018 Jun 17.

PMID:
29862628
14.

Characterization and non-parametric modeling of the developing serum proteome during infancy and early childhood.

Lietzén N, Cheng L, Moulder R, Siljander H, Laajala E, Härkönen T, Peet A, Vehtari A, Tillmann V, Knip M, Lähdesmäki H, Lahesmaa R.

Sci Rep. 2018 Apr 12;8(1):5883. doi: 10.1038/s41598-018-24019-5.

15.

Coxsackievirus B1 infections are associated with the initiation of insulin-driven autoimmunity that progresses to type 1 diabetes.

Sioofy-Khojine AB, Lehtonen J, Nurminen N, Laitinen OH, Oikarinen S, Huhtala H, Pakkanen O, Ruokoranta T, Hankaniemi MM, Toppari J, Vähä-Mäkilä M, Ilonen J, Veijola R, Knip M, Hyöty H.

Diabetologia. 2018 May;61(5):1193-1202. doi: 10.1007/s00125-018-4561-y. Epub 2018 Feb 5.

PMID:
29404673
16.

Infant Feeding in Relation to the Risk of Advanced Islet Autoimmunity and Type 1 Diabetes in Children With Increased Genetic Susceptibility: A Cohort Study.

Hakola L, Takkinen HM, Niinistö S, Ahonen S, Nevalainen J, Veijola R, Ilonen J, Toppari J, Knip M, Virtanen SM.

Am J Epidemiol. 2018 Jan 1;187(1):34-44. doi: 10.1093/aje/kwx191.

PMID:
29309515
17.

Class II HLA Genotype Association With First-Phase Insulin Response Is Explained by Islet Autoantibodies.

Koskinen MK, Lempainen J, Löyttyniemi E, Helminen O, Hekkala A, Härkönen T, Kiviniemi M, Simell O, Knip M, Ilonen J, Toppari J, Veijola R.

J Clin Endocrinol Metab. 2018 Aug 1;103(8):2870-2878. doi: 10.1210/jc.2017-02040.

PMID:
29300921
18.

Effect of Hydrolyzed Infant Formula vs Conventional Formula on Risk of Type 1 Diabetes: The TRIGR Randomized Clinical Trial.

Writing Group for the TRIGR Study Group, Knip M, Åkerblom HK, Al Taji E, Becker D, Bruining J, Castano L, Danne T, de Beaufort C, Dosch HM, Dupre J, Fraser WD, Howard N, Ilonen J, Konrad D, Kordonouri O, Krischer JP, Lawson ML, Ludvigsson J, Madacsy L, Mahon JL, Ormisson A, Palmer JP, Pozzilli P, Savilahti E, Serrano-Rios M, Songini M, Taback S, Vaarala O, White NH, Virtanen SM, Wasikowa R.

JAMA. 2018 Jan 2;319(1):38-48. doi: 10.1001/jama.2017.19826.

19.

HLA and non-HLA genes and familial predisposition to autoimmune diseases in families with a child affected by type 1 diabetes.

Parkkola A, Laine AP, Karhunen M, Härkönen T, Ryhänen SJ, Ilonen J, Knip M; Finnish Pediatric Diabetes Register.

PLoS One. 2017 Nov 28;12(11):e0188402. doi: 10.1371/journal.pone.0188402. eCollection 2017.

20.

Early life origin of type 1 diabetes.

Knip M, Luopajärvi K, Härkönen T.

Semin Immunopathol. 2017 Nov;39(6):653-667. doi: 10.1007/s00281-017-0665-6. Epub 2017 Nov 23. Review.

PMID:
29170800
21.

Enterovirus-associated changes in blood transcriptomic profiles of children with genetic susceptibility to type 1 diabetes.

Lietzen N, An LTT, Jaakkola MK, Kallionpää H, Oikarinen S, Mykkänen J, Knip M, Veijola R, Ilonen J, Toppari J, Hyöty H, Lahesmaa R, Elo LL.

Diabetologia. 2018 Feb;61(2):381-388. doi: 10.1007/s00125-017-4460-7. Epub 2017 Nov 8.

PMID:
29119244
22.

Exocrine pancreas function decreases during the progression of the beta-cell damaging process in young prediabetic children.

Kondrashova A, Nurminen N, Lehtonen J, Hyöty M, Toppari J, Ilonen J, Veijola R, Knip M, Hyöty H.

Pediatr Diabetes. 2018 May;19(3):398-402. doi: 10.1111/pedi.12592. Epub 2017 Oct 17.

PMID:
29044779
23.

Identification of a novel synaptic protein, TMTC3, involved in periventricular nodular heterotopia with intellectual disability and epilepsy.

Farhan SMK, Nixon KCJ, Everest M, Edwards TN, Long S, Segal D, Knip MJ, Arts HH, Chakrabarti R, Wang J, Robinson JF, Lee D, Mirsattari SM, Rupar CA, Siu VM; FORGE Canada Consortium, Poulter MO, Hegele RA, Kramer JM.

Hum Mol Genet. 2017 Nov 1;26(21):4278-4289. doi: 10.1093/hmg/ddx316.

24.

Modulation of Type 1 Diabetes Risk by the Intestinal Microbiome.

Knip M, Honkanen J.

Curr Diab Rep. 2017 Sep 23;17(11):105. doi: 10.1007/s11892-017-0933-9. Review.

PMID:
28942491
25.

Lipidomics of human umbilical cord serum: identification of unique sterol sulfates.

Wood PL, Siljander H, Knip M.

Future Sci OA. 2017 Apr 5;3(3):FSO193. doi: 10.4155/fsoa-2017-0012. eCollection 2017 Aug.

26.

Live attenuated enterovirus vaccine (OPV) is not associated with islet autoimmunity in children with genetic susceptibility to type 1 diabetes: prospective cohort study.

Viskari H, Oikarinen S, Hoppu S, Vuorinen T, Huhtala H, Toppari J, Veijola R, Ilonen J, Knip M, Hyöty H.

Diabetologia. 2018 Jan;61(1):203-209. doi: 10.1007/s00125-017-4410-4. Epub 2017 Sep 2.

PMID:
28866779
27.

Vitamin D intake during the first 4 years and onset of asthma by age 5: A nested case-control study.

Nwaru BI, Hadkhale K, Hämäläinen N, Takkinen HM, Ahonen S, Ilonen J, Toppari J, Niemelä O, Haapala AM, Veijola R, Knip M, Virtanen SM.

Pediatr Allergy Immunol. 2017 Nov;28(7):641-648. doi: 10.1111/pai.12773. Epub 2017 Sep 8.

PMID:
28815786
28.

Transglutaminase antibodies and celiac disease in children with type 1 diabetes and in their family members.

Parkkola A, Härkönen T, Ryhänen SJ, Uibo R, Ilonen J, Knip M; Finnish Pediatric Diabetes Register.

Pediatr Diabetes. 2018 Mar;19(2):305-313. doi: 10.1111/pedi.12563. Epub 2017 Jul 26.

PMID:
28745034
29.

Intestinal virome changes precede autoimmunity in type I diabetes-susceptible children.

Zhao G, Vatanen T, Droit L, Park A, Kostic AD, Poon TW, Vlamakis H, Siljander H, Härkönen T, Hämäläinen AM, Peet A, Tillmann V, Ilonen J, Wang D, Knip M, Xavier RJ, Virgin HW.

Proc Natl Acad Sci U S A. 2017 Jul 25;114(30):E6166-E6175. doi: 10.1073/pnas.1706359114. Epub 2017 Jul 10.

30.

Avoidance of Cow's Milk-Based Formula for At-Risk Infants Does Not Reduce Development of Celiac Disease: A Randomized Controlled Trial.

Hyytinen M, Savilahti E, Virtanen SM, Härkönen T, Ilonen J, Luopajärvi K, Uibo R, Vaarala O, Åkerblom HK, Knip M; Finnish TRIGR Pilot Study Group.

Gastroenterology. 2017 Oct;153(4):961-970.e3. doi: 10.1053/j.gastro.2017.06.049. Epub 2017 Jul 5.

PMID:
28687275
31.

Type 1 diabetes mellitus is a heterogeneous disease.

Knip M.

Nat Rev Endocrinol. 2017 Sep;13(9):1. doi: 10.1038/nrendo.2017.84. Epub 2017 Jul 7. No abstract available.

PMID:
28685767
32.

Early childhood infections precede development of beta-cell autoimmunity and type 1 diabetes in children with HLA-conferred disease risk.

Mustonen N, Siljander H, Peet A, Tillmann V, Härkönen T, Ilonen J, Hyöty H, Knip M; DIABIMMUNE Study Group.

Pediatr Diabetes. 2018 Mar;19(2):293-299. doi: 10.1111/pedi.12547. Epub 2017 Jun 9.

PMID:
28597957
33.

Primary islet autoantibody at initial seroconversion and autoantibodies at diagnosis of type 1 diabetes as markers of disease heterogeneity.

Ilonen J, Lempainen J, Hammais A, Laine AP, Härkönen T, Toppari J, Veijola R, Knip M; Finnish Pediatric Diabetes Register.

Pediatr Diabetes. 2018 Mar;19(2):284-292. doi: 10.1111/pedi.12545. Epub 2017 Jun 9.

PMID:
28597949
34.

Metabolically inactive insulin: friend or foe in the prevention of autoimmune diabetes?

Knip M.

Diabetologia. 2017 Aug;60(8):1382-1384. doi: 10.1007/s00125-017-4319-y. Epub 2017 Jun 3.

PMID:
28580535
35.

Ketoacidosis at diagnosis of type 1 diabetes: Effect of prospective studies with newborn genetic screening and follow up of risk children.

Hekkala AM, Ilonen J, Toppari J, Knip M, Veijola R.

Pediatr Diabetes. 2018 Mar;19(2):314-319. doi: 10.1111/pedi.12541. Epub 2017 May 23.

PMID:
28544185
36.

Fatty acid status in infancy is associated with the risk of type 1 diabetes-associated autoimmunity.

Niinistö S, Takkinen HM, Erlund I, Ahonen S, Toppari J, Ilonen J, Veijola R, Knip M, Vaarala O, Virtanen SM.

Diabetologia. 2017 Jul;60(7):1223-1233. doi: 10.1007/s00125-017-4280-9. Epub 2017 May 4.

PMID:
28474159
37.

Characterisation of rapid progressors to type 1 diabetes among children with HLA-conferred disease susceptibility.

Pöllänen PM, Lempainen J, Laine AP, Toppari J, Veijola R, Vähäsalo P, Ilonen J, Siljander H, Knip M.

Diabetologia. 2017 Jul;60(7):1284-1293. doi: 10.1007/s00125-017-4258-7. Epub 2017 Mar 31.

PMID:
28364254
38.

Diabetes: Loss of β-cell mass - an acute event before T1DM presentation?

Knip M.

Nat Rev Endocrinol. 2017 May;13(5):253-254. doi: 10.1038/nrendo.2017.33. Epub 2017 Mar 31. No abstract available.

PMID:
28361928
39.

Eliminating cows' milk, but not wheat, barley or rye, increases the risk of growth deceleration and nutritional inadequacies.

Tuokkola J, Luukkainen P, Nevalainen J, Ahonen S, Toppari J, Ilonen J, Veijola R, Knip M, Virtanen SM, Kaila M.

Acta Paediatr. 2017 Jul;106(7):1142-1149. doi: 10.1111/apa.13846. Epub 2017 Apr 25.

PMID:
28345135
40.

Serum carotenoid and tocopherol concentrations and risk of asthma in childhood: a nested case-control study.

Hämäläinen N, Nwaru BI, Erlund I, Takkinen HM, Ahonen S, Toppari J, Ilonen J, Veijola R, Knip M, Kaila M, Virtanen SM.

Clin Exp Allergy. 2017 Mar;47(3):401-409. doi: 10.1111/cea.12904.

PMID:
28198577
41.

The association of the HLA-A*24:02, B*39:01 and B*39:06 alleles with type 1 diabetes is restricted to specific HLA-DR/DQ haplotypes in Finns.

Mikk ML, Heikkinen T, El-Amir MI, Kiviniemi M, Laine AP, Härkönen T, Veijola R, Toppari J, Knip M, Ilonen J; Finnish Paediatric Diabetes Register.

HLA. 2017 Apr;89(4):215-224. doi: 10.1111/tan.12967. Epub 2017 Feb 10.

PMID:
28185422
42.

Correction: B-Cell Responses to Human Bocaviruses 1-4: New Insights from a Childhood Follow-Up Study.

Kantola K, Hedman L, Tanner L, Simell V, Mäkinen M, Partanen J, Sadeghi M, Veijola R, Knip M, Ilonen J, Hyöty H, Toppari J, Simell O, Hedman K, Söderlund-Venermo M.

PLoS One. 2017 Feb 8;12(2):e0172078. doi: 10.1371/journal.pone.0172078. eCollection 2017.

43.

Circulating CXCR5+PD-1+ICOS+ Follicular T Helper Cells Are Increased Close to the Diagnosis of Type 1 Diabetes in Children With Multiple Autoantibodies.

Viisanen T, Ihantola EL, Näntö-Salonen K, Hyöty H, Nurminen N, Selvenius J, Juutilainen A, Moilanen L, Pihlajamäki J, Veijola R, Toppari J, Knip M, Ilonen J, Kinnunen T.

Diabetes. 2017 Feb;66(2):437-447. doi: 10.2337/db16-0714. Epub 2016 Oct 10.

44.

Detection of enteroviruses in stools precedes islet autoimmunity by several months: possible evidence for slowly operating mechanisms in virus-induced autoimmunity.

Honkanen H, Oikarinen S, Nurminen N, Laitinen OH, Huhtala H, Lehtonen J, Ruokoranta T, Hankaniemi MM, Lecouturier V, Almond JW, Tauriainen S, Simell O, Ilonen J, Veijola R, Viskari H, Knip M, Hyöty H.

Diabetologia. 2017 Mar;60(3):424-431. doi: 10.1007/s00125-016-4177-z. Epub 2017 Jan 9.

PMID:
28070615
45.

A drop in the circulating concentrations of soluble receptor for advanced glycation end products is associated with seroconversion to autoantibody positivity but not with subsequent progression to clinical disease in children en route to type 1 diabetes.

Salonen KM, Ryhänen SJ, Forbes JM, Härkönen T, Ilonen J, Simell O, Veijola R, Groop PH, Knip M.

Diabetes Metab Res Rev. 2017 May;33(4). doi: 10.1002/dmrr.2872. Epub 2017 Jan 23.

PMID:
27883367
46.

Reply to "Antibiotics, intestinal dysbiosis and risk of celiac disease" by Hakim Rahmoune et al. [Digestive and Liver Disease].

Simre K, Uibo O, Tillmann V, Knip M, Uibo R.

Dig Liver Dis. 2017 Jan;49(1):106-107. doi: 10.1016/j.dld.2016.10.009. Epub 2016 Oct 25. No abstract available.

PMID:
27840057
47.

Reclassification of asymptomatic beta cell autoimmunity: a critical perspective.

Knip M, Selvenius J, Siljander H, Veijola R.

Diabetologia. 2017 Jan;60(1):39-42. Epub 2016 Oct 27.

PMID:
27787620
48.

Regional differences in milk and complementary feeding patterns in infants participating in an international nutritional type 1 diabetes prevention trial.

Nucci AM, Virtanen SM, Sorkio S, Bärlund S, Cuthbertson D, Uusitalo U, Lawson ML, Salonen M, Berseth CL, Ormisson A, Lehtonen E, Savilahti E, Becker DJ, Dupré J, Krischer JP, Knip M, Åkerblom HK; TRIGR Investigators.

Matern Child Nutr. 2017 Jul;13(3). doi: 10.1111/mcn.12354. Epub 2016 Oct 7.

49.

Human enterovirus and rhinovirus infections are associated with otitis media in a prospective birth cohort study.

Seppälä E, Sillanpää S, Nurminen N, Huhtala H, Toppari J, Ilonen J, Veijola R, Knip M, Sipilä M, Laranne J, Oikarinen S, Hyöty H.

J Clin Virol. 2016 Dec;85:1-6. doi: 10.1016/j.jcv.2016.10.010. Epub 2016 Oct 20.

PMID:
27780081
50.

Exploring the risk factors for differences in the cumulative incidence of coeliac disease in two neighboring countries: the prospective DIABIMMUNE study.

Simre K, Uibo O, Peet A, Tillmann V, Kool P, Hämäläinen AM, Härkönen T, Siljander H, Virtanen S, Ilonen J, Knip M, Uibo R; DIABIMMUNE Study Group.

Dig Liver Dis. 2016 Nov;48(11):1296-1301. doi: 10.1016/j.dld.2016.06.029. Epub 2016 Jul 6.

PMID:
27499360

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