Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 653

1.

Longitudinal Pattern of First-Phase Insulin Response Is Associated with Genetic Variants Outside the Class II HLA Region in Children with Multiple Autoantibodies.

Koskinen MK, Mikk ML, Laine AP, Lempainen J, Löyttyniemi E, Vähäsalo P, Hekkala A, Härkönen T, Kiviniemi M, Simell O, Knip M, Veijola R, Ilonen J, Toppari J.

Diabetes. 2019 Oct 7. pii: db190329. doi: 10.2337/db19-0329. [Epub ahead of print]

PMID:
31591105
2.

Coeliac disease and HLA-conferred susceptibility to autoimmunity are associated with IgE sensitization in young children.

Mustonen N, Siljander H, Peet A, Tillmann V, Härkönen T, Niemelä O, Uibo R, Ilonen J, Knip M; DIABIMMUNE Study Group.

Allergy. 2019 Sep 17. doi: 10.1111/all.14055. [Epub ahead of print] No abstract available.

PMID:
31531864
3.

Circulating metabolites in progression to islet autoimmunity and type 1 diabetes.

Lamichhane S, Kemppainen E, Trošt K, Siljander H, Hyöty H, Ilonen J, Toppari J, Veijola R, Hyötyläinen T, Knip M, Orešič M.

Diabetologia. 2019 Aug 23. doi: 10.1007/s00125-019-04980-0. [Epub ahead of print]

PMID:
31444528
4.

Association of Cereal, Gluten, and Dietary Fiber Intake With Islet Autoimmunity and Type 1 Diabetes.

Hakola L, Miettinen ME, Syrjälä E, Åkerlund M, Takkinen HM, Korhonen TE, Ahonen S, Ilonen J, Toppari J, Veijola R, Nevalainen J, Knip M, Virtanen SM.

JAMA Pediatr. 2019 Aug 12. doi: 10.1001/jamapediatrics.2019.2564. [Epub ahead of print]

PMID:
31403683
5.

Characteristics of familial type 1 diabetes: effects of the relationship to the affected family member on phenotype and genotype at diagnosis.

Turtinen M, Härkönen T, Parkkola A, Ilonen J, Knip M; Finnish Pediatric Diabetes Register.

Diabetologia. 2019 Jul 25. doi: 10.1007/s00125-019-4952-8. [Epub ahead of print]

PMID:
31346657
6.

Characteristics of Slow Progression to Type 1 Diabetes in Children With Increased HLA-Conferred Disease Risk.

Pöllänen PM, Lempainen J, Laine AP, Toppari J, Veijola R, Ilonen J, Siljander H, Knip M.

J Clin Endocrinol Metab. 2019 Nov 1;104(11):5585-5594. doi: 10.1210/jc.2019-01069.

PMID:
31314077
7.

Early Detection of Peripheral Blood Cell Signature in Children Developing β-Cell Autoimmunity at a Young Age.

Kallionpää H, Somani J, Tuomela S, Ullah U, de Albuquerque R, Lönnberg T, Komsi E, Siljander H, Honkanen J, Härkönen T, Peet A, Tillmann V, Chandra V, Anagandula MK, Frisk G, Otonkoski T, Rasool O, Lund R, Lähdesmäki H, Knip M, Lahesmaa R.

Diabetes. 2019 Oct;68(10):2024-2034. doi: 10.2337/db19-0287. Epub 2019 Jul 16.

PMID:
31311800
8.

Circulating CXCR5-PD-1hi peripheral T helper cells are associated with progression to type 1 diabetes.

Ekman I, Ihantola EL, Viisanen T, Rao DA, Näntö-Salonen K, Knip M, Veijola R, Toppari J, Ilonen J, Kinnunen T.

Diabetologia. 2019 Sep;62(9):1681-1688. doi: 10.1007/s00125-019-4936-8. Epub 2019 Jul 3.

9.

Microbiome and type 1 diabetes.

Siljander H, Honkanen J, Knip M.

EBioMedicine. 2019 Aug;46:512-521. doi: 10.1016/j.ebiom.2019.06.031. Epub 2019 Jun 27. Review.

10.

Early childhood infections and the use of antibiotics and antipyretic-analgesics in Finland, Estonia and Russian Karelia.

Mustonen N, Siljander H, Peet A, Tillmann V, Härkönen T, Ilonen J, Hyöty H, Knip M; DIABIMMUNE Study Group.

Acta Paediatr. 2019 Nov;108(11):2075-2082. doi: 10.1111/apa.14874. Epub 2019 Jun 23.

PMID:
31132164
11.

A Joint Modeling Approach for Childhood Meat, Fish and Egg Consumption and the Risk of Advanced Islet Autoimmunity.

Syrjälä E, Nevalainen J, Peltonen J, Takkinen HM, Hakola L, Åkerlund M, Veijola R, Ilonen J, Toppari J, Knip M, Virtanen SM.

Sci Rep. 2019 May 23;9(1):7760. doi: 10.1038/s41598-019-44196-1.

12.

Age at Seroconversion, HLA Genotype, and Specificity of Autoantibodies in Progression of Islet Autoimmunity in Childhood.

Bauer W, Veijola R, Lempainen J, Kiviniemi M, Härkönen T, Toppari J, Knip M, Gyenesei A, Ilonen J.

J Clin Endocrinol Metab. 2019 Oct 1;104(10):4521-4530. doi: 10.1210/jc.2019-00421.

PMID:
31120497
13.

Persistent Alterations in Plasma Lipid Profiles Before Introduction of Gluten in the Diet Associated With Progression to Celiac Disease.

Sen P, Carlsson C, Virtanen SM, Simell S, Hyöty H, Ilonen J, Toppari J, Veijola R, Hyötyläinen T, Knip M, Orešič M.

Clin Transl Gastroenterol. 2019 May 22;10(5):1-10. doi: 10.14309/ctg.0000000000000044.

14.

Individual components of the SWI/SNF chromatin remodelling complex have distinct roles in memory neurons of the Drosophila mushroom body.

Chubak MC, Nixon KCJ, Stone MH, Raun N, Rice SL, Sarikahya M, Jones SG, Lyons TA, Jakub TE, Mainland RLM, Knip MJ, Edwards TN, Kramer JM.

Dis Model Mech. 2019 Mar 25;12(3). pii: dmm037325. doi: 10.1242/dmm.037325.

15.

Early-life exposure to common virus infections did not differ between coeliac disease patients and controls.

Simre K, Uibo O, Peet A, Puustinen L, Oikarainen S, Tamminen K, Blazevic V, Tillmann V, Hämäläinen AM, Härkönen T, Siljander H, Virtanen SM, Ilonen J, Hyöty H, Knip M, Uibo R; DIABIMMUNE Study Group.

Acta Paediatr. 2019 Sep;108(9):1709-1716. doi: 10.1111/apa.14791. Epub 2019 Apr 11.

PMID:
30896051
16.

Rhinoviruses in infancy and risk of immunoglobulin E sensitization.

Korhonen L, Oikarinen S, Lehtonen J, Mustonen N, Tyni I, Niemelä O, Honkanen H, Huhtala H, Ilonen J, Hämäläinen AM, Peet A, Tillmann V, Siljander H, Knip M, Lönnrot M, Hyöty H; DIABIMMUNE Study Group.

J Med Virol. 2019 Aug;91(8):1470-1478. doi: 10.1002/jmv.25455. Epub 2019 Mar 25.

PMID:
30866076
17.

Development of T cell immunity to norovirus and rotavirus in children under five years of age.

Malm M, Hyöty H, Knip M, Vesikari T, Blazevic V.

Sci Rep. 2019 Mar 1;9(1):3199. doi: 10.1038/s41598-019-39840-9.

18.

FOXP3+ Regulatory T Cell Compartment Is Altered in Children With Newly Diagnosed Type 1 Diabetes but Not in Autoantibody-Positive at-Risk Children.

Viisanen T, Gazali AM, Ihantola EL, Ekman I, Näntö-Salonen K, Veijola R, Toppari J, Knip M, Ilonen J, Kinnunen T.

Front Immunol. 2019 Jan 22;10:19. doi: 10.3389/fimmu.2019.00019. eCollection 2019.

19.

Publisher Correction: Genomic variation and strain-specific functional adaptation in the human gut microbiome during early life.

Vatanen T, Plichta DR, Somani J, Münch PC, Arthur TD, Hall AB, Rudolf S, Oakeley EJ, Ke X, Young RA, Haiser HJ, Kolde R, Yassour M, Luopajärvi K, Siljander H, Virtanen SM, Ilonen J, Uibo R, Tillmann V, Mokurov S, Dorshakova N, Porter JA, McHardy AC, Lähdesmäki H, Vlamakis H, Huttenhower C, Knip M, Xavier RJ.

Nat Microbiol. 2019 Mar;4(3):545. doi: 10.1038/s41564-019-0393-x.

PMID:
30723264
20.

Development of atopic sensitization in Finnish and Estonian children: A latent class analysis in a multicenter cohort.

Schmidt F, Hose AJ, Mueller-Rompa S, Brick T, Hämäläinen AM, Peet A, Tillmann V, Niemelä O, Siljander H, Knip M, Weber J, von Mutius E, Ege MJ; DIABIMMUNE Study Group.

J Allergy Clin Immunol. 2019 May;143(5):1904-1913.e9. doi: 10.1016/j.jaci.2018.12.1014. Epub 2019 Jan 23.

PMID:
30682459
21.

Cord-Blood Lipidome in Progression to Islet Autoimmunity and Type 1 Diabetes.

Lamichhane S, Ahonen L, Dyrlund TS, Dickens AM, Siljander H, Hyöty H, Ilonen J, Toppari J, Veijola R, Hyötyläinen T, Knip M, Oresic M.

Biomolecules. 2019 Jan 21;9(1). pii: E33. doi: 10.3390/biom9010033.

22.

Serum 25-Hydroxyvitamin D Concentrations at Birth in Children Screened for HLA-DQB1 Conferred Risk for Type 1 Diabetes.

Mäkinen M, Löyttyniemi E, Koskinen M, Vähä-Mäkilä M, Siljander H, Nurmio M, Mykkänen J, Virtanen SM, Simell O, Hyöty H, Ilonen J, Knip M, Veijola R, Toppari J.

J Clin Endocrinol Metab. 2019 Jun 1;104(6):2277-2285. doi: 10.1210/jc.2018-02094.

23.

Genomic variation and strain-specific functional adaptation in the human gut microbiome during early life.

Vatanen T, Plichta DR, Somani J, Münch PC, Arthur TD, Hall AB, Rudolf S, Oakeley EJ, Ke X, Young RA, Haiser HJ, Kolde R, Yassour M, Luopajärvi K, Siljander H, Virtanen SM, Ilonen J, Uibo R, Tillmann V, Mokurov S, Dorshakova N, Porter JA, McHardy AC, Lähdesmäki H, Vlamakis H, Huttenhower C, Knip M, Xavier RJ.

Nat Microbiol. 2019 Mar;4(3):470-479. doi: 10.1038/s41564-018-0321-5. Epub 2018 Dec 17. Erratum in: Nat Microbiol. 2019 Feb 5;:.

24.

Activation of immune receptor Rx1 triggers distinct immune responses culminating in cell death after 4 hours.

Knip M, Richard MMS, Oskam L, van Engelen HTD, Aalders T, Takken FLW.

Mol Plant Pathol. 2019 Apr;20(4):575-588. doi: 10.1111/mpp.12776. Epub 2019 Jan 30.

25.

Developing a vaccine for type 1 diabetes by targeting coxsackievirus B.

Hyöty H, Leon F, Knip M.

Expert Rev Vaccines. 2018 Dec;17(12):1071-1083. doi: 10.1080/14760584.2018.1548281. Epub 2018 Nov 29. Review.

PMID:
30449209
26.

No evidence of the role of early chemical exposure in the development of β-cell autoimmunity.

Salo HM, Koponen J, Kiviranta H, Rantakokko P, Honkanen J, Härkönen T, Ilonen J, Virtanen SM, Tillmann V, Knip M, Vaarala O; DIABIMMUNE Study Group.

Environ Sci Pollut Res Int. 2019 Jan;26(2):1370-1378. doi: 10.1007/s11356-018-3659-6. Epub 2018 Nov 13.

27.

A longitudinal plasma lipidomics dataset from children who developed islet autoimmunity and type 1 diabetes.

Lamichhane S, Ahonen L, Dyrlund TS, Siljander H, Hyöty H, Ilonen J, Toppari J, Veijola R, Hyötyläinen T, Knip M, Orešič M.

Sci Data. 2018 Nov 13;5:180250. doi: 10.1038/sdata.2018.250.

28.

No Association Between Ljungan Virus Seropositivity and the Beta-cell Damaging Process in the Finnish Type 1 Diabetes Prediction and Prevention Study Cohort.

Jääskeläinen AJ, Nurminen N, Kolehmainen P, Smura T, Tauriainen S, Toppari J, Ilonen J, Veijola R, Knip M, Hyöty H, Vapalahti O, Kallio-Kokko H.

Pediatr Infect Dis J. 2019 Mar;38(3):314-316. doi: 10.1097/INF.0000000000002201.

PMID:
30346370
29.

Early childhood CMV infection may decelerate the progression to clinical type 1 diabetes.

Ekman I, Vuorinen T, Knip M, Veijola R, Toppari J, Hyöty H, Kinnunen T, Ilonen J, Lempainen J.

Pediatr Diabetes. 2019 Feb;20(1):73-77. doi: 10.1111/pedi.12788. Epub 2018 Nov 19.

PMID:
30338642
30.

Carotenoid Intake and Serum Concentration in Young Finnish Children and Their Relation with Fruit and Vegetable Consumption.

Prasad M, Takkinen HM, Uusitalo L, Tapanainen H, Ovaskainen ML, Alfthan G, Erlund I, Ahonen S, Åkerlund M, Toppari J, Ilonen J, Knip M, Veijola R, Virtanen SM.

Nutrients. 2018 Oct 17;10(10). pii: E1533. doi: 10.3390/nu10101533.

31.

Probiotic intervention in infancy is not associated with development of beta cell autoimmunity and type 1 diabetes.

Savilahti E, Härkönen T, Savilahti EM, Kukkonen K, Kuitunen M, Knip M.

Diabetologia. 2018 Dec;61(12):2668-2670. doi: 10.1007/s00125-018-4738-4. Epub 2018 Sep 20. No abstract available.

PMID:
30238182
32.

Enterovirus infection during pregnancy is inversely associated with atopic disease in the offspring.

Korhonen L, Seiskari T, Lehtonen J, Puustinen L, Surcel HM, Haapala AM, Niemelä O, Virtanen SM, Honkanen H, Karjalainen M, Ilonen J, Veijola R, Knip M, Lönnrot M, Hyöty H.

Clin Exp Allergy. 2018 Dec;48(12):1698-1704. doi: 10.1111/cea.13280. Epub 2018 Oct 16.

PMID:
30230072
33.

Prospects for primary prevention of type 1 diabetes by restoring a disappearing microbe.

Insel R, Knip M.

Pediatr Diabetes. 2018 Dec;19(8):1400-1406. doi: 10.1111/pedi.12756. Epub 2018 Sep 25. Review.

PMID:
30136344
34.

Serum, plasma and erythrocyte membrane lipidomes in infants fed formula supplemented with bovine milk fat globule membranes.

Grip T, Dyrlund TS, Ahonen L, Domellöf M, Hernell O, Hyötyläinen T, Knip M, Lönnerdal B, Orešič M, Timby N.

Pediatr Res. 2018 Nov;84(5):726-732. doi: 10.1038/s41390-018-0130-9. Epub 2018 Aug 4.

PMID:
30120403
35.

ISPAD Clinical Practice Consensus Guidelines 2018: Other complications and associated conditions in children and adolescents with type 1 diabetes.

Mahmud FH, Elbarbary NS, Fröhlich-Reiterer E, Holl RW, Kordonouri O, Knip M, Simmons K, Craig ME.

Pediatr Diabetes. 2018 Oct;19 Suppl 27:275-286. doi: 10.1111/pedi.12740. No abstract available.

36.

ISPAD Clinical Practice Consensus Guidelines 2018: Stages of type 1 diabetes in children and adolescents.

Couper JJ, Haller MJ, Greenbaum CJ, Ziegler AG, Wherrett DK, Knip M, Craig ME.

Pediatr Diabetes. 2018 Oct;19 Suppl 27:20-27. doi: 10.1111/pedi.12734. No abstract available.

PMID:
30051639
37.

Dynamics of Plasma Lipidome in Progression to Islet Autoimmunity and Type 1 Diabetes - Type 1 Diabetes Prediction and Prevention Study (DIPP).

Lamichhane S, Ahonen L, Dyrlund TS, Kemppainen E, Siljander H, Hyöty H, Ilonen J, Toppari J, Veijola R, Hyötyläinen T, Knip M, Oresic M.

Sci Rep. 2018 Jul 13;8(1):10635. doi: 10.1038/s41598-018-28907-8.

38.

Effector T Cell Resistance to Suppression and STAT3 Signaling during the Development of Human Type 1 Diabetes.

Ihantola EL, Viisanen T, Gazali AM, Näntö-Salonen K, Juutilainen A, Moilanen L, Rintamäki R, Pihlajamäki J, Veijola R, Toppari J, Knip M, Ilonen J, Kinnunen T.

J Immunol. 2018 Aug 15;201(4):1144-1153. doi: 10.4049/jimmunol.1701199. Epub 2018 Jul 13.

39.

Strain-Level Analysis of Mother-to-Child Bacterial Transmission during the First Few Months of Life.

Yassour M, Jason E, Hogstrom LJ, Arthur TD, Tripathi S, Siljander H, Selvenius J, Oikarinen S, Hyöty H, Virtanen SM, Ilonen J, Ferretti P, Pasolli E, Tett A, Asnicar F, Segata N, Vlamakis H, Lander ES, Huttenhower C, Knip M, Xavier RJ.

Cell Host Microbe. 2018 Jul 11;24(1):146-154.e4. doi: 10.1016/j.chom.2018.06.007.

40.

Sex as a determinant of type 1 diabetes at diagnosis.

Turtinen M, Härkönen T, Parkkola A, Ilonen J, Knip M; Finnish Pediatric Diabetes Register.

Pediatr Diabetes. 2018 Nov;19(7):1221-1228. doi: 10.1111/pedi.12697. Epub 2018 Jun 17.

PMID:
29862628
41.

Characterization and non-parametric modeling of the developing serum proteome during infancy and early childhood.

Lietzén N, Cheng L, Moulder R, Siljander H, Laajala E, Härkönen T, Peet A, Vehtari A, Tillmann V, Knip M, Lähdesmäki H, Lahesmaa R.

Sci Rep. 2018 Apr 12;8(1):5883. doi: 10.1038/s41598-018-24019-5.

42.

Coxsackievirus B1 infections are associated with the initiation of insulin-driven autoimmunity that progresses to type 1 diabetes.

Sioofy-Khojine AB, Lehtonen J, Nurminen N, Laitinen OH, Oikarinen S, Huhtala H, Pakkanen O, Ruokoranta T, Hankaniemi MM, Toppari J, Vähä-Mäkilä M, Ilonen J, Veijola R, Knip M, Hyöty H.

Diabetologia. 2018 May;61(5):1193-1202. doi: 10.1007/s00125-018-4561-y. Epub 2018 Feb 5.

PMID:
29404673
43.

Infant Feeding in Relation to the Risk of Advanced Islet Autoimmunity and Type 1 Diabetes in Children With Increased Genetic Susceptibility: A Cohort Study.

Hakola L, Takkinen HM, Niinistö S, Ahonen S, Nevalainen J, Veijola R, Ilonen J, Toppari J, Knip M, Virtanen SM.

Am J Epidemiol. 2018 Jan 1;187(1):34-44. doi: 10.1093/aje/kwx191.

PMID:
29309515
44.

Class II HLA Genotype Association With First-Phase Insulin Response Is Explained by Islet Autoantibodies.

Koskinen MK, Lempainen J, Löyttyniemi E, Helminen O, Hekkala A, Härkönen T, Kiviniemi M, Simell O, Knip M, Ilonen J, Toppari J, Veijola R.

J Clin Endocrinol Metab. 2018 Aug 1;103(8):2870-2878. doi: 10.1210/jc.2017-02040.

45.

Effect of Hydrolyzed Infant Formula vs Conventional Formula on Risk of Type 1 Diabetes: The TRIGR Randomized Clinical Trial.

Writing Group for the TRIGR Study Group, Knip M, Åkerblom HK, Al Taji E, Becker D, Bruining J, Castano L, Danne T, de Beaufort C, Dosch HM, Dupre J, Fraser WD, Howard N, Ilonen J, Konrad D, Kordonouri O, Krischer JP, Lawson ML, Ludvigsson J, Madacsy L, Mahon JL, Ormisson A, Palmer JP, Pozzilli P, Savilahti E, Serrano-Rios M, Songini M, Taback S, Vaarala O, White NH, Virtanen SM, Wasikowa R.

JAMA. 2018 Jan 2;319(1):38-48. doi: 10.1001/jama.2017.19826.

46.

HLA and non-HLA genes and familial predisposition to autoimmune diseases in families with a child affected by type 1 diabetes.

Parkkola A, Laine AP, Karhunen M, Härkönen T, Ryhänen SJ, Ilonen J, Knip M; Finnish Pediatric Diabetes Register.

PLoS One. 2017 Nov 28;12(11):e0188402. doi: 10.1371/journal.pone.0188402. eCollection 2017.

47.

Early life origin of type 1 diabetes.

Knip M, Luopajärvi K, Härkönen T.

Semin Immunopathol. 2017 Nov;39(6):653-667. doi: 10.1007/s00281-017-0665-6. Epub 2017 Nov 23. Review.

PMID:
29170800
48.

Enterovirus-associated changes in blood transcriptomic profiles of children with genetic susceptibility to type 1 diabetes.

Lietzen N, An LTT, Jaakkola MK, Kallionpää H, Oikarinen S, Mykkänen J, Knip M, Veijola R, Ilonen J, Toppari J, Hyöty H, Lahesmaa R, Elo LL.

Diabetologia. 2018 Feb;61(2):381-388. doi: 10.1007/s00125-017-4460-7. Epub 2017 Nov 8.

49.

Exocrine pancreas function decreases during the progression of the beta-cell damaging process in young prediabetic children.

Kondrashova A, Nurminen N, Lehtonen J, Hyöty M, Toppari J, Ilonen J, Veijola R, Knip M, Hyöty H.

Pediatr Diabetes. 2018 May;19(3):398-402. doi: 10.1111/pedi.12592. Epub 2017 Oct 17.

PMID:
29044779
50.

Identification of a novel synaptic protein, TMTC3, involved in periventricular nodular heterotopia with intellectual disability and epilepsy.

Farhan SMK, Nixon KCJ, Everest M, Edwards TN, Long S, Segal D, Knip MJ, Arts HH, Chakrabarti R, Wang J, Robinson JF, Lee D, Mirsattari SM, Rupar CA, Siu VM; FORGE Canada Consortium, Poulter MO, Hegele RA, Kramer JM.

Hum Mol Genet. 2017 Nov 1;26(21):4278-4289. doi: 10.1093/hmg/ddx316.

Supplemental Content

Support Center