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Items: 1 to 50 of 240

1.

Deficient Resident Memory T-Cell and Cd8 T-Cell Response to Commensals in Inflammatory Bowel Disease.

Noble A, Durant L, Hoyles L, McCartney AL, Man R, Segal J, Costello SP, Hendy P, Reddi D, Bouri S, Lim DNF, Pring T, O'Connor MJ, Datt P, Wilson A, Arebi N, Akbar A, Hart AL, Carding SR, Knight SC.

J Crohns Colitis. 2019 Oct 26. pii: jjz175. doi: 10.1093/ecco-jcc/jjz175. [Epub ahead of print]

PMID:
31665283
2.

Genomes in Focus: Development and Applications of CRISPR-Cas9 Imaging Technologies.

Knight SC, Tjian R, Doudna JA.

Angew Chem Int Ed Engl. 2018 Apr 9;57(16):4329-4337. doi: 10.1002/anie.201709201. Epub 2018 Feb 28. Review.

3.

Lectin-type oxidized LDL receptor-1 distinguishes population of human polymorphonuclear myeloid-derived suppressor cells in cancer patients.

Condamine T, Dominguez GA, Youn JI, Kossenkov AV, Mony S, Alicea-Torres K, Tcyganov E, Hashimoto A, Nefedova Y, Lin C, Partlova S, Garfall A, Vogl DT, Xu X, Knight SC, Malietzis G, Lee GH, Eruslanov E, Albelda SM, Wang X, Mehta JL, Bewtra M, Rustgi A, Hockstein N, Witt R, Masters G, Nam B, Smirnov D, Sepulveda MA, Gabrilovich DI.

Sci Immunol. 2016 Aug;1(2). pii: aaf8943. doi: 10.1126/sciimmunol.aaf8943. Epub 2016 Aug 5.

4.

Pilot study of immunological factors in non-inflammatory bowel disease enterocutaneous fistulas.

Rahbour G, Warusavitarne J, Hart AL, Tozer PJ, Ullah MR, Thomas GP, Gabe SM, Knight SC, Al-Hassi HO, Vaizey CJ.

Int J Surg. 2017 May;41:127-133. doi: 10.1016/j.ijsu.2017.03.079. Epub 2017 Mar 30.

5.

Two distinct RNase activities of CRISPR-C2c2 enable guide-RNA processing and RNA detection.

East-Seletsky A, O'Connell MR, Knight SC, Burstein D, Cate JH, Tjian R, Doudna JA.

Nature. 2016 Oct 13;538(7624):270-273. doi: 10.1038/nature19802. Epub 2016 Sep 26.

6.

Tight junctions in inflammatory bowel diseases and inflammatory bowel disease associated colorectal cancer.

Landy J, Ronde E, English N, Clark SK, Hart AL, Knight SC, Ciclitira PJ, Al-Hassi HO.

World J Gastroenterol. 2016 Mar 21;22(11):3117-26. doi: 10.3748/wjg.v22.i11.3117. Review.

7.

Dendritic Cell-T-Cell Circuitry in Health and Changes in Inflammatory Bowel Disease and Its Treatment.

Knight SC.

Dig Dis. 2016;34(1-2):51-7. doi: 10.1159/000442926. Epub 2016 Mar 16. Review.

8.

Body composition of the host influences dendritic cell phenotype in patients treated for colorectal cancer.

Malietzis G, Lee GH, Al-Hassi HO, Bernardo D, Blakemore AI, Kennedy RH, Moorghen M, Jenkins JT, Knight SC.

Tumour Biol. 2016 Aug;37(8):11359-64. doi: 10.1007/s13277-016-5009-y. Epub 2016 Mar 10.

9.

Age-related alterations in blood and colonic dendritic cell properties.

Vora R, Bernardo D, Durant L, Reddi D, Hart AL, Fell JM, Al-Hassi HO, Knight SC.

Oncotarget. 2016 Mar 15;7(11):11913-22. doi: 10.18632/oncotarget.7799.

10.

Chemokine (C-C Motif) Receptor 2 Mediates Dendritic Cell Recruitment to the Human Colon but Is Not Responsible for Differences Observed in Dendritic Cell Subsets, Phenotype, and Function Between the Proximal and Distal Colon.

Bernardo D, Durant L, Mann ER, Bassity E, Montalvillo E, Man R, Vora R, Reddi D, Bayiroglu F, Fernández-Salazar L, English NR, Peake ST, Landy J, Lee GH, Malietzis G, Siaw YH, Murugananthan AU, Hendy P, Sánchez-Recio E, Phillips RK, Garrote JA, Scott P, Parkhill J, Paulsen M, Hart AL, Al-Hassi HO, Arranz E, Walker AW, Carding SR, Knight SC.

Cell Mol Gastroenterol Hepatol. 2015 Sep 3;2(1):22-39.e5. eCollection 2016 Jan.

11.

Identification and molecular characterization of oat peptides implicated on coeliac immune response.

Comino I, Bernardo D, Bancel E, de Lourdes Moreno M, Sánchez B, Barro F, Šuligoj T, Ciclitira PJ, Cebolla Á, Knight SC, Branlard G, Sousa C.

Food Nutr Res. 2016 Feb 5;60:30324. doi: 10.3402/fnr.v60.30324. eCollection 2016.

12.

Dynamics of CRISPR-Cas9 genome interrogation in living cells.

Knight SC, Xie L, Deng W, Guglielmi B, Witkowsky LB, Bosanac L, Zhang ET, El Beheiry M, Masson JB, Dahan M, Liu Z, Doudna JA, Tjian R.

Science. 2015 Nov 13;350(6262):823-6. doi: 10.1126/science.aac6572.

13.

Variable alterations of the microbiota, without metabolic or immunological change, following faecal microbiota transplantation in patients with chronic pouchitis.

Landy J, Walker AW, Li JV, Al-Hassi HO, Ronde E, English NR, Mann ER, Bernardo D, McLaughlin SD, Parkhill J, Ciclitira PJ, Clark SK, Knight SC, Hart AL.

Sci Rep. 2015 Aug 12;5:12955. doi: 10.1038/srep12955.

14.

The prognostic significance and relationship with body composition of CCR7-positive cells in colorectal cancer.

Malietzis G, Lee GH, Bernardo D, Blakemore AI, Knight SC, Moorghen M, Al-Hassi HO, Jenkins JT.

J Surg Oncol. 2015 Jul;112(1):86-92. doi: 10.1002/jso.23959. Epub 2015 Jul 14.

15.

Prognostic Value of the Tumour-Infiltrating Dendritic Cells in Colorectal Cancer: A Systematic Review.

Malietzis G, Lee GH, Jenkins JT, Bernardo D, Moorghen M, Knight SC, Al-Hassi HO.

Cell Commun Adhes. 2015;22(1):9-14. doi: 10.3109/15419061.2015.1036859. Epub 2015 May 30. Review.

16.

Human colon-derived soluble factors modulate gut microbiota composition.

Hevia A, Bernardo D, Montalvillo E, Al-Hassi HO, Fernández-Salazar L, Garrote JA, Milani C, Ventura M, Arranz E, Knight SC, Margolles A, Sánchez B.

Front Oncol. 2015 Apr 13;5:86. doi: 10.3389/fonc.2015.00086. eCollection 2015.

17.

Immature myeloid cells directly contribute to skin tumor development by recruiting IL-17-producing CD4+ T cells.

Ortiz ML, Kumar V, Martner A, Mony S, Donthireddy L, Condamine T, Seykora J, Knight SC, Malietzis G, Lee GH, Moorghen M, Lenox B, Luetteke N, Celis E, Gabrilovich D.

J Exp Med. 2015 Mar 9;212(3):351-67. doi: 10.1084/jem.20140835. Epub 2015 Feb 9.

18.

Compartment-specific immunity in the human gut: properties and functions of dendritic cells in the colon versus the ileum.

Mann ER, Bernardo D, English NR, Landy J, Al-Hassi HO, Peake ST, Man R, Elliott TR, Spranger H, Lee GH, Parian A, Brant SR, Lazarev M, Hart AL, Li X, Knight SC.

Gut. 2016 Feb;65(2):256-70. doi: 10.1136/gutjnl-2014-307916. Epub 2015 Feb 9.

19.

Low Muscularity and Myosteatosis Is Related to the Host Systemic Inflammatory Response in Patients Undergoing Surgery for Colorectal Cancer.

Malietzis G, Johns N, Al-Hassi HO, Knight SC, Kennedy RH, Fearon KC, Aziz O, Jenkins JT.

Ann Surg. 2016 Feb;263(2):320-5. doi: 10.1097/SLA.0000000000001113.

20.

Human gut dendritic cells drive aberrant gut-specific t-cell responses in ulcerative colitis, characterized by increased IL-4 production and loss of IL-22 and IFNγ.

Mann ER, Bernardo D, Ng SC, Rigby RJ, Al-Hassi HO, Landy J, Peake ST, Spranger H, English NR, Thomas LV, Stagg AJ, Knight SC, Hart AL.

Inflamm Bowel Dis. 2014 Dec;20(12):2299-307. doi: 10.1097/MIB.0000000000000223.

PMID:
25397892
21.

Specific activation of dendritic cells enhances clearance of Bacillus anthracis following infection.

Thompson IJ, Mann ER, Stokes MG, English NR, Knight SC, Williamson D.

PLoS One. 2014 Nov 7;9(11):e109720. doi: 10.1371/journal.pone.0109720. eCollection 2014.

22.

Innate immune factors in the development and maintenance of pouchitis.

Landy J, Al-Hassi HO, Ronde E, English NR, Mann ER, Bernardo D, Ciclitira PJ, Clark SK, Knight SC, Hart AL.

Inflamm Bowel Dis. 2014 Nov;20(11):1942-9. doi: 10.1097/MIB.0000000000000182.

PMID:
25222658
23.

The role of CD40 expression in dendritic cells in cancer biology; a systematic review.

Lee GH, Askari A, Malietzis G, Bernardo D, Clark SK, Knight SC, Al-Hassi HO.

Curr Cancer Drug Targets. 2014;14(7):610-20. Review.

PMID:
25163469
24.

ER stress regulates myeloid-derived suppressor cell fate through TRAIL-R-mediated apoptosis.

Condamine T, Kumar V, Ramachandran IR, Youn JI, Celis E, Finnberg N, El-Deiry WS, Winograd R, Vonderheide RH, English NR, Knight SC, Yagita H, McCaffrey JC, Antonia S, Hockstein N, Witt R, Masters G, Bauer T, Gabrilovich DI.

J Clin Invest. 2014 Jun;124(6):2626-39. doi: 10.1172/JCI74056. Epub 2014 May 1.

25.

Constitutive gut-homing capacity on circulating myeloid dendritic cells in coeliac disease.

Comino I, Šuligoj T, Al-Hassi HO, Lee GH, Sousa C, Landy J, Ciclitira PJ, Knight SC, Bernardo D.

Rev Esp Enferm Dig. 2014 Jan;106(1):64-5. No abstract available.

26.

Altered human gut dendritic cell properties in ulcerative colitis are reversed by Lactobacillus plantarum extracellular encrypted peptide STp.

Al-Hassi HO, Mann ER, Sanchez B, English NR, Peake ST, Landy J, Man R, Urdaci M, Hart AL, Fernandez-Salazar L, Lee GH, Garrote JA, Arranz E, Margolles A, Stagg AJ, Knight SC, Bernardo D.

Mol Nutr Food Res. 2014 May;58(5):1132-43. doi: 10.1002/mnfr.201300596. Epub 2013 Dec 18.

27.

Probiotic modulation of dendritic cell function is influenced by ageing.

You J, Dong H, Mann ER, Knight SC, Yaqoob P.

Immunobiology. 2014 Feb;219(2):138-48. doi: 10.1016/j.imbio.2013.08.012. Epub 2013 Sep 5.

28.

Dysregulated circulating dendritic cell function in ulcerative colitis is partially restored by probiotic strain Lactobacillus casei Shirota.

Mann ER, You J, Horneffer-van der Sluis V, Bernardo D, Omar Al-Hassi H, Landy J, Peake ST, Thomas LV, Tee CT, Lee GH, Hart AL, Yaqoob P, Knight SC.

Mediators Inflamm. 2013;2013:573576. doi: 10.1155/2013/573576. Epub 2013 Jul 18.

29.

Lost therapeutic potential of monocyte-derived dendritic cells through lost tissue homing: stable restoration of gut specificity with retinoic acid.

Bernardo D, Mann ER, Al-Hassi HO, English NR, Man R, Lee GH, Ronde E, Landy J, Peake ST, Hart AL, Knight SC.

Clin Exp Immunol. 2013 Oct;174(1):109-19. doi: 10.1111/cei.12118.

30.

Mechanisms of action of anti-tumor necrosis factor α agents in Crohn's disease.

Peake ST, Bernardo D, Mann ER, Al-Hassi HO, Knight SC, Hart AL.

Inflamm Bowel Dis. 2013 Jun;19(7):1546-55. doi: 10.1097/MIB.0b013e318281333b. Review.

PMID:
23594837
31.

Ageing impairs the T cell response to dendritic cells.

You J, Dong H, Mann ER, Knight SC, Yaqoob P.

Immunobiology. 2013 Aug;218(8):1077-84. doi: 10.1016/j.imbio.2013.02.002. Epub 2013 Mar 1.

PMID:
23582781
32.

Intestinal dendritic cells: their role in intestinal inflammation, manipulation by the gut microbiota and differences between mice and men.

Mann ER, Landy JD, Bernardo D, Peake ST, Hart AL, Al-Hassi HO, Knight SC.

Immunol Lett. 2013 Feb;150(1-2):30-40. doi: 10.1016/j.imlet.2013.01.007. Epub 2013 Jan 23. Review.

PMID:
23352670
33.

Infliximab induces a dysregulated tissue-homing profile on human T-lymphocytes in-vitro: a novel mechanism for paradoxical inflammation?

Peake ST, Bernardo D, Mann ER, Al-Hassi HO, Knight SC, Hart AL.

J Crohns Colitis. 2013 Oct;7(9):765-7. doi: 10.1016/j.crohns.2013.01.001. Epub 2013 Jan 24. No abstract available.

PMID:
23352576
34.

A mechanistic role for leptin in human dendritic cell migration: differences between ileum and colon in health and Crohn's disease.

Al-Hassi HO, Bernardo D, Murugananthan AU, Mann ER, English NR, Jones A, Kamm MA, Arebi N, Hart AL, Blakemore AI, Stagg AJ, Knight SC.

Mucosal Immunol. 2013 Jul;6(4):751-61. doi: 10.1038/mi.2012.113. Epub 2012 Nov 21.

35.

Homing marker expression on circulating dendritic cells correlates with different phenotypes of Crohn's disease.

Peake ST, Bernardo D, Knight SC, Hart AL.

J Crohns Colitis. 2013 Aug;7(7):594-6. doi: 10.1016/j.crohns.2012.10.002. Epub 2012 Oct 24. No abstract available.

PMID:
23102650
36.

Skin- and gut-homing molecules on human circulating γδ T cells and their dysregulation in inflammatory bowel disease.

Mann ER, McCarthy NE, Peake ST, Milestone AN, Al-Hassi HO, Bernardo D, Tee CT, Landy J, Pitcher MC, Cochrane SA, Hart AL, Stagg AJ, Knight SC.

Clin Exp Immunol. 2012 Nov;170(2):122-30. doi: 10.1111/j.1365-2249.2012.04649.x.

37.

Microbiota/host crosstalk biomarkers: regulatory response of human intestinal dendritic cells exposed to Lactobacillus extracellular encrypted peptide.

Bernardo D, Sánchez B, Al-Hassi HO, Mann ER, Urdaci MC, Knight SC, Margolles A.

PLoS One. 2012;7(5):e36262. doi: 10.1371/journal.pone.0036262. Epub 2012 May 14.

38.

IL-6 promotes immune responses in human ulcerative colitis and induces a skin-homing phenotype in the dendritic cells and Tcells they stimulate.

Bernardo D, Vallejo-Díez S, Mann ER, Al-Hassi HO, Martínez-Abad B, Montalvillo E, Tee CT, Murugananthan AU, Núñez H, Peake ST, Hart AL, Fernández-Salazar L, Garrote JA, Arranz E, Knight SC.

Eur J Immunol. 2012 May;42(5):1337-53. doi: 10.1002/eji.201142327.

39.

T-cell proliferation and forkhead box P3 expression in human T cells are dependent on T-cell density: physics of a confined space?

Bernardo D, Al-Hassi HO, Mann ER, Tee CT, Murugananthan AU, Peake ST, Hart AL, Knight SC.

Hum Immunol. 2012 Mar;73(3):223-31. doi: 10.1016/j.humimm.2011.12.017. Epub 2012 Jan 3.

PMID:
22248741
40.

Smokers with active Crohn's disease have a clinically relevant dysbiosis of the gastrointestinal microbiota.

Benjamin JL, Hedin CR, Koutsoumpas A, Ng SC, McCarthy NE, Prescott NJ, Pessoa-Lopes P, Mathew CG, Sanderson J, Hart AL, Kamm MA, Knight SC, Forbes A, Stagg AJ, Lindsay JO, Whelan K.

Inflamm Bowel Dis. 2012 Jun;18(6):1092-100. doi: 10.1002/ibd.21864. Epub 2011 Aug 29.

PMID:
22102318
41.

Etiology of pouchitis.

Landy J, Al-Hassi HO, McLaughlin SD, Knight SC, Ciclitira PJ, Nicholls RJ, Clark SK, Hart AL.

Inflamm Bowel Dis. 2012 Jun;18(6):1146-55. doi: 10.1002/ibd.21911. Epub 2011 Oct 21. Review.

PMID:
22021180
42.

Human gut-specific homeostatic dendritic cells are generated from blood precursors by the gut microenvironment.

Mann ER, Bernardo D, Al-Hassi HO, English NR, Clark SK, McCarthy NE, Milestone AN, Cochrane SA, Hart AL, Stagg AJ, Knight SC.

Inflamm Bowel Dis. 2012 Jul;18(7):1275-86. doi: 10.1002/ibd.21893. Epub 2011 Oct 10.

PMID:
21987473
43.

Relationship between human intestinal dendritic cells, gut microbiota, and disease activity in Crohn's disease.

Ng SC, Benjamin JL, McCarthy NE, Hedin CR, Koutsoumpas A, Plamondon S, Price CL, Hart AL, Kamm MA, Forbes A, Knight SC, Lindsay JO, Whelan K, Stagg AJ.

Inflamm Bowel Dis. 2011 Oct;17(10):2027-37. doi: 10.1002/ibd.21590. Epub 2010 Dec 22.

PMID:
21910165
44.

Prospective study of immunological factors in non-inflammatory bowel disease enterocutaneous fistulas.

Rahbour G, Hart AL, Al-Hassi HO, Ullah MR, Gabe SM, Knight SC, Warusavitarne J, Vaizey CJ.

BMC Surg. 2011 May 27;11:12. doi: 10.1186/1471-2482-11-12.

45.

Randomised, double-blind, placebo-controlled trial of fructo-oligosaccharides in active Crohn's disease.

Benjamin JL, Hedin CR, Koutsoumpas A, Ng SC, McCarthy NE, Hart AL, Kamm MA, Sanderson JD, Knight SC, Forbes A, Stagg AJ, Whelan K, Lindsay JO.

Gut. 2011 Jul;60(7):923-9. doi: 10.1136/gut.2010.232025. Epub 2011 Jan 24.

PMID:
21262918
46.

Homing of immune cells: role in homeostasis and intestinal inflammation.

Hart AL, Ng SC, Mann E, Al-Hassi HO, Bernardo D, Knight SC.

Inflamm Bowel Dis. 2010 Nov;16(11):1969-77. doi: 10.1002/ibd.21304. Review.

PMID:
20848507
47.

Mechanistic study of the stereoselective polymerization of D,L-lactide using indium(III) halides.

Pietrangelo A, Knight SC, Gupta AK, Yao LJ, Hillmyer MA, Tolman WB.

J Am Chem Soc. 2010 Aug 25;132(33):11649-57. doi: 10.1021/ja103841h.

PMID:
20672812
48.

Lipid accumulation and dendritic cell dysfunction in cancer.

Herber DL, Cao W, Nefedova Y, Novitskiy SV, Nagaraj S, Tyurin VA, Corzo A, Cho HI, Celis E, Lennox B, Knight SC, Padhya T, McCaffrey TV, McCaffrey JC, Antonia S, Fishman M, Ferris RL, Kagan VE, Gabrilovich DI.

Nat Med. 2010 Aug;16(8):880-6. doi: 10.1038/nm.2172. Epub 2010 Jul 11.

49.

Intestinal dendritic cells: their role in bacterial recognition, lymphocyte homing, and intestinal inflammation.

Ng SC, Kamm MA, Stagg AJ, Knight SC.

Inflamm Bowel Dis. 2010 Oct;16(10):1787-807. doi: 10.1002/ibd.21247. Review.

PMID:
20222140
50.

Immunosuppressive effects via human intestinal dendritic cells of probiotic bacteria and steroids in the treatment of acute ulcerative colitis.

Ng SC, Plamondon S, Kamm MA, Hart AL, Al-Hassi HO, Guenther T, Stagg AJ, Knight SC.

Inflamm Bowel Dis. 2010 Aug;16(8):1286-98. doi: 10.1002/ibd.21222.

PMID:
20155842

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