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Items: 1 to 50 of 341

1.

Implementation of a genomic medicine multi-disciplinary team approach for rare disease in the clinical setting: a prospective exome sequencing case series.

Taylor J, Craft J, Blair E, Wordsworth S, Beeson D, Chandratre S, Cossins J, Lester T, Németh AH, Ormondroyd E, Patel SY, Pagnamenta AT, Taylor JC, Thomson KL, Watkins H, Wilkie AOM, Knight JC.

Genome Med. 2019 Jul 25;11(1):46. doi: 10.1186/s13073-019-0651-9.

2.

Effect of primary health care reforms in the province of Newfoundland and Labrador: Interrupted time-series analysis.

Knight JC, Moineddin R, Mathews M, Aubrey-Bassler K.

Can Fam Physician. 2019 Jul;65(7):e296-e304.

3.

The association between endometriosis and autoimmune diseases: a systematic review and meta-analysis.

Shigesi N, Kvaskoff M, Kirtley S, Feng Q, Fang H, Knight JC, Missmer SA, Rahmioglu N, Zondervan KT, Becker CM.

Hum Reprod Update. 2019 Jul 1;25(4):486-503. doi: 10.1093/humupd/dmz014.

4.

A genetics-led approach defines the drug target landscape of 30 immune-related traits.

Fang H; ULTRA-DD Consortium, De Wolf H, Knezevic B, Burnham KL, Osgood J, Sanniti A, Lledó Lara A, Kasela S, De Cesco S, Wegner JK, Handunnetthi L, McCann FE, Chen L, Sekine T, Brennan PE, Marsden BD, Damerell D, O'Callaghan CA, Bountra C, Bowness P, Sundström Y, Milani L, Berg L, Göhlmann HW, Peeters PJ, Fairfax BP, Sundström M, Knight JC.

Nat Genet. 2019 Jul;51(7):1082-1091. doi: 10.1038/s41588-019-0456-1. Epub 2019 Jun 28.

PMID:
31253980
5.

Joint sequencing of human and pathogen genomes reveals the genetics of pneumococcal meningitis.

Lees JA, Ferwerda B, Kremer PHC, Wheeler NE, Serón MV, Croucher NJ, Gladstone RA, Bootsma HJ, Rots NY, Wijmega-Monsuur AJ, Sanders EAM, Trzciński K, Wyllie AL, Zwinderman AH, van den Berg LH, van Rheenen W, Veldink JH, Harboe ZB, Lundbo LF, de Groot LCPGM, van Schoor NM, van der Velde N, Ängquist LH, Sørensen TIA, Nohr EA, Mentzer AJ, Mills TC, Knight JC, du Plessis M, Nzenze S, Weiser JN, Parkhill J, Madhi S, Benfield T, von Gottberg A, van der Ende A, Brouwer MC, Barrett JC, Bentley SD, van de Beek D.

Nat Commun. 2019 May 15;10(1):2176. doi: 10.1038/s41467-019-09976-3.

6.

Dual-isotope imaging allows in vivo immunohistochemistry using radiolabelled antibodies in tumours.

Knight JC, Mosley MJ, Kersemans V, Dias GM, Allen PD, Smart S, Cornelissen B.

Nucl Med Biol. 2019 Mar;70:14-22. doi: 10.1016/j.nucmedbio.2019.01.010. Epub 2019 Feb 5.

7.

Targeting phosphatidylserine for radionuclide-based molecular imaging of apoptosis.

Wuest M, Perreault A, Richter S, Knight JC, Wuest F.

Apoptosis. 2019 Apr;24(3-4):221-244. doi: 10.1007/s10495-019-01523-1. Review.

PMID:
30684144
8.

Primary health care services for patients with chronic disease in Newfoundland and Labrador: a descriptive analysis.

Buote R, Asghari S, Aubrey-Bassler K, Knight JC, Lukewich J.

CMAJ Open. 2019 Jan 15;7(1):E8-E14. doi: 10.9778/cmajo.20180091. Print 2019 Jan-Mar.

9.

GPUs Outperform Current HPC and Neuromorphic Solutions in Terms of Speed and Energy When Simulating a Highly-Connected Cortical Model.

Knight JC, Nowotny T.

Front Neurosci. 2018 Dec 12;12:941. doi: 10.3389/fnins.2018.00941. eCollection 2018.

10.

High-resolution air-clad imaging fibers.

Wood HAC, Harrington K, Birks TA, Knight JC, Stone JM.

Opt Lett. 2018 Nov 1;43(21):5311-5314. doi: 10.1364/OL.43.005311.

PMID:
30383002
11.

Transcriptomic Signatures in Sepsis and a Differential Response to Steroids. From the VANISH Randomized Trial.

Antcliffe DB, Burnham KL, Al-Beidh F, Santhakumaran S, Brett SJ, Hinds CJ, Ashby D, Knight JC, Gordon AC.

Am J Respir Crit Care Med. 2019 Apr 15;199(8):980-986. doi: 10.1164/rccm.201807-1419OC.

12.

Ultra-low background Raman sensing using a negative-curvature fibre and no distal optics.

Yerolatsitis S, Yu F, McAughtrie S, Tanner MG, Fleming H, Stone JM, Campbell CJ, Birks TA, Knight JC.

J Biophotonics. 2019 Mar;12(3):e201800239. doi: 10.1002/jbio.201800239. Epub 2018 Nov 19.

PMID:
30353666
13.

Translational molecular imaging in exocrine pancreatic cancer.

Cornelissen B, Knight JC, Mukherjee S, Evangelista L, Xavier C, Caobelli F, Del Vecchio S, Rbah-Vidal L, Barbet J, de Jong M, van Leeuwen FWB.

Eur J Nucl Med Mol Imaging. 2018 Dec;45(13):2442-2455. doi: 10.1007/s00259-018-4146-5. Epub 2018 Sep 17. Review.

14.

A comprehensive severity score for the morbidly adherent placenta: combining ultrasound and magnetic resonance imaging.

Knight JC, Lehnert S, Shanks AL, Atasi L, Delaney LR, Marine MB, Ibrahim SA, Brown BP.

Pediatr Radiol. 2018 Dec;48(13):1945-1954. doi: 10.1007/s00247-018-4235-4. Epub 2018 Sep 3.

PMID:
30178078
15.

Distinct HLA associations of LGI1 and CASPR2-antibody diseases.

Binks S, Varley J, Lee W, Makuch M, Elliott K, Gelfand JM, Jacob S, Leite MI, Maddison P, Chen M, Geschwind MD, Grant E, Sen A, Waters P, McCormack M, Cavalleri GL, Barnardo M, Knight JC, Irani SR.

Brain. 2018 Aug 1;141(8):2263-2271. doi: 10.1093/brain/awy109.

16.

Translating GWAS in rheumatic disease: approaches to establishing mechanism and function for genetic associations with ankylosing spondylitis.

Osgood JA, Knight JC.

Brief Funct Genomics. 2018 Sep 27;17(5):308-318. doi: 10.1093/bfgp/ely015. Review.

17.

PRACTITIONER APPLICATION: The Impact of Patient Navigation on Diabetes.

Knight JC.

J Healthc Manag. 2018 May-Jun;63(3):e41-e42. doi: 10.1097/JHM-D-18-00056. No abstract available.

PMID:
29734290
18.

Genomic Response to Vitamin D Supplementation in the Setting of a Randomized, Placebo-Controlled Trial.

Berlanga-Taylor AJ, Plant K, Dahl A, Lau E, Hill M, Sims D, Heger A, Emberson J, Armitage J, Clarke R, Knight JC.

EBioMedicine. 2018 May;31:133-142. doi: 10.1016/j.ebiom.2018.04.010. Epub 2018 Apr 10.

19.

Neuromodulated Synaptic Plasticity on the SpiNNaker Neuromorphic System.

Mikaitis M, Pineda García G, Knight JC, Furber SB.

Front Neurosci. 2018 Feb 27;12:105. doi: 10.3389/fnins.2018.00105. eCollection 2018.

20.

Evidence for a second ankylosing spondylitis-associated RUNX3 regulatory polymorphism.

Vecellio M, Cortes A, Roberts AR, Ellis J, Cohen CJ, Knight JC, Brown MA, Bowness P, Wordsworth BP.

RMD Open. 2018 Feb 8;4(1):e000628. doi: 10.1136/rmdopen-2017-000628. eCollection 2018.

21.

Risk of nontyphoidal Salmonella bacteraemia in African children is modified by STAT4.

Gilchrist JJ, Rautanen A, Fairfax BP, Mills TC, Naranbhai V, Trochet H, Pirinen M, Muthumbi E, Mwarumba S, Njuguna P, Mturi N, Msefula CL, Gondwe EN, MacLennan JM, Chapman SJ, Molyneux ME, Knight JC, Spencer CCA, Williams TN, MacLennan CA, Scott JAG, Hill AVS.

Nat Commun. 2018 Mar 9;9(1):1014. doi: 10.1038/s41467-017-02398-z.

22.

Quantitative characterization of endoscopic imaging fibers.

Wood HAC, Harrington K, Stone JM, Birks TA, Knight JC.

Opt Express. 2017 Feb 6;25(3):1985-1992. doi: 10.1364/OE.25.001985.

PMID:
29519047
23.

AltHapAlignR: improved accuracy of RNA-seq analyses through the use of alternative haplotypes.

Lee W, Plant K, Humburg P, Knight JC.

Bioinformatics. 2018 Jul 15;34(14):2401-2408. doi: 10.1093/bioinformatics/bty125.

24.

A community approach to mortality prediction in sepsis via gene expression analysis.

Sweeney TE, Perumal TM, Henao R, Nichols M, Howrylak JA, Choi AM, Bermejo-Martin JF, Almansa R, Tamayo E, Davenport EE, Burnham KL, Hinds CJ, Knight JC, Woods CW, Kingsmore SF, Ginsburg GS, Wong HR, Parnell GP, Tang B, Moldawer LL, Moore FE, Omberg L, Khatri P, Tsalik EL, Mangravite LM, Langley RJ.

Nat Commun. 2018 Feb 15;9(1):694. doi: 10.1038/s41467-018-03078-2.

25.

"Not pathogenic until proven otherwise": perspectives of UK clinical genomics professionals toward secondary findings in context of a Genomic Medicine Multidisciplinary Team and the 100,000 Genomes Project.

Ormondroyd E, Mackley MP, Blair E, Craft J, Knight JC, Taylor JC, Taylor J, Watkins H.

Genet Med. 2018 Mar;20(3):320-328. doi: 10.1038/gim.2017.157. Epub 2017 Oct 26.

26.

Uterocervical Angle Measurement Improves Prediction of Preterm Birth in Twin Gestation.

Knight JC, Tenbrink E, Onslow M, Patil AS.

Am J Perinatol. 2018 Jun;35(7):648-654. doi: 10.1055/s-0037-1608877. Epub 2017 Nov 30.

PMID:
29190844
27.

Unique transcriptome signatures and GM-CSF expression in lymphocytes from patients with spondyloarthritis.

Al-Mossawi MH, Chen L, Fang H, Ridley A, de Wit J, Yager N, Hammitzsch A, Pulyakhina I, Fairfax BP, Simone D, Yi Y, Bandyopadhyay S, Doig K, Gundle R, Kendrick B, Powrie F, Knight JC, Bowness P.

Nat Commun. 2017 Nov 15;8(1):1510. doi: 10.1038/s41467-017-01771-2.

28.

Measurement of resonant bend loss in anti-resonant hollow core optical fiber.

Carter RM, Yu F, Wadsworth WJ, Shephard JD, Birks T, Knight JC, Hand DP.

Opt Express. 2017 Aug 21;25(17):20612-20621. doi: 10.1364/OE.25.020612.

PMID:
29041739
29.

Experimental measurement of supercontinuum coherence in highly nonlinear soft-glass photonic crystal fibers.

Zhang Y, Kainerstorfer J, Knight JC, Omenetto FG.

Opt Express. 2017 Aug 7;25(16):18842-18852. doi: 10.1364/OE.25.018842.

PMID:
29041076
30.

Relation between family physician retention and avoidable hospital admission in Newfoundland and Labrador: a population-based cross-sectional study.

Knight JC, Mathews M, Aubrey-Bassler K.

CMAJ Open. 2017 Oct 6;5(4):E746-E752. doi: 10.9778/cmajo.20170007.

31.

Microvesicle Subsets in Sepsis Due to Community Acquired Pneumonia Compared to Faecal Peritonitis.

Lashin HMS, Nadkarni S, Oggero S, Jones HR, Knight JC, Hinds CJ, Perretti M.

Shock. 2018 Apr;49(4):393-401. doi: 10.1097/SHK.0000000000000989.

PMID:
28930915
32.

Classification of patients with sepsis according to blood genomic endotype: a prospective cohort study.

Scicluna BP, van Vught LA, Zwinderman AH, Wiewel MA, Davenport EE, Burnham KL, Nürnberg P, Schultz MJ, Horn J, Cremer OL, Bonten MJ, Hinds CJ, Wong HR, Knight JC, van der Poll T; MARS consortium.

Lancet Respir Med. 2017 Oct;5(10):816-826. doi: 10.1016/S2213-2600(17)30294-1. Epub 2017 Aug 29.

PMID:
28864056
33.

Imaging of Claudin-4 in Pancreatic Ductal Adenocarcinoma Using a Radiolabelled Anti-Claudin-4 Monoclonal Antibody.

Torres JB, Knight JC, Mosley MJ, Kersemans V, Koustoulidou S, Allen D, Kinchesh P, Smart S, Cornelissen B.

Mol Imaging Biol. 2018 Apr;20(2):292-299. doi: 10.1007/s11307-017-1112-8.

34.

89Zr-anti-γH2AX-TAT but not 18F-FDG Allows Early Monitoring of Response to Chemotherapy in a Mouse Model of Pancreatic Ductal Adenocarcinoma.

Knight JC, Mosley MJ, Bravo LC, Kersemans V, Allen PD, Mukherjee S, O'Neill E, Cornelissen B.

Clin Cancer Res. 2017 Nov 1;23(21):6498-6504. doi: 10.1158/1078-0432.CCR-17-0664. Epub 2017 Aug 3.

35.

In Vivo Pretargeted Imaging of HER2 and TAG-72 Expression Using the HaloTag Enzyme.

Knight JC, Mosley M, Uyeda HT, Cong M, Fan F, Faulkner S, Cornelissen B.

Mol Pharm. 2017 Jul 3;14(7):2307-2313. doi: 10.1021/acs.molpharmaceut.7b00172. Epub 2017 Jun 8.

36.

Investigation of a possible extended risk haplotype in the IL23R region associated with ankylosing spondylitis.

Roberts AR, Vecellio M, Cortes A, Knight JC, Cohen CJ, Wordsworth BP.

Genes Immun. 2017 Mar;18(2):105-108. doi: 10.1038/gene.2017.5. Epub 2017 Apr 6.

37.

Insights from early experience of a Rare Disease Genomic Medicine Multidisciplinary Team: a qualitative study.

Ormondroyd E, Mackley MP, Blair E, Craft J, Knight JC, Taylor J, Taylor JC, Wilkie AO, Watkins H.

Eur J Hum Genet. 2017 Jun;25(6):680-686. doi: 10.1038/ejhg.2017.37. Epub 2017 Mar 22.

38.

Enhanced understanding of the host-pathogen interaction in sepsis: new opportunities for omic approaches.

Goh C, Knight JC.

Lancet Respir Med. 2017 Mar;5(3):212-223. doi: 10.1016/S2213-2600(17)30045-0. Review.

PMID:
28266329
39.

Pathogenic implications for autoimmune mechanisms derived by comparative eQTL analysis of CD4+ versus CD8+ T cells.

Kasela S, Kisand K, Tserel L, Kaleviste E, Remm A, Fischer K, Esko T, Westra HJ, Fairfax BP, Makino S, Knight JC, Franke L, Metspalu A, Peterson P, Milani L.

PLoS Genet. 2017 Mar 1;13(3):e1006643. doi: 10.1371/journal.pgen.1006643. eCollection 2017 Mar.

40.

A functional SNP associated with atopic dermatitis controls cell type-specific methylation of the VSTM1 gene locus.

Kumar D, Puan KJ, Andiappan AK, Lee B, Westerlaken GH, Haase D, Melchiotti R, Li Z, Yusof N, Lum J, Koh G, Foo S, Yeong J, Alves AC, Pekkanen J, Sun LD, Irwanto A, Fairfax BP, Naranbhai V, Common JE, Tang M, Chuang CK, Jarvelin MR, Knight JC, Zhang X, Chew FT, Prabhakar S, Jianjun L, Wang Y, Zolezzi F, Poidinger M, Lane EB, Meyaard L, Rötzschke O.

Genome Med. 2017 Feb 20;9(1):18. doi: 10.1186/s13073-017-0404-6.

41.

High resolution HLA haplotyping by imputation for a British population bioresource.

Neville MJ, Lee W, Humburg P, Wong D, Barnardo M, Karpe F, Knight JC.

Hum Immunol. 2017 Mar;78(3):242-251. doi: 10.1016/j.humimm.2017.01.006. Epub 2017 Jan 19.

42.

Imaging the DNA damage response with PET and SPECT.

Knight JC, Koustoulidou S, Cornelissen B.

Eur J Nucl Med Mol Imaging. 2017 Jun;44(6):1065-1078. doi: 10.1007/s00259-016-3604-1. Epub 2017 Jan 5. Review.

43.

Anterior uterocervical angle measurement improves prediction of cerclage failure.

Knight JC, Tenbrink E, Sheng J, Patil AS.

J Perinatol. 2017 Apr;37(4):375-379. doi: 10.1038/jp.2016.241. Epub 2017 Jan 5.

PMID:
28055026
44.

miR-10b-5p is a novel Th17 regulator present in Th17 cells from ankylosing spondylitis.

Chen L, Al-Mossawi MH, Ridley A, Sekine T, Hammitzsch A, de Wit J, Simone D, Shi H, Penkava F, Kurowska-Stolarska M, Pulyakhina I, Knight JC, Kim TJ, Bowness P.

Ann Rheum Dis. 2017 Mar;76(3):620-625. doi: 10.1136/annrheumdis-2016-210175. Epub 2016 Dec 30.

PMID:
28039186
45.

Shared and Distinct Aspects of the Sepsis Transcriptomic Response to Fecal Peritonitis and Pneumonia.

Burnham KL, Davenport EE, Radhakrishnan J, Humburg P, Gordon AC, Hutton P, Svoren-Jabalera E, Garrard C, Hill AVS, Hinds CJ, Knight JC.

Am J Respir Crit Care Med. 2017 Aug 1;196(3):328-339. doi: 10.1164/rccm.201608-1685OC.

46.

Effect of Maternal Retroplacental Leiomyomas on Fetal Growth.

Knight JC, Elliott JO, Amburgey OL.

J Obstet Gynaecol Can. 2016 Dec;38(12):1100-1104. doi: 10.1016/j.jogc.2016.08.012. Epub 2016 Oct 14.

PMID:
27986183
47.
48.

HLA-C Level Is Regulated by a Polymorphic Oct1 Binding Site in the HLA-C Promoter Region.

Vince N, Li H, Ramsuran V, Naranbhai V, Duh FM, Fairfax BP, Saleh B, Knight JC, Anderson SK, Carrington M.

Am J Hum Genet. 2016 Dec 1;99(6):1353-1358. doi: 10.1016/j.ajhg.2016.09.023. Epub 2016 Nov 3.

49.

Synapse-Centric Mapping of Cortical Models to the SpiNNaker Neuromorphic Architecture.

Knight JC, Furber SB.

Front Neurosci. 2016 Sep 14;10:420. doi: 10.3389/fnins.2016.00420. eCollection 2016.

50.

Adaptive multiphoton endomicroscopy through a dynamically deformed multicore optical fiber using proximal detection.

Warren SC, Kim Y, Stone JM, Mitchell C, Knight JC, Neil MA, Paterson C, French PM, Dunsby C.

Opt Express. 2016 Sep 19;24(19):21474-84. doi: 10.1364/OE.24.021474.

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