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The Role of Pathological Aging in Cardiac and Pulmonary Fibrosis.

Murtha LA, Morten M, Schuliga MJ, Mabotuwana NS, Hardy SA, Waters DW, Burgess JK, Ngo DT, Sverdlov AL, Knight DA, Boyle AJ.

Aging Dis. 2019 Apr 1;10(2):419-428. doi: 10.14336/AD.2018.0601. eCollection 2019 Apr.


Functionalized core-shell Ag@TiO2 nanoparticles for enhanced Raman spectroscopy: a sensitive detection method for Cu(ii) ions.

Forato F, Talebzadeh S, Rousseau N, Mevellec JY, Bujoli B, Knight DA, Queffélec C, Humbert B.

Phys Chem Chem Phys. 2019 Feb 6;21(6):3066-3072. doi: 10.1039/c8cp07504b.


STAT3 Regulates the Onset of Oxidant-Induced Senescence in Lung Fibroblasts.

Waters DW, Blokland KEC, Pathinayake PS, Wei L, Schuliga M, Jaffar J, Westall GP, Hansbro PM, Prele CM, Mutsaers SE, Bartlett NW, Burgess JK, Grainge CL, Knight DA.

Am J Respir Cell Mol Biol. 2019 Jan 4. doi: 10.1165/rcmb.2018-0328OC. [Epub ahead of print]


Mitochondrial dysfunction contributes to the senescent phenotype of IPF lung fibroblasts.

Schuliga M, Pechkovsky DV, Read J, Waters DW, Blokland KEC, Reid AT, Hogaboam CM, Khalil N, Burgess JK, Prêle CM, Mutsaers SE, Jaffar J, Westall G, Grainge C, Knight DA.

J Cell Mol Med. 2018 Dec;22(12):5847-5861. doi: 10.1111/jcmm.13855. Epub 2018 Sep 26.


Influenza A virus infection dysregulates the expression of microRNA-22 and its targets; CD147 and HDAC4, in epithelium of asthmatics.

Moheimani F, Koops J, Williams T, Reid AT, Hansbro PM, Wark PA, Knight DA.

Respir Res. 2018 Aug 2;19(1):145. doi: 10.1186/s12931-018-0851-7.


Synthesis of a Reactive Oxygen Species-Responsive Doxorubicin Derivative.

Delehanty JB, Das S, Goldberg E, Sangtani A, Knight DA.

Molecules. 2018 Jul 21;23(7). pii: E1809. doi: 10.3390/molecules23071809.


JAK2 is dispensable for maintenance of JAK2 mutant B-cell acute lymphoblastic leukemias.

Kim SK, Knight DA, Jones LR, Vervoort S, Ng AP, Seymour JF, Bradner JE, Waibel M, Kats L, Johnstone RW.

Genes Dev. 2018 Jun 1;32(11-12):849-864. doi: 10.1101/gad.307504.117. Epub 2018 Jun 15.


Corticosteroid suppression of antiviral immunity increases bacterial loads and mucus production in COPD exacerbations.

Singanayagam A, Glanville N, Girkin JL, Ching YM, Marcellini A, Porter JD, Toussaint M, Walton RP, Finney LJ, Aniscenko J, Zhu J, Trujillo-Torralbo MB, Calderazzo MA, Grainge C, Loo SL, Veerati PC, Pathinayake PS, Nichol KS, Reid AT, James PL, Solari R, Wark PAB, Knight DA, Moffatt MF, Cookson WO, Edwards MR, Mallia P, Bartlett NW, Johnston SL.

Nat Commun. 2018 Jun 8;9(1):2229. doi: 10.1038/s41467-018-04574-1.


Tumor immune evasion arises through loss of TNF sensitivity.

Kearney CJ, Vervoort SJ, Hogg SJ, Ramsbottom KM, Freeman AJ, Lalaoui N, Pijpers L, Michie J, Brown KK, Knight DA, Sutton V, Beavis PA, Voskoboinik I, Darcy PK, Silke J, Trapani JA, Johnstone RW, Oliaro J.

Sci Immunol. 2018 May 18;3(23). pii: eaar3451. doi: 10.1126/sciimmunol.aar3451.


International research collaboration: The way forward.

Chotirmall SH, Dahlén SE, Carlsten C, Wong WSF, Chung KF, Gosens R, Knight DA; Singapore International Respiratory Consortium.

Respirology. 2018 Jul;23(7):654-655. doi: 10.1111/resp.13327. Epub 2018 May 17. No abstract available.


Fibroblast senescence in the pathology of idiopathic pulmonary fibrosis.

Waters DW, Blokland KEC, Pathinayake PS, Burgess JK, Mutsaers SE, Prele CM, Schuliga M, Grainge CL, Knight DA.

Am J Physiol Lung Cell Mol Physiol. 2018 Aug 1;315(2):L162-L172. doi: 10.1152/ajplung.00037.2018. Epub 2018 Apr 26.


Visualisation of Multiple Tight Junctional Complexes in Human Airway Epithelial Cells.

Buckley AG, Looi K, Iosifidis T, Ling KM, Sutanto EN, Martinovich KM, Kicic-Starcevich E, Garratt LW, Shaw NC, Lannigan FJ, Larcombe AN, Zosky G, Knight DA, Rigby PJ, Kicic A, Stick SM.

Biol Proced Online. 2018 Feb 1;20:3. doi: 10.1186/s12575-018-0070-0. eCollection 2018.


Accumulation mode particles and LPS exposure induce TLR-4 dependent and independent inflammatory responses in the lung.

Fonceca AM, Zosky GR, Bozanich EM, Sutanto EN, Kicic A, McNamara PS, Knight DA, Sly PD, Turner DJ, Stick SM.

Respir Res. 2018 Jan 22;19(1):15. doi: 10.1186/s12931-017-0701-z.


Effects of human rhinovirus on epithelial barrier integrity and function in children with asthma.

Looi K, Buckley AG, Rigby PJ, Garratt LW, Iosifidis T, Zosky GR, Larcombe AN, Lannigan FJ, Ling KM, Martinovich KM, Kicic-Starcevich E, Shaw NC, Sutanto EN, Knight DA, Kicic A, Stick SM.

Clin Exp Allergy. 2018 May;48(5):513-524. doi: 10.1111/cea.13097. Epub 2018 Feb 20.


Persistent induction of goblet cell differentiation in the airways: Therapeutic approaches.

Reid AT, Veerati PC, Gosens R, Bartlett NW, Wark PA, Grainge CL, Stick SM, Kicic A, Moheimani F, Hansbro PM, Knight DA.

Pharmacol Ther. 2018 May;185:155-169. doi: 10.1016/j.pharmthera.2017.12.009. Epub 2017 Dec 27. Review.


Conditionally reprogrammed primary airway epithelial cells maintain morphology, lineage and disease specific functional characteristics.

Martinovich KM, Iosifidis T, Buckley AG, Looi K, Ling KM, Sutanto EN, Kicic-Starcevich E, Garratt LW, Shaw NC, Montgomery S, Lannigan FJ, Knight DA, Kicic A, Stick SM.

Sci Rep. 2017 Dec 21;7(1):17971. doi: 10.1038/s41598-017-17952-4.


Restricted access or access all areas? a new cadherin-like protein upregulated in the inflamed esophagus.

Knight DA, Hansbro PM.

Mucosal Immunol. 2018 Jan;11(1):1-2. doi: 10.1038/mi.2017.56. No abstract available.


Divergent roles for Clusterin in Lung Injury and Repair.

Habiel DM, Camelo A, Espindola M, Burwell T, Hanna R, Miranda E, Carruthers A, Bell M, Coelho AL, Liu H, Pilataxi F, Clarke L, Grant E, Lewis A, Moore B, Knight DA, Hogaboam CM, Murray LA.

Sci Rep. 2017 Nov 13;7(1):15444. doi: 10.1038/s41598-017-15670-5.


The Processes and Mechanisms of Cardiac and Pulmonary Fibrosis.

Murtha LA, Schuliga MJ, Mabotuwana NS, Hardy SA, Waters DW, Burgess JK, Knight DA, Boyle AJ.

Front Physiol. 2017 Oct 12;8:777. doi: 10.3389/fphys.2017.00777. eCollection 2017. Review.


Autophagy and the unfolded protein response promote profibrotic effects of TGF-β1 in human lung fibroblasts.

Ghavami S, Yeganeh B, Zeki AA, Shojaei S, Kenyon NJ, Ott S, Samali A, Patterson J, Alizadeh J, Moghadam AR, Dixon IMC, Unruh H, Knight DA, Post M, Klonisch T, Halayko AJ.

Am J Physiol Lung Cell Mol Physiol. 2018 Mar 1;314(3):L493-L504. doi: 10.1152/ajplung.00372.2017. Epub 2017 Oct 26.


Regulation of xanthine dehydrogensase gene expression and uric acid production in human airway epithelial cells.

Huff RD, Hsu AC, Nichol KS, Jones B, Knight DA, Wark PAB, Hansbro PM, Hirota JA.

PLoS One. 2017 Sep 1;12(9):e0184260. doi: 10.1371/journal.pone.0184260. eCollection 2017.


Airway remodelling and inflammation in asthma are dependent on the extracellular matrix protein fibulin-1c.

Liu G, Cooley MA, Nair PM, Donovan C, Hsu AC, Jarnicki AG, Haw TJ, Hansbro NG, Ge Q, Brown AC, Tay H, Foster PS, Wark PA, Horvat JC, Bourke JE, Grainge CL, Argraves WS, Oliver BG, Knight DA, Burgess JK, Hansbro PM.

J Pathol. 2017 Dec;243(4):510-523. doi: 10.1002/path.4979.


Antifibrotic role of vascular endothelial growth factor in pulmonary fibrosis.

Murray LA, Habiel DM, Hohmann M, Camelo A, Shang H, Zhou Y, Coelho AL, Peng X, Gulati M, Crestani B, Sleeman MA, Mustelin T, Moore MW, Ryu C, Osafo-Addo AD, Elias JA, Lee CG, Hu B, Herazo-Maya JD, Knight DA, Hogaboam CM, Herzog EL.

JCI Insight. 2017 Aug 17;2(16). pii: 92192. doi: 10.1172/jci.insight.92192. eCollection 2017 Aug 17.


Mechanisms and treatments for severe, steroid-resistant allergic airway disease and asthma.

Hansbro PM, Kim RY, Starkey MR, Donovan C, Dua K, Mayall JR, Liu G, Hansbro NG, Simpson JL, Wood LG, Hirota JA, Knight DA, Foster PS, Horvat JC.

Immunol Rev. 2017 Jul;278(1):41-62. doi: 10.1111/imr.12543. Review.


Acute cigarette smoke exposure activates apoptotic and inflammatory programs but a second stimulus is required to induce epithelial to mesenchymal transition in COPD epithelium.

Murray LA, Dunmore R, Camelo A, Da Silva CA, Gustavsson MJ, Habiel DM, Hackett TL, Hogaboam CM, Sleeman MA, Knight DA.

Respir Res. 2017 May 3;18(1):82. doi: 10.1186/s12931-017-0565-2.


Preventive Health Care for Women Who Have Sex with Women.

Knight DA, Jarrett D.

Am Fam Physician. 2017 Mar 1;95(5):314-321.


Role for NLRP3 Inflammasome-mediated, IL-1β-Dependent Responses in Severe, Steroid-Resistant Asthma.

Kim RY, Pinkerton JW, Essilfie AT, Robertson AAB, Baines KJ, Brown AC, Mayall JR, Ali MK, Starkey MR, Hansbro NG, Hirota JA, Wood LG, Simpson JL, Knight DA, Wark PA, Gibson PG, O'Neill LAJ, Cooper MA, Horvat JC, Hansbro PM.

Am J Respir Crit Care Med. 2017 Aug 1;196(3):283-297. doi: 10.1164/rccm.201609-1830OC.


The fibrogenic actions of lung fibroblast-derived urokinase: a potential drug target in IPF.

Schuliga M, Jaffar J, Harris T, Knight DA, Westall G, Stewart AG.

Sci Rep. 2017 Jan 31;7:41770. doi: 10.1038/srep41770.


Epigenetic modifying enzyme expression in asthmatic airway epithelial cells and fibroblasts.

Stefanowicz D, Ullah J, Lee K, Shaheen F, Olumese E, Fishbane N, Koo HK, Hallstrand TS, Knight DA, Hackett TL.

BMC Pulm Med. 2017 Jan 31;17(1):24. doi: 10.1186/s12890-017-0371-0.


Inflammasomes in the lung.

Pinkerton JW, Kim RY, Robertson AAB, Hirota JA, Wood LG, Knight DA, Cooper MA, O'Neill LAJ, Horvat JC, Hansbro PM.

Mol Immunol. 2017 Jun;86:44-55. doi: 10.1016/j.molimm.2017.01.014. Epub 2017 Jan 24. Review.


Use of biologics to treat acute exacerbations and manage disease in asthma, COPD and IPF.

Murray LA, Grainge C, Wark PA, Knight DA.

Pharmacol Ther. 2017 Jan;169:1-12. doi: 10.1016/j.pharmthera.2016.11.003. Epub 2016 Nov 24. Review.


Impaired airway epithelial cell responses from children with asthma to rhinoviral infection.

Kicic A, Stevens PT, Sutanto EN, Kicic-Starcevich E, Ling KM, Looi K, Martinovich KM, Garratt LW, Iosifidis T, Shaw NC, Buckley AG, Rigby PJ, Lannigan FJ, Knight DA, Stick SM.

Clin Exp Allergy. 2016 Nov;46(11):1441-1455. doi: 10.1111/cea.12767. Epub 2016 Jul 1.


Selective targeting of CREB-binding protein/β-catenin inhibits growth of and extracellular matrix remodelling by airway smooth muscle.

Koopmans T, Crutzen S, Menzen MH, Halayko AJ, Hackett TL, Knight DA, Gosens R.

Br J Pharmacol. 2016 Dec;173(23):3327-3341. doi: 10.1111/bph.13620. Epub 2016 Oct 25.


Animal models of COPD: What do they tell us?

Jones B, Donovan C, Liu G, Gomez HM, Chimankar V, Harrison CL, Wiegman CH, Adcock IM, Knight DA, Hirota JA, Hansbro PM.

Respirology. 2017 Jan;22(1):21-32. doi: 10.1111/resp.12908. Epub 2016 Oct 12. Review.


Effect of human rhinovirus infection on airway epithelium tight junction protein disassembly and transepithelial permeability.

Looi K, Troy NM, Garratt LW, Iosifidis T, Bosco A, Buckley AG, Ling KM, Martinovich KM, Kicic-Starcevich E, Shaw NC, Sutanto EN, Zosky GR, Rigby PJ, Larcombe AN, Knight DA, Kicic A, Stick SM.

Exp Lung Res. 2016;42(7):380-395. Epub 2016 Oct 11.


The genetic and epigenetic landscapes of the epithelium in asthma.

Moheimani F, Hsu AC, Reid AT, Williams T, Kicic A, Stick SM, Hansbro PM, Wark PA, Knight DA.

Respir Res. 2016 Sep 22;17(1):119. Review.


Transforming growth factor (TGF) β1 and Smad signalling pathways: A likely key to EMT-associated COPD pathogenesis.

Mahmood MQ, Reid D, Ward C, Muller HK, Knight DA, Sohal SS, Walters EH.

Respirology. 2017 Jan;22(1):133-140. doi: 10.1111/resp.12882. Epub 2016 Sep 11.


Elucidating novel disease mechanisms in severe asthma.

Kim RY, Rae B, Neal R, Donovan C, Pinkerton J, Balachandran L, Starkey MR, Knight DA, Horvat JC, Hansbro PM.

Clin Transl Immunology. 2016 Jul 15;5(7):e91. doi: 10.1038/cti.2016.37. eCollection 2016 Jul. Review.


Fibulin-1 regulates the pathogenesis of tissue remodeling in respiratory diseases.

Liu G, Cooley MA, Jarnicki AG, Hsu AC, Nair PM, Haw TJ, Fricker M, Gellatly SL, Kim RY, Inman MD, Tjin G, Wark PA, Walker MM, Horvat JC, Oliver BG, Argraves WS, Knight DA, Burgess JK, Hansbro PM.

JCI Insight. 2016 Jun 16;1(9). pii: e86380.


Reduced transforming growth factor β1 (TGF-β1) in the repair of airway epithelial cells of children with asthma.

Ling KM, Sutanto EN, Iosifidis T, Kicic-Starcevich E, Looi K, Garratt LW, Martinovich KM, Lannigan FJ, Knight DA, Stick SM, Kicic A.

Respirology. 2016 Oct;21(7):1219-26. doi: 10.1111/resp.12810. Epub 2016 May 24.


Impaired Antiviral Stress Granule and IFN-β Enhanceosome Formation Enhances Susceptibility to Influenza Infection in Chronic Obstructive Pulmonary Disease Epithelium.

Hsu AC, Parsons K, Moheimani F, Knight DA, Hansbro PM, Fujita T, Wark PA.

Am J Respir Cell Mol Biol. 2016 Jul;55(1):117-27. doi: 10.1165/rcmb.2015-0306OC.


Airway epithelial repair in health and disease: Orchestrator or simply a player?

Iosifidis T, Garratt LW, Coombe DR, Knight DA, Stick SM, Kicic A.

Respirology. 2016 Apr;21(3):438-48. doi: 10.1111/resp.12731. Epub 2016 Jan 25. Review.


Host immunity contributes to the anti-melanoma activity of BRAF inhibitors.

Knight DA, Ngiow SF, Li M, Parmenter T, Mok S, Cass A, Haynes NM, Kinross K, Yagita H, Koya RC, Graeber TG, Ribas A, McArthur GA, Smyth MJ.

J Clin Invest. 2016 Jan;126(1):402-3. doi: 10.1172/JCI84828. Epub 2015 Nov 23. No abstract available.


A pathogenic role for tumor necrosis factor-related apoptosis-inducing ligand in chronic obstructive pulmonary disease.

Haw TJ, Starkey MR, Nair PM, Pavlidis S, Liu G, Nguyen DH, Hsu AC, Hanish I, Kim RY, Collison AM, Inman MD, Wark PA, Foster PS, Knight DA, Mattes J, Yagita H, Adcock IM, Horvat JC, Hansbro PM.

Mucosal Immunol. 2016 Jul;9(4):859-72. doi: 10.1038/mi.2015.111. Epub 2015 Nov 11.


Kinetic analysis of the hydrolysis of methyl parathion using citrate-stabilized 10 nm gold nanoparticles.

Nita R, Trammell SA, Ellis GA, Moore MH, Soto CM, Leary DH, Fontana J, Talebzadeh SF, Knight DA.

Chemosphere. 2016 Feb;144:1916-9. doi: 10.1016/j.chemosphere.2015.10.036. Epub 2015 Nov 11.


Mucosal production of uric acid by airway epithelial cells contributes to particulate matter-induced allergic sensitization.

Gold MJ, Hiebert PR, Park HY, Stefanowicz D, Le A, Starkey MR, Deane A, Brown AC, Liu G, Horvat JC, Ibrahim ZA, Sukkar MB, Hansbro PM, Carlsten C, VanEeden S, Sin DD, McNagny KM, Knight DA, Hirota JA.

Mucosal Immunol. 2016 May;9(3):809-20. doi: 10.1038/mi.2015.104. Epub 2015 Oct 28.


Epithelial mesenchymal transition in smokers: large versus small airways and relation to airflow obstruction.

Mahmood MQ, Sohal SS, Shukla SD, Ward C, Hardikar A, Noor WD, Muller HK, Knight DA, Walters EH.

Int J Chron Obstruct Pulmon Dis. 2015 Aug 4;10:1515-24. doi: 10.2147/COPD.S81032. eCollection 2015.


Disruption of β-catenin/CBP signaling inhibits human airway epithelial-mesenchymal transition and repair.

Moheimani F, Roth HM, Cross J, Reid AT, Shaheen F, Warner SM, Hirota JA, Kicic A, Hallstrand TS, Kahn M, Stick SM, Hansbro PM, Hackett TL, Knight DA.

Int J Biochem Cell Biol. 2015 Nov;68:59-69. doi: 10.1016/j.biocel.2015.08.014. Epub 2015 Aug 24.


Elevated H3K18 acetylation in airway epithelial cells of asthmatic subjects.

Stefanowicz D, Lee JY, Lee K, Shaheen F, Koo HK, Booth S, Knight DA, Hackett TL.

Respir Res. 2015 Aug 5;16:95. doi: 10.1186/s12931-015-0254-y.


Alpha-1 Antitrypsin Mitigates the Inhibition of Airway Epithelial Cell Repair by Neutrophil Elastase.

Garratt LW, Sutanto EN, Ling KM, Looi K, Iosifidis T, Martinovich KM, Shaw NC, Buckley AG, Kicic-Starcevich E, Lannigan FJ, Knight DA, Stick SM, Kicic A; Australian Respiratory Early Surveillance Team for Cystic Fibrosis.

Am J Respir Cell Mol Biol. 2016 Mar;54(3):341-9. doi: 10.1165/rcmb.2015-0074OC.


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