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Items: 39

1.

Oxidative stress in autoimmune rheumatic diseases.

Smallwood MJ, Nissim A, Knight AR, Whiteman M, Haigh R, Winyard PG.

Free Radic Biol Med. 2018 Sep;125:3-14. doi: 10.1016/j.freeradbiomed.2018.05.086. Epub 2018 May 30. Review.

PMID:
29859343
2.

A high-sensitivity electrochemiluminescence-based ELISA for the measurement of the oxidative stress biomarker, 3-nitrotyrosine, in human blood serum and cells.

Knight AR, Taylor EL, Lukaszewski R, Jensen KT, Jones HE, Carré JE, Isupov MN, Littlechild JA, Bailey SJ, Brewer E, McDonald TJ, Pitt AR, Spickett CM, Winyard PG.

Free Radic Biol Med. 2018 May 20;120:246-254. doi: 10.1016/j.freeradbiomed.2018.03.026. Epub 2018 Mar 17.

PMID:
29555590
3.

Clinical Relevance of Biomarkers of Oxidative Stress.

Frijhoff J, Winyard PG, Zarkovic N, Davies SS, Stocker R, Cheng D, Knight AR, Taylor EL, Oettrich J, Ruskovska T, Gasparovic AC, Cuadrado A, Weber D, Poulsen HE, Grune T, Schmidt HH, Ghezzi P.

Antioxid Redox Signal. 2015 Nov 10;23(14):1144-70. doi: 10.1089/ars.2015.6317. Epub 2015 Oct 26. Review.

4.
5.

Understanding the effects of oxygen administration in haemorrhagic shock.

Knight AR, Fry LE, Clancy RL, Pierce JD.

Nurs Crit Care. 2011 Jan-Feb;16(1):28-35. doi: 10.1111/j.1478-5153.2010.00403.x. Review.

PMID:
21199552
6.

Herbicidal activity of cineole derivatives.

Barton AF, Dell B, Knight AR.

J Agric Food Chem. 2010 Sep 22;58(18):10147-55. doi: 10.1021/jf101827v.

PMID:
20715837
7.

Mitochondria: the hemi of the cell.

Cusimano EM, Knight AR, Slusser JG, Clancy RL, Pierce JD.

Adv Emerg Nurs J. 2009 Jan-Mar;31(1):54-62. doi: 10.1097/TME.0b013e3181956200. Review.

PMID:
20118854
8.

Discovery and optimization of potent and selective functional antagonists of the human adenosine A2B receptor.

Bedford ST, Benwell KR, Brooks T, Chen I, Comer M, Dugdale S, Haymes T, Jordan AM, Kennett GA, Knight AR, Klenke B, LeStrat L, Merrett A, Misra A, Lightowler S, Padfield A, Poullennec K, Reece M, Simmonite H, Wong M, Yule IA.

Bioorg Med Chem Lett. 2009 Oct 15;19(20):5945-9. doi: 10.1016/j.bmcl.2009.08.040. Epub 2009 Aug 14.

PMID:
19733067
9.

Discovery and functional evaluation of diverse novel human CB(1) receptor ligands.

Foloppe N, Benwell K, Brooks TD, Kennett G, Knight AR, Misra A, Monck NJ.

Bioorg Med Chem Lett. 2009 Aug 1;19(15):4183-90. doi: 10.1016/j.bmcl.2009.05.114. Epub 2009 Jun 2.

PMID:
19520572
10.

Antagonists of the human A(2A) adenosine receptor. 4. Design, synthesis, and preclinical evaluation of 7-aryltriazolo[4,5-d]pyrimidines.

Gillespie RJ, Bamford SJ, Botting R, Comer M, Denny S, Gaur S, Griffin M, Jordan AM, Knight AR, Lerpiniere J, Leonardi S, Lightowler S, McAteer S, Merrett A, Misra A, Padfield A, Reece M, Saadi M, Selwood DL, Stratton GC, Surry D, Todd R, Tong X, Ruston V, Upton R, Weiss SM.

J Med Chem. 2009 Jan 8;52(1):33-47. doi: 10.1021/jm800961g.

PMID:
19072055
11.

Antagonists of the human adenosine A2A receptor. Part 3: Design and synthesis of pyrazolo[3,4-d]pyrimidines, pyrrolo[2,3-d]pyrimidines and 6-arylpurines.

Gillespie RJ, Cliffe IA, Dawson CE, Dourish CT, Gaur S, Jordan AM, Knight AR, Lerpiniere J, Misra A, Pratt RM, Roffey J, Stratton GC, Upton R, Weiss SM, Williamson DS.

Bioorg Med Chem Lett. 2008 May 1;18(9):2924-9. doi: 10.1016/j.bmcl.2008.03.072. Epub 2008 Mar 30.

PMID:
18411049
12.

Antagonists of the human adenosine A2A receptor. Part 2: Design and synthesis of 4-arylthieno[3,2-d]pyrimidine derivatives.

Gillespie RJ, Cliffe IA, Dawson CE, Dourish CT, Gaur S, Giles PR, Jordan AM, Knight AR, Lawrence A, Lerpiniere J, Misra A, Pratt RM, Todd RS, Upton R, Weiss SM, Williamson DS.

Bioorg Med Chem Lett. 2008 May 1;18(9):2920-3. doi: 10.1016/j.bmcl.2008.03.076. Epub 2008 Mar 30.

PMID:
18407496
13.

Antagonists of the human adenosine A2A receptor. Part 1: Discovery and synthesis of thieno[3,2-d]pyrimidine-4-methanone derivatives.

Gillespie RJ, Adams DR, Bebbington D, Benwell K, Cliffe IA, Dawson CE, Dourish CT, Fletcher A, Gaur S, Giles PR, Jordan AM, Knight AR, Knutsen LJ, Lawrence A, Lerpiniere J, Misra A, Porter RH, Pratt RM, Shepherd R, Upton R, Ward SE, Weiss SM, Williamson DS.

Bioorg Med Chem Lett. 2008 May 1;18(9):2916-9. doi: 10.1016/j.bmcl.2008.03.075. Epub 2008 Mar 30.

PMID:
18406614
14.

Discovery of a novel class of selective human CB1 inverse agonists.

Foloppe N, Allen NH, Bentley CH, Brooks TD, Kennett G, Knight AR, Leonardi S, Misra A, Monck NJ, Sellwood DM.

Bioorg Med Chem Lett. 2008 Feb 1;18(3):1199-206. Epub 2007 Dec 7.

PMID:
18083560
15.

Fluid resuscitation therapy for hemorrhagic shock.

Spaniol JR, Knight AR, Zebley JL, Anderson D, Pierce JD.

J Trauma Nurs. 2007 Jul-Sep;14(3):152-60; quiz 161-2. Review.

PMID:
18080579
16.

Identification of non-furan containing A2A antagonists using database mining and molecular similarity approaches.

Richardson CM, Gillespie RJ, Williamson DS, Jordan AM, Fink A, Knight AR, Sellwood DM, Misra A.

Bioorg Med Chem Lett. 2006 Dec 1;16(23):5993-7. Epub 2006 Sep 12.

PMID:
16971117
17.

Synthesis and biological evaluation of novel hexahydro-pyrido[3',2':4,5]pyrrolo[1,2-a]pyrazines as potent and selective 5-HT(2C) receptor agonists.

Richter HG, Adams DR, Benardeau A, Bickerdike MJ, Bentley JM, Blench TJ, Cliffe IA, Dourish C, Hebeisen P, Kennett GA, Knight AR, Malcolm CS, Mattei P, Misra A, Mizrahi J, Monck NJ, Plancher JM, Roever S, Roffey JR, Taylor S, Vickers SP.

Bioorg Med Chem Lett. 2006 Mar 1;16(5):1207-11. Epub 2005 Dec 19.

PMID:
16361098
18.

Pyrrolo(iso)quinoline derivatives as 5-HT(2C) receptor agonists.

Adams DR, Bentley JM, Benwell KR, Bickerdike MJ, Bodkin CD, Cliffe IA, Dourish CT, George AR, Kennett GA, Knight AR, Malcolm CS, Mansell HL, Misra A, Quirk K, Roffey JR, Vickers SP.

Bioorg Med Chem Lett. 2006 Feb;16(3):677-80. Epub 2005 Oct 27.

PMID:
16257207
19.

Identification of 4-methyl-1,2,3,4,10,10a-hexahydropyrazino[1,2-a]indoles as 5-HT2C receptor agonists.

Röver S, Adams DR, Bénardeau A, Bentley JM, Bickerdike MJ, Bourson A, Cliffe IA, Coassolo P, Davidson JE, Dourish CT, Hebeisen P, Kennett GA, Knight AR, Malcolm CS, Mattei P, Misra A, Mizrahi J, Muller M, Porter RH, Richter H, Taylor S, Vickers SP.

Bioorg Med Chem Lett. 2005 Aug 1;15(15):3604-8.

PMID:
15975787
20.

Pharmacological characterisation of the agonist radioligand binding site of 5-HT(2A), 5-HT(2B) and 5-HT(2C) receptors.

Knight AR, Misra A, Quirk K, Benwell K, Revell D, Kennett G, Bickerdike M.

Naunyn Schmiedebergs Arch Pharmacol. 2004 Aug;370(2):114-23. Epub 2004 Jul 30.

PMID:
15322733
21.

Indoline derivatives as 5-HT(2C) receptor agonists.

Bentley JM, Adams DR, Bebbington D, Benwell KR, Bickerdike MJ, Davidson JE, Dawson CE, Dourish CT, Duncton MA, Gaur S, George AR, Giles PR, Hamlyn RJ, Kennett GA, Knight AR, Malcolm CS, Mansell HL, Misra A, Monck NJ, Pratt RM, Quirk K, Roffey JR, Vickers SP, Cliffe IA.

Bioorg Med Chem Lett. 2004 May 3;14(9):2367-70.

PMID:
15081042
22.

Discovery of nonxanthine adenosine A2A receptor antagonists for the treatment of Parkinson's disease.

Weiss SM, Benwell K, Cliffe IA, Gillespie RJ, Knight AR, Lerpiniere J, Misra A, Pratt RM, Revell D, Upton R, Dourish CT.

Neurology. 2003 Dec 9;61(11 Suppl 6):S101-6.

PMID:
14663021
23.

Solubilisation and immunoprecipitation of rat striatal adenosine A(2A) receptors.

Harvey V, Jones J, Misra A, Knight AR, Quirk K.

Eur J Pharmacol. 2001 Nov 16;431(2):171-7.

PMID:
11728423
24.

Characterisation of agonist binding on human 5-HT2C receptor isoforms.

Quirk K, Lawrence A, Jones J, Misra A, Harvey V, Lamb H, Revell D, Porter RH, Knight AR.

Eur J Pharmacol. 2001 May 11;419(2-3):107-12.

PMID:
11426831
25.

Monospecific antibodies as probes for the stoichiometry of recombinant GABA(A) receptors.

Knight AR, Stephenson FA, Tallman JF, Ramabahdran TV.

Receptors Channels. 2000;7(3):213-26.

PMID:
11342389
26.

Molecular size of recombinant alpha1beta1 and alpha1beta1gamma2 GABAA receptors expressed in Sf9 cells.

Knight AR, Hartnett C, Marks C, Brown M, Gallager D, Tallman J, Ramabhadran TV.

Receptors Channels. 1998;6(1):1-18.

PMID:
9664619
27.

The pharmacology of adenylyl cyclase modulation by GABAB receptors in rat brain slices.

Knight AR, Bowery NG.

Neuropharmacology. 1996 Jun;35(6):703-12.

PMID:
8887979
28.

GABA receptors in rats with spontaneous generalized nonconvulsive epilepsy.

Knight AR, Bowery NG.

J Neural Transm Suppl. 1992;35:189-96.

PMID:
1324980
29.

The human sigma site, which resembles that in NCB20 cells, may correspond to a low-affinity site in guinea pig brain.

Knight AR, Gillard J, Wong EH, Middlemiss DN.

Neurosci Lett. 1991 Oct 14;131(2):233-6.

PMID:
1684840
30.

Spironolactone causes a rapid down regulation of sigma recognition sites in guinea pig brain and liver.

Knight AR, Wyatt C, Middlemiss DN.

Neuropharmacology. 1991 Aug;30(8):923-5.

PMID:
1664074
31.

The pharmacological properties of the imidazobenzodiazepine, FG 8205, a novel partial agonist at the benzodiazepine receptor.

Tricklebank MD, Honoré T, Iversen SD, Kemp JA, Knight AR, Marshall GR, Rupniak NM, Singh L, Tye S, Watjen F, et al.

Br J Pharmacol. 1990 Nov;101(3):753-61.

32.

Structure and activity of hydrogenated derivatives of (+)-5-methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imine (MK-801).

Lyle TA, Magill CA, Britcher SF, Denny GH, Thompson WJ, Murphy JS, Knight AR, Kemp JA, Marshall GR, Middlemiss DN, et al.

J Med Chem. 1990 Mar;33(3):1047-52.

PMID:
2155319
33.

[3H]MK-801 labels a site on the N-methyl-D-aspartate receptor channel complex in rat brain membranes.

Wong EH, Knight AR, Woodruff GN.

J Neurochem. 1988 Jan;50(1):274-81.

PMID:
2826686
34.

Glycine modulates [3H]MK-801 binding to the NMDA receptor in rat brain.

Wong EH, Knight AR, Ransom R.

Eur J Pharmacol. 1987 Oct 27;142(3):487-8. No abstract available.

PMID:
2828080
35.

The anticonvulsant MK-801 is a potent N-methyl-D-aspartate antagonist.

Wong EH, Kemp JA, Priestley T, Knight AR, Woodruff GN, Iversen LL.

Proc Natl Acad Sci U S A. 1986 Sep;83(18):7104-8.

36.

Effect of angiotensin converting-enzyme inhibition on potassium-mediated aldosterone secretion in essential hypertension.

Barnes JN, Drew PJ, Furniss SS, Holly JM, Knight AR, Skehan JD, Goodwin FJ.

Clin Sci (Lond). 1985 Jun;68(6):625-30.

PMID:
2485263
37.

Bopindolol: a new long acting beta-receptor antagonist; its effects on haemodynamics, and on the renin response to tilting.

Turner DR, Goodwin FJ, Knight AR, Littlejohns DW, Sharman VL, Vere DW.

Br J Clin Pharmacol. 1984 Mar;17(3):295-9.

38.

The early detection of colorectal cancer.

Miller SF, Knight AR.

Cancer. 1977 Aug;40(2):945-9.

PMID:
890677
39.

Characterization of DNAs from coprinus lagopus and mucor azygospora.

Dutta SK, Penn SR, Knight AR, Ojha M.

Experientia. 1972 May 15;28(5):582-4. No abstract available.

PMID:
5064815

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