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Items: 1 to 50 of 89

1.

The monothiol glutaredoxin GrxD is essential for sensing iron starvation in Aspergillus fumigatus.

Misslinger M, Scheven MT, Hortschansky P, López-Berges MS, Heiss K, Beckmann N, Heigl T, Hermann M, Krüger T, Kniemeyer O, Brakhage AA, Haas H.

PLoS Genet. 2019 Sep 16;15(9):e1008379. doi: 10.1371/journal.pgen.1008379. eCollection 2019 Sep.

2.

Conidial surface proteins at the interface of fungal infections.

Blango MG, Kniemeyer O, Brakhage AA.

PLoS Pathog. 2019 Sep 12;15(9):e1007939. doi: 10.1371/journal.ppat.1007939. eCollection 2019 Sep. No abstract available.

3.

Stress-Induced Changes in the Lipid Microenvironment of β-(1,3)-d-Glucan Synthase Cause Clinically Important Echinocandin Resistance in Aspergillus fumigatus.

Satish S, Jiménez-Ortigosa C, Zhao Y, Lee MH, Dolgov E, Krüger T, Park S, Denning DW, Kniemeyer O, Brakhage AA, Perlin DS.

MBio. 2019 Jun 4;10(3). pii: e00779-19. doi: 10.1128/mBio.00779-19.

4.

Human Anti-fungal Th17 Immunity and Pathology Rely on Cross-Reactivity against Candida albicans.

Bacher P, Hohnstein T, Beerbaum E, Röcker M, Blango MG, Kaufmann S, Röhmel J, Eschenhagen P, Grehn C, Seidel K, Rickerts V, Lozza L, Stervbo U, Nienen M, Babel N, Milleck J, Assenmacher M, Cornely OA, Ziegler M, Wisplinghoff H, Heine G, Worm M, Siegmund B, Maul J, Creutz P, Tabeling C, Ruwwe-Glösenkamp C, Sander LE, Knosalla C, Brunke S, Hube B, Kniemeyer O, Brakhage AA, Schwarz C, Scheffold A.

Cell. 2019 Mar 7;176(6):1340-1355.e15. doi: 10.1016/j.cell.2019.01.041. Epub 2019 Feb 21.

PMID:
30799037
5.

Crosstalk between Ras and inositol phosphate signaling revealed by lithium action on inositol monophosphatase in Schizophyllum commune.

Murry R, Kniemeyer O, Krause K, Saiardi A, Kothe E.

Adv Biol Regul. 2019 May;72:78-88. doi: 10.1016/j.jbior.2019.01.001. Epub 2019 Jan 3.

6.

Redox Proteomic Analysis Reveals Oxidative Modifications of Proteins by Increased Levels of Intracellular Reactive Oxygen Species during Hypoxia Adaptation of Aspergillus fumigatus.

Shekhova E, Ivanova L, Krüger T, Stroe MC, Macheleidt J, Kniemeyer O, Brakhage AA.

Proteomics. 2019 Mar;19(5):e1800339. doi: 10.1002/pmic.201800339. Epub 2019 Feb 13.

PMID:
30632700
7.

Arabidopsis thaliana responds to colonisation of Piriformospora indica by secretion of symbiosis-specific proteins.

Thürich J, Meichsner D, Furch ACU, Pfalz J, Krüger T, Kniemeyer O, Brakhage A, Oelmüller R.

PLoS One. 2018 Dec 27;13(12):e0209658. doi: 10.1371/journal.pone.0209658. eCollection 2018.

8.

Identification of Proteomic Markers in Head and Neck Cancer Using MALDI-MS Imaging, LC-MS/MS, and Immunohistochemistry.

Hoffmann F, Umbreit C, Krüger T, Pelzel D, Ernst G, Kniemeyer O, Guntinas-Lichius O, Berndt A, von Eggeling F.

Proteomics Clin Appl. 2019 Jan;13(1):e1700173. doi: 10.1002/prca.201700173. Epub 2018 Nov 26.

PMID:
30411850
9.

Module-detection approaches for the integration of multilevel omics data highlight the comprehensive response of Aspergillus fumigatus to caspofungin.

Conrad T, Kniemeyer O, Henkel SG, Krüger T, Mattern DJ, Valiante V, Guthke R, Jacobsen ID, Brakhage AA, Vlaic S, Linde J.

BMC Syst Biol. 2018 Oct 20;12(1):88. doi: 10.1186/s12918-018-0620-8.

10.

Proteome Analysis Reveals the Conidial Surface Protein CcpA Essential for Virulence of the Pathogenic Fungus Aspergillus fumigatus.

Voltersen V, Blango MG, Herrmann S, Schmidt F, Heinekamp T, Strassburger M, Krüger T, Bacher P, Lother J, Weiss E, Hünniger K, Liu H, Hortschansky P, Scheffold A, Löffler J, Krappmann S, Nietzsche S, Kurzai O, Einsele H, Kniemeyer O, Filler SG, Reichard U, Brakhage AA.

MBio. 2018 Oct 2;9(5). pii: e01557-18. doi: 10.1128/mBio.01557-18.

11.

ATP Content and Cell Viability as Indicators for Cryostress Across the Diversity of Life.

Bajerski F, Stock J, Hanf B, Darienko T, Heine-Dobbernack E, Lorenz M, Naujox L, Keller ERJ, Schumacher HM, Friedl T, Eberth S, Mock HP, Kniemeyer O, Overmann J.

Front Physiol. 2018 Jul 17;9:921. doi: 10.3389/fphys.2018.00921. eCollection 2018.

12.

The regulator of G-protein signalling Thn1 links pheromone response to volatile production in Schizophyllum commune.

Wirth S, Kunert M, Ahrens LM, Krause K, Broska S, Paetz C, Kniemeyer O, Jung EM, Boland W, Kothe E.

Environ Microbiol. 2018 Oct;20(10):3684-3699. doi: 10.1111/1462-2920.14369. Epub 2018 Sep 17.

PMID:
30062773
13.

UV-Raman Spectroscopic Identification of Fungal Spores Important for Respiratory Diseases.

Žukovskaja O, Kloß S, Blango MG, Ryabchykov O, Kniemeyer O, Brakhage AA, Bocklitz TW, Cialla-May D, Weber K, Popp J.

Anal Chem. 2018 Aug 7;90(15):8912-8918. doi: 10.1021/acs.analchem.8b01038. Epub 2018 Jul 16.

PMID:
29956919
14.

Additional oxidative stress reroutes the global response of Aspergillus fumigatus to iron depletion.

Kurucz V, Krüger T, Antal K, Dietl AM, Haas H, Pócsi I, Kniemeyer O, Emri T.

BMC Genomics. 2018 May 10;19(1):357. doi: 10.1186/s12864-018-4730-x.

15.

Proteomics of Aspergillus fumigatus Conidia-containing Phagolysosomes Identifies Processes Governing Immune Evasion.

Schmidt H, Vlaic S, Krüger T, Schmidt F, Balkenhol J, Dandekar T, Guthke R, Kniemeyer O, Heinekamp T, Brakhage AA.

Mol Cell Proteomics. 2018 Jun;17(6):1084-1096. doi: 10.1074/mcp.RA117.000069. Epub 2018 Mar 5.

16.

Processing of Candida albicans Ece1p Is Critical for Candidalysin Maturation and Fungal Virulence.

Richardson JP, Mogavero S, Moyes DL, Blagojevic M, Krüger T, Verma AH, Coleman BM, De La Cruz Diaz J, Schulz D, Ponde NO, Carrano G, Kniemeyer O, Wilson D, Bader O, Enoiu SI, Ho J, Kichik N, Gaffen SL, Hube B, Naglik JR.

MBio. 2018 Jan 23;9(1). pii: e02178-17. doi: 10.1128/mBio.02178-17.

17.

Phenotypic and Proteomic Analysis of the Aspergillus fumigatus ΔPrtT, ΔXprG and ΔXprGPrtT Protease-Deficient Mutants.

Shemesh E, Hanf B, Hagag S, Attias S, Shadkchan Y, Fichtman B, Harel A, Krüger T, Brakhage AA, Kniemeyer O, Osherov N.

Front Microbiol. 2017 Dec 12;8:2490. doi: 10.3389/fmicb.2017.02490. eCollection 2017.

18.

Quantitative Analysis of Proteome Modulations in Alveolar Epithelial Type II Cells in Response to Pulmonary Aspergillus fumigatus Infection.

Seddigh P, Bracht T, Molinier-Frenkel V, Castellano F, Kniemeyer O, Schuster M, Weski J, Hasenberg A, Kraus A, Poschet G, Hager T, Theegarten D, Opitz CA, Brakhage AA, Sitek B, Hasenberg M, Gunzer M.

Mol Cell Proteomics. 2017 Dec;16(12):2184-2198. doi: 10.1074/mcp.RA117.000072. Epub 2017 Sep 26.

19.

Induction of Mitochondrial Reactive Oxygen Species Production by Itraconazole, Terbinafine, and Amphotericin B as a Mode of Action against Aspergillus fumigatus.

Shekhova E, Kniemeyer O, Brakhage AA.

Antimicrob Agents Chemother. 2017 Oct 24;61(11). pii: e00978-17. doi: 10.1128/AAC.00978-17. Print 2017 Nov.

20.

Proteomic profiling of the antifungal drug response of Aspergillus fumigatus to voriconazole.

Amarsaikhan N, Albrecht-Eckardt D, Sasse C, Braus GH, Ogel ZB, Kniemeyer O.

Int J Med Microbiol. 2017 Oct;307(7):398-408. doi: 10.1016/j.ijmm.2017.07.011. Epub 2017 Aug 5.

PMID:
28811086
21.

Identification of Proteins Interacting with Cytoplasmic High-Mobility Group Box 1 during the Hepatocellular Response to Ischemia Reperfusion Injury.

Zhang T, Wei W, Dirsch O, Krüger T, Kan C, Xie C, Kniemeyer O, Fang H, Settmacher U, Dahmen U.

Int J Mol Sci. 2017 Jan 16;18(1). pii: E167. doi: 10.3390/ijms18010167.

22.

Lipid Signaling via Pkh1/2 Regulates Fungal CO2 Sensing through the Kinase Sch9.

Pohlers S, Martin R, Krüger T, Hellwig D, Hänel F, Kniemeyer O, Saluz HP, Van Dijck P, Ernst JF, Brakhage A, Mühlschlegel FA, Kurzai O.

MBio. 2017 Jan 31;8(1). pii: e02211-16. doi: 10.1128/mBio.02211-16.

23.

Regulatory T Cell Specificity Directs Tolerance versus Allergy against Aeroantigens in Humans.

Bacher P, Heinrich F, Stervbo U, Nienen M, Vahldieck M, Iwert C, Vogt K, Kollet J, Babel N, Sawitzki B, Schwarz C, Bereswill S, Heimesaat MM, Heine G, Gadermaier G, Asam C, Assenmacher M, Kniemeyer O, Brakhage AA, Ferreira F, Wallner M, Worm M, Scheffold A.

Cell. 2016 Nov 3;167(4):1067-1078.e16. doi: 10.1016/j.cell.2016.09.050. Epub 2016 Oct 20.

24.

Smelling the difference: Transcriptome, proteome and volatilome changes after mating.

Freihorst D, Brunsch M, Wirth S, Krause K, Kniemeyer O, Linde J, Kunert M, Boland W, Kothe E.

Fungal Genet Biol. 2018 Mar;112:2-11. doi: 10.1016/j.fgb.2016.08.007. Epub 2016 Sep 1.

PMID:
27593501
25.

Immunoproteomic Analysis of Antibody Responses to Extracellular Proteins of Candida albicans Revealing the Importance of Glycosylation for Antigen Recognition.

Luo T, Krüger T, Knüpfer U, Kasper L, Wielsch N, Hube B, Kortgen A, Bauer M, Giamarellos-Bourboulis EJ, Dimopoulos G, Brakhage AA, Kniemeyer O.

J Proteome Res. 2016 Aug 5;15(8):2394-406. doi: 10.1021/acs.jproteome.5b01065. Epub 2016 Jul 22.

PMID:
27386892
26.

Immunoproteomics of Aspergillus for the development of biomarkers and immunotherapies.

Kniemeyer O, Ebel F, Krüger T, Bacher P, Scheffold A, Luo T, Strassburger M, Brakhage AA.

Proteomics Clin Appl. 2016 Oct;10(9-10):910-921. doi: 10.1002/prca.201600053. Epub 2016 Jul 6. Review.

PMID:
27312145
27.

The transcriptional regulators SteA and StuA contribute to keratin degradation and sexual reproduction of the dermatophyte Arthroderma benhamiae.

Kröber A, Etzrodt S, Bach M, Monod M, Kniemeyer O, Staib P, Brakhage AA.

Curr Genet. 2017 Feb;63(1):103-116. doi: 10.1007/s00294-016-0608-0. Epub 2016 May 11.

PMID:
27170358
28.

Identification and Characterization of a Novel Aspergillus fumigatus Rhomboid Family Putative Protease, RbdA, Involved in Hypoxia Sensing and Virulence.

Vaknin Y, Hillmann F, Iannitti R, Ben Baruch N, Sandovsky-Losica H, Shadkchan Y, Romani L, Brakhage A, Kniemeyer O, Osherov N.

Infect Immun. 2016 May 24;84(6):1866-1878. doi: 10.1128/IAI.00011-16. Print 2016 Jun.

29.

Candidalysin is a fungal peptide toxin critical for mucosal infection.

Moyes DL, Wilson D, Richardson JP, Mogavero S, Tang SX, Wernecke J, Höfs S, Gratacap RL, Robbins J, Runglall M, Murciano C, Blagojevic M, Thavaraj S, Förster TM, Hebecker B, Kasper L, Vizcay G, Iancu SI, Kichik N, Häder A, Kurzai O, Luo T, Krüger T, Kniemeyer O, Cota E, Bader O, Wheeler RT, Gutsmann T, Hube B, Naglik JR.

Nature. 2016 Apr 7;532(7597):64-8. doi: 10.1038/nature17625. Epub 2016 Mar 30.

30.

The hypoxia-induced dehydrogenase HorA is required for coenzyme Q10 biosynthesis, azole sensitivity and virulence of Aspergillus fumigatus.

Kroll K, Shekhova E, Mattern DJ, Thywissen A, Jacobsen ID, Strassburger M, Heinekamp T, Shelest E, Brakhage AA, Kniemeyer O.

Mol Microbiol. 2016 Jul;101(1):92-108. doi: 10.1111/mmi.13377. Epub 2016 May 3.

31.

Proteomic Profiling of Serological Responses to Aspergillus fumigatus Antigens in Patients with Invasive Aspergillosis.

Teutschbein J, Simon S, Lother J, Springer J, Hortschansky P, Morton CO, Löffler J, Einsele H, Conneally E, Rogers TR, Guthke R, Brakhage AA, Kniemeyer O.

J Proteome Res. 2016 May 6;15(5):1580-91. doi: 10.1021/acs.jproteome.6b00042. Epub 2016 Mar 24.

PMID:
26974881
32.

HapX Mediates Iron Homeostasis in the Pathogenic Dermatophyte Arthroderma benhamiae but Is Dispensable for Virulence.

Kröber A, Scherlach K, Hortschansky P, Shelest E, Staib P, Kniemeyer O, Brakhage AA.

PLoS One. 2016 Mar 9;11(3):e0150701. doi: 10.1371/journal.pone.0150701. eCollection 2016.

33.

Challenges and Strategies for Proteome Analysis of the Interaction of Human Pathogenic Fungi with Host Immune Cells.

Krüger T, Luo T, Schmidt H, Shopova I, Kniemeyer O.

Proteomes. 2015 Dec 14;3(4):467-495. doi: 10.3390/proteomes3040467. Review.

34.

Influence of zygomycete-derived D'orenone on IAA signalling in Tricholoma-spruce ectomycorrhiza.

Wagner K, Krause K, David A, Kai M, Jung EM, Sammer D, Kniemeyer O, Boland W, Kothe E.

Environ Microbiol. 2016 Sep;18(8):2470-80. doi: 10.1111/1462-2920.13160. Epub 2016 Jan 18.

PMID:
26636983
35.

A phosphorylation code of the Aspergillus nidulans global regulator VelvetA (VeA) determines specific functions.

Rauscher S, Pacher S, Hedtke M, Kniemeyer O, Fischer R.

Mol Microbiol. 2016 Mar;99(5):909-24. doi: 10.1111/mmi.13275. Epub 2015 Dec 9.

36.

Tricholoma vaccinum host communication during ectomycorrhiza formation.

Wagner K, Linde J, Krause K, Gube M, Koestler T, Sammer D, Kniemeyer O, Kothe E.

FEMS Microbiol Ecol. 2015 Nov;91(11). pii: fiv120. doi: 10.1093/femsec/fiv120. Epub 2015 Oct 7.

PMID:
26449385
37.

Network Modeling Reveals Cross Talk of MAP Kinases during Adaptation to Caspofungin Stress in Aspergillus fumigatus.

Altwasser R, Baldin C, Weber J, Guthke R, Kniemeyer O, Brakhage AA, Linde J, Valiante V.

PLoS One. 2015 Sep 10;10(9):e0136932. doi: 10.1371/journal.pone.0136932. eCollection 2015.

38.

Clinical-scale isolation of the total Aspergillus fumigatus-reactive T-helper cell repertoire for adoptive transfer.

Bacher P, Jochheim-Richter A, Mockel-Tenbrink N, Kniemeyer O, Wingenfeld E, Alex R, Ortigao A, Karpova D, Lehrnbecher T, Ullmann AJ, Hamprecht A, Cornely O, Brakhage AA, Assenmacher M, Bonig H, Scheffold A.

Cytotherapy. 2015 Oct;17(10):1396-405. doi: 10.1016/j.jcyt.2015.05.011. Epub 2015 Jul 15.

PMID:
26188965
39.

Hitting the caspofungin salvage pathway of human-pathogenic fungi with the novel lasso peptide humidimycin (MDN-0010).

Valiante V, Monteiro MC, Martín J, Altwasser R, El Aouad N, González I, Kniemeyer O, Mellado E, Palomo S, de Pedro N, Pérez-Victoria I, Tormo JR, Vicente F, Reyes F, Genilloud O, Brakhage AA.

Antimicrob Agents Chemother. 2015 Sep;59(9):5145-53. doi: 10.1128/AAC.00683-15. Epub 2015 Jun 8.

40.

Insights into the cellular responses to hypoxia in filamentous fungi.

Hillmann F, Shekhova E, Kniemeyer O.

Curr Genet. 2015 Aug;61(3):441-55. doi: 10.1007/s00294-015-0487-9. Epub 2015 Apr 25. Review.

PMID:
25911540
41.

Comparative proteomics of a tor inducible Aspergillus fumigatus mutant reveals involvement of the Tor kinase in iron regulation.

Baldin C, Valiante V, Krüger T, Schafferer L, Haas H, Kniemeyer O, Brakhage AA.

Proteomics. 2015 Jul;15(13):2230-43. doi: 10.1002/pmic.201400584. Epub 2015 May 26.

PMID:
25728394
42.

Fungus-specific CD4(+) T cells for rapid identification of invasive pulmonary mold infection.

Bacher P, Steinbach A, Kniemeyer O, Hamprecht A, Assenmacher M, Vehreschild MJ, Vehreschild JJ, Brakhage AA, Cornely OA, Scheffold A.

Am J Respir Crit Care Med. 2015 Feb 1;191(3):348-52. doi: 10.1164/rccm.201407-1235LE. No abstract available.

PMID:
25635493
43.

Interference of Aspergillus fumigatus with the immune response.

Heinekamp T, Schmidt H, Lapp K, Pähtz V, Shopova I, Köster-Eiserfunke N, Krüger T, Kniemeyer O, Brakhage AA.

Semin Immunopathol. 2015 Mar;37(2):141-52. doi: 10.1007/s00281-014-0465-1. Epub 2014 Nov 18. Review.

44.

Characterization of the Aspergillus fumigatus detoxification systems for reactive nitrogen intermediates and their impact on virulence.

Lapp K, Vödisch M, Kroll K, Strassburger M, Kniemeyer O, Heinekamp T, Brakhage AA.

Front Microbiol. 2014 Sep 11;5:469. doi: 10.3389/fmicb.2014.00469. eCollection 2014.

45.

Identification of immunogenic antigens from Aspergillus fumigatus by direct multiparameter characterization of specific conventional and regulatory CD4+ T cells.

Bacher P, Kniemeyer O, Teutschbein J, Thön M, Vödisch M, Wartenberg D, Scharf DH, Koester-Eiserfunke N, Schütte M, Dübel S, Assenmacher M, Brakhage AA, Scheffold A.

J Immunol. 2014 Oct 1;193(7):3332-43. doi: 10.4049/jimmunol.1400776. Epub 2014 Aug 29.

46.

Identification of hypoxia-inducible target genes of Aspergillus fumigatus by transcriptome analysis reveals cellular respiration as an important contributor to hypoxic survival.

Kroll K, Pähtz V, Hillmann F, Vaknin Y, Schmidt-Heck W, Roth M, Jacobsen ID, Osherov N, Brakhage AA, Kniemeyer O.

Eukaryot Cell. 2014 Sep;13(9):1241-53. doi: 10.1128/EC.00084-14. Epub 2014 Aug 1.

47.

The novel globin protein fungoglobin is involved in low oxygen adaptation of Aspergillus fumigatus.

Hillmann F, Linde J, Beckmann N, Cyrulies M, Strassburger M, Heinekamp T, Haas H, Guthke R, Kniemeyer O, Brakhage AA.

Mol Microbiol. 2014 Aug;93(3):539-53. doi: 10.1111/mmi.12679. Epub 2014 Jul 7.

48.

Surface structure characterization of Aspergillus fumigatus conidia mutated in the melanin synthesis pathway and their human cellular immune response.

Bayry J, Beaussart A, Dufrêne YF, Sharma M, Bansal K, Kniemeyer O, Aimanianda V, Brakhage AA, Kaveri SV, Kwon-Chung KJ, Latgé JP, Beauvais A.

Infect Immun. 2014 Aug;82(8):3141-53. doi: 10.1128/IAI.01726-14. Epub 2014 May 12.

49.

Urine protein profiling identified alpha-1-microglobulin and haptoglobin as biomarkers for early diagnosis of acute allograft rejection following kidney transplantation.

Stubendorff B, Finke S, Walter M, Kniemeyer O, von Eggeling F, Gruschwitz T, Steiner T, Ott U, Wolf G, Wunderlich H, Junker K.

World J Urol. 2014 Dec;32(6):1619-24. doi: 10.1007/s00345-014-1263-z. Epub 2014 Feb 19.

PMID:
24549629
50.

Antigen-specific expansion of human regulatory T cells as a major tolerance mechanism against mucosal fungi.

Bacher P, Kniemeyer O, Schönbrunn A, Sawitzki B, Assenmacher M, Rietschel E, Steinbach A, Cornely OA, Brakhage AA, Thiel A, Scheffold A.

Mucosal Immunol. 2014 Jul;7(4):916-28. doi: 10.1038/mi.2013.107. Epub 2013 Dec 4.

PMID:
24301658

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