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Items: 1 to 50 of 203


Population pharmacokinetics of vancomycin in obesity: finding the optimal dose for (morbidly) obese individuals.

Smit C, Wasmann RE, Goulooze SC, Wiezer MJ, van Dongen EPA, Mouton JW, Brüggemann RJM, Knibbe CAJ.

Br J Clin Pharmacol. 2019 Oct 29. doi: 10.1111/bcp.14144. [Epub ahead of print]


Supervised Multidimensional Item Response Theory Modeling of Pediatric Iatrogenic Withdrawal Symptoms.

Goulooze SC, Ista E, van Dijk M, Hankemeier T, Tibboel D, Knibbe CAJ, Krekels EHJ.

CPT Pharmacometrics Syst Pharmacol. 2019 Oct 15. doi: 10.1002/psp4.12469. [Epub ahead of print]


Enteral Acetaminophen Bioavailability in Pediatric Intensive Care Patients Determined With an Oral Microtracer and Pharmacokinetic Modeling to Optimize Dosing.

Kleiber N, Calvier E, Mooij MG, Krekels EHJ, Vaes WHJ, Tibboel D, Knibbe CAJ, de Wildt SN.

Crit Care Med. 2019 Dec;47(12):e975-e983. doi: 10.1097/CCM.0000000000004032.


Pharmacokinetics and Pharmacodynamics of Drugs in Obese Pediatric Patients: How to Map Uncharted Clinical Territories.

Krekels EHJ, Knibbe CAJ.

Handb Exp Pharmacol. 2019 Oct 10. doi: 10.1007/164_2019_250. [Epub ahead of print]


Fixed Dosing of Liposomal Amphotericin B in Morbidly Obese Individuals.

Wasmann RE, Smit C, van Dongen EPH, Wiezer RMJ, Adler-Moore J, de Beer YM, Burger DM, Knibbe CAJ, Brüggemann RJM.

Clin Infect Dis. 2019 Sep 7. pii: ciz885. doi: 10.1093/cid/ciz885. [Epub ahead of print]


Rapidly maturing fentanyl clearance in preterm neonates.

Völler S, Flint RB, Andriessen P, Allegaert K, Zimmermann LJI, Liem KD, Koch BCP, Simons SHP, Knibbe CAJ; DINO study group.

Arch Dis Child Fetal Neonatal Ed. 2019 Nov;104(6):F598-F603. doi: 10.1136/archdischild-2018-315920. Epub 2019 Feb 1.


Population Pharmacokinetics of Intravenous Salbutamol in Children with Refractory Status Asthmaticus.

Vet NJ, de Winter BCM, Koninckx M, Boeschoten SA, Boehmer ALM, Verhallen JT, Plötz FB, Vaessen-Verberne AA, van der Nagel BCH, Knibbe CAJ, Buysse CMP, de Wildt SN, Koch BCP, de Hoog M.

Clin Pharmacokinet. 2019 Aug 21. doi: 10.1007/s40262-019-00811-y. [Epub ahead of print]


Dose-linearity of the pharmacokinetics of an intravenous [14 C]midazolam microdose in children.

van Groen BD, Vaes WH, Park BK, Krekels EHJ, van Duijn E, Kõrgvee LT, Maruszak W, Grynkiewicz G, Garner RC, Knibbe CAJ, Tibboel D, de Wildt SN, Turner MA.

Br J Clin Pharmacol. 2019 Oct;85(10):2332-2340. doi: 10.1111/bcp.14047. Epub 2019 Jul 30.


A Pediatric Covariate Function for CYP3A-Mediated Midazolam Clearance Can Scale Clearance of Selected CYP3A Substrates in Children.

Brussee JM, Krekels EHJ, Calvier EAM, Palić S, Rostami-Hodjegan A, Danhof M, Barrett JS, de Wildt SN, Knibbe CAJ.

AAPS J. 2019 Jun 27;21(5):81. doi: 10.1208/s12248-019-0351-9.


Larger Dose Reductions of Vancomycin Required in Neonates with Patent Ductus Arteriosus Receiving Indomethacin versus Ibuprofen.

Cristea S, Allegaert K, Falcao AC, Falcao F, Silva R, Smits A, Knibbe CAJ, Krekels EHJ.

Antimicrob Agents Chemother. 2019 Jul 25;63(8). pii: e00853-19. doi: 10.1128/AAC.00853-19. Print 2019 Aug.


Tobramycin Clearance Is Best Described by Renal Function Estimates in Obese and Non-obese Individuals: Results of a Prospective Rich Sampling Pharmacokinetic Study.

Smit C, Wasmann RE, Wiezer MJ, van Dongen HPA, Mouton JW, Brüggemann RJM, Knibbe CAJ.

Pharm Res. 2019 May 30;36(8):112. doi: 10.1007/s11095-019-2651-2.


Population Pharmacokinetics of Alemtuzumab (Campath) in Pediatric Hematopoietic Cell Transplantation: Towards Individualized Dosing to Improve Outcome.

Admiraal R, Jol-van der Zijde CM, Furtado Silva JM, Knibbe CAJ, Lankester AC, Boelens JJ, Hale G, Etuk A, Wilson M, Adams S, Veys P, van Kesteren C, Bredius RGM.

Clin Pharmacokinet. 2019 Dec;58(12):1609-1620. doi: 10.1007/s40262-019-00782-0.


Recently Registered Midazolam Doses for Preterm Neonates Do Not Lead to Equal Exposure: A Population Pharmacokinetic Model.

Völler S, Flint RB, Beggah F, Reiss I, Andriessen P, Zimmermann LJI, van den Anker JN, Liem KD, Koch BCP, de Wildt S, Knibbe CAJ, Simons SHP.

J Clin Pharmacol. 2019 Oct;59(10):1300-1308. doi: 10.1002/jcph.1429. Epub 2019 May 15.


Population pharmacokinetics of oxycodone in plasma and cerebrospinal fluid after epidural and intravenous administration.

Lamminsalo M, Piirainen P, Kokki H, Knibbe CAJ, Ranta VP, Välitalo P, Kokki M.

Expert Opin Drug Deliv. 2019 Jun;16(6):649-656. doi: 10.1080/17425247.2019.1618267. Epub 2019 May 22.


Asthma medication in children who are overweight/obese: justified treatment?

Lentferink YE, Boogaart NE, Balemans WAF, Knibbe CAJ, van der Vorst MMJ.

BMC Pediatr. 2019 May 11;19(1):148. doi: 10.1186/s12887-019-1526-3.


A Prospective Clinical Study Characterizing the Influence of Morbid Obesity on the Pharmacokinetics of Gentamicin: Towards Individualized Dosing in Obese Patients.

Smit C, Wasmann RE, Goulooze SC, Hazebroek EJ, Van Dongen EPA, Burgers DMT, Mouton JW, Brüggemann RJM, Knibbe CAJ.

Clin Pharmacokinet. 2019 Oct;58(10):1333-1343. doi: 10.1007/s40262-019-00762-4.


Scaling Drug Clearance from Adults to the Young Children for Drugs Undergoing Hepatic Metabolism: A Simulation Study to Search for the Simplest Scaling Method.

Calvier EAM, Krekels EHJ, Johnson TN, Rostami-Hodjegan A, Tibboel D, Knibbe CAJ.

AAPS J. 2019 Mar 8;21(3):38. doi: 10.1208/s12248-019-0295-0.


Increased Arterial Stiffness in Adolescents With Obesity.

Lentferink YE, Kromwijk LAJ, van der Aa MP, Knibbe CAJ, van der Vorst MMJ.

Glob Pediatr Health. 2019 Feb 25;6:2333794X19831297. doi: 10.1177/2333794X19831297. eCollection 2019.


Commentary on the EMA Reflection Paper on the use of extrapolation in the development of medicines for paediatrics.

Ollivier C, Thomson A, Manolis E, Blake K, Karlsson KE, Knibbe CAJ, Pons G, Hemmings R.

Br J Clin Pharmacol. 2019 Apr;85(4):659-668. doi: 10.1111/bcp.13883. Epub 2019 Feb 28.


Children Are Not Small Adults, but Can We Treat Them As Such?

Krekels EHJ, Calvier EAM, van der Graaf PH, Knibbe CAJ.

CPT Pharmacometrics Syst Pharmacol. 2019 Jan;8(1):34-38. doi: 10.1002/psp4.12366. Epub 2019 Jan 28.


Pharmacokinetics and probability of target attainment for micafungin in normal-weight and morbidly obese adults.

Wasmann RE, Smit C, Ter Heine R, Koele SE, van Dongen EPH, Wiezer RMJ, Burger DM, Knibbe CAJ, Brüggemann RJM.

J Antimicrob Chemother. 2019 Apr 1;74(4):978-985. doi: 10.1093/jac/dky554.


Population Pharmacokinetic Modeling of Acetaminophen and Metabolites in Children After Cardiac Surgery With Cardiopulmonary Bypass.

Mian P, Valkenburg AJ, Allegaert K, Koch BCP, Breatnach CV, Knibbe CAJ, Tibboel D, Krekels EHJ.

J Clin Pharmacol. 2019 Jun;59(6):847-855. doi: 10.1002/jcph.1373. Epub 2019 Jan 11.


Covariates in Pharmacometric Repeated Time-to-Event Models: Old and New (Pre)Selection Tools.

Goulooze SC, Krekels EHJ, Hankemeier T, Knibbe CAJ.

AAPS J. 2018 Dec 18;21(1):11. doi: 10.1208/s12248-018-0278-6.


Skin autofluorescence in children with and without obesity.

Lentferink YE, van Teeseling L, Knibbe CAJ, van der Vorst MMJ.

J Pediatr Endocrinol Metab. 2019 Jan 28;32(1):41-47. doi: 10.1515/jpem-2018-0237.


Efficacy of Metformin Treatment with Respect to Weight Reduction in Children and Adults with Obesity: A Systematic Review.

Lentferink YE, Knibbe CAJ, van der Vorst MMJ.

Drugs. 2018 Dec;78(18):1887-1901. doi: 10.1007/s40265-018-1025-0.


Can Population Modelling Principles be Used to Identify Key PBPK Parameters for Paediatric Clearance Predictions? An Innovative Application of Optimal Design Theory.

Calvier EAM, Nguyen TT, Johnson TN, Rostami-Hodjegan A, Tibboel D, Krekels EHJ, Knibbe CAJ.

Pharm Res. 2018 Sep 14;35(11):209. doi: 10.1007/s11095-018-2487-1.


Short- and long-term impact of remifentanil on thermal detection and pain thresholds after cardiac surgery: A randomised controlled trial.

de Hoogd S, Valkenburg AJ, van Dongen EPA, Daeter EJ, van Rosmalen J, Dahan A, Tibboel D, Knibbe CAJ.

Eur J Anaesthesiol. 2019 Jan;36(1):32-39. doi: 10.1097/EJA.0000000000000887.


Long-term metformin treatment in adolescents with obesity and insulin resistance, results of an open label extension study.

Lentferink YE, van der Aa MP, van Mill EGAH, Knibbe CAJ, van der Vorst MMJ.

Nutr Diabetes. 2018 Sep 10;8(1):47. doi: 10.1038/s41387-018-0057-6.


Characterization of Intestinal and Hepatic CYP3A-Mediated Metabolism of Midazolam in Children Using a Physiological Population Pharmacokinetic Modelling Approach.

Brussee JM, Yu H, Krekels EHJ, Palić S, Brill MJE, Barrett JS, Rostami-Hodjegan A, de Wildt SN, Knibbe CAJ.

Pharm Res. 2018 Jul 30;35(9):182. doi: 10.1007/s11095-018-2458-6.


Simulation-based suggestions to improve ibuprofen dosing for patent ductus arteriosus in preterm newborns.

Flint RB, Ter Heine R, Spaans E, Burger DM, de Klerk JCA, Allegaert K, Knibbe CAJ, Simons SHP.

Eur J Clin Pharmacol. 2018 Dec;74(12):1585-1591. doi: 10.1007/s00228-018-2529-y. Epub 2018 Jul 28.


Comment on "Effect of Age-Related Factors on the Pharmacokinetics of Lamotrigine and Potential Implications for Maintenance Dose Optimisation in Future Clinical Trials".

Standing JF, Anderson BJ, Hennig S, Holford NH, Johnston TN, Knibbe CAJ, Lonsdale DO, Rostami-Hodjegan A.

Clin Pharmacokinet. 2018 Nov;57(11):1471-1472. doi: 10.1007/s40262-018-0697-7. No abstract available.


Author's Reply to Reith: "Higher Midazolam Clearance in Obese Adolescents Compared with Morbidly Obese Adults".

van Rongen A, van den Anker JN, Knibbe CAJ.

Clin Pharmacokinet. 2018 Oct;57(10):1357-1358. doi: 10.1007/s40262-018-0692-z. No abstract available.


Psychostimulants: Influence on Body Mass Index and Height in a Pediatric Population with Attention-Deficit/Hyperactivity Disorder?

Lentferink YE, van de Garde EMW, Knibbe CAJ, van der Vorst MMJ.

J Child Adolesc Psychopharmacol. 2018 Oct;28(8):530-536. doi: 10.1089/cap.2017.0163. Epub 2018 May 16.


Increased Metformin Clearance in Overweight and Obese Adolescents: A Pharmacokinetic Substudy of a Randomized Controlled Trial.

van Rongen A, van der Aa MP, Matic M, van Schaik RHN, Deneer VHM, van der Vorst MM, Knibbe CAJ.

Paediatr Drugs. 2018 Aug;20(4):365-374. doi: 10.1007/s40272-018-0293-1.


First-Pass CYP3A-Mediated Metabolism of Midazolam in the Gut Wall and Liver in Preterm Neonates.

Brussee JM, Yu H, Krekels EHJ, de Roos B, Brill MJE, van den Anker JN, Rostami-Hodjegan A, de Wildt SN, Knibbe CAJ.

CPT Pharmacometrics Syst Pharmacol. 2018 Jun;7(6):374-383. doi: 10.1002/psp4.12295. Epub 2018 May 10.


Author's Reply to Reith: "Morbidly Obese Patients Exhibit Increased CYP2E1-Mediated Oxidation of Acetaminophen".

van Rongen A, Välitalo PAJ, Knibbe CAJ.

Clin Pharmacokinet. 2018 Jul;57(7):897-899. doi: 10.1007/s40262-018-0665-2. No abstract available.


Pharmacokinetics of Anidulafungin in Obese and Normal-Weight Adults.

Wasmann RE, Ter Heine R, van Dongen EP, Burger DM, Lempers VJ, Knibbe CA, Brüggemann RJ.

Antimicrob Agents Chemother. 2018 Jun 26;62(7). pii: e00063-18. doi: 10.1128/AAC.00063-18. Print 2018 Jul.


Pharmacokinetic considerations for pediatric patients receiving analgesia in the intensive care unit; targeting postoperative, ECMO and hypothermia patients.

Zeilmaker GA, Pokorna P, Mian P, Wildschut ED, Knibbe CAJ, Krekels EHJ, Allegaert K, Tibboel D.

Expert Opin Drug Metab Toxicol. 2018 Apr;14(4):417-428. doi: 10.1080/17425255.2018.1461836. Epub 2018 Apr 11. Review.


The Influence of Normalization Weight in Population Pharmacokinetic Covariate Models.

Goulooze SC, Völler S, Välitalo PAJ, Calvier EAM, Aarons L, Krekels EHJ, Knibbe CAJ.

Clin Pharmacokinet. 2019 Jan;58(1):131-138. doi: 10.1007/s40262-018-0652-7.


Obesity and drug pharmacology: a review of the influence of obesity on pharmacokinetic and pharmacodynamic parameters.

Smit C, De Hoogd S, Brüggemann RJM, Knibbe CAJ.

Expert Opin Drug Metab Toxicol. 2018 Mar;14(3):275-285. doi: 10.1080/17425255.2018.1440287. Epub 2018 Feb 15. Review.


Drugs Being Eliminated via the Same Pathway Will Not Always Require Similar Pediatric Dose Adjustments.

Calvier EAM, Krekels EHJ, Yu H, Välitalo PAJ, Johnson TN, Rostami-Hodjegan A, Tibboel D, van der Graaf PH, Danhof M, Knibbe CAJ.

CPT Pharmacometrics Syst Pharmacol. 2018 Mar;7(3):175-185. doi: 10.1002/psp4.12273. Epub 2018 Feb 5.


Predictors of Insulin Resistance in Children versus Adolescents with Obesity.

Lentferink YE, Elst MAJ, Knibbe CAJ, van der Vorst MMJ.

J Obes. 2017;2017:3793868. doi: 10.1155/2017/3793868. Epub 2017 Dec 10.


Kernel-Based Visual Hazard Comparison (kbVHC): a Simulation-Free Diagnostic for Parametric Repeated Time-to-Event Models.

Goulooze SC, Välitalo PAJ, Knibbe CAJ, Krekels EHJ.

AAPS J. 2017 Nov 27;20(1):5. doi: 10.1208/s12248-017-0162-9.


Drug Dosing in Obese Children: Challenges and Evidence-Based Strategies.

Xiong Y, Fukuda T, Knibbe CAJ, Vinks AA.

Pediatr Clin North Am. 2017 Dec;64(6):1417-1438. doi: 10.1016/j.pcl.2017.08.011. Review.


Predicting CYP3A-mediated midazolam metabolism in critically ill neonates, infants, children and adults with inflammation and organ failure.

Brussee JM, Vet NJ, Krekels EHJ, Valkenburg AJ, Jacqz-Aigrain E, van Gerven JMA, Swart EL, van den Anker JN, Tibboel D, de Hoog M, de Wildt SN, Knibbe CAJ.

Br J Clin Pharmacol. 2018 Feb;84(2):358-368. doi: 10.1111/bcp.13459. Epub 2017 Nov 29.


Amikacin Pharmacokinetics To Optimize Dosing in Neonates with Perinatal Asphyxia Treated with Hypothermia.

Cristea S, Smits A, Kulo A, Knibbe CAJ, van Weissenbruch M, Krekels EHJ, Allegaert K.

Antimicrob Agents Chemother. 2017 Nov 22;61(12). pii: e01282-17. doi: 10.1128/AAC.01282-17. Print 2017 Dec.


Intravenous Paracetamol Dosing Guidelines for Pain Management in (pre)term Neonates Using the Paediatric Study Decision Tree.

Mian P, Knibbe CAJ, Calvier EAM, Tibboel D, Allegaert K.

Curr Pharm Des. 2017;23(38):5839-5849. doi: 10.2174/1381612823666170921143104. Review.


Big Data Analyses for Continuous Evaluation of Pharmacotherapy: A Proof of Principle with Doxapram in Preterm Infants.

Flint RB, Weteringen WV, Voller S, Poppe JA, Koch BCP, de Groot R, Tibboel D, Knibbe CAJ, Reiss IKM, Simons SHP, Dino Research Group.

Curr Pharm Des. 2017;23(38):5919-5927. doi: 10.2174/1381612823666170918121556.


Augmented Renal Clearance in Critically Ill Pediatric Patients: Does It Impact the Outcome of Pharmacotherapy?

van den Anker JN, Knibbe CAJ, Tibboel D.

Pediatr Crit Care Med. 2017 Sep;18(9):901-902. doi: 10.1097/PCC.0000000000001264. No abstract available.


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