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Items: 1 to 50 of 84

1.

SIPA1L2 controls trafficking and local signaling of TrkB-containing amphisomes at presynaptic terminals.

Andres-Alonso M, Ammar MR, Butnaru I, Gomes GM, Acuña Sanhueza G, Raman R, Yuanxiang P, Borgmeyer M, Lopez-Rojas J, Raza SA, Brice N, Hausrat TJ, Macharadze T, Diaz-Gonzalez S, Carlton M, Failla AV, Stork O, Schweizer M, Gundelfinger ED, Kneussel M, Spilker C, Karpova A, Kreutz MR.

Nat Commun. 2019 Nov 29;10(1):5448. doi: 10.1038/s41467-019-13224-z.

2.

Motor protein binding and mitochondrial transport are altered by pathogenic TUBB4A variants.

Vulinovic F, Krajka V, Hausrat TJ, Seibler P, Alvarez-Fischer D, Madoev H, Park JS, Kumar KR, Sue CM, Lohmann K, Kneussel M, Klein C, Rakovic A.

Hum Mutat. 2019 Dec;40(12):2444. doi: 10.1002/humu.23913. Epub 2019 Nov 4. No abstract available.

PMID:
31758849
3.

The Microtubule Severing Protein Katanin Regulates Proliferation of Neuronal Progenitors in Embryonic and Adult Neurogenesis.

Lombino FL, Muhia M, Lopez-Rojas J, Brill MS, Thies E, Ruschkies L, Lutz D, Richter M, Hausrat TJ, Lopes AT, McNally FJ, Hermans-Borgmeyer I, Dunleavy JEM, Hoffmeister-Ullerich S, Frotscher M, Misgeld T, Kreutz MR, de Anda FC, Kneussel M.

Sci Rep. 2019 Nov 4;9(1):15940. doi: 10.1038/s41598-019-52367-3.

4.

Selective Inactivation of Reelin in Inhibitory Interneurons Leads to Subtle Changes in the Dentate Gyrus But Leaves Cortical Layering and Behavior Unaffected.

Pahle J, Muhia M, Wagener RJ, Tippmann A, Bock HH, Graw J, Herz J, Staiger JF, Drakew A, Kneussel M, Rune GM, Frotscher M, Brunne B.

Cereb Cortex. 2019 Oct 30. pii: bhz196. doi: 10.1093/cercor/bhz196. [Epub ahead of print]

PMID:
31667489
5.

Disturbed Prefrontal Cortex Activity in the Absence of Schizophrenia-Like Behavioral Dysfunction in Arc/Arg3.1 Deficient Mice.

Gao X, Grendel J, Muhia M, Castro-Gomez S, Süsens U, Isbrandt D, Kneussel M, Kuhl D, Ohana O.

J Neurosci. 2019 Oct 9;39(41):8149-8163. doi: 10.1523/JNEUROSCI.0623-19.2019. Epub 2019 Sep 5.

PMID:
31488612
6.

Myosin XVI Regulates Actin Cytoskeleton Dynamics in Dendritic Spines of Purkinje Cells and Affects Presynaptic Organization.

Roesler MK, Lombino FL, Freitag S, Schweizer M, Hermans-Borgmeyer I, Schwarz JR, Kneussel M, Wagner W.

Front Cell Neurosci. 2019 Aug 13;13:330. doi: 10.3389/fncel.2019.00330. eCollection 2019.

7.

Myosin V regulates synaptopodin clustering and localization in the dendrites of hippocampal neurons.

Konietzny A, González-Gallego J, Bär J, Perez-Alvarez A, Drakew A, Demmers JAA, Dekkers DHW, Hammer JA 3rd, Frotscher M, Oertner TG, Wagner W, Kneussel M, Mikhaylova M.

J Cell Sci. 2019 Aug 22;132(16). pii: jcs230177. doi: 10.1242/jcs.230177.

8.

Myosin VI Drives Clathrin-Mediated AMPA Receptor Endocytosis to Facilitate Cerebellar Long-Term Depression.

Wagner W, Lippmann K, Heisler FF, Gromova KV, Lombino FL, Roesler MK, Pechmann Y, Hornig S, Schweizer M, Polo S, Schwarz JR, Eilers J, Kneussel M.

Cell Rep. 2019 Jul 2;28(1):11-20.e9. doi: 10.1016/j.celrep.2019.06.005.

9.

Elucidating the Molecular Basis for Inhibitory Neurotransmission Regulation by Artemisinins.

Kasaragod VB, Hausrat TJ, Schaefer N, Kuhn M, Christensen NR, Tessmer I, Maric HM, Madsen KL, Sotriffer C, Villmann C, Kneussel M, Schindelin H.

Neuron. 2019 Feb 20;101(4):673-689.e11. doi: 10.1016/j.neuron.2019.01.001. Epub 2019 Jan 28.

10.

Excessive tubulin polyglutamylation causes neurodegeneration and perturbs neuronal transport.

Magiera MM, Bodakuntla S, Žiak J, Lacomme S, Marques Sousa P, Leboucher S, Hausrat TJ, Bosc C, Andrieux A, Kneussel M, Landry M, Calas A, Balastik M, Janke C.

EMBO J. 2018 Dec 3;37(23). pii: e100440. doi: 10.15252/embj.2018100440. Epub 2018 Nov 12.

11.

Muskelin Coordinates PrPC Lysosome versus Exosome Targeting and Impacts Prion Disease Progression.

Heisler FF, Pechmann Y, Wieser I, Altmeppen HC, Veenendaal L, Muhia M, Schweizer M, Glatzel M, Krasemann S, Kneussel M.

Neuron. 2018 Sep 19;99(6):1155-1169.e9. doi: 10.1016/j.neuron.2018.08.010. Epub 2018 Aug 30.

12.

Clinical relevance of cytoskeleton associated proteins for ovarian cancer.

Schiewek J, Schumacher U, Lange T, Joosse SA, Wikman H, Pantel K, Mikhaylova M, Kneussel M, Linder S, Schmalfeldt B, Oliveira-Ferrer L, Windhorst S.

J Cancer Res Clin Oncol. 2018 Nov;144(11):2195-2205. doi: 10.1007/s00432-018-2710-9. Epub 2018 Aug 9.

PMID:
30094535
13.

Motor protein binding and mitochondrial transport are altered by pathogenic TUBB4A variants.

Vulinovic F, Krajka V, Hausrat TJ, Seibler P, Alvarez-Fischer D, Madoev H, Park JS, Kumar KR, Sue CM, Lohmann K, Kneussel M, Klein C, Rakovic A.

Hum Mutat. 2018 Dec;39(12):1901-1915. doi: 10.1002/humu.23602. Epub 2018 Sep 7. Erratum in: Hum Mutat. 2019 Dec;40(12):2444.

PMID:
30079973
14.

Neurobeachin and the Kinesin KIF21B Are Critical for Endocytic Recycling of NMDA Receptors and Regulate Social Behavior.

Gromova KV, Muhia M, Rothammer N, Gee CE, Thies E, Schaefer I, Kress S, Kilimann MW, Shevchuk O, Oertner TG, Kneussel M.

Cell Rep. 2018 May 29;23(9):2705-2717. doi: 10.1016/j.celrep.2018.04.112.

15.

The BEACH protein LRBA is required for hair bundle maintenance in cochlear hair cells and for hearing.

Vogl C, Butola T, Haag N, Hausrat TJ, Leitner MG, Moutschen M, Lefèbvre PP, Speckmann C, Garrett L, Becker L, Fuchs H, Hrabe de Angelis M, Nietzsche S, Kessels MM, Oliver D, Kneussel M, Kilimann MW, Strenzke N.

EMBO Rep. 2017 Nov;18(11):2015-2029. doi: 10.15252/embr.201643689. Epub 2017 Sep 11.

16.

Gephyrin-binding peptides visualize postsynaptic sites and modulate neurotransmission.

Maric HM, Hausrat TJ, Neubert F, Dalby NO, Doose S, Sauer M, Kneussel M, Strømgaard K.

Nat Chem Biol. 2017 Feb;13(2):153-160. doi: 10.1038/nchembio.2246. Epub 2016 Nov 28.

PMID:
27893705
17.

Activity-Dependent Regulation of Distinct Transport and Cytoskeletal Remodeling Functions of the Dendritic Kinesin KIF21B.

Ghiretti AE, Thies E, Tokito MK, Lin T, Ostap EM, Kneussel M, Holzbaur ELF.

Neuron. 2016 Nov 23;92(4):857-872. doi: 10.1016/j.neuron.2016.10.003. Epub 2016 Nov 3.

18.

Branch-Specific Microtubule Destabilization Mediates Axon Branch Loss during Neuromuscular Synapse Elimination.

Brill MS, Kleele T, Ruschkies L, Wang M, Marahori NA, Reuter MS, Hausrat TJ, Weigand E, Fisher M, Ahles A, Engelhardt S, Bishop DL, Kneussel M, Misgeld T.

Neuron. 2016 Nov 23;92(4):845-856. doi: 10.1016/j.neuron.2016.09.049. Epub 2016 Oct 20.

19.

Precise Somatotopic Thalamocortical Axon Guidance Depends on LPA-Mediated PRG-2/Radixin Signaling.

Cheng J, Sahani S, Hausrat TJ, Yang JW, Ji H, Schmarowski N, Endle H, Liu X, Li Y, Böttche R, Radyushkin K, Maric HM, Hoerder-Suabedissen A, Molnár Z, Prouvot PH, Trimbuch T, Ninnemann O, Huai J, Fan W, Visentin B, Sabbadini R, Strømgaard K, Stroh A, Luhmann HJ, Kneussel M, Nitsch R, Vogt J.

Neuron. 2016 Oct 5;92(1):126-142. doi: 10.1016/j.neuron.2016.08.035. Epub 2016 Sep 15.

20.

The Kinesin KIF21B Regulates Microtubule Dynamics and Is Essential for Neuronal Morphology, Synapse Function, and Learning and Memory.

Muhia M, Thies E, Labonté D, Ghiretti AE, Gromova KV, Xompero F, Lappe-Siefke C, Hermans-Borgmeyer I, Kuhl D, Schweizer M, Ohana O, Schwarz JR, Holzbaur ELF, Kneussel M.

Cell Rep. 2016 May 3;15(5):968-977. doi: 10.1016/j.celrep.2016.03.086. Epub 2016 Apr 21.

21.

Postsynaptic Neurotransmitter Receptor Reserve Pools for Synaptic Potentiation.

Kneussel M, Hausrat TJ.

Trends Neurosci. 2016 Mar;39(3):170-182. doi: 10.1016/j.tins.2016.01.002. Epub 2016 Jan 30. Review.

PMID:
26833258
22.

Ubiquitin ligase TRIM3 controls hippocampal plasticity and learning by regulating synaptic γ-actin levels.

Schreiber J, Végh MJ, Dawitz J, Kroon T, Loos M, Labonté D, Li KW, Van Nierop P, Van Diepen MT, De Zeeuw CI, Kneussel M, Meredith RM, Smit AB, Van Kesteren RE.

J Cell Biol. 2015 Nov 9;211(3):569-86. doi: 10.1083/jcb.201506048. Epub 2015 Nov 2.

23.

Drosophila homologue of Diaphanous 1 (DIAPH1) controls the metastatic potential of colon cancer cells by regulating microtubule-dependent adhesion.

Lin YN, Bhuwania R, Gromova K, Failla AV, Lange T, Riecken K, Linder S, Kneussel M, Izbicki JR, Windhorst S.

Oncotarget. 2015 Jul 30;6(21):18577-89.

24.

Structure-function-behavior relationship in estrogen-induced synaptic plasticity.

Vierk R, Bayer J, Freitag S, Muhia M, Kutsche K, Wolbers T, Kneussel M, Sommer T, Rune GM.

Horm Behav. 2015 Aug;74:139-48. doi: 10.1016/j.yhbeh.2015.05.008. Epub 2015 May 24.

PMID:
26012713
25.

Radixin regulates synaptic GABAA receptor density and is essential for reversal learning and short-term memory.

Hausrat TJ, Muhia M, Gerrow K, Thomas P, Hirdes W, Tsukita S, Heisler FF, Herich L, Dubroqua S, Breiden P, Feldon J, Schwarz JR, Yee BK, Smart TG, Triller A, Kneussel M.

Nat Commun. 2015 Apr 20;6:6872. doi: 10.1038/ncomms7872.

26.

GSK3 and KIF5 regulate activity-dependent sorting of gephyrin between axons and dendrites.

Rathgeber L, Gromova KV, Schaefer I, Breiden P, Lohr C, Kneussel M.

Eur J Cell Biol. 2015 Mar-Apr;94(3-4):173-8. doi: 10.1016/j.ejcb.2015.01.005. Epub 2015 Feb 4.

27.

MmTX1 and MmTX2 from coral snake venom potently modulate GABAA receptor activity.

Rosso JP, Schwarz JR, Diaz-Bustamante M, Céard B, Gutiérrez JM, Kneussel M, Pongs O, Bosmans F, Bougis PE.

Proc Natl Acad Sci U S A. 2015 Feb 24;112(8):E891-900. doi: 10.1073/pnas.1415488112. Epub 2015 Feb 9.

28.

The LisH motif of muskelin is crucial for oligomerization and governs intracellular localization.

Delto CF, Heisler FF, Kuper J, Sander B, Kneussel M, Schindelin H.

Structure. 2015 Feb 3;23(2):364-73. doi: 10.1016/j.str.2014.11.016. Epub 2015 Jan 8.

29.

Molecular basis of the alternative recruitment of GABA(A) versus glycine receptors through gephyrin.

Maric HM, Kasaragod VB, Hausrat TJ, Kneussel M, Tretter V, Strømgaard K, Schindelin H.

Nat Commun. 2014 Dec 22;5:5767. doi: 10.1038/ncomms6767.

PMID:
25531214
30.

Selective synaptic targeting of the excitatory and inhibitory presynaptic organizers FGF22 and FGF7.

Terauchi A, Timmons KM, Kikuma K, Pechmann Y, Kneussel M, Umemori H.

J Cell Sci. 2015 Jan 15;128(2):281-92. doi: 10.1242/jcs.158337. Epub 2014 Nov 27.

31.

Design and synthesis of high-affinity dimeric inhibitors targeting the interactions between gephyrin and inhibitory neurotransmitter receptors.

Maric HM, Kasaragod VB, Haugaard-Kedström L, Hausrat TJ, Kneussel M, Schindelin H, Strømgaard K.

Angew Chem Int Ed Engl. 2015 Jan 7;54(2):490-4. doi: 10.1002/anie.201409043. Epub 2014 Nov 20.

PMID:
25413248
32.

The kinesin KIF21B participates in the cell surface delivery of γ2 subunit-containing GABAA receptors.

Labonté D, Thies E, Kneussel M.

Eur J Cell Biol. 2014 Aug-Sep;93(8-9):338-46. doi: 10.1016/j.ejcb.2014.07.007. Epub 2014 Aug 2.

33.

SnapShot: receptor dynamics at plastic synapses.

Kneussel M, Triller A, Choquet D.

Cell. 2014 Jun 19;157(7):1738-1738.e1. doi: 10.1016/j.cell.2014.06.002.

34.

Synaptic recruitment of gephyrin regulates surface GABAA receptor dynamics for the expression of inhibitory LTP.

Petrini EM, Ravasenga T, Hausrat TJ, Iurilli G, Olcese U, Racine V, Sibarita JB, Jacob TC, Moss SJ, Benfenati F, Medini P, Kneussel M, Barberis A.

Nat Commun. 2014 Jun 4;5:3921. doi: 10.1038/ncomms4921.

35.

GRIP1 interlinks N-cadherin and AMPA receptors at vesicles to promote combined cargo transport into dendrites.

Heisler FF, Lee HK, Gromova KV, Pechmann Y, Schurek B, Ruschkies L, Schroeder M, Schweizer M, Kneussel M.

Proc Natl Acad Sci U S A. 2014 Apr 1;111(13):5030-5. doi: 10.1073/pnas.1304301111. Epub 2014 Mar 17.

36.

TRIM3 regulates the motility of the kinesin motor protein KIF21B.

Labonté D, Thies E, Pechmann Y, Groffen AJ, Verhage M, Smit AB, van Kesteren RE, Kneussel M.

PLoS One. 2013 Sep 24;8(9):e75603. doi: 10.1371/journal.pone.0075603. eCollection 2013.

37.

Myosin motors at neuronal synapses: drivers of membrane transport and actin dynamics.

Kneussel M, Wagner W.

Nat Rev Neurosci. 2013 Apr;14(4):233-47. doi: 10.1038/nrn3445. Epub 2013 Mar 13. Review.

PMID:
23481482
38.

TRPM4 cation channel mediates axonal and neuronal degeneration in experimental autoimmune encephalomyelitis and multiple sclerosis.

Schattling B, Steinbach K, Thies E, Kruse M, Menigoz A, Ufer F, Flockerzi V, Brück W, Pongs O, Vennekens R, Kneussel M, Freichel M, Merkler D, Friese MA.

Nat Med. 2012 Dec;18(12):1805-11. doi: 10.1038/nm.3015. Epub 2012 Nov 18.

PMID:
23160238
39.

Spatio-temporal expression analysis of the calcium-binding protein calumenin in the rodent brain.

Vasiljevic M, Heisler FF, Hausrat TJ, Fehr S, Milenkovic I, Kneussel M, Sieghart W.

Neuroscience. 2012 Jan 27;202:29-41. doi: 10.1016/j.neuroscience.2011.11.069. Epub 2011 Dec 6.

40.

Gephyrin regulates GABAergic and glutamatergic synaptic transmission in hippocampal cell cultures.

Varley ZK, Pizzarelli R, Antonelli R, Stancheva SH, Kneussel M, Cherubini E, Zacchi P.

J Biol Chem. 2011 Jun 10;286(23):20942-51. doi: 10.1074/jbc.M111.234641. Epub 2011 Apr 20. Erratum in: J Biol Chem. 2011 Sep 2;286(35):31062.

41.

Muskelin regulates actin filament- and microtubule-based GABA(A) receptor transport in neurons.

Heisler FF, Loebrich S, Pechmann Y, Maier N, Zivkovic AR, Tokito M, Hausrat TJ, Schweizer M, Bähring R, Holzbaur EL, Schmitz D, Kneussel M.

Neuron. 2011 Apr 14;70(1):66-81. doi: 10.1016/j.neuron.2011.03.008.

42.

Neuroligin 1 is dynamically exchanged at postsynaptic sites.

Schapitz IU, Behrend B, Pechmann Y, Lappe-Siefke C, Kneussel SJ, Wallace KE, Stempel AV, Buck F, Grant SG, Schweizer M, Schmitz D, Schwarz JR, Holzbaur EL, Kneussel M.

J Neurosci. 2010 Sep 22;30(38):12733-44. doi: 10.1523/JNEUROSCI.0896-10.2010.

43.

Tubulin post-translational modifications: encoding functions on the neuronal microtubule cytoskeleton.

Janke C, Kneussel M.

Trends Neurosci. 2010 Aug;33(8):362-72. doi: 10.1016/j.tins.2010.05.001. Epub 2010 Jun 11. Review.

PMID:
20541813
44.

Cellular transport and membrane dynamics of the glycine receptor.

Dumoulin A, Triller A, Kneussel M.

Front Mol Neurosci. 2010 Feb 5;2:28. doi: 10.3389/neuro.02.028.2009. eCollection 2009.

45.

Extracellular neurotransmitter receptor clustering: think outside the box.

Kneussel M.

J Mol Cell Biol. 2010 Jun;2(3):107-9. doi: 10.1093/jmcb/mjp049. Epub 2009 Dec 14.

PMID:
20008862
46.

Multifunctional basic motif in the glycine receptor intracellular domain induces subunit-specific sorting.

Melzer N, Villmann C, Becker K, Harvey K, Harvey RJ, Vogel N, Kluck CJ, Kneussel M, Becker CM.

J Biol Chem. 2010 Feb 5;285(6):3730-9. doi: 10.1074/jbc.M109.030460. Epub 2009 Dec 3.

47.

Behavioral deficits and subregion-specific suppression of LTP in mice expressing a population of mutant NMDA receptors throughout the hippocampus.

Chen PE, Errington ML, Kneussel M, Chen G, Annala AJ, Rudhard YH, Rast GF, Specht CG, Tigaret CM, Nassar MA, Morris RG, Bliss TV, Schoepfer R.

Learn Mem. 2009 Sep 30;16(10):635-44. doi: 10.1101/lm.1316909. Print 2009 Oct.

48.

The ataxia (axJ) mutation causes abnormal GABAA receptor turnover in mice.

Lappe-Siefke C, Loebrich S, Hevers W, Waidmann OB, Schweizer M, Fehr S, Fritschy JM, Dikic I, Eilers J, Wilson SM, Kneussel M.

PLoS Genet. 2009 Sep;5(9):e1000631. doi: 10.1371/journal.pgen.1000631. Epub 2009 Sep 4.

49.

Synaptic activation modifies microtubules underlying transport of postsynaptic cargo.

Maas C, Belgardt D, Lee HK, Heisler FF, Lappe-Siefke C, Magiera MM, van Dijk J, Hausrat TJ, Janke C, Kneussel M.

Proc Natl Acad Sci U S A. 2009 May 26;106(21):8731-6. doi: 10.1073/pnas.0812391106. Epub 2009 May 13.

50.

Shank1 mRNA: dendritic transport by kinesin and translational control by the 5'untranslated region.

Falley K, Schütt J, Iglauer P, Menke K, Maas C, Kneussel M, Kindler S, Wouters FS, Richter D, Kreienkamp HJ.

Traffic. 2009 Jul;10(7):844-57. doi: 10.1111/j.1600-0854.2009.00912.x. Epub 2009 Apr 11.

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