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Items: 26

1.

Targeted delivery of antisense oligonucleotides to pancreatic β-cells.

Ämmälä C, Drury WJ 3rd, Knerr L, Ahlstedt I, Stillemark-Billton P, Wennberg-Huldt C, Andersson EM, Valeur E, Jansson-Löfmark R, Janzén D, Sundström L, Meuller J, Claesson J, Andersson P, Johansson C, Lee RG, Prakash TP, Seth PP, Monia BP, Andersson S.

Sci Adv. 2018 Oct 17;4(10):eaat3386. doi: 10.1126/sciadv.aat3386. eCollection 2018 Oct.

2.

Synthesis of Diverse α-Fluoroalkoxyaryl Derivatives and Their Use for the Generation of Fluorinated Macrocycles.

Cogswell TJ, Dahlén A, Knerr L.

Chemistry. 2019 Jan 24;25(5):1184-1187. doi: 10.1002/chem.201804440. Epub 2018 Dec 13.

PMID:
30329185
3.

Exploring physicochemical space via a bioisostere of the trifluoromethyl and ethyl groups (BITE): attenuating lipophilicity in fluorinated analogues of Gilenya® for multiple sclerosis.

Erdeljac N, Kehr G, Ahlqvist M, Knerr L, Gilmour R.

Chem Commun (Camb). 2018 Oct 23;54(85):12002-12005. doi: 10.1039/c8cc05643a.

PMID:
30221278
4.

Design of Selective sPLA2-X Inhibitor (-)-2-{2-[Carbamoyl-6-(trifluoromethoxy)-1H-indol-1-yl]pyridine-2-yl}propanoic Acid.

Giordanetto F, Knerr L, Nordberg P, Pettersen D, Selmi N, Beisel HG, de la Motte H, Månsson Å, Dahlström M, Broddefalk J, Saarinen G, Klingegård F, Hurt-Camejo E, Rosengren B, Wikström J, Wågberg M, Brengdahl J, Rohman M, Sandmark J, Åkerud T, Roth RG, Jansen F, Ahlqvist M.

ACS Med Chem Lett. 2018 Jun 23;9(7):600-605. doi: 10.1021/acsmedchemlett.7b00507. eCollection 2018 Jul 12.

PMID:
30034586
5.

Discovery of a Series of Indole-2 Carboxamides as Selective Secreted Phospholipase A2 Type X (sPLA2-X) Inhibitors.

Knerr L, Giordanetto F, Nordberg P, Pettersen D, Selmi N, Beisel HG, de la Motte H, Olsson T, Perkins TDJ, Herslöf M, Månsson Å, Dahlström M, Starke I, Broddefalk J, Saarinen G, Klingegård F, Hurt-Camejo E, Rosengren B, Brengdahl J, Jansen F, Rohman M, Sandmark J, Hallberg K, Åkerud T, Roth RG, Ahlqvist M.

ACS Med Chem Lett. 2018 Jun 23;9(7):594-599. doi: 10.1021/acsmedchemlett.7b00505. eCollection 2018 Jul 12.

PMID:
30034585
6.

The Conundrum of GSK3 Inhibitors: Is it the Dawn of a New Beginning?

Bhat RV, Andersson U, Andersson S, Knerr L, Bauer U, Sundgren-Andersson AK.

J Alzheimers Dis. 2018;64(s1):S547-S554. doi: 10.3233/JAD-179934. Review.

PMID:
29758944
7.

Development of Novel Melanocortin Receptor Agonists Based on the Cyclic Peptide Framework of Sunflower Trypsin Inhibitor-1.

Durek T, Cromm PM, White AM, Schroeder CI, Kaas Q, Weidmann J, Ahmad Fuaad A, Cheneval O, Harvey PJ, Daly NL, Zhou Y, Dellsén A, Österlund T, Larsson N, Knerr L, Bauer U, Kessler H, Cai M, Hruby VJ, Plowright AT, Craik DJ.

J Med Chem. 2018 Apr 26;61(8):3674-3684. doi: 10.1021/acs.jmedchem.8b00170. Epub 2018 Apr 11.

8.

Fluorine-Directed Glycosylation Enables the Stereocontrolled Synthesis of Selective SGLT2 Inhibitors for Type II Diabetes.

Sadurní A, Kehr G, Ahlqvist M, Wernevik J, Sjögren HP, Kankkonen C, Knerr L, Gilmour R.

Chemistry. 2018 Feb 26;24(12):2832-2836. doi: 10.1002/chem.201705373. Epub 2017 Dec 20.

PMID:
29211300
9.

Direct Synthesis of N-Alkyl Arylglycines by Organocatalytic Asymmetric Transfer Hydrogenation of N-Alkyl Aryl Imino Esters.

Mazuela J, Antonsson T, Johansson MJ, Knerr L, Marsden SP.

Org Lett. 2017 Oct 20;19(20):5541-5544. doi: 10.1021/acs.orglett.7b02627. Epub 2017 Oct 5.

10.

Targeted delivery for regenerative medicines: an untapped opportunity for drug conjugates.

Valeur E, Knerr L, Ölwegård-Halvarsson M, Lemurell M.

Drug Discov Today. 2017 Jun;22(6):841-847. doi: 10.1016/j.drudis.2016.12.004. Epub 2016 Dec 14.

PMID:
27988360
11.

Discovery of AZD2716: A Novel Secreted Phospholipase A2 (sPLA2) Inhibitor for the Treatment of Coronary Artery Disease.

Giordanetto F, Pettersen D, Starke I, Nordberg P, Dahlström M, Knerr L, Selmi N, Rosengren B, Larsson LO, Sandmark J, Castaldo M, Dekker N, Karlsson U, Hurt-Camejo E.

ACS Med Chem Lett. 2016 Aug 9;7(10):884-889. eCollection 2016 Oct 13.

12.

Therapeutic Potential of Foldamers: From Chemical Biology Tools To Drug Candidates?

Gopalakrishnan R, Frolov AI, Knerr L, Drury WJ 3rd, Valeur E.

J Med Chem. 2016 Nov 10;59(21):9599-9621. Epub 2016 Jul 29. Review.

PMID:
27362955
13.

Discovery of a novel pyrazole series of group X secreted phospholipase A2 inhibitor (sPLA2X) via fragment based virtual screening.

Chen H, Knerr L, Åkerud T, Hallberg K, Öster L, Rohman M, Österlund K, Beisel HG, Olsson T, Brengdhal J, Sandmark J, Bodin C.

Bioorg Med Chem Lett. 2014 Nov 15;24(22):5251-5. doi: 10.1016/j.bmcl.2014.09.058. Epub 2014 Sep 30.

PMID:
25316315
14.

Stapled Vasoactive Intestinal Peptide (VIP) Derivatives Improve VPAC2 Agonism and Glucose-Dependent Insulin Secretion.

Giordanetto F, Revell JD, Knerr L, Hostettler M, Paunovic A, Priest C, Janefeldt A, Gill A.

ACS Med Chem Lett. 2013 Oct 16;4(12):1163-8. doi: 10.1021/ml400257h. eCollection 2013 Dec 12.

15.

Heart regeneration: opportunities and challenges for drug discovery with novel chemical and therapeutic methods or agents.

Plowright AT, Engkvist O, Gill A, Knerr L, Wang QD.

Angew Chem Int Ed Engl. 2014 Apr 14;53(16):4056-75. doi: 10.1002/anie.201307034. Epub 2014 Jan 27. Review.

PMID:
24470316
16.

Design, synthesis, and SAR of a series of activated protein C (APC) inhibitors with selectivity against thrombin for the treatment of haemophilia.

Bach P, Knerr L, Fjellström O, Hansson K, Mattsson C, Gustafsson D.

Bioorg Med Chem Lett. 2014 Feb 1;24(3):821-7. doi: 10.1016/j.bmcl.2013.12.094. Epub 2013 Dec 29.

PMID:
24418773
17.

Discovery of N-[[1-[2-(tert-butylcarbamoylamino)ethyl]-4-(hydroxymethyl)-4-piperidyl]methyl]-3,5-dichloro-benzamide as a selective T-type calcium channel (Cav3.2) inhibitor.

Giordanetto F, Wållberg A, Knerr L, Selmi N, Ullah V, Thorstensson F, Lindelöf Å, Karlsson S, Nikitidis G, Llinas A, Wang QD, Lindqvist A, Högberg G, Lindhardt E, Åstrand A, Duker G.

Bioorg Med Chem Lett. 2013 Jan 1;23(1):119-24. doi: 10.1016/j.bmcl.2012.10.140. Epub 2012 Nov 12.

PMID:
23200256
18.

Discovery of N-(1-adamantyl)-2-(4-alkylpiperazin-1-yl)acetamide derivatives as T-type calcium channel (Cav3.2) inhibitors.

Giordanetto F, Knerr L, Selmi N, Llinàs A, Lindqvist A, Wang QD, Ståhlberg P, Thorstensson F, Ullah V, Nilsson K, O'Mahony G, Högberg G, Lindhardt E, Strand A, Duker G.

Bioorg Med Chem Lett. 2011 Sep 15;21(18):5557-61. doi: 10.1016/j.bmcl.2011.06.092. Epub 2011 Jun 30.

PMID:
21782423
19.

T-type calcium channels inhibitors: a patent review.

Giordanetto F, Knerr L, Wållberg A.

Expert Opin Ther Pat. 2011 Jan;21(1):85-101. doi: 10.1517/13543776.2011.536532. Epub 2010 Nov 19. Review.

PMID:
21087200
20.

Imidazopyridines as VLA-4 integrin antagonists.

Phillips DJ, Davenport RJ, Demaude TA, Galleway FP, Jones MW, Knerr L, Perry BG, Ratcliffe AJ.

Bioorg Med Chem Lett. 2008 Jul 15;18(14):4146-9. doi: 10.1016/j.bmcl.2008.05.075. Epub 2008 May 23. Erratum in: Bioorg Med Chem Lett. 2008 Sep 1;18(17):4913.

PMID:
18539454
21.

2,6-Quinolinyl derivatives as potent VLA-4 antagonists.

Lassoie MA, Broeders F, Collart P, Defrère L, de Laveleye-Defais F, Demaude T, Gassama A, Guillaumet G, Hayez JC, Kiss L, Knerr L, Nicolas JM, Norsikian S, Quéré L, Routier S, Verbois V, Provins L.

Bioorg Med Chem Lett. 2007 Jan 1;17(1):142-6. Epub 2006 Oct 10.

PMID:
17035017
22.
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24.

Nicotinic acetylcholine receptor labeled with a tritiated, photoactivatable agonist: a new tool for investigating the functional, activated state.

Kotzyba-Hibert F, Kessler P, Zerbib V, Grutter T, Bogen C, Takeda K, Hammadi A, Knerr L, Goeldner M.

Bioconjug Chem. 1997 Jul-Aug;8(4):472-80.

PMID:
9258443
25.

Inheritance and linkage relationships of isozyme loci in cucumber (Cucumis sativus L.).

Knerr LD, Staub JE.

Theor Appl Genet. 1992 Jun;84(1-2):217-24. doi: 10.1007/BF00224003.

PMID:
24203050
26.

Genetic diversity in Cucumis sativus L. assessed by variation at 18 allozyme coding loci.

Knerr LD, Staub JE, Holder DJ, May BP.

Theor Appl Genet. 1989 Jul;78(1):119-28. doi: 10.1007/BF00299764.

PMID:
24227040

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