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Items: 1 to 50 of 93

1.

A common mechanism of action of the selective serotonin reuptake inhibitors citalopram and fluoxetine: reversal of chronic psychosocial stress-induced increase in CRE/CREB-directed gene transcription in transgenic reporter gene mice.

Böer U, Noll C, Cierny I, Krause D, Hiemke C, Knepel W.

Eur J Pharmacol. 2010 May 10;633(1-3):33-8. doi: 10.1016/j.ejphar.2010.01.016. Epub 2010 Feb 1.

PMID:
20122921
2.

The homeodomain of PAX6 is essential for PAX6-dependent activation of the rat glucagon gene promoter: evidence for a PH0-like binding that induces an active conformation.

Grapp M, Teichler S, Kitz J, Dibaj P, Dickel C, Knepel W, Krätzner R.

Biochim Biophys Acta. 2009 May;1789(5):403-12. doi: 10.1016/j.bbagrm.2009.02.001. Epub 2009 Feb 13.

PMID:
19217949
3.

Loss of insulin-induced inhibition of glucagon gene transcription in hamster pancreatic islet alpha cells by long-term insulin exposure.

González M, Böer U, Dickel C, Quentin T, Cierny I, Oetjen E, Knepel W.

Diabetologia. 2008 Nov;51(11):2012-21. doi: 10.1007/s00125-008-1134-5. Epub 2008 Sep 2.

PMID:
18762908
4.

Stimulation by lithium of the interaction between the transcription factor CREB and its co-activator TORC.

Heinrich A, Böer U, Tzvetkov M, Oetjen E, Knepel W.

Biosci Rep. 2009 Apr;29(2):77-87. doi: 10.1042/BSR20080116.

5.

Chronic lithium salt treatment reduces CRE/CREB-directed gene transcription and reverses its upregulation by chronic psychosocial stress in transgenic reporter gene mice.

Böer U, Cierny I, Krause D, Heinrich A, Lin H, Mayr G, Hiemke C, Knepel W.

Neuropsychopharmacology. 2008 Sep;33(10):2407-15. Epub 2007 Nov 28.

6.

Activation of the dual-leucine-zipper-bearing kinase and induction of beta-cell apoptosis by the immunosuppressive drug cyclosporin A.

Plaumann S, Blume R, Börchers S, Steinfelder HJ, Knepel W, Oetjen E.

Mol Pharmacol. 2008 Mar;73(3):652-9. Epub 2007 Nov 27.

PMID:
18042735
7.

A peroxisome proliferator-activated receptor gamma-retinoid X receptor heterodimer physically interacts with the transcriptional activator PAX6 to inhibit glucagon gene transcription.

Krätzner R, Fröhlich F, Lepler K, Schröder M, Röher K, Dickel C, Tzvetkov MV, Quentin T, Oetjen E, Knepel W.

Mol Pharmacol. 2008 Feb;73(2):509-17. Epub 2007 Oct 25.

PMID:
17962386
8.

Enhancement by lithium of cAMP-induced CRE/CREB-directed gene transcription conferred by TORC on the CREB basic leucine zipper domain.

Böer U, Eglins J, Krause D, Schnell S, Schöfl C, Knepel W.

Biochem J. 2007 Nov 15;408(1):69-77.

9.

Inhibition of MafA transcriptional activity and human insulin gene transcription by interleukin-1beta and mitogen-activated protein kinase kinase kinase in pancreatic islet beta cells.

Oetjen E, Blume R, Cierny I, Schlag C, Kutschenko A, Krätzner R, Stein R, Knepel W.

Diabetologia. 2007 Aug;50(8):1678-87. Epub 2007 Jun 22.

PMID:
17583797
10.

CRE/CREB-driven up-regulation of gene expression by chronic social stress in CRE-luciferase transgenic mice: reversal by antidepressant treatment.

Böer U, Alejel T, Beimesche S, Cierny I, Krause D, Knepel W, Flügge G.

PLoS One. 2007 May 9;2(5):e431.

11.
12.

Characterization of a novel Foxa (hepatocyte nuclear factor-3) site in the glucagon promoter that is conserved between rodents and humans.

Sharma SK, Leinemann U, Ratke R, Oetjen E, Blume R, Dickel C, Knepel W.

Biochem J. 2005 Aug 1;389(Pt 3):831-41.

13.
14.

Protein kinase B activity is sufficient to mimic the effect of insulin on glucagon gene transcription.

Schinner S, Barthel A, Dellas C, Grzeskowiak R, Sharma SK, Oetjen E, Blume R, Knepel W.

J Biol Chem. 2005 Feb 25;280(8):7369-76. Epub 2004 Dec 7.

15.

Inhibition of human insulin gene transcription by the immunosuppressive drugs cyclosporin A and tacrolimus in primary, mature islets of transgenic mice.

Oetjen E, Baun D, Beimesche S, Krause D, Cierny I, Blume R, Dickel C, Wehner S, Knepel W.

Mol Pharmacol. 2003 Jun;63(6):1289-95.

PMID:
12761338
16.

Regulation of human insulin gene transcription by the immunosuppressive drugs cyclosporin A and tacrolimus at concentrations that inhibit calcineurin activity and involving the transcription factor CREB.

Oetjen E, Grapentin D, Blume R, Seeger M, Krause D, Eggers A, Knepel W.

Naunyn Schmiedebergs Arch Pharmacol. 2003 Mar;367(3):227-36. Epub 2003 Feb 20.

PMID:
12644894
17.

Repression of glucagon gene transcription by peroxisome proliferator-activated receptor gamma through inhibition of Pax6 transcriptional activity.

Schinner S, Dellas C, Schroder M, Heinlein CA, Chang C, Fischer J, Knepel W.

J Biol Chem. 2002 Jan 18;277(3):1941-8. Epub 2001 Nov 13.

18.
20.
21.

Tissue-specific transcriptional activity of a pancreatic islet cell-specific enhancer sequence/Pax6-binding site determined in normal adult tissues in vivo using transgenic mice.

Beimesche S, Neubauer A, Herzig S, Grzeskowiak R, Diedrich T, Cierny I, Scholz D, Alejel T, Knepel W.

Mol Endocrinol. 1999 May;13(5):718-28.

PMID:
10319322
22.

Characterization of a novel calcium response element in the glucagon gene.

Fürstenau U, Schwaninger M, Blume R, Jendrusch EM, Knepel W.

J Biol Chem. 1999 Feb 26;274(9):5851-60.

24.

Inhibition of CREB- and cAMP response element-mediated gene transcription by the immunosuppressive drugs cyclosporin A and FK506 in T cells.

Krüger M, Schwaninger M, Blume R, Oetjen E, Knepel W.

Naunyn Schmiedebergs Arch Pharmacol. 1997 Oct;356(4):433-40.

PMID:
9349628
25.

Characterization of a novel protein kinase C response element in the glucagon gene.

Fürstenau U, Schwaninger M, Blume R, Kennerknecht I, Knepel W.

Mol Cell Biol. 1997 Apr;17(4):1805-16.

26.
27.

Nuclear protein binding and functional activity of a variant insulin gene found in non-insulin-dependent diabetes mellitus.

Yildiz N, Diedrich T, Knepel W.

Exp Clin Endocrinol Diabetes. 1996;104(3):218-27.

PMID:
8817239
29.

Inhibition by antidepressant drugs of cyclic AMP response element-binding protein/cyclic AMP response element-directed gene transcription.

Schwaninger M, Schöfl C, Blume R, Rössig L, Knepel W.

Mol Pharmacol. 1995 Jun;47(6):1112-8.

PMID:
7603449
30.

Involvement of the Ca(2+)-dependent phosphatase calcineurin in gene transcription that is stimulated by cAMP through cAMP response elements.

Schwaninger M, Blume R, Krüger M, Lux G, Oetjen E, Knepel W.

J Biol Chem. 1995 Apr 14;270(15):8860-6.

32.

Interaction of the transcription factor CREB with pancreatic islet cell-specific enhancer elements.

Diedrich T, Knepel W.

Biol Chem Hoppe Seyler. 1995 Jan;376(1):39-44.

PMID:
7612187
33.

Distinct properties of the cAMP-responsive element of the rat insulin I gene.

Oetjen E, Diedrich T, Eggers A, Eckert B, Knepel W.

J Biol Chem. 1994 Oct 28;269(43):27036-44.

34.

Inhibition of cAMP-responsive element-mediated gene transcription by cyclosporin A and FK506 after membrane depolarization.

Schwaninger M, Blume R, Oetjen E, Lux G, Knepel W.

J Biol Chem. 1993 Nov 5;268(31):23111-5.

35.
36.
37.

Transcriptional control of pancreatic islet hormones gene expression.

Knepel W.

Exp Clin Endocrinol. 1993;101(1):39-45. Review.

PMID:
8477822
38.
39.
40.
42.

Opioids and cytosolic calcium in rat anterior pituitary: dynorphin preparation showed LHRH-like action due to contamination.

Knepel W, Schöfl C, Wesemeyer G, Götz DM.

Experientia. 1988 Dec 1;44(11-12):1003-5.

PMID:
2904377
43.

Alpha-cell-specific expression of the glucagon gene is conferred to the glucagon promoter element by the interactions of DNA-binding proteins.

Philippe J, Drucker DJ, Knepel W, Jepeal L, Misulovin Z, Habener JF.

Mol Cell Biol. 1988 Nov;8(11):4877-88.

44.

Arachidonic acid elevates cytosolic free calcium concentration in rat anterior pituitary cells.

Knepel W, Schöfl C, Götz DM.

Naunyn Schmiedebergs Arch Pharmacol. 1988 Sep;338(3):303-9.

PMID:
3143079
47.

GRF elevates cytosolic free calcium concentration in rat anterior pituitary cells.

Schöfl C, Sandow J, Knepel W.

Am J Physiol. 1987 Nov;253(5 Pt 1):E591-4.

PMID:
2446504
48.
49.
50.

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