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A common mechanism of action of the selective serotonin reuptake inhibitors citalopram and fluoxetine: reversal of chronic psychosocial stress-induced increase in CRE/CREB-directed gene transcription in transgenic reporter gene mice.
Böer U, Noll C, Cierny I, Krause D, Hiemke C, Knepel W.
Eur J Pharmacol. 2010 May 10;633(1-3):33-8. doi: 10.1016/j.ejphar.2010.01.016. Epub 2010 Feb 1.
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The immunosuppressive drugs cyclosporin A and tacrolimus inhibit membrane depolarization-induced CREB transcriptional activity at the coactivator level.
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Heterodimeric Pbx-Prep1 homeodomain protein binding to the glucagon gene restricting transcription in a cell type-dependent manner.
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Inhibition of cyclic AMP response element-binding protein/cyclic AMP response element-mediated transcription by the immunosuppressive drugs cyclosporin A and FK506 depends on the promoter context.
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Characterization of a novel calcium response element in the glucagon gene.
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Gene-specific transcriptional activity of the insulin cAMP-responsive element is conferred by NF-Y in combination with cAMP response element-binding protein.
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Inhibition of CREB- and cAMP response element-mediated gene transcription by the immunosuppressive drugs cyclosporin A and FK506 in T cells.
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Characterization of a novel protein kinase C response element in the glucagon gene.
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Mol Cell Biol. 1997 Apr;17(4):1805-16.
Glucagon gene G3 enhancer: evidence that activity depends on combination of an islet-specific factor and a winged helix protein.
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Biol Chem. 1997 Feb;378(2):89-98.
Nuclear protein binding and functional activity of a variant insulin gene found in non-insulin-dependent diabetes mellitus.
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Exp Clin Endocrinol Diabetes. 1996;104(3):218-27.
Calcium-mobilizing insulin secretagogues stimulate transcription that is directed by the cyclic adenosine 3',5'-monophosphate/calcium response element in a pancreatic islet beta-cell line.
Eckert B, Schwaninger M, Knepel W.
Endocrinology. 1996 Jan;137(1):225-33.
Inhibition by antidepressant drugs of cyclic AMP response element-binding protein/cyclic AMP response element-directed gene transcription.
Schwaninger M, Schöfl C, Blume R, Rössig L, Knepel W.
Mol Pharmacol. 1995 Jun;47(6):1112-8.
Involvement of the Ca(2+)-dependent phosphatase calcineurin in gene transcription that is stimulated by cAMP through cAMP response elements.
Schwaninger M, Blume R, Krüger M, Lux G, Oetjen E, Knepel W.
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Transcriptional activity of domain A of the rat glucagon G3 element conferred by an islet-specific nuclear protein that also binds to similar pancreatic islet cell-specific enhancer sequences (PISCES).
Wrege A, Diedrich T, Hochhuth C, Knepel W.
Gene Expr. 1995;4(4-5):205-16.
Interaction of the transcription factor CREB with pancreatic islet cell-specific enhancer elements.
Diedrich T, Knepel W.
Biol Chem Hoppe Seyler. 1995 Jan;376(1):39-44.
Distinct properties of the cAMP-responsive element of the rat insulin I gene.
Oetjen E, Diedrich T, Eggers A, Eckert B, Knepel W.
J Biol Chem. 1994 Oct 28;269(43):27036-44.
Inhibition of cAMP-responsive element-mediated gene transcription by cyclosporin A and FK506 after membrane depolarization.
Schwaninger M, Blume R, Oetjen E, Lux G, Knepel W.
J Biol Chem. 1993 Nov 5;268(31):23111-5.
The immunosuppressive drugs cyclosporin A and FK506 inhibit calcineurin phosphatase activity and gene transcription mediated through the cAMP-responsive element in a nonimmune cell line.
Schwaninger M, Blume R, Oetjen E, Knepel W.
Naunyn Schmiedebergs Arch Pharmacol. 1993 Nov;348(5):541-5.
Membrane depolarization and calcium influx induce glucagon gene transcription in pancreatic islet cells through the cyclic AMP-responsive element.
Schwaninger M, Lux G, Blume R, Oetjen E, Hidaka H, Knepel W.
J Biol Chem. 1993 Mar 5;268(7):5168-77.
Transcriptional control of pancreatic islet hormones gene expression.
Knepel W.
Exp Clin Endocrinol. 1993;101(1):39-45. Review.
The pancreatic islet-specific glucagon G3 transcription factors recognize control elements in the rat somatostatin and insulin-I genes.
Knepel W, Vallejo M, Chafitz JA, Habener JF.
Mol Endocrinol. 1991 Oct;5(10):1457-66.
Transcriptional activation of the rat glucagon gene by the cyclic AMP-responsive element in pancreatic islet cells.
Knepel W, Chafitz J, Habener JF.
Mol Cell Biol. 1990 Dec;10(12):6799-804.
A pancreatic islet cell-specific enhancer-like element in the glucagon gene contains two domains binding distinct cellular proteins.
Knepel W, Jepeal L, Habener JF.
J Biol Chem. 1990 May 25;265(15):8725-35.
cAMP- and diacylglycerol-mediated pathways elevate cytosolic free calcium concentration via dihydropyridine-sensitive, omega-conotoxin-insensitive calcium channels in normal rat anterior pituitary cells.
Schöfl C, Meier K, Götz DM, Knepel W.
Naunyn Schmiedebergs Arch Pharmacol. 1989 Jan-Feb;339(1-2):1-7.
Opioids and cytosolic calcium in rat anterior pituitary: dynorphin preparation showed LHRH-like action due to contamination.
Knepel W, Schöfl C, Wesemeyer G, Götz DM.
Experientia. 1988 Dec 1;44(11-12):1003-5.
Alpha-cell-specific expression of the glucagon gene is conferred to the glucagon promoter element by the interactions of DNA-binding proteins.
Philippe J, Drucker DJ, Knepel W, Jepeal L, Misulovin Z, Habener JF.
Mol Cell Biol. 1988 Nov;8(11):4877-88.
Arachidonic acid elevates cytosolic free calcium concentration in rat anterior pituitary cells.
Knepel W, Schöfl C, Götz DM.
Naunyn Schmiedebergs Arch Pharmacol. 1988 Sep;338(3):303-9.
Potassium depolarization elevates cytosolic free calcium concentration in rat anterior pituitary cells through 1,4-dihydropyridine-sensitive, omega-conotoxin-insensitive calcium channels.
Meier K, Knepel W, Schöfl C.
Endocrinology. 1988 Jun;122(6):2764-70.
Subcellular distribution of dynorphin-like immunoreactivity in rat adenohypophysis in comparison with luteinizing hormone and follicle-stimulating hormone.
Schwenk M, Jackisch R, Knepel W.
Life Sci. 1987 Nov 23;41(21):2403-9.
GRF elevates cytosolic free calcium concentration in rat anterior pituitary cells.
Schöfl C, Sandow J, Knepel W.
Am J Physiol. 1987 Nov;253(5 Pt 1):E591-4.
Intracellular free calcium concentration in rat anterior pituitary cells as indicated by fura-2: effect of arginine-vasopressin.
Knepel W, Schöfl C.
Naunyn Schmiedebergs Arch Pharmacol. 1987 Sep;336(3):321-6.
Release of dynorphin-like immunoreactivity from rat adenohypophysis in vitro during inhibition of anterior pituitary hormone secretion from individual cell types.
Schwaninger M, Knepel W, Döhler KD, Sandow J.
Endocrinology. 1987 Jul;121(1):167-74.
Stimulation by melittin of adrenocorticotropin and beta-endorphin release from rat adenohypophysis in vitro.
Knepel W, Gerhards C.
Prostaglandins. 1987 Mar;33(3):479-90.
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