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Bone Marrow Immunohistochemistry and Flow Cytometry in the Diagnosis of Malignant Hematologic Diseases With Emphasis on Lymphomas: A Comparative Retrospective Study.

Landry M, Bienz MN, Sawan B, Temmar R, Beauregard P, Chaunt F, Lavigne J, Knecht H.

Appl Immunohistochem Mol Morphol. 2019 Jul 8. doi: 10.1097/PAI.0000000000000787. [Epub ahead of print]


Standardized next-generation sequencing of immunoglobulin and T-cell receptor gene recombinations for MRD marker identification in acute lymphoblastic leukaemia; a EuroClonality-NGS validation study.

Brüggemann M, Kotrová M, Knecht H, Bartram J, Boudjogrha M, Bystry V, Fazio G, Froňková E, Giraud M, Grioni A, Hancock J, Herrmann D, Jiménez C, Krejci A, Moppett J, Reigl T, Salson M, Scheijen B, Schwarz M, Songia S, Svaton M, van Dongen JJM, Villarese P, Wakeman S, Wright G, Cazzaniga G, Davi F, García-Sanz R, Gonzalez D, Groenen PJTA, Hummel M, Macintyre EA, Stamatopoulos K, Pott C, Trka J, Darzentas N, Langerak AW; EuroClonality-NGS working group.

Leukemia. 2019 Sep;33(9):2241-2253. doi: 10.1038/s41375-019-0496-7. Epub 2019 Jun 26.


Quality control and quantification in IG/TR next-generation sequencing marker identification: protocols and bioinformatic functionalities by EuroClonality-NGS.

Knecht H, Reigl T, Kotrová M, Appelt F, Stewart P, Bystry V, Krejci A, Grioni A, Pal K, Stranska K, Plevova K, Rijntjes J, Songia S, Svatoň M, Froňková E, Bartram J, Scheijen B, Herrmann D, García-Sanz R, Hancock J, Moppett J, van Dongen JJM, Cazzaniga G, Davi F, Groenen PJTA, Hummel M, Macintyre EA, Stamatopoulos K, Trka J, Langerak AW, Gonzalez D, Pott C, Brüggemann M, Darzentas N; EuroClonality-NGS Working Group.

Leukemia. 2019 Sep;33(9):2254-2265. doi: 10.1038/s41375-019-0499-4. Epub 2019 Jun 21.


Next-generation amplicon TRB locus sequencing can overcome limitations of flow-cytometric Vβ expression analysis and confirms clonality in all T-cell prolymphocytic leukemia cases.

Kotrova M, Novakova M, Oberbeck S, Mayer P, Schrader A, Knecht H, Hrusak O, Herling M, Brüggemann M.

Cytometry A. 2018 Nov;93(11):1118-1124. doi: 10.1002/cyto.a.23604. Epub 2018 Nov 10.


Distinct 3D Structural Patterns of Lamin A/C Expression in Hodgkin and Reed-Sternberg Cells.

Contu F, Rangel-Pozzo A, Trokajlo P, Wark L, Klewes L, Johnson NA, Petrogiannis-Haliotis T, Gartner JG, Garini Y, Vanni R, Knecht H, Mai S.

Cancers (Basel). 2018 Aug 24;10(9). pii: E286. doi: 10.3390/cancers10090286.


Impact of Mosquito Age and Insecticide Exposure on Susceptibility of Aedes albopictus (Diptera: Culicidae) to Infection with Zika Virus.

Knecht H, Richards SL, Balanay JAG, White AV.

Pathogens. 2018 Aug 12;7(3). pii: E67. doi: 10.3390/pathogens7030067.


Super-resolution binding activated localization microscopy through reversible change of DNA conformation.

Szczurek A, Birk U, Knecht H, Dobrucki J, Mai S, Cremer C.

Nucleus. 2018 Jan 1;9(1):182-189. doi: 10.1080/19491034.2017.1419846.


Atopobium and Fusobacterium as novel candidates for sarcoidosis-associated microbiota.

Zimmermann A, Knecht H, Häsler R, Zissel G, Gaede KI, Hofmann S, Nebel A, Müller-Quernheim J, Schreiber S, Fischer A.

Eur Respir J. 2017 Dec 14;50(6). pii: 1600746. doi: 10.1183/13993003.00746-2016. Print 2017 Dec.


Erdheim-Chester Disease: The Importance of Information Integration.

Nikonova A, Esfahani K, Chausse G, Probst S, Petrogiannis-Haliotis T, Knecht H, Gyger G.

Case Rep Oncol. 2017 Jul 11;10(2):613-619. doi: 10.1159/000477658. eCollection 2017 May-Aug.


LMP1 and Dynamic Progressive Telomere Dysfunction: A Major Culprit in EBV-Associated Hodgkin's Lymphoma.

Knecht H, Mai S.

Viruses. 2017 Jun 27;9(7). pii: E164. doi: 10.3390/v9070164. Review.


Disruption of direct 3D telomere-TRF2 interaction through two molecularly disparate mechanisms is a hallmark of primary Hodgkin and Reed-Sternberg cells.

Knecht H, Johnson NA, Haliotis T, Lichtensztejn D, Mai S.

Lab Invest. 2017 Jul;97(7):772-781. doi: 10.1038/labinvest.2017.33. Epub 2017 Apr 24.


GvL effects in T-prolymphocytic leukemia: evidence from MRD kinetics and TCR repertoire analyses.

Sellner L, Brüggemann M, Schlitt M, Knecht H, Herrmann D, Reigl T, Krejci A, Bystry V, Darzentas N, Rieger M, Dietrich S, Luft T, Ho AD, Kneba M, Dreger P.

Bone Marrow Transplant. 2017 Apr;52(4):656. doi: 10.1038/bmt.2017.12. No abstract available.


ARResT/Interrogate: an interactive immunoprofiler for IG/TR NGS data.

Bystry V, Reigl T, Krejci A, Demko M, Hanakova B, Grioni A, Knecht H, Schlitt M, Dreger P, Sellner L, Herrmann D, Pingeon M, Boudjoghra M, Rijntjes J, Pott C, Langerak AW, Groenen PJTA, Davi F, Brüggemann M, Darzentas N; EuroClonality-NGS.

Bioinformatics. 2017 Feb 1;33(3):435-437. doi: 10.1093/bioinformatics/btw634.


Retrospective study of intravascular large B-cell lymphoma cases diagnosed in Quebec: A retrospective study of 29 case reports.

Brunet V, Marouan S, Routy JP, Hashem MA, Bernier V, Simard R, Petrella T, Lamarre L, Théorêt G, Carrier C, Knecht H, Fleury I, Pavic M.

Medicine (Baltimore). 2017 Feb;96(5):e5985. doi: 10.1097/MD.0000000000005985. Erratum in: Medicine (Baltimore). 2017 May;96(20):e7018.


Imaging chromatin nanostructure with binding-activated localization microscopy based on DNA structure fluctuations.

Szczurek A, Klewes L, Xing J, Gourram A, Birk U, Knecht H, Dobrucki JW, Mai S, Cremer C.

Nucleic Acids Res. 2017 May 5;45(8):e56. doi: 10.1093/nar/gkw1301.


GvL effects in T-prolymphocytic leukemia: evidence from MRD kinetics and TCR repertoire analyses.

Sellner L, Brüggemann M, Schlitt M, Knecht H, Herrmann D, Reigl T, Krejci A, Bystry V, Darzentas N, Rieger M, Dietrich S, Luft T, Ho AD, Kneba M, Dreger P.

Bone Marrow Transplant. 2017 Apr;52(4):544-551. doi: 10.1038/bmt.2016.305. Epub 2016 Dec 12. Erratum in: Bone Marrow Transplant. 2017 Apr;52(4):656.


Unraveling the microbial community of a cold groundwater catchment system.

Braun B, Schröder J, Knecht H, Szewzyk U.

Water Res. 2016 Dec 15;107:113-126. doi: 10.1016/j.watres.2016.10.040. Epub 2016 Oct 18.


Interleukin-15 deficiency promotes the development of T-cell acute lymphoblastic leukemia in non-obese diabetes mice with severe combined immunodeficiency.

Bobbala D, Kandhi R, Chen X, Mayhue M, Bouchard E, Yan J, Knecht H, Barabé F, Ramanathan S, Ilangumaran S.

Leukemia. 2016 Aug;30(8):1749-52. doi: 10.1038/leu.2016.28. Epub 2016 Feb 15. No abstract available.


DNA Superresolution Structure of Reed-Sternberg Cells Differs Between Long-Lasting Remission Versus Relapsing Hodgkin's Lymphoma Patients.

Righolt CH, Knecht H, Mai S.

J Cell Biochem. 2016 Jul;117(7):1633-7. doi: 10.1002/jcb.25456. Epub 2015 Dec 31.


Dynamic changes of the luminal and mucosa-associated gut microbiota during and after antibiotic therapy with paromomycin.

Heinsen FA, Knecht H, Neulinger SC, Schmitz RA, Knecht C, Kühbacher T, Rosenstiel PC, Schreiber S, Friedrichs AK, Ott SJ.

Gut Microbes. 2015 Jul 4;6(4):243-54. doi: 10.1080/19490976.2015.1062959.


High-Throughput, Amplicon-Based Sequencing of the CREBBP Gene as a Tool to Develop a Universal Platform-Independent Assay.

Fuellgrabe MW, Herrmann D, Knecht H, Kuenzel S, Kneba M, Pott C, Brüggemann M.

PLoS One. 2015 Jun 9;10(6):e0129195. doi: 10.1371/journal.pone.0129195. eCollection 2015.


LMP1 mediates multinuclearity through downregulation of shelterin proteins and formation of telomeric aggregates.

Lajoie V, Lemieux B, Sawan B, Lichtensztejn D, Lichtensztejn Z, Wellinger R, Mai S, Knecht H.

Blood. 2015 Mar 26;125(13):2101-10. doi: 10.1182/blood-2014-08-594176. Epub 2015 Jan 7.


Rapid separation of mononuclear hodgkin from multinuclear reed-sternberg cells.

Kongruttanachok N, Cayre YE, Knecht H, Mai S.

Lab Hematol. 2014 Mar 1;20(1):2-6. doi: 10.1532/LH96.12023.


Differences in nuclear DNA organization between lymphocytes, Hodgkin and Reed-Sternberg cells revealed by structured illumination microscopy.

Righolt CH, Guffei A, Knecht H, Young IT, Stallinga S, van Vliet LJ, Mai S.

J Cell Biochem. 2014 Aug;115(8):1441-8. doi: 10.1002/jcb.24800.


Effects of β-lactam antibiotics and fluoroquinolones on human gut microbiota in relation to Clostridium difficile associated diarrhea.

Knecht H, Neulinger SC, Heinsen FA, Knecht C, Schilhabel A, Schmitz RA, Zimmermann A, dos Santos VM, Ferrer M, Rosenstiel PC, Schreiber S, Friedrichs AK, Ott SJ.

PLoS One. 2014 Feb 28;9(2):e89417. doi: 10.1371/journal.pone.0089417. eCollection 2014.


Salinity affects compositional traits of epibacterial communities on the brown macroalga Fucus vesiculosus.

Stratil SB, Neulinger SC, Knecht H, Friedrichs AK, Wahl M.

FEMS Microbiol Ecol. 2014 May;88(2):272-9. doi: 10.1111/1574-6941.12292. Epub 2014 Mar 10.


Differential effects of antibiotic therapy on the structure and function of human gut microbiota.

Pérez-Cobas AE, Artacho A, Knecht H, Ferrús ML, Friedrichs A, Ott SJ, Moya A, Latorre A, Gosalbes MJ.

PLoS One. 2013 Nov 25;8(11):e80201. doi: 10.1371/journal.pone.0080201. eCollection 2013.


Genomic Instability: The Driving Force behind Refractory/Relapsing Hodgkin's Lymphoma.

Knecht H, Righolt C, Mai S.

Cancers (Basel). 2013 Jun 5;5(2):714-25. doi: 10.3390/cancers5020714.


Functional consequences of microbial shifts in the human gastrointestinal tract linked to antibiotic treatment and obesity.

Hernández E, Bargiela R, Diez MS, Friedrichs A, Pérez-Cobas AE, Gosalbes MJ, Knecht H, Martínez-Martínez M, Seifert J, von Bergen M, Artacho A, Ruiz A, Campoy C, Latorre A, Ott SJ, Moya A, Suárez A, Martins dos Santos VA, Ferrer M.

Gut Microbes. 2013 Jul-Aug;4(4):306-15. doi: 10.4161/gmic.25321. Epub 2013 Jun 12.


Temperature-driven shifts in the epibiotic bacterial community composition of the brown macroalga Fucus vesiculosus.

Stratil SB, Neulinger SC, Knecht H, Friedrichs AK, Wahl M.

Microbiologyopen. 2013 Apr;2(2):338-49. doi: 10.1002/mbo3.79. Epub 2013 Mar 13.


Gut microbiota disturbance during antibiotic therapy: a multi-omic approach.

Pérez-Cobas AE, Gosalbes MJ, Friedrichs A, Knecht H, Artacho A, Eismann K, Otto W, Rojo D, Bargiela R, von Bergen M, Neulinger SC, Däumer C, Heinsen FA, Latorre A, Barbas C, Seifert J, dos Santos VM, Ott SJ, Ferrer M, Moya A.

Gut. 2013 Nov;62(11):1591-601. doi: 10.1136/gutjnl-2012-303184. Epub 2012 Dec 12.


Three-dimensional Telomere Signatures of Hodgkin- and Reed-Sternberg Cells at Diagnosis Identify Patients with Poor Response to Conventional Chemotherapy.

Knecht H, Kongruttanachok N, Sawan B, Brossard J, Prévost S, Turcotte E, Lichtensztejn Z, Lichtensztejn D, Mai S.

Transl Oncol. 2012 Aug;5(4):269-77. Epub 2012 Aug 1.


Effects of probiotics and antibiotics on the intestinal homeostasis in a computer controlled model of the large intestine.

Rehman A, Heinsen FA, Koenen ME, Venema K, Knecht H, Hellmig S, Schreiber S, Ott SJ.

BMC Microbiol. 2012 Mar 27;12:47. doi: 10.1186/1471-2180-12-47.


Nuclear remodeling as a mechanism for genomic instability in cancer.

Gadji M, Vallente R, Klewes L, Righolt C, Wark L, Kongruttanachok N, Knecht H, Mai S.

Adv Cancer Res. 2011;112:77-126. doi: 10.1016/B978-0-12-387688-1.00004-1. Review.


3D nuclear organization of telomeres in the Hodgkin cell lines U-HO1 and U-HO1-PTPN1: PTPN1 expression prevents the formation of very short telomeres including "t-stumps".

Knecht H, Brüderlein S, Wegener S, Lichtensztejn D, Lichtensztejn Z, Lemieux B, Möller P, Mai S.

BMC Cell Biol. 2010 Dec 14;11:99. doi: 10.1186/1471-2121-11-99.


3D imaging of telomeres and nuclear architecture: An emerging tool of 3D nano-morphology-based diagnosis.

Knecht H, Mai S.

J Cell Physiol. 2011 Apr;226(4):859-67. doi: 10.1002/jcp.22425. Review.


Dynamic chromosomal rearrangements in Hodgkin's lymphoma are due to ongoing three-dimensional nuclear remodeling and breakage-bridge-fusion cycles.

Guffei A, Sarkar R, Klewes L, Righolt C, Knecht H, Mai S.

Haematologica. 2010 Dec;95(12):2038-46. doi: 10.3324/haematol.2010.030171. Epub 2010 Sep 7.


3D structural and functional characterization of the transition from Hodgkin to Reed-Sternberg cells.

Knecht H, Brüderlein S, Mai S, Möller P, Sawan B.

Ann Anat. 2010 Sep 20;192(5):302-8. doi: 10.1016/j.aanat.2010.07.006. Epub 2010 Aug 6. Review.


3D Telomere FISH defines LMP1-expressing Reed-Sternberg cells as end-stage cells with telomere-poor 'ghost' nuclei and very short telomeres.

Knecht H, Sawan B, Lichtensztejn Z, Lichtensztejn D, Mai S.

Lab Invest. 2010 Apr;90(4):611-9. doi: 10.1038/labinvest.2010.2. Epub 2010 Feb 8.


Significance of CD23 expression in diffuse areas of follicular lymphoma.

Sawan B, Knecht H.

Appl Immunohistochem Mol Morphol. 2009 Oct;17(5):463-4. doi: 10.1097/PAI.0b013e31819df5a8. No abstract available.


The 3D nuclear organization of telomeres marks the transition from Hodgkin to Reed-Sternberg cells.

Knecht H, Sawan B, Lichtensztejn D, Lemieux B, Wellinger RJ, Mai S.

Leukemia. 2009 Mar;23(3):565-73. doi: 10.1038/leu.2008.314. Epub 2008 Nov 27.


Bone steady-state is established at reduced bone strength after spinal cord injury: a longitudinal study using peripheral quantitative computed tomography (pQCT).

Frotzler A, Berger M, Knecht H, Eser P.

Bone. 2008 Sep;43(3):549-55. doi: 10.1016/j.bone.2008.05.006. Epub 2008 May 16.


Successful treatment of warm antibody (IgG/C3 positive) autoimmune hemolytic anemia in hairy-cell leukemia with 2-CdA in the elderly.

Viens D, St-Hilaire E, Beauregard P, Dufresne J, Knecht H.

Leuk Lymphoma. 2008 Jul;49(7):1424-6. doi: 10.1080/10428190802074627. No abstract available.


Device-related complications of long-term intrathecal drug therapy via implanted pumps.

Flückiger B, Knecht H, Grossmann S, Felleiter P.

Spinal Cord. 2008 Sep;46(9):639-43. doi: 10.1038/sc.2008.24. Epub 2008 Mar 11.


Successful control of methicillin-resistant Staphylococcus aureus in a spinal cord injury center: a 10-year prospective study including molecular typing.

Kappel C, Widmer A, Geng V, von Arx P, Frei R, Koch HG, Knecht H.

Spinal Cord. 2008 Jun;46(6):438-44. Epub 2007 Oct 16.


Agreement of measures obtained radiographically and by the OSI CA-6000 Spine Motion Analyzer for cervical spinal motion.

Petersen CM, Schuit D, Johnson RD, Knecht H, Levine P.

Man Ther. 2008 Jun;13(3):200-5. Epub 2007 Mar 26.


Application of bacteriophages to control intestinal Escherichia coli O157:H7 levels in ruminants.

Sheng H, Knecht HJ, Kudva IT, Hovde CJ.

Appl Environ Microbiol. 2006 Aug;72(8):5359-66.


Role of Escherichia coli O157:H7 virulence factors in colonization at the bovine terminal rectal mucosa.

Sheng H, Lim JY, Knecht HJ, Li J, Hovde CJ.

Infect Immun. 2006 Aug;74(8):4685-93.


Paragliding accidents with spinal cord injury: 10 years' experience at a single institution.

Gauler R, Moulin P, Koch HG, Wick L, Sauter B, Michel D, Knecht H.

Spine (Phila Pa 1976). 2006 May 1;31(10):1125-30.


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