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Items: 1 to 50 of 130

1.

Phosphorylation of Parkin at serine 65 is essential for its activation in vivo.

McWilliams TG, Barini E, Pohjolan-Pirhonen R, Brooks SP, Singh F, Burel S, Balk K, Kumar A, Montava-Garriga L, Prescott AR, Hassoun SM, Mouton-Liger F, Ball G, Hills R, Knebel A, Ulusoy A, Di Monte DA, Tamjar J, Antico O, Fears K, Smith L, Brambilla R, Palin E, Valori M, Eerola-Rautio J, Tienari P, Corti O, Dunnett SB, Ganley IG, Suomalainen A, Muqit MMK.

Open Biol. 2018 Nov 7;8(11). pii: 180108. doi: 10.1098/rsob.180108.

2.

Covalent Organic Framework-Covalent Organic Framework Bilayer Membranes for Highly Selective Gas Separation.

Fan H, Mundstock A, Feldhoff A, Knebel A, Gu J, Meng H, Caro J.

J Am Chem Soc. 2018 Aug 15;140(32):10094-10098. doi: 10.1021/jacs.8b05136. Epub 2018 Jul 20.

PMID:
30021065
3.

The MALDI-TOF E2/E3 Ligase Assay as Universal Tool for Drug Discovery in the Ubiquitin Pathway.

De Cesare V, Johnson C, Barlow V, Hastie J, Knebel A, Trost M.

Cell Chem Biol. 2018 Sep 20;25(9):1117-1127.e4. doi: 10.1016/j.chembiol.2018.06.004. Epub 2018 Jul 12.

4.

Executive dysfunction in Parkinson's disease: A meta-analysis on the Wisconsin Card Sorting Test literature.

Lange F, Brückner C, Knebel A, Seer C, Kopp B.

Neurosci Biobehav Rev. 2018 Oct;93:38-56. doi: 10.1016/j.neubiorev.2018.06.014. Epub 2018 Jun 23. Review.

PMID:
29944959
5.

RNF12 X-Linked Intellectual Disability Mutations Disrupt E3 Ligase Activity and Neural Differentiation.

Bustos F, Segarra-Fas A, Chaugule VK, Brandenburg L, Branigan E, Toth R, Macartney T, Knebel A, Hay RT, Walden H, Findlay GM.

Cell Rep. 2018 May 8;23(6):1599-1611. doi: 10.1016/j.celrep.2018.04.022.

6.

Activity-based E3 ligase profiling uncovers an E3 ligase with esterification activity.

Pao KC, Wood NT, Knebel A, Rafie K, Stanley M, Mabbitt PD, Sundaramoorthy R, Hofmann K, van Aalten DMF, Virdee S.

Nature. 2018 Apr;556(7701):381-385. doi: 10.1038/s41586-018-0026-1. Epub 2018 Apr 11.

PMID:
29643511
7.

The Interaction of Guest Molecules with Co-MOF-74: A Vis/NIR and Raman Approach.

Strauss I, Mundstock A, Hinrichs D, Himstedt R, Knebel A, Reinhardt C, Dorfs D, Caro J.

Angew Chem Int Ed Engl. 2018 Jun 18;57(25):7434-7439. doi: 10.1002/anie.201801966. Epub 2018 Apr 18.

PMID:
29532985
8.

High-Flux Membranes Based on the Covalent Organic Framework COF-LZU1 for Selective Dye Separation by Nanofiltration.

Fan H, Gu J, Meng H, Knebel A, Caro J.

Angew Chem Int Ed Engl. 2018 Apr 3;57(15):4083-4087. doi: 10.1002/anie.201712816. Epub 2018 Mar 8.

PMID:
29405529
9.

Hierarchical Nanostructures of Metal-Organic Frameworks Applied in Gas Separating ZIF-8-on-ZIF-67 Membranes.

Knebel A, Wulfert-Holzmann P, Friebe S, Pavel J, Strauß I, Mundstock A, Steinbach F, Caro J.

Chemistry. 2018 Apr 17;24(22):5728-5733. doi: 10.1002/chem.201705562. Epub 2018 Feb 19.

PMID:
29393536
10.

Rab-GTPase binding effector protein 2 (RABEP2) is a primed substrate for Glycogen Synthase kinase-3 (GSK3).

Logie L, Van Aalten L, Knebel A, Force T, Hastie CJ, MacLauchlan H, Campbell DG, Gourlay R, Prescott A, Davidson J, Fuller W, Sutherland C.

Sci Rep. 2017 Dec 15;7(1):17682. doi: 10.1038/s41598-017-17087-6.

11.

Defibrillation of soft porous metal-organic frameworks with electric fields.

Knebel A, Geppert B, Volgmann K, Kolokolov DI, Stepanov AG, Twiefel J, Heitjans P, Volkmer D, Caro J.

Science. 2017 Oct 20;358(6361):347-351. doi: 10.1126/science.aal2456.

PMID:
29051376
12.

National Institutes of Health Research Plan on Rehabilitation: NIH Medical Rehabilitation Coordinating Committee.

NIH Medical Rehabilitation Coordinating Committee, O'Mara A, Rowland JH, Greenwell TN, Wiggs CL, Fleg J, Joseph L, McGowan J, Panagis JS, Washabaugh C, Peng GCY, Bray R, Cernich AN, Cruz TH, Marden S, Michel ME, Nitkin R, Quatrano L, Spong CY, Shekim L, Jones TLZ, Juliano-Bult D, Panchinson DM, Chen D, Jakeman L, Knebel A, Tully LA, Chan L, Damiano D, Tian B, McInnes P, Khalsa P, Reider E, Shurtleff D, Elwood W, Ballard R, Ershow AG, Begg L.

Phys Ther. 2017 Apr 1;97(4):104-407. doi: 10.1093/ptj/pzx026.

13.

Parkin-phosphoubiquitin complex reveals cryptic ubiquitin-binding site required for RBR ligase activity.

Kumar A, Chaugule VK, Condos TEC, Barber KR, Johnson C, Toth R, Sundaramoorthy R, Knebel A, Shaw GS, Walden H.

Nat Struct Mol Biol. 2017 May;24(5):475-483. doi: 10.1038/nsmb.3400. Epub 2017 Apr 17.

14.

Roles of the TRAF6 and Pellino E3 ligases in MyD88 and RANKL signaling.

Strickson S, Emmerich CH, Goh ETH, Zhang J, Kelsall IR, Macartney T, Hastie CJ, Knebel A, Peggie M, Marchesi F, Arthur JSC, Cohen P.

Proc Natl Acad Sci U S A. 2017 Apr 25;114(17):E3481-E3489. doi: 10.1073/pnas.1702367114. Epub 2017 Apr 12.

15.

Switching Thin Films of Azobenzene-Containing Metal-Organic Frameworks with Visible Light.

Müller K, Knebel A, Zhao F, Bléger D, Caro J, Heinke L.

Chemistry. 2017 Apr 24;23(23):5434-5438. doi: 10.1002/chem.201700989. Epub 2017 Apr 3.

PMID:
28370503
16.

CUL-2LRR-1 and UBXN-3 drive replisome disassembly during DNA replication termination and mitosis.

Sonneville R, Moreno SP, Knebel A, Johnson C, Hastie CJ, Gartner A, Gambus A, Labib K.

Nat Cell Biol. 2017 May;19(5):468-479. doi: 10.1038/ncb3500. Epub 2017 Apr 3.

17.

A single MIU motif of MINDY-1 recognizes K48-linked polyubiquitin chains.

Kristariyanto YA, Abdul Rehman SA, Weidlich S, Knebel A, Kulathu Y.

EMBO Rep. 2017 Mar;18(3):392-402. doi: 10.15252/embr.201643205. Epub 2017 Jan 12.

18.

Tunable molecular separation by nanoporous membranes.

Wang Z, Knebel A, Grosjean S, Wagner D, Bräse S, Wöll C, Caro J, Heinke L.

Nat Commun. 2016 Dec 20;7:13872. doi: 10.1038/ncomms13872.

19.

Dimethyl fumarate blocks pro-inflammatory cytokine production via inhibition of TLR induced M1 and K63 ubiquitin chain formation.

McGuire VA, Ruiz-Zorrilla Diez T, Emmerich CH, Strickson S, Ritorto MS, Sutavani RV, Weiβ A, Houslay KF, Knebel A, Meakin PJ, Phair IR, Ashford ML, Trost M, Arthur JS.

Sci Rep. 2016 Aug 8;6:31159. doi: 10.1038/srep31159.

20.

UBQLN2 Mediates Autophagy-Independent Protein Aggregate Clearance by the Proteasome.

Hjerpe R, Bett JS, Keuss MJ, Solovyova A, McWilliams TG, Johnson C, Sahu I, Varghese J, Wood N, Wightman M, Osborne G, Bates GP, Glickman MH, Trost M, Knebel A, Marchesi F, Kurz T.

Cell. 2016 Aug 11;166(4):935-949. doi: 10.1016/j.cell.2016.07.001. Epub 2016 Jul 28.

21.

Synthesis of Isomeric Phosphoubiquitin Chains Reveals that Phosphorylation Controls Deubiquitinase Activity and Specificity.

Huguenin-Dezot N, De Cesare V, Peltier J, Knebel A, Kristaryianto YA, Rogerson DT, Kulathu Y, Trost M, Chin JW.

Cell Rep. 2016 Jul 26;16(4):1180-1193. doi: 10.1016/j.celrep.2016.06.064. Epub 2016 Jul 14.

22.

Characterization of the mammalian family of DCN-type NEDD8 E3 ligases.

Keuss MJ, Thomas Y, Mcarthur R, Wood NT, Knebel A, Kurz T.

J Cell Sci. 2016 Apr 1;129(7):1441-54. doi: 10.1242/jcs.181784. Epub 2016 Feb 18.

23.

Comparative Study of MIL-96(Al) as Continuous Metal-Organic Frameworks Layer and Mixed-Matrix Membrane.

Knebel A, Friebe S, Bigall NC, Benzaqui M, Serre C, Caro J.

ACS Appl Mater Interfaces. 2016 Mar 23;8(11):7536-44. doi: 10.1021/acsami.5b12541. Epub 2016 Mar 8.

PMID:
26886432
24.

Characterisation of the Cullin-3 mutation that causes a severe form of familial hypertension and hyperkalaemia.

Schumacher FR, Siew K, Zhang J, Johnson C, Wood N, Cleary SE, Al Maskari RS, Ferryman JT, Hardege I, Yasmin, Figg NL, Enchev R, Knebel A, O'Shaughnessy KM, Kurz T.

EMBO Mol Med. 2015 Oct;7(10):1285-306. doi: 10.15252/emmm.201505444.

25.

Might your respiratory patient have alpha-1 antitrypsin deficiency?

Sandhaus RA, Knebel AR.

Heart Lung. 2015 Nov-Dec;44(6):463-4. doi: 10.1016/j.hrtlng.2015.07.003. Epub 2015 Aug 8. No abstract available.

26.

Disruption of the autoinhibited state primes the E3 ligase parkin for activation and catalysis.

Kumar A, Aguirre JD, Condos TE, Martinez-Torres RJ, Chaugule VK, Toth R, Sundaramoorthy R, Mercier P, Knebel A, Spratt DE, Barber KR, Shaw GS, Walden H.

EMBO J. 2015 Oct 14;34(20):2506-21. doi: 10.15252/embj.201592337. Epub 2015 Aug 7.

27.

Binding to serine 65-phosphorylated ubiquitin primes Parkin for optimal PINK1-dependent phosphorylation and activation.

Kazlauskaite A, Martínez-Torres RJ, Wilkie S, Kumar A, Peltier J, Gonzalez A, Johnson C, Zhang J, Hope AG, Peggie M, Trost M, van Aalten DM, Alessi DR, Prescott AR, Knebel A, Walden H, Muqit MM.

EMBO Rep. 2015 Aug;16(8):939-54. doi: 10.15252/embr.201540352. Epub 2015 Jun 25.

28.

Hsp72 is targeted to the mitotic spindle by Nek6 to promote K-fiber assembly and mitotic progression.

O'Regan L, Sampson J, Richards MW, Knebel A, Roth D, Hood FE, Straube A, Royle SJ, Bayliss R, Fry AM.

J Cell Biol. 2015 May 11;209(3):349-58. doi: 10.1083/jcb.201409151. Epub 2015 May 4.

29.

Ubiquitination of the Dishevelled DIX domain blocks its head-to-tail polymerization.

Madrzak J, Fiedler M, Johnson CM, Ewan R, Knebel A, Bienz M, Chin JW.

Nat Commun. 2015 Apr 24;6:6718. doi: 10.1038/ncomms7718.

30.

Orthogonal thiol functionalization at a single atomic center for profiling transthiolation activity of E1 activating enzymes.

Stanley M, Han C, Knebel A, Murphy P, Shpiro N, Virdee S.

ACS Chem Biol. 2015 Jun 19;10(6):1542-54. doi: 10.1021/acschembio.5b00118. Epub 2015 Apr 15.

PMID:
25845023
31.

Biophysical studies on interactions and assembly of full-size E3 ubiquitin ligase: suppressor of cytokine signaling 2 (SOCS2)-elongin BC-cullin 5-ring box protein 2 (RBX2).

Bulatov E, Martin EM, Chatterjee S, Knebel A, Shimamura S, Konijnenberg A, Johnson C, Zinn N, Grandi P, Sobott F, Ciulli A.

J Biol Chem. 2015 Feb 13;290(7):4178-91. doi: 10.1074/jbc.M114.616664. Epub 2014 Dec 11.

32.

Ubiquitin C-terminal hydrolases cleave isopeptide- and peptide-linked ubiquitin from structured proteins but do not edit ubiquitin homopolymers.

Bett JS, Ritorto MS, Ewan R, Jaffray EG, Virdee S, Chin JW, Knebel A, Kurz T, Trost M, Tatham MH, Hay RT.

Biochem J. 2015 Mar 15;466(3):489-98. doi: 10.1042/BJ20141349.

33.

Screening of DUB activity and specificity by MALDI-TOF mass spectrometry.

Ritorto MS, Ewan R, Perez-Oliva AB, Knebel A, Buhrlage SJ, Wightman M, Kelly SM, Wood NT, Virdee S, Gray NS, Morrice NA, Alessi DR, Trost M.

Nat Commun. 2014 Aug 27;5:4763. doi: 10.1038/ncomms5763.

34.

Parkin is activated by PINK1-dependent phosphorylation of ubiquitin at Ser65.

Kazlauskaite A, Kondapalli C, Gourlay R, Campbell DG, Ritorto MS, Hofmann K, Alessi DR, Knebel A, Trost M, Muqit MM.

Biochem J. 2014 May 15;460(1):127-39. doi: 10.1042/BJ20140334.

35.

How is emotional awareness related to emotion regulation strategies and self-reported negative affect in the general population?

Subic-Wrana C, Beutel ME, Brähler E, Stöbel-Richter Y, Knebel A, Lane RD, Wiltink J.

PLoS One. 2014 Mar 17;9(3):e91846. doi: 10.1371/journal.pone.0091846. eCollection 2014.

36.

Informing the gestalt: an ethical framework for allocating scarce federal public health and medical resources to states during disasters.

Knebel AR, Sharpe VA, Danis M, Toomey LM, Knickerbocker DK.

Disaster Med Public Health Prep. 2014 Feb;8(1):79-88. doi: 10.1017/dmp.2014.9. Epub 2014 Mar 10.

37.

Altered orientation of spatial attention in depersonalization disorder.

Adler J, Beutel ME, Knebel A, Berti S, Unterrainer J, Michal M.

Psychiatry Res. 2014 May 15;216(2):230-5. doi: 10.1016/j.psychres.2014.02.021. Epub 2014 Feb 19.

PMID:
24594203
38.

TRIAD1 and HHARI bind to and are activated by distinct neddylated Cullin-RING ligase complexes.

Kelsall IR, Duda DM, Olszewski JL, Hofmann K, Knebel A, Langevin F, Wood N, Wightman M, Schulman BA, Alpi AF.

EMBO J. 2013 Oct 30;32(21):2848-60. doi: 10.1038/emboj.2013.209. Epub 2013 Sep 27.

39.

Implementing panic-focused psychodynamic psychotherapy into clinical practice.

Beutel ME, Scheurich V, Knebel A, Michal M, Wiltink J, Graf-Morgenstern M, Tschan R, Milrod B, Wellek S, Subic-Wrana C.

Can J Psychiatry. 2013 Jun;58(6):326-34.

PMID:
23768260
40.

CSN- and CAND1-dependent remodelling of the budding yeast SCF complex.

Zemla A, Thomas Y, Kedziora S, Knebel A, Wood NT, Rabut G, Kurz T.

Nat Commun. 2013;4:1641. doi: 10.1038/ncomms2628.

PMID:
23535662
41.

Systematic review of strategies to manage and allocate scarce resources during mass casualty events.

Timbie JW, Ringel JS, Fox DS, Pillemer F, Waxman DA, Moore M, Hansen CK, Knebel AR, Ricciardi R, Kellermann AL.

Ann Emerg Med. 2013 Jun;61(6):677-689.e101. doi: 10.1016/j.annemergmed.2013.02.005. Epub 2013 Mar 20. Review.

PMID:
23522610
42.

The anti-inflammatory drug BAY 11-7082 suppresses the MyD88-dependent signalling network by targeting the ubiquitin system.

Strickson S, Campbell DG, Emmerich CH, Knebel A, Plater L, Ritorto MS, Shpiro N, Cohen P.

Biochem J. 2013 May 1;451(3):427-37. doi: 10.1042/BJ20121651.

43.

The CUL3-KLHL3 E3 ligase complex mutated in Gordon's hypertension syndrome interacts with and ubiquitylates WNK isoforms: disease-causing mutations in KLHL3 and WNK4 disrupt interaction.

Ohta A, Schumacher FR, Mehellou Y, Johnson C, Knebel A, Macartney TJ, Wood NT, Alessi DR, Kurz T.

Biochem J. 2013 Apr 1;451(1):111-22. doi: 10.1042/BJ20121903.

44.

A blueprint for genomic nursing science.

Genomic Nursing State of the Science Advisory Panel, Calzone KA, Jenkins J, Bakos AD, Cashion AK, Donaldson N, Feero WG, Feetham S, Grady PA, Hinshaw AS, Knebel AR, Robinson N, Ropka ME, Seibert D, Stevens KR, Tully LA, Webb JA.

J Nurs Scholarsh. 2013 Mar;45(1):96-104. doi: 10.1111/jnu.12007. Epub 2013 Jan 31.

45.

Medical planning and response for a nuclear detonation: a practical guide.

Coleman CN, Adams S, Adrianopoli C, Ansari A, Bader JL, Buddemeier B, Caro JJ, Casagrande R, Case C Jr, Caspary K, Chang AS, Chang HF, Chao N, Cliffer KD, Confer D, Deitchman S, Derenzo EG, Dobbs A, Dodgen D, Donnelly EH, Gorman S, Grace MB, Hatchett R, Hick JL, Hrdina C, Jones R, Kane E, Knebel A, Koerner JF, Laffan AM, Larson L, Livinski A, Mackinney J, Maidment BW, Manning R, Marinissen MJ, Martin C, Michael G, Murrain-Hill P, Nemhauser JB, Norwood AE, Nystrom S, Raheem M, Redlener I, Sheehan K, Simon SL, Taylor TP, Toner E, Wallace KS, Wieder J, Weinstock DM, Wiley AL Jr, Yeskey K, Miller CW, Whitcomb RC Jr.

Biosecur Bioterror. 2012 Dec;10(4):346-71. doi: 10.1089/bsp.2012.1025. Erratum in: Biosecur Bioterror. 2013 Mar;11(11):88. Miller, Charles W [added]; Whitcomb, Robert C Jr [added].

PMID:
23244500
46.

User-managed inventory: an approach to forward-deployment of urgently needed medical countermeasures for mass-casualty and terrorism incidents.

Coleman CN, Hrdina C, Casagrande R, Cliffer KD, Mansoura MK, Nystrom S, Hatchett R, Caro JJ, Knebel AR, Wallace KS, Adams SA.

Disaster Med Public Health Prep. 2012 Dec;6(4):408-14. doi: 10.1001/dmp.2012.46a.

PMID:
23241473
47.

PINK1 is activated by mitochondrial membrane potential depolarization and stimulates Parkin E3 ligase activity by phosphorylating Serine 65.

Kondapalli C, Kazlauskaite A, Zhang N, Woodroof HI, Campbell DG, Gourlay R, Burchell L, Walden H, Macartney TJ, Deak M, Knebel A, Alessi DR, Muqit MM.

Open Biol. 2012 May;2(5):120080. doi: 10.1098/rsob.120080.

48.

The Dac-tag, an affinity tag based on penicillin-binding protein 5.

Lee DW, Peggie M, Deak M, Toth R, Gage ZO, Wood N, Schilde C, Kurz T, Knebel A.

Anal Biochem. 2012 Sep 1;428(1):64-72. doi: 10.1016/j.ab.2012.06.007. Epub 2012 Jun 15.

49.

Hepatitis B assays in serum, plasma and whole blood on filter paper.

Mayer TK, Vargas RL, Knebel AE, Williams SA, Culver SP, Clark DM, King LR.

BMC Clin Pathol. 2012 May 20;12:8. doi: 10.1186/1472-6890-12-8.

50.

UBXN7 docks on neddylated cullin complexes using its UIM motif and causes HIF1α accumulation.

Bandau S, Knebel A, Gage ZO, Wood NT, Alexandru G.

BMC Biol. 2012 Apr 26;10:36. doi: 10.1186/1741-7007-10-36.

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