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Items: 1 to 50 of 98

1.

Colitis susceptibility in mice with reactive oxygen species deficiency is mediated by mucus barrier and immune defense defects.

Aviello G, Singh AK, O'Neill S, Conroy E, Gallagher W, D'Agostino G, Walker AW, Bourke B, Scholz D, Knaus UG.

Mucosal Immunol. 2019 Sep 25. doi: 10.1038/s41385-019-0205-x. [Epub ahead of print]

PMID:
31554901
2.

House dust mite-treated PAR2 over-expressor mouse: A novel model of atopic dermatitis.

Smith L, Gatault S, Casals-Diaz L, Kelly PA, Camerer E, Métais C, Knaus UG, Eissner G, Steinhoff M.

Exp Dermatol. 2019 Sep 5. doi: 10.1111/exd.14030. [Epub ahead of print]

PMID:
31487753
3.

Correction to: NADPH Oxidases in Inflammatory Bowel Disease.

Stenke E, Bourke B, Knaus UG.

Methods Mol Biol. 2019;1982:C1. doi: 10.1007/978-1-4939-9424-3_39.

PMID:
31338798
4.

Pharmacological characterization of the seven human NOX isoforms and their inhibitors.

Augsburger F, Filippova A, Rasti D, Seredenina T, Lam M, Maghzal G, Mahiout Z, Jansen-Dürr P, Knaus UG, Doroshow J, Stocker R, Krause KH, Jaquet V.

Redox Biol. 2019 Sep;26:101272. doi: 10.1016/j.redox.2019.101272. Epub 2019 Jul 11.

5.

NAPDH Oxidases in Inflammatory Bowel Disease.

Stenke E, Bourke B, Knaus UG.

Methods Mol Biol. 2019;1982:695-713. doi: 10.1007/978-1-4939-9424-3_38. Erratum in: Methods Mol Biol. 2019;1982:C1.

PMID:
31172500
6.

Protein-Protein Interaction Assay to Analyze NOX4/p22phox Heterodimerization.

O'Neill S, Knaus UG.

Methods Mol Biol. 2019;1982:447-458. doi: 10.1007/978-1-4939-9424-3_26.

PMID:
31172488
7.

NADPH oxidases and ROS signaling in the gastrointestinal tract.

Aviello G, Knaus UG.

Mucosal Immunol. 2018 Jul;11(4):1011-1023. doi: 10.1038/s41385-018-0021-8. Epub 2018 May 9. Review.

PMID:
29743611
8.

Quantitative interaction analysis permits molecular insights into functional NOX4 NADPH oxidase heterodimer assembly.

O'Neill S, Mathis M, Kovačič L, Zhang S, Reinhardt J, Scholz D, Schopfer U, Bouhelal R, Knaus UG.

J Biol Chem. 2018 Jun 8;293(23):8750-8760. doi: 10.1074/jbc.RA117.001045. Epub 2018 Apr 19.

9.

Hydrogen peroxide production by lactobacilli promotes epithelial restitution during colitis.

Singh AK, Hertzberger RY, Knaus UG.

Redox Biol. 2018 Jun;16:11-20. doi: 10.1016/j.redox.2018.02.003. Epub 2018 Feb 12.

10.

Toll-like receptor 3 L412F polymorphism promotes a persistent clinical phenotype in pulmonary sarcoidosis.

Cooke G, Kamal I, Strengert M, Hams E, Mawhinney L, Tynan A, O'Reilly C, O'Dwyer DN, Kunkel SL, Knaus UG, Shields DC, Moller DR, Bowie AG, Fallon PG, Hogaboam CM, Armstrong ME, Donnelly SC.

QJM. 2018 Apr 1;111(4):217-224. doi: 10.1093/qjmed/hcx243.

11.

Corrigendum to "European contribution to the study of ROS: A summary of the findings and prospects for the future from the COST action BM1203 (EU-ROS)" [Redox Biol. 13 (2017) 94-162].

Egea J, Fabregat I, Frapart YM, Ghezzi P, Görlach A, Kietzmann T, Kubaichuk K, Knaus UG, Lopez MG, Olaso-Gonzalez G, Petry A, Schulz R, Vina J, Winyard P, Abbas K, Ademowo OS, Afonso CB, Andreadou I, Antelmann H, Antunes F, Aslan M, Bachschmid MM, Barbosa RM, Belousov V, Berndt C, Bernlohr D, Bertrán E, Bindoli A, Bottari SP, Brito PM, Carrara G, Casas AI, Chatzi A, Chondrogianni N, Conrad M, Cooke MS, Costa JG, Cuadrado A, My-Chan Dang P, De Smet B, Debelec-Butuner B, Dias IHK, Dunn JD, Edson AJ, El Assar M, El-Benna J, Ferdinandy P, Fernandes AS, Fladmark KE, Förstermann U, Giniatullin R, Giricz Z, Görbe A, Griffiths H, Hampl V, Hanf A, Herget J, Hernansanz-Agustín P, Hillion M, Huang J, Ilikay S, Jansen-Dürr P, Jaquet V, Joles JA, Kalyanaraman B, Kaminskyy D, Karbaschi M, Kleanthous M, Klotz LO, Korac B, Korkmaz KS, Koziel R, Kračun D, Krause KH, Křen V, Krieg T, Laranjinha J, Lazou A, Li H, Martínez-Ruiz A, Matsui R, McBean GJ, Meredith SP, Messens J, Miguel V, Mikhed Y, Milisav I, Milković L, Miranda-Vizuete A, Mojović M, Monsalve M, Mouthuy PA, Mulvey J, Münzel T, Muzykantov V, Nguyen ITN, Oelze M, Oliveira NG, Palmeira CM, Papaevgeniou N, Pavićević A, Pedre B, Peyrot F, Phylactides M, Pircalabioru GG, Pitt AR, Poulsen HE, Prieto I, Rigobello MP, Robledinos-Antón N, Rodríguez-Mañas L, Rolo AP, Rousset F, Ruskovska T, Saraiva N, Sasson S, Schröder K, Semen K, Seredenina T, Shakirzyanova A, Smith GL, Soldati T, Sousa BC, Spickett CM, Stancic A, Stasia MJ, Steinbrenner H, Stepanić V, Steven S, Tokatlidis K, Tuncay E, Turan B, Ursini F, Vacek J, Vajnerova O, Valentová K, Van Breusegem F, Varisli L, Veal EA, Yalçın AS, Yelisyeyeva O, Žarković N, Zatloukalová M, Zielonka J, Touyz RM, Papapetropoulos A, Grune T, Lamas S, Schmidt HHHW, Di Lisa F, Daiber A.

Redox Biol. 2018 Apr;14:694-696. doi: 10.1016/j.redox.2017.10.001. Epub 2017 Oct 26. No abstract available.

12.

NOX1 loss-of-function genetic variants in patients with inflammatory bowel disease.

Schwerd T, Bryant RV, Pandey S, Capitani M, Meran L, Cazier JB, Jung J, Mondal K, Parkes M, Mathew CG, Fiedler K, McCarthy DJ; WGS500 Consortium; Oxford IBD cohort study investigators; COLORS in IBD group investigators; UK IBD Genetics Consortium, Sullivan PB, Rodrigues A, Travis SPL, Moore C, Sambrook J, Ouwehand WH, Roberts DJ, Danesh J; INTERVAL Study, Russell RK, Wilson DC, Kelsen JR, Cornall R, Denson LA, Kugathasan S, Knaus UG, Serra EG, Anderson CA, Duerr RH, McGovern DP, Cho J, Powrie F, Li VS, Muise AM, Uhlig HH.

Mucosal Immunol. 2018 Mar;11(2):562-574. doi: 10.1038/mi.2017.74. Epub 2017 Nov 1.

13.

First Identification of Biallelic Inherited DUOX2 Inactivating Mutations as a Cause of Very Early Onset Inflammatory Bowel Disease.

Parlato M, Charbit-Henrion F, Hayes P, Tiberti A, Aloi M, Cucchiara S, Bègue B, Bras M, Pouliet A, Rakotobe S, Ruemmele F, Knaus UG, Cerf-Bensussan N.

Gastroenterology. 2017 Aug;153(2):609-611.e3. doi: 10.1053/j.gastro.2016.12.053. Epub 2017 Jul 3. No abstract available.

PMID:
28683258
14.

Crohn's Strictures-Moving Away from the Knife.

Stenke E, Bourke B, Knaus U.

Front Pediatr. 2017 Jun 16;5:141. doi: 10.3389/fped.2017.00141. eCollection 2017. Review.

15.

European contribution to the study of ROS: A summary of the findings and prospects for the future from the COST action BM1203 (EU-ROS).

Egea J, Fabregat I, Frapart YM, Ghezzi P, Görlach A, Kietzmann T, Kubaichuk K, Knaus UG, Lopez MG, Olaso-Gonzalez G, Petry A, Schulz R, Vina J, Winyard P, Abbas K, Ademowo OS, Afonso CB, Andreadou I, Antelmann H, Antunes F, Aslan M, Bachschmid MM, Barbosa RM, Belousov V, Berndt C, Bernlohr D, Bertrán E, Bindoli A, Bottari SP, Brito PM, Carrara G, Casas AI, Chatzi A, Chondrogianni N, Conrad M, Cooke MS, Costa JG, Cuadrado A, My-Chan Dang P, De Smet B, Debelec-Butuner B, Dias IHK, Dunn JD, Edson AJ, El Assar M, El-Benna J, Ferdinandy P, Fernandes AS, Fladmark KE, Förstermann U, Giniatullin R, Giricz Z, Görbe A, Griffiths H, Hampl V, Hanf A, Herget J, Hernansanz-Agustín P, Hillion M, Huang J, Ilikay S, Jansen-Dürr P, Jaquet V, Joles JA, Kalyanaraman B, Kaminskyy D, Karbaschi M, Kleanthous M, Klotz LO, Korac B, Korkmaz KS, Koziel R, Kračun D, Krause KH, Křen V, Krieg T, Laranjinha J, Lazou A, Li H, Martínez-Ruiz A, Matsui R, McBean GJ, Meredith SP, Messens J, Miguel V, Mikhed Y, Milisav I, Milković L, Miranda-Vizuete A, Mojović M, Monsalve M, Mouthuy PA, Mulvey J, Münzel T, Muzykantov V, Nguyen ITN, Oelze M, Oliveira NG, Palmeira CM, Papaevgeniou N, Pavićević A, Pedre B, Peyrot F, Phylactides M, Pircalabioru GG, Pitt AR, Poulsen HE, Prieto I, Rigobello MP, Robledinos-Antón N, Rodríguez-Mañas L, Rolo AP, Rousset F, Ruskovska T, Saraiva N, Sasson S, Schröder K, Semen K, Seredenina T, Shakirzyanova A, Smith GL, Soldati T, Sousa BC, Spickett CM, Stancic A, Stasia MJ, Steinbrenner H, Stepanić V, Steven S, Tokatlidis K, Tuncay E, Turan B, Ursini F, Vacek J, Vajnerova O, Valentová K, Van Breusegem F, Varisli L, Veal EA, Yalçın AS, Yelisyeyeva O, Žarković N, Zatloukalová M, Zielonka J, Touyz RM, Papapetropoulos A, Grune T, Lamas S, Schmidt HHHW, Di Lisa F, Daiber A.

Redox Biol. 2017 Oct;13:94-162. doi: 10.1016/j.redox.2017.05.007. Epub 2017 May 18. Review. Erratum in: Redox Biol. 2018 Apr;14 :694-696.

16.

Pathogen control at the intestinal mucosa - H2O2 to the rescue.

Knaus UG, Hertzberger R, Pircalabioru GG, Yousefi SP, Branco Dos Santos F.

Gut Microbes. 2017 Jan 2;8(1):67-74. doi: 10.1080/19490976.2017.1279378. Epub 2017 Jan 12. Review.

17.

Cellular ROS imaging with hydro-Cy3 dye is strongly influenced by mitochondrial membrane potential.

Zhdanov AV, Aviello G, Knaus UG, Papkovsky DB.

Biochim Biophys Acta Gen Subj. 2017 Feb;1861(2):198-204. doi: 10.1016/j.bbagen.2016.10.023. Epub 2016 Nov 4.

PMID:
27818165
18.

Reduction of falls and fractures after permanent pacemaker implantation in elderly patients with sinus node dysfunction.

Brenner R, Ammann P, Yoon SI, Christen S, Hellermann J, Girod G, Knaus U, Duru F, Krasniqi N, Ramsay D, Sticherling C, Lippuner K, Kühne M.

Europace. 2017 Jul 1;19(7):1220-1226. doi: 10.1093/europace/euw156.

PMID:
27702858
19.

NADPH oxidase-derived H2O2 subverts pathogen signaling by oxidative phosphotyrosine conversion to PB-DOPA.

Alvarez LA, Kovačič L, Rodríguez J, Gosemann JH, Kubica M, Pircalabioru GG, Friedmacher F, Cean A, Ghişe A, Sărăndan MB, Puri P, Daff S, Plettner E, von Kriegsheim A, Bourke B, Knaus UG.

Proc Natl Acad Sci U S A. 2016 Sep 13;113(37):10406-11. doi: 10.1073/pnas.1605443113. Epub 2016 Aug 25.

20.

Defensive Mutualism Rescues NADPH Oxidase Inactivation in Gut Infection.

Pircalabioru G, Aviello G, Kubica M, Zhdanov A, Paclet MH, Brennan L, Hertzberger R, Papkovsky D, Bourke B, Knaus UG.

Cell Host Microbe. 2016 May 11;19(5):651-63. doi: 10.1016/j.chom.2016.04.007.

21.

ROS in gastrointestinal inflammation: Rescue Or Sabotage?

Aviello G, Knaus UG.

Br J Pharmacol. 2017 Jun;174(12):1704-1718. doi: 10.1111/bph.13428. Epub 2016 Mar 3. Review.

22.

Defects in NADPH Oxidase Genes NOX1 and DUOX2 in Very Early Onset Inflammatory Bowel Disease.

Hayes P, Dhillon S, O'Neill K, Thoeni C, Hui KY, Elkadri A, Guo CH, Kovacic L, Aviello G, Alvarez LA, Griffiths AM, Snapper SB, Brant SR, Doroshow JH, Silverberg MS, Peter I, McGovern DP, Cho J, Brumell JH, Uhlig HH, Bourke B, Muise AA, Knaus UG.

Cell Mol Gastroenterol Hepatol. 2015 Sep 1;1(5):489-502.

23.

Genetic disorders coupled to ROS deficiency.

O'Neill S, Brault J, Stasia MJ, Knaus UG.

Redox Biol. 2015 Dec;6:135-156. doi: 10.1016/j.redox.2015.07.009. Epub 2015 Jul 17. Review.

24.

Redox regulation of genome stability by effects on gene expression, epigenetic pathways and DNA damage/repair.

Mikhed Y, Görlach A, Knaus UG, Daiber A.

Redox Biol. 2015 Aug;5:275-289. doi: 10.1016/j.redox.2015.05.008. Epub 2015 Jun 3. Review.

25.

Ubiquitin C-terminal hydrolase-L1 increases cancer cell invasion by modulating hydrogen peroxide generated via NADPH oxidase 4.

Kim HJ, Magesh V, Lee JJ, Kim S, Knaus UG, Lee KJ.

Oncotarget. 2015 Jun 30;6(18):16287-303.

26.

Mouse macrophages completely lacking Rho subfamily GTPases (RhoA, RhoB, and RhoC) have severe lamellipodial retraction defects, but robust chemotactic navigation and altered motility.

Königs V, Jennings R, Vogl T, Horsthemke M, Bachg AC, Xu Y, Grobe K, Brakebusch C, Schwab A, Bähler M, Knaus UG, Hanley PJ.

J Biol Chem. 2014 Oct 31;289(44):30772-84. doi: 10.1074/jbc.M114.563270. Epub 2014 Sep 11.

27.

RhoA determines disease progression by controlling neutrophil motility and restricting hyperresponsiveness.

Jennings RT, Strengert M, Hayes P, El-Benna J, Brakebusch C, Kubica M, Knaus UG.

Blood. 2014 Jun 5;123(23):3635-45. doi: 10.1182/blood-2014-02-557843. Epub 2014 Apr 29.

PMID:
24782506
28.

Neutrophil migration through extracellular matrix.

Jennings RT, Knaus UG.

Methods Mol Biol. 2014;1124:209-18. doi: 10.1007/978-1-62703-845-4_13.

PMID:
24504954
29.

Rho family and Rap GTPase activation assays.

Jennings RT, Knaus UG.

Methods Mol Biol. 2014;1124:79-88. doi: 10.1007/978-1-62703-845-4_6.

PMID:
24504947
30.

Mucosal reactive oxygen species are required for antiviral response: role of Duox in influenza a virus infection.

Strengert M, Jennings R, Davanture S, Hayes P, Gabriel G, Knaus UG.

Antioxid Redox Signal. 2014 Jun 10;20(17):2695-709. doi: 10.1089/ars.2013.5353. Epub 2013 Oct 15.

PMID:
24128054
31.

Cj1411c encodes for a cytochrome P450 involved in Campylobacter jejuni 81-176 pathogenicity.

Alvarez LA, Bourke B, Pircalabioru G, Georgiev AY, Knaus UG, Daff S, Corcionivoschi N.

PLoS One. 2013 Sep 26;8(9):e75534. doi: 10.1371/journal.pone.0075534. eCollection 2013.

32.

Balancing reactive oxygen species in the epigenome: NADPH oxidases as target and perpetrator.

Hayes P, Knaus UG.

Antioxid Redox Signal. 2013 May 20;18(15):1937-45. doi: 10.1089/ars.2012.4895. Epub 2012 Nov 5. Review.

PMID:
23126619
33.

Mucosal reactive oxygen species decrease virulence by disrupting Campylobacter jejuni phosphotyrosine signaling.

Corcionivoschi N, Alvarez LA, Sharp TH, Strengert M, Alemka A, Mantell J, Verkade P, Knaus UG, Bourke B.

Cell Host Microbe. 2012 Jul 19;12(1):47-59. doi: 10.1016/j.chom.2012.05.018.

34.

Impaired function of the Tie-2 receptor contributes to vascular leakage and lethality in anthrax.

Ghosh CC, Mukherjee A, David S, Knaus UG, Stearns-Kurosawa DJ, Kurosawa S, Parikh SM.

Proc Natl Acad Sci U S A. 2012 Jun 19;109(25):10024-9. doi: 10.1073/pnas.1120755109. Epub 2012 Jun 4. Erratum in: Proc Natl Acad Sci U S A. 2012 Nov 6;109(45):18625.

35.

Anti-invasive adjuvant therapy with imipramine blue enhances chemotherapeutic efficacy against glioma.

Munson JM, Fried L, Rowson SA, Bonner MY, Karumbaiah L, Diaz B, Courtneidge SA, Knaus UG, Brat DJ, Arbiser JL, Bellamkonda RV.

Sci Transl Med. 2012 Mar 28;4(127):127ra36. doi: 10.1126/scitranslmed.3003016.

36.

Constitutive NADPH oxidase 4 activity resides in the composition of the B-loop and the penultimate C terminus.

von Löhneysen K, Noack D, Hayes P, Friedman JS, Knaus UG.

J Biol Chem. 2012 Mar 16;287(12):8737-45. doi: 10.1074/jbc.M111.332494. Epub 2012 Jan 25.

37.

Analysis of epithelial barrier integrity in polarized lung epithelial cells.

Strengert M, Knaus UG.

Methods Mol Biol. 2011;763:195-206. doi: 10.1007/978-1-61779-191-8_13.

PMID:
21874453
38.

Oxidases and peroxidases in cardiovascular and lung disease: new concepts in reactive oxygen species signaling.

Al Ghouleh I, Khoo NK, Knaus UG, Griendling KK, Touyz RM, Thannickal VJ, Barchowsky A, Nauseef WM, Kelley EE, Bauer PM, Darley-Usmar V, Shiva S, Cifuentes-Pagano E, Freeman BA, Gladwin MT, Pagano PJ.

Free Radic Biol Med. 2011 Oct 1;51(7):1271-88. doi: 10.1016/j.freeradbiomed.2011.06.011. Epub 2011 Jun 14. Review.

39.

Structural insights into Nox4 and Nox2: motifs involved in function and cellular localization.

von Löhneysen K, Noack D, Wood MR, Friedman JS, Knaus UG.

Mol Cell Biol. 2010 Feb;30(4):961-75. doi: 10.1128/MCB.01393-09. Epub 2009 Dec 7.

40.

Fulvene-5 potently inhibits NADPH oxidase 4 and blocks the growth of endothelial tumors in mice.

Bhandarkar SS, Jaconi M, Fried LE, Bonner MY, Lefkove B, Govindarajan B, Perry BN, Parhar R, Mackelfresh J, Sohn A, Stouffs M, Knaus U, Yancopoulos G, Reiss Y, Benest AV, Augustin HG, Arbiser JL.

J Clin Invest. 2009 Aug;119(8):2359-65. doi: 10.1172/JCI33877. Epub 2009 Jul 13.

41.

Heterodimerization controls localization of Duox-DuoxA NADPH oxidases in airway cells.

Luxen S, Noack D, Frausto M, Davanture S, Torbett BE, Knaus UG.

J Cell Sci. 2009 Apr 15;122(Pt 8):1238-47. doi: 10.1242/jcs.044123.

42.

Lung epithelial injury by B. anthracis lethal toxin is caused by MKK-dependent loss of cytoskeletal integrity.

Lehmann M, Noack D, Wood M, Perego M, Knaus UG.

PLoS One. 2009;4(3):e4755. doi: 10.1371/journal.pone.0004755. Epub 2009 Mar 9.

43.

RhoA GTPase activation by TLR2 and TLR3 ligands: connecting via Src to NF-kappa B.

Manukyan M, Nalbant P, Luxen S, Hahn KM, Knaus UG.

J Immunol. 2009 Mar 15;182(6):3522-9. doi: 10.4049/jimmunol.0802280.

44.

Mutational analysis reveals distinct features of the Nox4-p22 phox complex.

von Löhneysen K, Noack D, Jesaitis AJ, Dinauer MC, Knaus UG.

J Biol Chem. 2008 Dec 12;283(50):35273-82. doi: 10.1074/jbc.M804200200. Epub 2008 Oct 10.

45.

Inhibitory action of NoxA1 on dual oxidase activity in airway cells.

Pacquelet S, Lehmann M, Luxen S, Regazzoni K, Frausto M, Noack D, Knaus UG.

J Biol Chem. 2008 Sep 5;283(36):24649-58. doi: 10.1074/jbc.M709108200. Epub 2008 Jul 7.

46.

Rac and Rap GTPase activation assays.

Knaus UG, Bamberg A, Bokoch GM.

Methods Mol Biol. 2007;412:59-67. doi: 10.1007/978-1-59745-467-4_5.

PMID:
18453105
47.

P21-activated kinase is required for mitotic progression and regulates Plk1.

Maroto B, Ye MB, von Lohneysen K, Schnelzer A, Knaus UG.

Oncogene. 2008 Aug 21;27(36):4900-8. doi: 10.1038/onc.2008.131. Epub 2008 Apr 21.

PMID:
18427546
48.

PAK is required for the disruption of E-cadherin adhesion by the small GTPase Rac.

Lozano E, Frasa MA, Smolarczyk K, Knaus UG, Braga VM.

J Cell Sci. 2008 Apr 1;121(Pt 7):933-8. doi: 10.1242/jcs.016121. Epub 2008 Mar 4.

49.

Silencing of DUOX NADPH oxidases by promoter hypermethylation in lung cancer.

Luxen S, Belinsky SA, Knaus UG.

Cancer Res. 2008 Feb 15;68(4):1037-45. doi: 10.1158/0008-5472.CAN-07-5782.

50.

Regulation of Nox1 activity via protein kinase A-mediated phosphorylation of NoxA1 and 14-3-3 binding.

Kim JS, Diebold BA, Babior BM, Knaus UG, Bokoch GM.

J Biol Chem. 2007 Nov 30;282(48):34787-800. Epub 2007 Oct 3.

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