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Items: 1 to 50 of 101

1.

Cofilin-1 phosphorylation catalyzed by ERK1/2 alters cardiac actin dynamics in dilated cardiomyopathy caused by lamin A/C gene mutation.

Chatzifrangkeskou M, Yadin D, Marais T, Chardonnet S, Cohen-Tannoudji M, Mougenot N, Schmitt A, Crasto S, Di Pasquale E, Macquart C, Tanguy Y, Jebeniani I, Pucéat M, Morales Rodriguez B, Goldmann WH, Dal Ferro M, Biferi MG, Knaus P, Bonne G, Worman HJ, Muchir A.

Hum Mol Genet. 2018 Jun 5. doi: 10.1093/hmg/ddy215. [Epub ahead of print]

PMID:
29878125
2.

BMPR2 inhibits activin and BMP signaling via wild-type ALK2.

Olsen OE, Sankar M, Elsaadi S, Hella H, Buene G, Darvekar SR, Misund K, Katagiri T, Knaus P, Holien T.

J Cell Sci. 2018 Jun 11;131(11). pii: jcs213512. doi: 10.1242/jcs.213512.

PMID:
29739878
3.

Impaired proteoglycan glycosylation, elevated TGF-β signaling, and abnormal osteoblast differentiation as the basis for bone fragility in a mouse model for gerodermia osteodysplastica.

Chan WL, Steiner M, Witkos T, Egerer J, Busse B, Mizumoto S, Pestka JM, Zhang H, Hausser I, Khayal LA, Ott CE, Kolanczyk M, Willie B, Schinke T, Paganini C, Rossi A, Sugahara K, Amling M, Knaus P, Chan D, Lowe M, Mundlos S, Kornak U.

PLoS Genet. 2018 Mar 21;14(3):e1007242. doi: 10.1371/journal.pgen.1007242. eCollection 2018 Mar.

4.

Cell-specific responses to the cytokine TGFβ are determined by variability in protein levels.

Strasen J, Sarma U, Jentsch M, Bohn S, Sheng C, Horbelt D, Knaus P, Legewie S, Loewer A.

Mol Syst Biol. 2018 Jan 25;14(1):e7733. doi: 10.15252/msb.20177733.

5.

BMPs as new insulin sensitizers: enhanced glucose uptake in mature 3T3-L1 adipocytes via PPARγ and GLUT4 upregulation.

Schreiber I, Dörpholz G, Ott CE, Kragesteen B, Schanze N, Lee CT, Köhrle J, Mundlos S, Ruschke K, Knaus P.

Sci Rep. 2017 Dec 8;7(1):17192. doi: 10.1038/s41598-017-17595-5.

6.

Correction for Bagarova et al., "Constitutively Active ALK2 Receptor Mutants Require Type II Receptor Cooperation".

Bagarova J, Vonner AJ, Armstrong KA, Börgermann J, Lai CSC, Deng DY, Beppu H, Alfano I, Filippakopoulos P, Morrell NW, Bullock AN, Knaus P, Mishina Y, Yu PB.

Mol Cell Biol. 2017 Sep 12;37(19). pii: e00284-17. doi: 10.1128/MCB.00284-17. Print 2017 Oct 1. No abstract available.

7.

IRS4, a novel modulator of BMP/Smad and Akt signalling during early muscle differentiation.

Dörpholz G, Murgai A, Jatzlau J, Horbelt D, Belverdi MP, Heroven C, Schreiber I, Wendel G, Ruschke K, Stricker S, Knaus P.

Sci Rep. 2017 Aug 18;7(1):8778. doi: 10.1038/s41598-017-08676-6.

8.

Role of bone morphogenetic proteins in sprouting angiogenesis: differential BMP receptor-dependent signaling pathways balance stalk vs. tip cell competence.

Benn A, Hiepen C, Osterland M, Schütte C, Zwijsen A, Knaus P.

FASEB J. 2017 Nov;31(11):4720-4733. doi: 10.1096/fj.201700193RR. Epub 2017 Jul 21.

9.

Putting Cells into Context.

Stricker S, Knaus P, Simon HG.

Front Cell Dev Biol. 2017 Apr 5;5:32. doi: 10.3389/fcell.2017.00032. eCollection 2017. No abstract available.

10.

The Role of Titanium Surface Nanostructuring on Preosteoblast Morphology, Adhesion, and Migration.

Zhukova Y, Hiepen C, Knaus P, Osterland M, Prohaska S, Dunlop JWC, Fratzl P, Skorb EV.

Adv Healthc Mater. 2017 Aug;6(15). doi: 10.1002/adhm.201601244. Epub 2017 Mar 30.

PMID:
28371540
11.

Emerging regulators of BMP bioavailability.

Sánchez-Duffhues G, Hiepen C, Knaus P, Ten Dijke P.

Bone. 2016 Dec;93:220-221. doi: 10.1016/j.bone.2016.01.022. Epub 2016 Jan 26. No abstract available.

PMID:
26825814
12.

An investigation of BMP-7 mediated alterations to BMP signalling components in human tenocyte-like cells.

Klatte-Schulz F, Giese G, Differ C, Minkwitz S, Ruschke K, Puts R, Knaus P, Wildemann B.

Sci Rep. 2016 Jul 11;6:29703. doi: 10.1038/srep29703.

13.

Activation of Mechanosensitive Transcription Factors in Murine C2C12 Mesenchymal Precursors by Focused Low-Intensity Pulsed Ultrasound (FLIPUS).

Puts R, Rikeit P, Ruschke K, Kadow-Romacker A, Hwang S, Jenderka KV, Knaus P, Raum K.

IEEE Trans Ultrason Ferroelectr Freq Control. 2016 Oct;63(10):1505-1513. Epub 2016 Jul 7.

PMID:
27392348
14.

Bone morphogenetic protein 2/SMAD signalling in human ligamentocytes of degenerated and aged anterior cruciate ligaments.

Ruschke K, Meier C, Ullah M, Krebs AC, Silberreis K, Kohl B, Knaus P, Jagielski M, Arens S, Schulze-Tanzil G.

Osteoarthritis Cartilage. 2016 Oct;24(10):1816-1825. doi: 10.1016/j.joca.2016.05.014. Epub 2016 May 18.

15.

Dynamin-dependent endocytosis of Bone Morphogenetic Protein2 (BMP2) and its receptors is dispensable for the initiation of Smad signaling.

Paarmann P, Dörpholz G, Fiebig J, Amsalem AR, Ehrlich M, Henis YI, Müller T, Knaus P.

Int J Biochem Cell Biol. 2016 Jul;76:51-63. doi: 10.1016/j.biocel.2016.04.010. Epub 2016 Apr 23.

PMID:
27113717
16.

YAP-Mediated Mechanotransduction in Skeletal Muscle.

Fischer M, Rikeit P, Knaus P, Coirault C.

Front Physiol. 2016 Feb 16;7:41. doi: 10.3389/fphys.2016.00041. eCollection 2016. Review.

17.

BMP signaling in vascular biology and dysfunction.

García de Vinuesa A, Abdelilah-Seyfried S, Knaus P, Zwijsen A, Bailly S.

Cytokine Growth Factor Rev. 2016 Feb;27:65-79. doi: 10.1016/j.cytogfr.2015.12.005. Epub 2015 Dec 15. Review.

PMID:
26823333
18.

Actions from head to toe: An update on Bone/Body Morphogenetic Proteins in health and disease.

Hiepen C, Yadin D, Rikeit P, Dörpholz G, Knaus P.

Cytokine Growth Factor Rev. 2016 Feb;27:1-11. doi: 10.1016/j.cytogfr.2015.12.006. Epub 2016 Jan 6.

PMID:
26803465
19.

Differential regulation of translation and endocytosis of alternatively spliced forms of the type II bone morphogenetic protein (BMP) receptor.

Amsalem AR, Marom B, Shapira KE, Hirschhorn T, Preisler L, Paarmann P, Knaus P, Henis YI, Ehrlich M.

Mol Biol Cell. 2016 Feb 15;27(4):716-30. doi: 10.1091/mbc.E15-08-0547. Epub 2016 Jan 6.

20.

Structural insights into BMP receptors: Specificity, activation and inhibition.

Yadin D, Knaus P, Mueller TD.

Cytokine Growth Factor Rev. 2016 Feb;27:13-34. doi: 10.1016/j.cytogfr.2015.11.005. Epub 2015 Nov 24. Review.

PMID:
26690041
21.

VE-cadherin facilitates BMP-induced endothelial cell permeability and signaling.

Benn A, Bredow C, Casanova I, Vukičević S, Knaus P.

J Cell Sci. 2016 Jan 1;129(1):206-18. doi: 10.1242/jcs.179960. Epub 2015 Nov 23.

22.

A Focused Low-Intensity Pulsed Ultrasound (FLIPUS) System for Cell Stimulation: Physical and Biological Proof of Principle.

Puts R, Ruschke K, Ambrosi TH, Kadow-Romacker A, Knaus P, Jenderka KV, Raum K.

IEEE Trans Ultrason Ferroelectr Freq Control. 2016 Jan;63(1):91-100. doi: 10.1109/TUFFC.2015.2498042. Epub 2015 Nov 4.

PMID:
26552085
23.

Bone morphogenetic protein signaling in bone homeostasis.

Sánchez-Duffhues G, Hiepen C, Knaus P, Ten Dijke P.

Bone. 2015 Nov;80:43-59. doi: 10.1016/j.bone.2015.05.025. Epub 2015 Jun 5. Review.

PMID:
26051467
24.

Nanoscale control of surface immobilized BMP-2: toward a quantitative assessment of BMP-mediated signaling events.

Schwab EH, Pohl TL, Haraszti T, Schwaerzer GK, Hiepen C, Spatz JP, Knaus P, Cavalcanti-Adam EA.

Nano Lett. 2015 Mar 11;15(3):1526-34. doi: 10.1021/acs.nanolett.5b00315. Epub 2015 Feb 12.

PMID:
25668064
25.

MiR-497∼195 cluster microRNAs regulate osteoblast differentiation by targeting BMP signaling.

Grünhagen J, Bhushan R, Degenkolbe E, Jäger M, Knaus P, Mundlos S, Robinson PN, Ott CE.

J Bone Miner Res. 2015 May;30(5):796-808. doi: 10.1002/jbmr.2412.

26.

Small molecules dorsomorphin and LDN-193189 inhibit myostatin/GDF8 signaling and promote functional myoblast differentiation.

Horbelt D, Boergermann JH, Chaikuad A, Alfano I, Williams E, Lukonin I, Timmel T, Bullock AN, Knaus P.

J Biol Chem. 2015 Feb 6;290(6):3390-404. doi: 10.1074/jbc.M114.604397. Epub 2014 Nov 3.

27.

BMP2-induced chemotaxis requires PI3K p55γ/p110α-dependent phosphatidylinositol (3,4,5)-triphosphate production and LL5β recruitment at the cytocortex.

Hiepen C, Benn A, Denkis A, Lukonin I, Weise C, Boergermann JH, Knaus P.

BMC Biol. 2014 May 30;12:43. doi: 10.1186/1741-7007-12-43.

28.

BMP growth factor signaling in a biomechanical context.

Kopf J, Paarmann P, Hiepen C, Horbelt D, Knaus P.

Biofactors. 2014 Mar-Apr;40(2):171-87. doi: 10.1002/biof.1137. Epub 2013 Oct 4. Review.

PMID:
24123658
29.

BMP10 as a potent inducer of trophoblast differentiation in human embryonic and induced pluripotent stem cells.

Lichtner B, Knaus P, Lehrach H, Adjaye J.

Biomaterials. 2013 Dec;34(38):9789-802. doi: 10.1016/j.biomaterials.2013.08.084. Epub 2013 Sep 23.

PMID:
24070570
30.

Growth and differentiation factor 3 induces expression of genes related to differentiation in a model of cancer stem cells and protects them from retinoic acid-induced apoptosis.

Tykwinska K, Lauster R, Knaus P, Rosowski M.

PLoS One. 2013 Aug 12;8(8):e70612. doi: 10.1371/journal.pone.0070612. eCollection 2013.

31.

Constitutively active ALK2 receptor mutants require type II receptor cooperation.

Bagarova J, Vonner AJ, Armstrong KA, Börgermann J, Lai CS, Deng DY, Beppu H, Alfano I, Filippakopoulos P, Morrell NW, Bullock AN, Knaus P, Mishina Y, Yu PB.

Mol Cell Biol. 2013 Jun;33(12):2413-24. doi: 10.1128/MCB.01595-12. Epub 2013 Apr 9. Erratum in: Mol Cell Biol. 2017 Sep 12;37(19):.

32.

The "artificial artery" as in vitro perfusion model.

Janke D, Jankowski J, Rüth M, Buschmann I, Lemke HD, Jacobi D, Knaus P, Spindler E, Zidek W, Lehmann K, Jankowski V.

PLoS One. 2013;8(3):e57227. doi: 10.1371/journal.pone.0057227. Epub 2013 Mar 7.

33.

miR-181a promotes osteoblastic differentiation through repression of TGF-β signaling molecules.

Bhushan R, Grünhagen J, Becker J, Robinson PN, Ott CE, Knaus P.

Int J Biochem Cell Biol. 2013 Mar;45(3):696-705. doi: 10.1016/j.biocel.2012.12.008. Epub 2012 Dec 20.

PMID:
23262291
34.

Antagonism of GxxPG fragments ameliorates manifestations of aortic disease in Marfan syndrome mice.

Guo G, Muñoz-García B, Ott CE, Grünhagen J, Mousa SA, Pletschacher A, von Kodolitsch Y, Knaus P, Robinson PN.

Hum Mol Genet. 2013 Feb 1;22(3):433-43. doi: 10.1093/hmg/dds439. Epub 2012 Oct 24.

PMID:
23100322
35.

Structure of the bone morphogenetic protein receptor ALK2 and implications for fibrodysplasia ossificans progressiva.

Chaikuad A, Alfano I, Kerr G, Sanvitale CE, Boergermann JH, Triffitt JT, von Delft F, Knapp S, Knaus P, Bullock AN.

J Biol Chem. 2012 Oct 26;287(44):36990-8. doi: 10.1074/jbc.M112.365932. Epub 2012 Sep 12.

36.

SMAD versus non-SMAD signaling is determined by lateral mobility of bone morphogenetic protein (BMP) receptors.

Guzman A, Zelman-Femiak M, Boergermann JH, Paschkowsky S, Kreuzaler PA, Fratzl P, Harms GS, Knaus P.

J Biol Chem. 2012 Nov 16;287(47):39492-504. doi: 10.1074/jbc.M112.387639. Epub 2012 Sep 7.

37.

Of flies, mice and men: a systematic approach to understanding the early life origins of chronic lung disease.

Krauss-Etschmann S, Bush A, Bellusci S, Brusselle GG, Dahlén SE, Dehmel S, Eickelberg O, Gibson G, Hylkema MN, Knaus P, Königshoff M, Lloyd CM, Macciarini P, Mailleux A, Marsland BJ, Postma DS, Roberts G, Samakovlis C, Stocks J, Vandesompele J, Wjst M, Holloway J.

Thorax. 2013 Apr;68(4):380-4. doi: 10.1136/thoraxjnl-2012-201902. Epub 2012 Jul 10. Review.

PMID:
22781122
38.

BMP2 and mechanical loading cooperatively regulate immediate early signalling events in the BMP pathway.

Kopf J, Petersen A, Duda GN, Knaus P.

BMC Biol. 2012 Apr 30;10:37. doi: 10.1186/1741-7007-10-37.

39.

BMPs are mediators in tissue crosstalk of the regenerating musculoskeletal system.

Ruschke K, Hiepen C, Becker J, Knaus P.

Cell Tissue Res. 2012 Mar;347(3):521-44. doi: 10.1007/s00441-011-1283-6. Epub 2012 Feb 12. Review.

PMID:
22327483
40.

Oligomeric interactions of TGF-β and BMP receptors.

Ehrlich M, Gutman O, Knaus P, Henis YI.

FEBS Lett. 2012 Jul 4;586(14):1885-96. doi: 10.1016/j.febslet.2012.01.040. Epub 2012 Jan 27. Review.

41.

A portrait of Transforming Growth Factor β superfamily signalling: Background matters.

Horbelt D, Denkis A, Knaus P.

Int J Biochem Cell Biol. 2012 Mar;44(3):469-74. doi: 10.1016/j.biocel.2011.12.013. Epub 2011 Dec 31. Review.

PMID:
22226817
42.

Surface immobilization of bone morphogenetic protein 2 via a self-assembled monolayer formation induces cell differentiation.

Pohl TL, Boergermann JH, Schwaerzer GK, Knaus P, Cavalcanti-Adam EA.

Acta Biomater. 2012 Feb;8(2):772-80. doi: 10.1016/j.actbio.2011.10.019. Epub 2011 Oct 20.

PMID:
22040684
43.

Spatial segregation of BMP/Smad signaling affects osteoblast differentiation in C2C12 cells.

Heining E, Bhushan R, Paarmann P, Henis YI, Knaus P.

PLoS One. 2011;6(10):e25163. doi: 10.1371/journal.pone.0025163. Epub 2011 Oct 5.

44.

New insights into the molecular mechanism of multiple synostoses syndrome (SYNS): mutation within the GDF5 knuckle epitope causes noggin-resistance.

Schwaerzer GK, Hiepen C, Schrewe H, Nickel J, Ploeger F, Sebald W, Mueller T, Knaus P.

J Bone Miner Res. 2012 Feb;27(2):429-42. doi: 10.1002/jbmr.532.

45.

Fetal and postnatal mouse bone tissue contains more calcium than is present in hydroxyapatite.

Lange C, Li C, Manjubala I, Wagermaier W, Kühnisch J, Kolanczyk M, Mundlos S, Knaus P, Fratzl P.

J Struct Biol. 2011 Nov;176(2):159-67. doi: 10.1016/j.jsb.2011.08.003. Epub 2011 Aug 10.

PMID:
21855638
46.

Comprehensive analysis of TGF-β and BMP receptor interactomes.

Poorgholi Belverdi M, Krause C, Guzman A, Knaus P.

Eur J Cell Biol. 2012 Apr;91(4):287-93. doi: 10.1016/j.ejcb.2011.05.004. Epub 2011 Jun 28. Review.

PMID:
21715044
47.

Homomeric and heteromeric complexes among TGF-β and BMP receptors and their roles in signaling.

Ehrlich M, Horbelt D, Marom B, Knaus P, Henis YI.

Cell Signal. 2011 Sep;23(9):1424-32. doi: 10.1016/j.cellsig.2011.04.004. Epub 2011 Apr 14. Review.

PMID:
21515362
48.

Formation of stable homomeric and transient heteromeric bone morphogenetic protein (BMP) receptor complexes regulates Smad protein signaling.

Marom B, Heining E, Knaus P, Henis YI.

J Biol Chem. 2011 Jun 3;286(22):19287-96. doi: 10.1074/jbc.M110.210377. Epub 2011 Apr 6.

49.

MicroRNAs differentially expressed in postnatal aortic development downregulate elastin via 3' UTR and coding-sequence binding sites.

Ott CE, Grünhagen J, Jäger M, Horbelt D, Schwill S, Kallenbach K, Guo G, Manke T, Knaus P, Mundlos S, Robinson PN.

PLoS One. 2011 Jan 31;6(1):e16250. doi: 10.1371/journal.pone.0016250.

50.

Noggin.

Krause C, Guzman A, Knaus P.

Int J Biochem Cell Biol. 2011 Apr;43(4):478-81. doi: 10.1016/j.biocel.2011.01.007. Epub 2011 Jan 21. Review.

PMID:
21256973

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