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Items: 1 to 50 of 189

1.

Nabilone for non-motor symptoms of Parkinson's disease: a randomized placebo-controlled, double-blind, parallel-group, enriched enrolment randomized withdrawal study (The NMS-Nab Study).

Peball M, Werkmann M, Ellmerer P, Stolz R, Valent D, Knaus HG, Ulmer H, Djamshidian A, Poewe W, Seppi K.

J Neural Transm (Vienna). 2019 Aug;126(8):1061-1072. doi: 10.1007/s00702-019-02021-z. Epub 2019 May 25.

2.

High resolution combined molecular and structural optical imaging of colorectal cancer in a xenograft mouse model.

Feroldi F, Verlaan M, Knaus H, Davidoiu V, Vugts DJ, van Dongen GAMS, Molthoff CFM, de Boer JF.

Biomed Opt Express. 2018 Nov 13;9(12):6186-6204. doi: 10.1364/BOE.9.006186. eCollection 2018 Dec 1.

3.

Signatures of CD8+ T cell dysfunction in AML patients and their reversibility with response to chemotherapy.

Knaus HA, Berglund S, Hackl H, Blackford AL, Zeidner JF, Montiel-Esparza R, Mukhopadhyay R, Vanura K, Blazar BR, Karp JE, Luznik L, Gojo I.

JCI Insight. 2018 Nov 2;3(21). pii: 120974. doi: 10.1172/jci.insight.120974.

4.

A Multi-center Phase I Trial of Ipilimumab in Patients with Myelodysplastic Syndromes following Hypomethylating Agent Failure.

Zeidan AM, Knaus HA, Robinson TM, Towlerton AMH, Warren EH, Zeidner JF, Blackford AL, Duffield AS, Rizzieri D, Frattini MG, Levy YM, Schroeder MA, Ferguson A, Sheldon KE, DeZern AE, Gojo I, Gore SD, Streicher H, Luznik L, Smith BD.

Clin Cancer Res. 2018 Aug 1;24(15):3519-3527. doi: 10.1158/1078-0432.CCR-17-3763. Epub 2018 May 1.

5.

Shaker-related voltage-gated potassium channels Kv1 in human hippocampus.

Willis M, Leitner I, Seppi K, Trieb M, Wietzorrek G, Marksteiner J, Knaus HG.

Brain Struct Funct. 2018 Jul;223(6):2663-2671. doi: 10.1007/s00429-018-1653-x. Epub 2018 Mar 21.

PMID:
29564531
6.

Small-conductance calcium-activated potassium type 2 channels (SK2, KCa2.2) in human brain.

Willis M, Trieb M, Leitner I, Wietzorrek G, Marksteiner J, Knaus HG.

Brain Struct Funct. 2017 Mar;222(2):973-979. doi: 10.1007/s00429-016-1258-1. Epub 2016 Jun 29.

7.

Loss of the mismatched human leukocyte antigen haplotype in two acute myelogenous leukemia relapses after haploidentical bone marrow transplantation with post-transplantation cyclophosphamide.

McCurdy SR, Iglehart BS, Batista DA, Gocke CD, Ning Y, Knaus HA, Jackson AM, Leffell MS, Luznik L, Gojo I.

Leukemia. 2016 Oct;30(10):2102-2106. doi: 10.1038/leu.2016.144. Epub 2016 May 23. No abstract available.

8.

Differential distribution of the sodium-activated potassium channels slick and slack in mouse brain.

Rizzi S, Knaus HG, Schwarzer C.

J Comp Neurol. 2016 Jul 1;524(10):2093-116. doi: 10.1002/cne.23934. Epub 2015 Dec 15.

9.

Identification of potential novel interaction partners of the sodium-activated potassium channels Slick and Slack in mouse brain.

Rizzi S, Schwarzer C, Kremser L, Lindner HH, Knaus HG.

Biochem Biophys Rep. 2015 Oct 9;4:291-298. doi: 10.1016/j.bbrep.2015.09.024. eCollection 2015 Dec.

10.

Immunomodulatory Drugs: Immune Checkpoint Agents in Acute Leukemia.

Knaus HA, Kanakry CG, Luznik L, Gojo I.

Curr Drug Targets. 2017;18(3):315-331. doi: 10.2174/1389450116666150518095346. Review.

11.

Small-conductance Ca2+-activated potassium type 2 channels regulate the formation of contextual fear memory.

Murthy SR, Sherrin T, Jansen C, Nijholt I, Robles M, Dolga AM, Andreotti N, Sabatier JM, Knaus HG, Penner R, Todorovic C, Blank T.

PLoS One. 2015 May 4;10(5):e0127264. doi: 10.1371/journal.pone.0127264. eCollection 2015.

12.

SAR-guided development and characterization of a potent antitumor compound toward B-cell neoplasms with no detectable cytotoxicity toward healthy cells.

Brunhofer-Bolzer G, Le T, Dyckmanns N, Knaus HA, Pausz C, Freund P, Jäger U, Erker T, Vanura K.

J Med Chem. 2015 Feb 12;58(3):1244-53. doi: 10.1021/jm501848m. Epub 2015 Jan 20.

PMID:
25562417
13.

Subcellular expression and neuroprotective effects of SK channels in human dopaminergic neurons.

Dolga AM, de Andrade A, Meissner L, Knaus HG, Höllerhage M, Christophersen P, Zischka H, Plesnila N, Höglinger GU, Culmsee C.

Cell Death Dis. 2014 Jan 16;5:e999. doi: 10.1038/cddis.2013.530.

14.

Identification of voltage-gated K(+) channel beta 2 (Kvβ2) subunit as a novel interaction partner of the pain transducer Transient Receptor Potential Vanilloid 1 channel (TRPV1).

Bavassano C, Marvaldi L, Langeslag M, Sarg B, Lindner H, Klimaschewski L, Kress M, Ferrer-Montiel A, Knaus HG.

Biochim Biophys Acta. 2013 Dec;1833(12):3166-3175. doi: 10.1016/j.bbamcr.2013.09.001. Epub 2013 Sep 11.

15.

Monitoring the metabolic state of fungal hyphae and the presence of melanin by nonlinear spectral imaging.

Knaus H, Blab GA, Agronskaia AV, van den Heuvel DJ, Gerritsen HC, Wösten HA.

Appl Environ Microbiol. 2013 Oct;79(20):6345-50. doi: 10.1128/AEM.02291-13. Epub 2013 Aug 9.

16.

Palmitoylation of the β4-subunit regulates surface expression of large conductance calcium-activated potassium channel splice variants.

Chen L, Bi D, Tian L, McClafferty H, Steeb F, Ruth P, Knaus HG, Shipston MJ.

J Biol Chem. 2013 May 3;288(18):13136-44. doi: 10.1074/jbc.M113.461830. Epub 2013 Mar 16.

17.

Direct association of the reticulon protein RTN1A with the ryanodine receptor 2 in neurons.

Kaya L, Meissner B, Riedl MC, Muik M, Schwarzer C, Ferraguti F, Sarg B, Lindner H, Schweigreiter R, Knaus HG, Romanin C, Bandtlow CE.

Biochim Biophys Acta. 2013 Jun;1833(6):1421-33. doi: 10.1016/j.bbamcr.2013.02.012. Epub 2013 Feb 27.

18.

Distinct acyl protein transferases and thioesterases control surface expression of calcium-activated potassium channels.

Tian L, McClafferty H, Knaus HG, Ruth P, Shipston MJ.

J Biol Chem. 2012 Apr 27;287(18):14718-25. doi: 10.1074/jbc.M111.335547. Epub 2012 Mar 7.

19.

Control of hypothalamic-pituitary-adrenal stress axis activity by the intermediate conductance calcium-activated potassium channel, SK4.

Liang Z, Chen L, McClafferty H, Lukowski R, MacGregor D, King JT, Rizzi S, Sausbier M, McCobb DP, Knaus HG, Ruth P, Shipston MJ.

J Physiol. 2011 Dec 15;589(Pt 24):5965-86. doi: 10.1113/jphysiol.2011.219378. Epub 2011 Oct 31.

20.

rKv1.2 overexpression in the central medial thalamic area decreases caffeine-induced arousal.

Cazzin C, Piccoli L, Massagrande M, Garbati N, Michielin F, Knaus HG, Ring CJ, Morrison AD, Merlo-Pich E, Rovo Z, Astori S, Lüthi A, Corti C, Corsi M.

Genes Brain Behav. 2011 Nov;10(8):817-27. doi: 10.1111/j.1601-183X.2011.00719.x. Epub 2011 Aug 7.

21.

KCa2 channels activation prevents [Ca2+]i deregulation and reduces neuronal death following glutamate toxicity and cerebral ischemia.

Dolga AM, Terpolilli N, Kepura F, Nijholt IM, Knaus HG, D'Orsi B, Prehn JH, Eisel UL, Plant T, Plesnila N, Culmsee C.

Cell Death Dis. 2011 Apr 21;2:e147. doi: 10.1038/cddis.2011.30.

22.

Single burr hole endoscopic biopsy with third ventriculostomy-measurements and computer-assisted planning.

Knaus H, Matthias S, Koch A, Thomale UW.

Childs Nerv Syst. 2011 Aug;27(8):1233-41. doi: 10.1007/s00381-011-1405-1. Epub 2011 Feb 16.

PMID:
21327590
23.

Palmitoylation of the S0-S1 linker regulates cell surface expression of voltage- and calcium-activated potassium (BK) channels.

Jeffries O, Geiger N, Rowe IC, Tian L, McClafferty H, Chen L, Bi D, Knaus HG, Ruth P, Shipston MJ.

J Biol Chem. 2010 Oct 22;285(43):33307-14. doi: 10.1074/jbc.M110.153940. Epub 2010 Aug 6.

24.

Quantitative proteomics of the Cav2 channel nano-environments in the mammalian brain.

Müller CS, Haupt A, Bildl W, Schindler J, Knaus HG, Meissner M, Rammner B, Striessnig J, Flockerzi V, Fakler B, Schulte U.

Proc Natl Acad Sci U S A. 2010 Aug 24;107(34):14950-7. doi: 10.1073/pnas.1005940107. Epub 2010 Jul 28.

25.

Altered expression and function of small-conductance (SK) Ca(2+)-activated K+ channels in pilocarpine-treated epileptic rats.

Oliveira MS, Skinner F, Arshadmansab MF, Garcia I, Mello CF, Knaus HG, Ermolinsky BS, Otalora LF, Garrido-Sanabria ER.

Brain Res. 2010 Aug 12;1348:187-99. doi: 10.1016/j.brainres.2010.05.095. Epub 2010 Jun 8.

26.

Membrane trafficking of large conductance calcium-activated potassium channels is regulated by alternative splicing of a transplantable, acidic trafficking motif in the RCK1-RCK2 linker.

Chen L, Jeffries O, Rowe IC, Liang Z, Knaus HG, Ruth P, Shipston MJ.

J Biol Chem. 2010 Jul 23;285(30):23265-75. doi: 10.1074/jbc.M110.139758. Epub 2010 May 17.

27.

Navigated endoscopic surgery for multiloculated hydrocephalus in children.

Schulz M, Bohner G, Knaus H, Haberl H, Thomale UW.

J Neurosurg Pediatr. 2010 May;5(5):434-42. doi: 10.3171/2010.1.PEDS09359.

PMID:
20433253
28.

L-type calcium channel CaV 1.2 in transgenic mice overexpressing human AbetaPP751 with the London (V717I) and Swedish (K670M/N671L) mutations.

Willis M, Kaufmann WA, Wietzorrek G, Hutter-Paier B, Moosmang S, Humpel C, Hofmann F, Windisch M, Knaus HG, Marksteiner J.

J Alzheimers Dis. 2010;20(4):1167-80. doi: 10.3233/JAD-2010-091117.

PMID:
20413896
29.

Large-conductance calcium-activated potassium channels in purkinje cell plasma membranes are clustered at sites of hypolemmal microdomains.

Kaufmann WA, Ferraguti F, Fukazawa Y, Kasugai Y, Shigemoto R, Laake P, Sexton JA, Ruth P, Wietzorrek G, Knaus HG, Storm JF, Ottersen OP.

J Comp Neurol. 2009 Jul 10;515(2):215-30. doi: 10.1002/cne.22066.

PMID:
19412945
30.

Palmitoylation gates phosphorylation-dependent regulation of BK potassium channels.

Tian L, Jeffries O, McClafferty H, Molyvdas A, Rowe IC, Saleem F, Chen L, Greaves J, Chamberlain LH, Knaus HG, Ruth P, Shipston MJ.

Proc Natl Acad Sci U S A. 2008 Dec 30;105(52):21006-11. doi: 10.1073/pnas.0806700106. Epub 2008 Dec 19.

31.

TNF-alpha-mediates neuroprotection against glutamate-induced excitotoxicity via NF-kappaB-dependent up-regulation of K2.2 channels.

Dolga AM, Granic I, Blank T, Knaus HG, Spiess J, Luiten PG, Eisel UL, Nijholt IM.

J Neurochem. 2008 Nov;107(4):1158-67. doi: 10.1111/j.1471-4159.2008.05701.x. Epub 2008 Sep 24.

32.

Measurements of burr-hole localization for endoscopic procedures in the third ventricle in children.

Knaus H, Abbushi A, Hoffmann KT, Schwarz K, Haberl H, Thomale UW.

Childs Nerv Syst. 2009 Mar;25(3):293-9. doi: 10.1007/s00381-008-0712-7. Epub 2008 Sep 19.

PMID:
18802708
33.

Chromogranin B and Secretogranin II in transgenic mice overexpressing human APP751 with the London (V717I) and Swedish (K670M/N671L) mutations and in Alzheimer patients.

Willis M, Prokesch M, Hutter-Paier B, Windisch M, Stridsberg M, Mahata SK, Kirchmair R, Wietzorrek G, Knaus HG, Jellinger K, Humpel C, Marksteiner J.

J Alzheimers Dis. 2008 Mar;13(2):123-35.

PMID:
18376054
34.

Down-regulation of BK channel expression in the pilocarpine model of temporal lobe epilepsy.

Pacheco Otalora LF, Hernandez EF, Arshadmansab MF, Francisco S, Willis M, Ermolinsky B, Zarei M, Knaus HG, Garrido-Sanabria ER.

Brain Res. 2008 Mar 20;1200:116-31. doi: 10.1016/j.brainres.2008.01.017. Epub 2008 Jan 18.

35.

Presence of HSV-1 immediate early genes and clonally expanded T-cells with a memory effector phenotype in human trigeminal ganglia.

Derfuss T, Segerer S, Herberger S, Sinicina I, Hüfner K, Ebelt K, Knaus HG, Steiner I, Meinl E, Dornmair K, Arbusow V, Strupp M, Brandt T, Theil D.

Brain Pathol. 2007 Oct;17(4):389-98. Epub 2007 Sep 4.

PMID:
17784877
36.

Hypothalamic-pituitary-adrenal axis hyporesponsiveness to restraint stress in mice deficient for large-conductance calcium- and voltage-activated potassium (BK) channels.

Brunton PJ, Sausbier M, Wietzorrek G, Sausbier U, Knaus HG, Russell JA, Ruth P, Shipston MJ.

Endocrinology. 2007 Nov;148(11):5496-506. Epub 2007 Jul 26.

PMID:
17656462
37.

Endocytic trafficking signals in KCNMB2 regulate surface expression of a large conductance voltage and Ca(2+)-activated K+ channel.

Zarei MM, Song M, Wilson RJ, Cox N, Colom LV, Knaus HG, Stefani E, Toro L.

Neuroscience. 2007 Jun 15;147(1):80-9. Epub 2007 May 22.

PMID:
17521822
38.

Free energy of membrane protein unfolding derived from single-molecule force measurements.

Preiner J, Janovjak H, Rankl C, Knaus H, Cisneros DA, Kedrov A, Kienberger F, Muller DJ, Hinterdorfer P.

Biophys J. 2007 Aug 1;93(3):930-7. Epub 2007 May 4.

39.

Localization and expression of substance P in transgenic mice overexpressing human APP751 with the London (V717I) and Swedish (K670M/N671L) mutations.

Willis M, Hutter-Paier B, Wietzorrek G, Windisch M, Humpel C, Knaus HG, Marksteiner J.

Brain Res. 2007 Apr 27;1143:199-207. Epub 2007 Jan 30.

PMID:
17328871
40.

Transmembrane helices have rough energy surfaces.

Janovjak H, Knaus H, Muller DJ.

J Am Chem Soc. 2007 Jan 17;129(2):246-7. No abstract available.

PMID:
17212383
41.

Kv1.3 channels are a therapeutic target for T cell-mediated autoimmune diseases.

Beeton C, Wulff H, Standifer NE, Azam P, Mullen KM, Pennington MW, Kolski-Andreaco A, Wei E, Grino A, Counts DR, Wang PH, LeeHealey CJ, S Andrews B, Sankaranarayanan A, Homerick D, Roeck WW, Tehranzadeh J, Stanhope KL, Zimin P, Havel PJ, Griffey S, Knaus HG, Nepom GT, Gutman GA, Calabresi PA, Chandy KG.

Proc Natl Acad Sci U S A. 2006 Nov 14;103(46):17414-9. Epub 2006 Nov 6.

42.

BKCa-Cav channel complexes mediate rapid and localized Ca2+-activated K+ signaling.

Berkefeld H, Sailer CA, Bildl W, Rohde V, Thumfart JO, Eble S, Klugbauer N, Reisinger E, Bischofberger J, Oliver D, Knaus HG, Schulte U, Fakler B.

Science. 2006 Oct 27;314(5799):615-20.

43.

A noncanonical SH3 domain binding motif links BK channels to the actin cytoskeleton via the SH3 adapter cortactin.

Tian L, Chen L, McClafferty H, Sailer CA, Ruth P, Knaus HG, Shipston MJ.

FASEB J. 2006 Dec;20(14):2588-90. Epub 2006 Oct 25.

PMID:
17065230
44.

Immunolocalization of BK channels in hippocampal pyramidal neurons.

Sailer CA, Kaufmann WA, Kogler M, Chen L, Sausbier U, Ottersen OP, Ruth P, Shipston MJ, Knaus HG.

Eur J Neurosci. 2006 Jul;24(2):442-54.

PMID:
16903852
46.

A high-capacity membrane potential FRET-based assay for NaV1.8 channels.

Liu CJ, Priest BT, Bugianesi RM, Dulski PM, Felix JP, Dick IE, Brochu RM, Knaus HG, Middleton RE, Kaczorowski GJ, Slaughter RS, Garcia ML, Köhler MG.

Assay Drug Dev Technol. 2006 Feb;4(1):37-48.

PMID:
16506887
47.

The epilepsy-linked Lgi1 protein assembles into presynaptic Kv1 channels and inhibits inactivation by Kvbeta1.

Schulte U, Thumfart JO, Klöcker N, Sailer CA, Bildl W, Biniossek M, Dehn D, Deller T, Eble S, Abbass K, Wangler T, Knaus HG, Fakler B.

Neuron. 2006 Mar 2;49(5):697-706.

48.

Ca2+ -activated K+ channels of the BK-type in the mouse brain.

Sausbier U, Sausbier M, Sailer CA, Arntz C, Knaus HG, Neuhuber W, Ruth P.

Histochem Cell Biol. 2006 Jun;125(6):725-41. Epub 2005 Dec 14.

PMID:
16362320
49.

Functionally diverse complement of large conductance calcium- and voltage-activated potassium channel (BK) alpha-subunits generated from a single site of splicing.

Chen L, Tian L, MacDonald SH, McClafferty H, Hammond MS, Huibant JM, Ruth P, Knaus HG, Shipston MJ.

J Biol Chem. 2005 Sep 30;280(39):33599-609. Epub 2005 Aug 4.

50.

The voltage-gated potassium channel Kv1.3 is highly expressed on inflammatory infiltrates in multiple sclerosis brain.

Rus H, Pardo CA, Hu L, Darrah E, Cudrici C, Niculescu T, Niculescu F, Mullen KM, Allie R, Guo L, Wulff H, Beeton C, Judge SI, Kerr DA, Knaus HG, Chandy KG, Calabresi PA.

Proc Natl Acad Sci U S A. 2005 Aug 2;102(31):11094-9. Epub 2005 Jul 25.

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