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Items: 18


Pgam5 released from damaged mitochondria induces mitochondrial biogenesis via Wnt signaling.

Bernkopf DB, Jalal K, Brückner M, Knaup KX, Gentzel M, Schambony A, Behrens J.

J Cell Biol. 2018 Apr 2;217(4):1383-1394. doi: 10.1083/jcb.201708191. Epub 2018 Feb 8.


Hypoxia-inducible factor-1α is a critical transcription factor for IL-10-producing B cells in autoimmune disease.

Meng X, Grötsch B, Luo Y, Knaup KX, Wiesener MS, Chen XX, Jantsch J, Fillatreau S, Schett G, Bozec A.

Nat Commun. 2018 Jan 17;9(1):251. doi: 10.1038/s41467-017-02683-x.


HIF is not essential for suppression of experimental tumor growth by mTOR inhibition.

Knaup KX, Guenther R, Stoeckert J, Monti JM, Eckardt KU, Wiesener MS.

J Cancer. 2017 Jul 1;8(10):1809-1817. doi: 10.7150/jca.16486. eCollection 2017.


4-Azidobenzyl ferrocenylcarbamate as an anticancer prodrug activated under reductive conditions.

Kinski E, Marzenell P, Hofer W, Hagen H, Raskatov JA, Knaup KX, Zolnhofer EM, Meyer K, Mokhir A.

J Inorg Biochem. 2016 Jul;160:218-24. doi: 10.1016/j.jinorgbio.2016.02.023. Epub 2016 Mar 2.


Renal uptake of the antiapoptotic protein survivin is mediated by megalin at the apical membrane of the proximal tubule.

Jobst-Schwan T, Knaup KX, Nielsen R, Hackenbeck T, Buettner-Herold M, Lechler P, Kroening S, Goppelt-Struebe M, Schloetzer-Schrehardt U, Fürnrohr BG, Voll RE, Amann K, Eckardt KU, Christensen EI, Wiesener MS.

Am J Physiol Renal Physiol. 2013 Sep 1;305(5):F734-44. doi: 10.1152/ajprenal.00546.2012. Epub 2013 Jul 3.


Hypoxia regulates the sperm associated antigen 4 (SPAG4) via HIF, which is expressed in renal clear cell carcinoma and promotes migration and invasion in vitro.

Knaup KX, Monti J, Hackenbeck T, Jobst-Schwan T, Klanke B, Schietke RE, Wacker I, Behrens J, Amann K, Eckardt KU, Warnecke C, Wiesener MS.

Mol Carcinog. 2014 Dec;53(12):970-8. doi: 10.1002/mc.22065. Epub 2013 Jul 2.


Renal tubular HIF-2α expression requires VHL inactivation and causes fibrosis and cysts.

Schietke RE, Hackenbeck T, Tran M, Günther R, Klanke B, Warnecke CL, Knaup KX, Shukla D, Rosenberger C, Koesters R, Bachmann S, Betz P, Schley G, Schödel J, Willam C, Winkler T, Amann K, Eckardt KU, Maxwell P, Wiesener MS.

PLoS One. 2012;7(1):e31034. doi: 10.1371/journal.pone.0031034. Epub 2012 Jan 27.


The GTPase RAB20 is a HIF target with mitochondrial localization mediating apoptosis in hypoxia.

Hackenbeck T, Huber R, Schietke R, Knaup KX, Monti J, Wu X, Klanke B, Frey B, Gaipl U, Wullich B, Ferbus D, Goubin G, Warnecke C, Eckardt KU, Wiesener MS.

Biochim Biophys Acta. 2011 Jan;1813(1):1-13. doi: 10.1016/j.bbamcr.2010.10.019. Epub 2010 Nov 5.


Hypoxia-inducible protein 2 is a novel lipid droplet protein and a specific target gene of hypoxia-inducible factor-1.

Gimm T, Wiese M, Teschemacher B, Deggerich A, Schödel J, Knaup KX, Hackenbeck T, Hellerbrand C, Amann K, Wiesener MS, Höning S, Eckardt KU, Warnecke C.

FASEB J. 2010 Nov;24(11):4443-58. doi: 10.1096/fj.10-159806. Epub 2010 Jul 12.


The glial cell response is an essential component of hypoxia-induced erythropoiesis in mice.

Weidemann A, Kerdiles YM, Knaup KX, Rafie CA, Boutin AT, Stockmann C, Takeda N, Scadeng M, Shih AY, Haase VH, Simon MC, Kleinfeld D, Johnson RS.

J Clin Invest. 2009 Nov;119(11):3373-83. doi: 10.1172/JCI39378. Epub 2009 Oct 5.


HIF-1 or HIF-2 induction is sufficient to achieve cell cycle arrest in NIH3T3 mouse fibroblasts independent from hypoxia.

Hackenbeck T, Knaup KX, Schietke R, Schödel J, Willam C, Wu X, Warnecke C, Eckardt KU, Wiesener MS.

Cell Cycle. 2009 May 1;8(9):1386-95. Epub 2009 May 27.


Mutual regulation of hypoxia-inducible factor and mammalian target of rapamycin as a function of oxygen availability.

Knaup KX, Jozefowski K, Schmidt R, Bernhardt WM, Weidemann A, Juergensen JS, Warnecke C, Eckardt KU, Wiesener MS.

Mol Cancer Res. 2009 Jan;7(1):88-98. doi: 10.1158/1541-7786.MCR-08-0288.


Role of hypoxia-inducible factor 1 alpha in the integrity of articular cartilage in murine knee joints.

Gelse K, Pfander D, Obier S, Knaup KX, Wiesener M, Hennig FF, Swoboda B.

Arthritis Res Ther. 2008;10(5):R111. doi: 10.1186/ar2508. Epub 2008 Sep 12.


The specific contribution of hypoxia-inducible factor-2alpha to hypoxic gene expression in vitro is limited and modulated by cell type-specific and exogenous factors.

Warnecke C, Weidemann A, Volke M, Schietke R, Wu X, Knaup KX, Hackenbeck T, Bernhardt W, Willam C, Eckardt KU, Wiesener MS.

Exp Cell Res. 2008 Jun 10;314(10):2016-27. doi: 10.1016/j.yexcr.2008.03.003. Epub 2008 Mar 18.


Erythropoietin gene expression in renal carcinoma is considerably more frequent than paraneoplastic polycythemia.

Wiesener MS, Münchenhagen P, Gläser M, Sobottka BA, Knaup KX, Jozefowski K, Jürgensen JS, Roigas J, Warnecke C, Gröne HJ, Maxwell PH, Willam C, Eckardt KU.

Int J Cancer. 2007 Dec 1;121(11):2434-42.


Identification of a putative p53 binding sequence within the human mitochondrial genome.

Heyne K, Mannebach S, Wuertz E, Knaup KX, Mahyar-Roemer M, Roemer K.

FEBS Lett. 2004 Dec 3;578(1-2):198-202.


No anti-apoptotic effects of single copies of mutant p53 genes in drug-treated tumor cells.

Fritzsche C, Zeller G, Knaup KX, Roemer K.

Anticancer Drugs. 2004 Aug;15(7):679-88.


Cell type-specific regulation of calmodulin 2 expression by mutant p53.

Knaup KX, Roemer K.

FEBS Lett. 2004 Jul 2;569(1-3):70-4.

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