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Targeting the Enteric Nervous System to Treat Metabolic Disorders? "Enterosynes" as Therapeutic Gut Factors.

Knauf C, Abot A, Wemelle E, Cani PD.

Neuroendocrinology. 2019 Jul 2. doi: 10.1159/000500602. [Epub ahead of print] Review.


The Gut Microbiome Influences Host Endocrine Functions.

Rastelli M, Cani PD, Knauf C.

Endocr Rev. 2019 Oct 1;40(5):1271-1284. doi: 10.1210/er.2018-00280.


Elabela and Apelin actions in healthy and pathological pregnancies.

Eberlé D, Marousez L, Hanssens S, Knauf C, Breton C, Deruelle P, Lesage J.

Cytokine Growth Factor Rev. 2019 Apr;46:45-53. doi: 10.1016/j.cytogfr.2019.03.003. Epub 2019 Mar 16.


Pharmacological inhibition of the F1 -ATPase/P2Y1 pathway suppresses the effect of apolipoprotein A1 on endothelial nitric oxide synthesis and vasorelaxation.

Cabou C, Honorato P, Briceño L, Ghezali L, Duparc T, León M, Combes G, Frayssinhes L, Fournel A, Abot A, Masri B, Parada N, Aguilera V, Aguayo C, Knauf C, González M, Radojkovic C, Martinez LO.

Acta Physiol (Oxf). 2019 Jul;226(3):e13268. doi: 10.1111/apha.13268. Epub 2019 Apr 4.


Central Effects of Beta-Blockers May Be Due to Nitric Oxide and Hydrogen Peroxide Release Independently of Their Ability to Cross the Blood-Brain Barrier.

Laurens C, Abot A, Delarue A, Knauf C.

Front Neurosci. 2019 Jan 31;13:33. doi: 10.3389/fnins.2019.00033. eCollection 2019.


Mitochondrial Dynamin-Related Protein 1 (DRP1) translocation in response to cerebral glucose is impaired in a rat model of early alteration in hypothalamic glucose sensing.

Desmoulins L, Chrétien C, Paccoud R, Collins S, Cruciani-Guglielmacci C, Galinier A, Liénard F, Quinault A, Grall S, Allard C, Fenech C, Carneiro L, Mouillot T, Fournel A, Knauf C, Magnan C, Fioramonti X, Pénicaud L, Leloup C.

Mol Metab. 2019 Feb;20:166-177. doi: 10.1016/j.molmet.2018.11.007. Epub 2018 Nov 27.


Bisphenol S exposure affects gene expression related to intestinal glucose absorption and glucose metabolism in mice.

Rezg R, Abot A, Mornagui B, Knauf C.

Environ Sci Pollut Res Int. 2019 Feb;26(4):3636-3642. doi: 10.1007/s11356-018-3823-z. Epub 2018 Dec 7.


Inflammation and Gut-Brain Axis During Type 2 Diabetes: Focus on the Crosstalk Between Intestinal Immune Cells and Enteric Nervous System.

Bessac A, Cani PD, Meunier E, Dietrich G, Knauf C.

Front Neurosci. 2018 Oct 10;12:725. doi: 10.3389/fnins.2018.00725. eCollection 2018. Review.


Impact of Intestinal Peptides on the Enteric Nervous System: Novel Approaches to Control Glucose Metabolism and Food Intake.

Abot A, Cani PD, Knauf C.

Front Endocrinol (Lausanne). 2018 Jun 22;9:328. doi: 10.3389/fendo.2018.00328. eCollection 2018. Review.


Predominant Role of Nuclear Versus Membrane Estrogen Receptor α in Arterial Protection: Implications for Estrogen Receptor α Modulation in Cardiovascular Prevention/Safety.

Guivarc'h E, Buscato M, Guihot AL, Favre J, Vessières E, Grimaud L, Wakim J, Melhem NJ, Zahreddine R, Adlanmerini M, Loufrani L, Knauf C, Katzenellenbogen JA, Katzenellenbogen BS, Foidart JM, Gourdy P, Lenfant F, Arnal JF, Henrion D, Fontaine C.

J Am Heart Assoc. 2018 Jun 29;7(13). pii: e008950. doi: 10.1161/JAHA.118.008950.


Effects of Bisphenol S on hypothalamic neuropeptides regulating feeding behavior and apelin/APJ system in mice.

Rezg R, Abot A, Mornagui B, Aydi S, Knauf C.

Ecotoxicol Environ Saf. 2018 Oct;161:459-466. doi: 10.1016/j.ecoenv.2018.06.001. Epub 2018 Jun 14.


Gut Microbes and Health: A Focus on the Mechanisms Linking Microbes, Obesity, and Related Disorders.

Rastelli M, Knauf C, Cani PD.

Obesity (Silver Spring). 2018 May;26(5):792-800. doi: 10.1002/oby.22175. Review.


Galanin enhances systemic glucose metabolism through enteric Nitric Oxide Synthase-expressed neurons.

Abot A, Lucas A, Bautzova T, Bessac A, Fournel A, Le-Gonidec S, Valet P, Moro C, Cani PD, Knauf C.

Mol Metab. 2018 Apr;10:100-108. doi: 10.1016/j.molmet.2018.01.020. Epub 2018 Jan 31.


Identification of an analgesic lipopeptide produced by the probiotic Escherichia coli strain Nissle 1917.

Pérez-Berezo T, Pujo J, Martin P, Le Faouder P, Galano JM, Guy A, Knauf C, Tabet JC, Tronnet S, Barreau F, Heuillet M, Dietrich G, Bertrand-Michel J, Durand T, Oswald E, Cenac N.

Nat Commun. 2017 Nov 3;8(1):1314. doi: 10.1038/s41467-017-01403-9.


Hepatocyte Nuclear Factor-1β Controls Mitochondrial Respiration in Renal Tubular Cells.

Casemayou A, Fournel A, Bagattin A, Schanstra J, Belliere J, Decramer S, Marsal D, Gillet M, Chassaing N, Huart A, Pontoglio M, Knauf C, Bascands JL, Chauveau D, Faguer S.

J Am Soc Nephrol. 2017 Nov;28(11):3205-3217. doi: 10.1681/ASN.2016050508. Epub 2017 Jul 24.


Mitochondrial Dynamics Mediated by Mitofusin 1 Is Required for POMC Neuron Glucose-Sensing and Insulin Release Control.

Ramírez S, Gómez-Valadés AG, Schneeberger M, Varela L, Haddad-Tóvolli R, Altirriba J, Noguera E, Drougard A, Flores-Martínez Á, Imbernón M, Chivite I, Pozo M, Vidal-Itriago A, Garcia A, Cervantes S, Gasa R, Nogueiras R, Gama-Pérez P, Garcia-Roves PM, Cano DA, Knauf C, Servitja JM, Horvath TL, Gomis R, Zorzano A, Claret M.

Cell Metab. 2017 Jun 6;25(6):1390-1399.e6. doi: 10.1016/j.cmet.2017.05.010.


Transfer of dysbiotic gut microbiota has beneficial effects on host liver metabolism.

Nicolas S, Blasco-Baque V, Fournel A, Gilleron J, Klopp P, Waget A, Ceppo F, Marlin A, Padmanabhan R, Iacovoni JS, Tercé F, Cani PD, Tanti JF, Burcelin R, Knauf C, Cormont M, Serino M.

Mol Syst Biol. 2017 Mar 16;13(3):921. doi: 10.15252/msb.20167356.


Maternal undernutrition programs the apelinergic system of adipose tissue in adult male rat offspring.

Lecoutre S, Marousez L, Drougard A, Knauf C, Guinez C, Eberlé D, Laborie C, Vieau D, Lesage J, Breton C.

J Dev Orig Health Dis. 2017 Feb;8(1):3-7. doi: 10.1017/S2040174416000702.


How gut microbes talk to organs: The role of endocrine and nervous routes.

Cani PD, Knauf C.

Mol Metab. 2016 May 27;5(9):743-52. doi: 10.1016/j.molmet.2016.05.011. eCollection 2016 Sep. Review.


Central chronic apelin infusion decreases energy expenditure and thermogenesis in mice.

Drougard A, Fournel A, Marlin A, Meunier E, Abot A, Bautzova T, Duparc T, Louche K, Batut A, Lucas A, Le-Gonidec S, Lesage J, Fioramonti X, Moro C, Valet P, Cani PD, Knauf C.

Sci Rep. 2016 Aug 23;6:31849. doi: 10.1038/srep31849.


Maternal obesity alters the apelinergic system at the feto-maternal interface.

Hanssens S, Marx-Deseure A, Lecoutre S, Butruille L, Fournel A, Knauf C, Besengez C, Breton C, Storme L, Deruelle P, Lesage J.

Placenta. 2016 Mar;39:41-4. doi: 10.1016/j.placenta.2016.01.006. Epub 2016 Jan 12.


Glucosensing in the gastrointestinal tract: Impact on glucose metabolism.

Fournel A, Marlin A, Abot A, Pasquio C, Cirillo C, Cani PD, Knauf C.

Am J Physiol Gastrointest Liver Physiol. 2016 May 1;310(9):G645-58. doi: 10.1152/ajpgi.00015.2016. Epub 2016 Mar 3. Review.


Apelin Controls Fetal and Neonatal Glucose Homeostasis and Is Altered by Maternal Undernutrition.

Mayeur S, Wattez JS, Lukaszewski MA, Lecoutre S, Butruille L, Drougard A, Eberlé D, Bastide B, Laborie C, Storme L, Knauf C, Vieau D, Breton C, Lesage J.

Diabetes. 2016 Mar;65(3):554-60. doi: 10.2337/db15-0228. Epub 2015 Dec 2.


Apelin targets gut contraction to control glucose metabolism via the brain.

Fournel A, Drougard A, Duparc T, Marlin A, Brierley SM, Castro J, Le-Gonidec S, Masri B, Colom A, Lucas A, Rousset P, Cenac N, Vergnolle N, Valet P, Cani PD, Knauf C.

Gut. 2017 Feb;66(2):258-269. doi: 10.1136/gutjnl-2015-310230. Epub 2015 Nov 12.


Apelin regulates FoxO3 translocation to mediate cardioprotective responses to myocardial injury and obesity.

Boal F, Roumegoux J, Alfarano C, Timotin A, Calise D, Anesia R, Drougard A, Knauf C, Lagente C, Roncalli J, Desmoulin F, Tronchere H, Valet P, Parini A, Kunduzova O.

Sci Rep. 2015 Nov 6;5:16104. doi: 10.1038/srep16104.


Apelin receptors: From signaling to antidiabetic strategy.

Chaves-Almagro C, Castan-Laurell I, Dray C, Knauf C, Valet P, Masri B.

Eur J Pharmacol. 2015 Sep 15;763(Pt B):149-59. doi: 10.1016/j.ejphar.2015.05.017. Epub 2015 May 22. Review.


[The APJ receptor: a new therapeutic approach in diabetic treatment].

Masri B, Dray C, Knauf C, Valet P, Castan-Laurell I.

Med Sci (Paris). 2015 Mar;31(3):275-81. doi: 10.1051/medsci/20153103013. Epub 2015 Apr 8. Review. French.


Impact of hypothalamic reactive oxygen species in the regulation of energy metabolism and food intake.

Drougard A, Fournel A, Valet P, Knauf C.

Front Neurosci. 2015 Feb 24;9:56. doi: 10.3389/fnins.2015.00056. eCollection 2015. Review.


The uterine and vascular actions of estetrol delineate a distinctive profile of estrogen receptor α modulation, uncoupling nuclear and membrane activation.

Abot A, Fontaine C, Buscato M, Solinhac R, Flouriot G, Fabre A, Drougard A, Rajan S, Laine M, Milon A, Muller I, Henrion D, Adlanmerini M, Valéra MC, Gompel A, Gerard C, Péqueux C, Mestdagt M, Raymond-Letron I, Knauf C, Ferriere F, Valet P, Gourdy P, Katzenellenbogen BS, Katzenellenbogen JA, Lenfant F, Greene GL, Foidart JM, Arnal JF.

EMBO Mol Med. 2014 Oct;6(10):1328-46. doi: 10.15252/emmm.201404112.


Apelin stimulates both cholecystokinin and glucagon-like peptide 1 secretions in vitro and in vivo in rodents.

Wattez JS, Ravallec R, Cudennec B, Knauf C, Dhulster P, Valet P, Breton C, Vieau D, Lesage J.

Peptides. 2013 Oct;48:134-6. doi: 10.1016/j.peptides.2013.08.005. Epub 2013 Aug 14.


Hypothalamic actions of apelin on energy metabolism: new insight on glucose homeostasis and metabolic disorders.

Knauf C, Drougard A, Fournel A, Duparc T, Valet P.

Horm Metab Res. 2013 Dec;45(13):928-34. doi: 10.1055/s-0033-1351321. Epub 2013 Aug 15.


Gut microbiota controls adipose tissue expansion, gut barrier and glucose metabolism: novel insights into molecular targets and interventions using prebiotics.

Geurts L, Neyrinck AM, Delzenne NM, Knauf C, Cani PD.

Benef Microbes. 2014 Mar;5(1):3-17. doi: 10.3920/BM2012.0065. Review.


Hypothalamic apelin/reactive oxygen species signaling controls hepatic glucose metabolism in the onset of diabetes.

Drougard A, Duparc T, Brenachot X, Carneiro L, Gouazé A, Fournel A, Geurts L, Cadoudal T, Prats AC, Pénicaud L, Vieau D, Lesage J, Leloup C, Benani A, Cani PD, Valet P, Knauf C.

Antioxid Redox Signal. 2014 Feb 1;20(4):557-73. doi: 10.1089/ars.2013.5182. Epub 2013 Sep 18.


The apelinergic system: sexual dimorphism and tissue-specific modulations by obesity and insulin resistance in female mice.

Butruille L, Drougard A, Knauf C, Moitrot E, Valet P, Storme L, Deruelle P, Lesage J.

Peptides. 2013 Aug;46:94-101. doi: 10.1016/j.peptides.2013.05.013. Epub 2013 Jun 5.


Maternal hypertension induced by NO blockade does not program adult metabolic diseases in growth-restricted rat fetuses.

Butruille L, Mayeur S, Moitrot E, Storme L, Knauf C, Lesage J, Deruelle P.

Metabolism. 2013 Mar;62(3):442-5. doi: 10.1016/j.metabol.2012.09.006. Epub 2012 Oct 30.


Hedgehog partial agonism drives Warburg-like metabolism in muscle and brown fat.

Teperino R, Amann S, Bayer M, McGee SL, Loipetzberger A, Connor T, Jaeger C, Kammerer B, Winter L, Wiche G, Dalgaard K, Selvaraj M, Gaster M, Lee-Young RS, Febbraio MA, Knauf C, Cani PD, Aberger F, Penninger JM, Pospisilik JA, Esterbauer H.

Cell. 2012 Oct 12;151(2):414-26. doi: 10.1016/j.cell.2012.09.021.


Food intake adaptation to dietary fat involves PSA-dependent rewiring of the arcuate melanocortin system in mice.

Benani A, Hryhorczuk C, Gouazé A, Fioramonti X, Brenachot X, Guissard C, Krezymon A, Duparc T, Colom A, Nédélec E, Rigault C, Lemoine A, Gascuel J, Gerardy-Schahn R, Valet P, Knauf C, Lorsignol A, Pénicaud L.

J Neurosci. 2012 Aug 29;32(35):11970-9. doi: 10.1523/JNEUROSCI.0624-12.2012.


p53-PGC-1α pathway mediates oxidative mitochondrial damage and cardiomyocyte necrosis induced by monoamine oxidase-A upregulation: role in chronic left ventricular dysfunction in mice.

Villeneuve C, Guilbeau-Frugier C, Sicard P, Lairez O, Ordener C, Duparc T, De Paulis D, Couderc B, Spreux-Varoquaux O, Tortosa F, Garnier A, Knauf C, Valet P, Borchi E, Nediani C, Gharib A, Ovize M, Delisle MB, Parini A, Mialet-Perez J.

Antioxid Redox Signal. 2013 Jan 1;18(1):5-18. doi: 10.1089/ars.2011.4373. Epub 2012 Aug 10.


Prenatal fasudil exposure alleviates fetal growth but programs hyperphagia and overweight in the adult male rat.

Butruille L, Mayeur S, Duparc T, Knauf C, Moitrot E, Fajardy I, Valet P, Storme L, Deruelle P, Lesage J.

Eur J Pharmacol. 2012 Aug 15;689(1-3):278-84. doi: 10.1016/j.ejphar.2012.05.040. Epub 2012 Jun 7.


Maternal hypertension induces tissue-specific modulations of the apelinergic system in the fetoplacental unit in rat.

Ivars J, Butruille L, Knauf C, Bouckenooghe T, Mayeur S, Vieau D, Valet P, Deruelle P, Lesage J.

Peptides. 2012 May;35(1):136-8. doi: 10.1016/j.peptides.2012.03.005. Epub 2012 Mar 15.


Apelin, a promising target for type 2 diabetes treatment?

Castan-Laurell I, Dray C, Knauf C, Kunduzova O, Valet P.

Trends Endocrinol Metab. 2012 May;23(5):234-41. doi: 10.1016/j.tem.2012.02.005. Epub 2012 Mar 22. Review.


Apelin and the proopiomelanocortin system: a new regulatory pathway of hypothalamic α-MSH release.

Reaux-Le Goazigo A, Bodineau L, De Mota N, Jeandel L, Chartrel N, Knauf C, Raad C, Valet P, Llorens-Cortes C.

Am J Physiol Endocrinol Metab. 2011 Nov;301(5):E955-66. doi: 10.1152/ajpendo.00090.2011. Epub 2011 Aug 16.


Altered gut microbiota and endocannabinoid system tone in obese and diabetic leptin-resistant mice: impact on apelin regulation in adipose tissue.

Geurts L, Lazarevic V, Derrien M, Everard A, Van Roye M, Knauf C, Valet P, Girard M, Muccioli GG, François P, de Vos WM, Schrenzel J, Delzenne NM, Cani PD.

Front Microbiol. 2011 Jul 13;2:149. doi: 10.3389/fmicb.2011.00149. eCollection 2011.


Apelin, diabetes, and obesity.

Castan-Laurell I, Dray C, Attané C, Duparc T, Knauf C, Valet P.

Endocrine. 2011 Aug;40(1):1-9. doi: 10.1007/s12020-011-9507-9. Review.


Central apelin controls glucose homeostasis via a nitric oxide-dependent pathway in mice.

Duparc T, Colom A, Cani PD, Massaly N, Rastrelli S, Drougard A, Le Gonidec S, Moulédous L, Frances B, Leclercq I, Llorens-Cortes C, Pospisilik JA, Delzenne NM, Valet P, Castan-Laurell I, Knauf C.

Antioxid Redox Signal. 2011 Sep 15;15(6):1477-96. doi: 10.1089/ars.2010.3454. Epub 2011 May 25.


Deletion of Lkb1 in pro-opiomelanocortin neurons impairs peripheral glucose homeostasis in mice.

Claret M, Smith MA, Knauf C, Al-Qassab H, Woods A, Heslegrave A, Piipari K, Emmanuel JJ, Colom A, Valet P, Cani PD, Begum G, White A, Mucket P, Peters M, Mizuno K, Batterham RL, Giese KP, Ashworth A, Burcelin R, Ashford ML, Carling D, Withers DJ.

Diabetes. 2011 Mar;60(3):735-45. doi: 10.2337/db10-1055. Epub 2011 Jan 24.


Jejunum inflammation in obese and diabetic mice impairs enteric glucose detection and modifies nitric oxide release in the hypothalamus.

Duparc T, Naslain D, Colom A, Muccioli GG, Massaly N, Delzenne NM, Valet P, Cani PD, Knauf C.

Antioxid Redox Signal. 2011 Feb 1;14(3):415-23. doi: 10.1089/ars.2010.3330. Epub 2010 Sep 29.


Drosophila genome-wide obesity screen reveals hedgehog as a determinant of brown versus white adipose cell fate.

Pospisilik JA, Schramek D, Schnidar H, Cronin SJ, Nehme NT, Zhang X, Knauf C, Cani PD, Aumayr K, Todoric J, Bayer M, Haschemi A, Puviindran V, Tar K, Orthofer M, Neely GG, Dietzl G, Manoukian A, Funovics M, Prager G, Wagner O, Ferrandon D, Aberger F, Hui CC, Esterbauer H, Penninger JM.

Cell. 2010 Jan 8;140(1):148-60. doi: 10.1016/j.cell.2009.12.027.


Ventromedial hypothalamic nitric oxide production is necessary for hypoglycemia detection and counterregulation.

Fioramonti X, Marsollier N, Song Z, Fakira KA, Patel RM, Brown S, Duparc T, Pica-Mendez A, Sanders NM, Knauf C, Valet P, McCrimmon RJ, Beuve A, Magnan C, Routh VH.

Diabetes. 2010 Feb;59(2):519-28. doi: 10.2337/db09-0421. Epub 2009 Nov 23.


Cannabinoid CB2 receptor potentiates obesity-associated inflammation, insulin resistance and hepatic steatosis.

Deveaux V, Cadoudal T, Ichigotani Y, Teixeira-Clerc F, Louvet A, Manin S, Nhieu JT, Belot MP, Zimmer A, Even P, Cani PD, Knauf C, Burcelin R, Bertola A, Le Marchand-Brustel Y, Gual P, Mallat A, Lotersztajn S.

PLoS One. 2009 Jun 9;4(6):e5844. doi: 10.1371/journal.pone.0005844.

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