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Items: 14

1.

A Defective Pentose Phosphate Pathway Reduces Inflammatory Macrophage Responses during Hypercholesterolemia.

Baardman J, Verberk SGS, Prange KHM, van Weeghel M, van der Velden S, Ryan DG, Wüst RCI, Neele AE, Speijer D, Denis SW, Witte ME, Houtkooper RH, O'neill LA, Knatko EV, Dinkova-Kostova AT, Lutgens E, de Winther MPJ, Van den Bossche J.

Cell Rep. 2018 Nov 20;25(8):2044-2052.e5. doi: 10.1016/j.celrep.2018.10.092.

2.

Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1.

Mills EL, Ryan DG, Prag HA, Dikovskaya D, Menon D, Zaslona Z, Jedrychowski MP, Costa ASH, Higgins M, Hams E, Szpyt J, Runtsch MC, King MS, McGouran JF, Fischer R, Kessler BM, McGettrick AF, Hughes MM, Carroll RG, Booty LM, Knatko EV, Meakin PJ, Ashford MLJ, Modis LK, Brunori G, Sévin DC, Fallon PG, Caldwell ST, Kunji ERS, Chouchani ET, Frezza C, Dinkova-Kostova AT, Hartley RC, Murphy MP, O'Neill LA.

Nature. 2018 Apr 5;556(7699):113-117. doi: 10.1038/nature25986. Epub 2018 Mar 28.

3.

Transcription factors NRF2 and HSF1 have opposing functions in autophagy.

Dayalan Naidu S, Dikovskaya D, Gaurilcikaite E, Knatko EV, Healy ZR, Mohan H, Koh G, Laurell A, Ball G, Olagnier D, de la Vega L, Ganley IG, Talalay P, Dinkova-Kostova AT.

Sci Rep. 2017 Sep 8;7(1):11023. doi: 10.1038/s41598-017-11262-5.

4.

Activation of Nrf2 Signaling Augments Vesicular Stomatitis Virus Oncolysis via Autophagy-Driven Suppression of Antiviral Immunity.

Olagnier D, Lababidi RR, Hadj SB, Sze A, Liu Y, Naidu SD, Ferrari M, Jiang Y, Chiang C, Beljanski V, Goulet ML, Knatko EV, Dinkova-Kostova AT, Hiscott J, Lin R.

Mol Ther. 2017 Aug 2;25(8):1900-1916. doi: 10.1016/j.ymthe.2017.04.022. Epub 2017 May 17.

5.

Whole-Exome Sequencing Validates a Preclinical Mouse Model for the Prevention and Treatment of Cutaneous Squamous Cell Carcinoma.

Knatko EV, Praslicka B, Higgins M, Evans A, Purdie KJ, Harwood CA, Proby CM, Ooi A, Dinkova-Kostova AT.

Cancer Prev Res (Phila). 2017 Jan;10(1):67-75. doi: 10.1158/1940-6207.CAPR-16-0218. Epub 2016 Dec 6.

6.

Loss of Nrf2 abrogates the protective effect of Keap1 downregulation in a preclinical model of cutaneous squamous cell carcinoma.

Knatko EV, Higgins M, Fahey JW, Dinkova-Kostova AT.

Sci Rep. 2016 May 24;6:25804. doi: 10.1038/srep25804.

7.

Pharmacokinetics and pharmacodynamics of orally administered acetylenic tricyclic bis(cyanoenone), a highly potent Nrf2 activator with a reversible covalent mode of action.

Kostov RV, Knatko EV, McLaughlin LA, Henderson CJ, Zheng S, Huang JT, Honda T, Dinkova-Kostova AT.

Biochem Biophys Res Commun. 2015 Sep 25;465(3):402-7. doi: 10.1016/j.bbrc.2015.08.016. Epub 2015 Aug 8.

8.

Nrf2 Activation Protects against Solar-Simulated Ultraviolet Radiation in Mice and Humans.

Knatko EV, Ibbotson SH, Zhang Y, Higgins M, Fahey JW, Talalay P, Dawe RS, Ferguson J, Huang JT, Clarke R, Zheng S, Saito A, Kalra S, Benedict AL, Honda T, Proby CM, Dinkova-Kostova AT.

Cancer Prev Res (Phila). 2015 Jun;8(6):475-86. doi: 10.1158/1940-6207.CAPR-14-0362. Epub 2015 Mar 24.

9.

Synthesis of (13) C2 (15) N2 -labeled anti-inflammatory and cytoprotective tricyclic bis(cyanoenone) ([(13) C2 (15) N2 ]-TBE-31) as an internal standard for quantification by stable isotope dilution LC-MS method.

Zheng S, Huang JT, Knatko EV, Sharp S, Higgins M, Ojima I, Dinkova-Kostova AT, Honda T.

J Labelled Comp Radiopharm. 2014 Aug;57(10):606-10. doi: 10.1002/jlcr.3230. Epub 2014 Sep 5.

PMID:
25196444
10.

The indirect antioxidant sulforaphane protects against thiopurine-mediated photooxidative stress.

Benedict AL, Knatko EV, Dinkova-Kostova AT.

Carcinogenesis. 2012 Dec;33(12):2457-66. doi: 10.1093/carcin/bgs293. Epub 2012 Sep 15.

11.

Highly potent activation of Nrf2 by topical tricyclic bis(cyano enone): implications for protection against UV radiation during thiopurine therapy.

Kalra S, Knatko EV, Zhang Y, Honda T, Yamamoto M, Dinkova-Kostova AT.

Cancer Prev Res (Phila). 2012 Jul;5(7):973-81. doi: 10.1158/1940-6207.CAPR-12-0041. Epub 2012 Jun 1.

12.

Oral azathioprine leads to higher incorporation of 6-thioguanine in DNA of skin than liver: the protective role of the Keap1/Nrf2/ARE pathway.

Kalra S, Zhang Y, Knatko EV, Finlayson S, Yamamoto M, Dinkova-Kostova AT.

Cancer Prev Res (Phila). 2011 Oct;4(10):1665-74. doi: 10.1158/1940-6207.CAPR-11-0137. Epub 2011 Jul 29.

13.

Functional mapping of the fission yeast DNA polymerase delta B-subunit Cdc1 by site-directed and random pentapeptide insertion mutagenesis.

Sanchez Garcia J, Baranovskiy AG, Knatko EV, Gray FC, Tahirov TH, MacNeill SA.

BMC Mol Biol. 2009 Aug 17;10:82. doi: 10.1186/1471-2199-10-82.

14.

Essential functions of Sds22p in chromosome stability and nuclear localization of PP1.

Peggie MW, MacKelvie SH, Bloecher A, Knatko EV, Tatchell K, Stark MJ.

J Cell Sci. 2002 Jan 1;115(Pt 1):195-206.

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