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Items: 1 to 50 of 951

1.

Quantifying Target Occupancy of Small Molecules Within Living Cells.

Robers MB, Friedman-Ohana R, Huber K, Kilpatrick L, Vasta JD, Berger BT, Chaudhry C, Hill S, Müller S, Knapp S, Wood KV.

Annu Rev Biochem. 2020 Mar 24. doi: 10.1146/annurev-biochem-011420-092302. [Epub ahead of print]

PMID:
32208767
2.

A roadmap for research in octoploid strawberry.

Whitaker VM, Knapp SJ, Hardigan MA, Edger PP, Slovin JP, Bassil NV, Hytönen T, Mackenzie KK, Lee S, Jung S, Main D, Barbey CR, Verma S.

Hortic Res. 2020 Mar 15;7:33. doi: 10.1038/s41438-020-0252-1. eCollection 2020. Review.

3.

A Highly Selective Chemical Probe for Activin Receptor-like Kinases ALK4 and ALK5.

Hanke T, Wong JF, Berger BT, Abdi I, Berger LM, Tesch R, Tredup C, Bullock AN, Müller S, Knapp S.

ACS Chem Biol. 2020 Mar 20. doi: 10.1021/acschembio.0c00076. [Epub ahead of print]

PMID:
32176847
4.

Natural Selection Towards Wild-Type in Composite Cross Populations of Winter Wheat.

Knapp S, Döring TF, Jones HE, Snape J, Wingen LU, Wolfe MS, Leverington-Waite M, Griffiths S.

Front Plant Sci. 2020 Feb 25;10:1757. doi: 10.3389/fpls.2019.01757. eCollection 2019.

5.

Co-inhibition of BET proteins and PI3Kα triggers mitochondrial apoptosis in rhabdomyosarcoma cells.

Boedicker C, Hussong M, Grimm C, Dolgikh N, Meister MT, Enßle JC, Wanior M, Knapp S, Schweiger MR, Fulda S.

Oncogene. 2020 Mar 11. doi: 10.1038/s41388-020-1229-0. [Epub ahead of print]

PMID:
32161312
6.

Genome Synteny Has Been Conserved Among the Octoploid Progenitors of Cultivated Strawberry Over Millions of Years of Evolution.

Hardigan MA, Feldmann MJ, Lorant A, Bird KA, Famula R, Acharya C, Cole G, Edger PP, Knapp SJ.

Front Plant Sci. 2020 Feb 7;10:1789. doi: 10.3389/fpls.2019.01789. eCollection 2019.

7.

Identification of molecular targets for the targeted treatment of gastric cancer using dasatinib.

Montenegro RC, Howarth A, Ceroni A, Fedele V, Farran B, Mesquita FP, Frejno M, Berger BT, Heinzlmeir S, Sailem HZ, Tesch R, Ebner D, Knapp S, Burbano R, Kuster B, Müller S.

Oncotarget. 2020 Feb 4;11(5):535-549. doi: 10.18632/oncotarget.27462. eCollection 2020 Feb 4.

8.

Horticultural availability and homeowner preferences drive plant diversity and composition in urban yards.

Cavender-Bares J, Padullés Cubino J, Pearse WD, Hobbie SE, Lange AJ, Knapp S, Nelson KC.

Ecol Appl. 2020 Jan 23:e02082. doi: 10.1002/eap.2082. [Epub ahead of print]

PMID:
31971651
9.

Elevated Coefficient of Variation in Total Fecal Bile Acids Precedes Diagnosis of Necrotizing Enterocolitis.

Knapp S, Kehring A, Stepp J, Calton CM, Gephart SM, Bandlamuri S, Boyle KE, Dietz GI, Johnson H, Romo RE, Spencer M, Bedrick AD, Halpern MD.

Sci Rep. 2020 Jan 14;10(1):249. doi: 10.1038/s41598-019-57178-0.

10.

Effects of epigenetic pathway inhibitors on corticotroph tumour AtT20 cells.

Lines KE, Filippakopoulos P, Stevenson M, Müller S, Lockstone HE, Wright B, Knapp S, Buck D, Bountra C, Thakker RV.

Endocr Relat Cancer. 2020 Mar;27(3):163-174. doi: 10.1530/ERC-19-0448.

11.

Activation by substoichiometric inhibition.

Merdanovic M, Burston SG, Schmitz AL, Köcher S, Knapp S, Clausen T, Kaiser M, Huber R, Ehrmann M.

Proc Natl Acad Sci U S A. 2020 Jan 21;117(3):1414-1418. doi: 10.1073/pnas.1918721117. Epub 2020 Jan 6.

PMID:
31907318
12.

Histone deacetylase 1 (HDAC1): A key player of T cell-mediated arthritis.

Göschl L, Preglej T, Boucheron N, Saferding V, Müller L, Platzer A, Hirahara K, Shih HY, Backlund J, Matthias P, Niederreiter B, Hladik A, Kugler M, Gualdoni GA, Scheinecker C, Knapp S, Seiser C, Holmdahl R, Tillmann K, Plasenzotti R, Podesser B, Aletaha D, Smolen JS, Karonitsch T, Steiner G, Ellmeier W, Bonelli M.

J Autoimmun. 2020 Mar;108:102379. doi: 10.1016/j.jaut.2019.102379. Epub 2019 Dec 26.

PMID:
31883829
13.

The Transcription Factor MAZR/PATZ1 Regulates the Development of FOXP3+ Regulatory T Cells.

Andersen L, Gülich AF, Alteneder M, Preglej T, Orola MJ, Dhele N, Stolz V, Schebesta A, Hamminger P, Hladik A, Floess S, Krausgruber T, Faux T, Andrabi SBA, Huehn J, Knapp S, Sparwasser T, Bock C, Laiho A, Elo LL, Rasool O, Lahesmaa R, Sakaguchi S, Ellmeier W.

Cell Rep. 2019 Dec 24;29(13):4447-4459.e6. doi: 10.1016/j.celrep.2019.11.089.

14.

Structural Insights into Interaction Mechanisms of Alternative Piperazine-urea YEATS Domain Binders in MLLT1.

Ni X, Heidenreich D, Christott T, Bennett J, Moustakim M, Brennan PE, Fedorov O, Knapp S, Chaikuad A.

ACS Med Chem Lett. 2019 Nov 25;10(12):1661-1666. doi: 10.1021/acsmedchemlett.9b00460. eCollection 2019 Dec 12.

PMID:
31857843
15.

Reply to: Revisiting the origin of octoploid strawberry.

Edger PP, McKain MR, Yocca AE, Knapp SJ, Qiao Q, Zhang T.

Nat Genet. 2020 Jan;52(1):5-7. doi: 10.1038/s41588-019-0544-2. Epub 2019 Dec 16. No abstract available.

16.

Hair eruption initiates and commensal skin microbiota aggravate adverse events of anti-EGFR therapy.

Klufa J, Bauer T, Hanson B, Herbold C, Starkl P, Lichtenberger B, Srutkova D, Schulz D, Vujic I, Mohr T, Rappersberger K, Bodenmiller B, Kozakova H, Knapp S, Loy A, Sibilia M.

Sci Transl Med. 2019 Dec 11;11(522). pii: eaax2693. doi: 10.1126/scitranslmed.aax2693.

PMID:
31826981
17.

[b]-Annulated Halogen-Substituted Indoles as Potential DYRK1A Inhibitors.

Lechner C, Flaßhoff M, Falke H, Preu L, Loaëc N, Meijer L, Knapp S, Chaikuad A, Kunick C.

Molecules. 2019 Nov 13;24(22). pii: E4090. doi: 10.3390/molecules24224090.

18.

Does Race Influence Decision Making for Advanced Heart Failure Therapies?

Breathett K, Yee E, Pool N, Hebdon M, Crist JD, Knapp S, Larsen A, Solola S, Luy L, Herrera-Theut K, Zabala L, Stone J, McEwen MM, Calhoun E, Sweitzer NK.

J Am Heart Assoc. 2019 Nov 19;8(22):e013592. doi: 10.1161/JAHA.119.013592. Epub 2019 Nov 11.

19.

Fast Iterative Synthetic Approach toward Identification of Novel Highly Selective p38 MAP Kinase Inhibitors.

Röhm S, Berger BT, Schröder M, Chaikuad A, Winkel R, Hekking KFW, Benningshof JJC, Müller G, Tesch R, Kudolo M, Forster M, Laufer S, Knapp S.

J Med Chem. 2019 Dec 12;62(23):10757-10782. doi: 10.1021/acs.jmedchem.9b01227. Epub 2019 Nov 26.

PMID:
31702918
20.

Lessons from LIMK1 enzymology and their impact on inhibitor design.

Salah E, Chatterjee D, Beltrami A, Tumber A, Preuss F, Canning P, Chaikuad A, Knaus P, Knapp S, Bullock AN, Mathea S.

Biochem J. 2019 Nov 15;476(21):3197-3209. doi: 10.1042/BCJ20190517.

21.

A Novel Biphenyl-based Chemotype of Retinoid X Receptor Ligands Enables Subtype and Heterodimer Preferences.

Pollinger J, Schierle S, Gellrich L, Ohrndorf J, Kaiser A, Heitel P, Chaikuad A, Knapp S, Merk D.

ACS Med Chem Lett. 2019 Aug 16;10(9):1346-1352. doi: 10.1021/acsmedchemlett.9b00306. eCollection 2019 Sep 12.

PMID:
31531208
22.

Discovery of the First in Vivo Active Inhibitors of the Soluble Epoxide Hydrolase Phosphatase Domain.

Kramer JS, Woltersdorf S, Duflot T, Hiesinger K, Lillich FF, Knöll F, Wittmann SK, Klingler FM, Brunst S, Chaikuad A, Morisseau C, Hammock BD, Buccellati C, Sala A, Rovati GE, Leuillier M, Fraineau S, Rondeaux J, Hernandez-Olmos V, Heering J, Merk D, Pogoryelov D, Steinhilber D, Knapp S, Bellien J, Proschak E.

J Med Chem. 2019 Sep 26;62(18):8443-8460. doi: 10.1021/acs.jmedchem.9b00445. Epub 2019 Sep 17.

PMID:
31436984
23.

Disease Resistance Genetics and Genomics in Octoploid Strawberry.

Barbey CR, Lee S, Verma S, Bird KA, Yocca AE, Edger PP, Knapp SJ, Whitaker VM, Folta KM.

G3 (Bethesda). 2019 Oct 7;9(10):3315-3332. doi: 10.1534/g3.119.400597.

24.

Dichotomous keys to the species of Solanum L. (Solanaceae) in continental Africa, Madagascar (incl. the Indian Ocean islands), Macaronesia and the Cape Verde Islands.

Knapp S, Vorontsova MS, Särkinen T.

PhytoKeys. 2019 Jul 19;127:39-76. doi: 10.3897/phytokeys.127.34326. eCollection 2019.

25.

Platelet PI3K Modulates Innate Leukocyte Extravasation during Acid-Induced Acute Lung Inflammation.

Kral-Pointner JB, Schrottmaier WC, Salzmann M, Mussbacher M, Schmidt GJ, Moser B, Heber S, Birnecker B, Paar H, Zellner M, Knapp S, Assinger A, Schabbauer G.

Thromb Haemost. 2019 Oct;19(10):1642-1654. doi: 10.1055/s-0039-1693693. Epub 2019 Aug 1.

PMID:
31370072
26.

Increasing Economic Burden in Hospitalized Patients With Cirrhosis: Analysis of a National Database.

Desai AP, Mohan P, Nokes B, Sheth D, Knapp S, Boustani M, Chalasani N, Fallon MB, Calhoun EA.

Clin Transl Gastroenterol. 2019 Jul;10(7):e00062. doi: 10.14309/ctg.0000000000000062.

27.

Alzheimer's disease medication and risk of all-cause mortality and all-cause hospitalization: A retrospective cohort study.

Bhattacharjee S, Patanwala AE, Lo-Ciganic WH, Malone DC, Lee JK, Knapp SM, Warholak T, Burke WJ.

Alzheimers Dement (N Y). 2019 Jul 10;5:294-302. doi: 10.1016/j.trci.2019.05.005. eCollection 2019.

28.

Association between the cervicovaginal microbiome, BRCA1 mutation status, and risk of ovarian cancer: a case-control study.

Nené NR, Reisel D, Leimbach A, Franchi D, Jones A, Evans I, Knapp S, Ryan A, Ghazali S, Timms JF, Paprotka T, Bjørge L, Zikan M, Cibula D, Colombo N, Widschwendter M.

Lancet Oncol. 2019 Aug;20(8):1171-1182. doi: 10.1016/S1470-2045(19)30340-7. Epub 2019 Jul 9. Erratum in: Lancet Oncol. 2019 Sep;20(9):e468. Lancet Oncol. 2019 Oct;20(10):e559.

PMID:
31300207
29.

High-Throughput Purification of Protein Kinases from Escherichia coli and Insect Cells.

Mathea S, Salah E, Knapp S.

Methods Mol Biol. 2019;2025:191-202. doi: 10.1007/978-1-4939-9624-7_8.

PMID:
31267453
30.

The origins and adaptation of European potatoes reconstructed from historical genomes.

Gutaker RM, Weiß CL, Ellis D, Anglin NL, Knapp S, Luis Fernández-Alonso J, Prat S, Burbano HA.

Nat Ecol Evol. 2019 Jul;3(7):1093-1101. doi: 10.1038/s41559-019-0921-3. Epub 2019 Jun 24.

PMID:
31235927
31.

A revision of the Morelloid Clade of Solanum L. (Solanaceae) in North and Central America and the Caribbean.

Knapp S, Barboza GE, Bohs L, Särkinen T.

PhytoKeys. 2019 May 30;123:1-144. doi: 10.3897/phytokeys.123.31738. eCollection 2019.

32.

Interval Endurance and Resistance Training as Part of a Community-Based Secondary Prevention Program for Patients With Diabetes Mellitus and Coronary Artery Disease.

Christle JW, Knapp S, Geisberger M, Cervenka M, Moneghetti K, Myers J, Halle M, Boscheri A.

J Cardiopulm Rehabil Prev. 2020 Jan;40(1):17-23. doi: 10.1097/HCR.0000000000000426.

PMID:
31192806
33.

Operando Spectroscopic and Kinetic Characterization of Aerobic Allylic C-H Acetoxylation Catalyzed by Pd(OAc)2/4,5-Diazafluoren-9-one.

Jaworski JN, Kozack CV, Tereniak SJ, Knapp SMM, Landis CR, Miller JT, Stahl SS.

J Am Chem Soc. 2019 Jul 3;141(26):10462-10474. doi: 10.1021/jacs.9b04699. Epub 2019 Jun 25.

PMID:
31184479
34.

Identification of mutations in circulating cell-free tumour DNA as a biomarker in hepatocellular carcinoma.

Howell J, Atkinson SR, Pinato DJ, Knapp S, Ward C, Minisini R, Burlone ME, Leutner M, Pirisi M, Büttner R, Khan SA, Thursz M, Odenthal M, Sharma R.

Eur J Cancer. 2019 Jul;116:56-66. doi: 10.1016/j.ejca.2019.04.014. Epub 2019 Jun 4.

PMID:
31173963
35.

Synthesis and Structure-Activity Relationships of 3,5-Disubstituted-pyrrolo[2,3- b]pyridines as Inhibitors of Adaptor-Associated Kinase 1 with Antiviral Activity.

Verdonck S, Pu SY, Sorrell FJ, Elkins JM, Froeyen M, Gao LJ, Prugar LI, Dorosky DE, Brannan JM, Barouch-Bentov R, Knapp S, Dye JM, Herdewijn P, Einav S, De Jonghe S.

J Med Chem. 2019 Jun 27;62(12):5810-5831. doi: 10.1021/acs.jmedchem.9b00136. Epub 2019 Jun 12.

PMID:
31136173
36.

Early consequences of allopolyploidy alter floral evolution in Nicotiana (Solanaceae).

McCarthy EW, Landis JB, Kurti A, Lawhorn AJ, Chase MW, Knapp S, Le Comber SC, Leitch AR, Litt A.

BMC Plant Biol. 2019 Apr 27;19(1):162. doi: 10.1186/s12870-019-1771-5.

37.

A chemical toolbox for the study of bromodomains and epigenetic signaling.

Wu Q, Heidenreich D, Zhou S, Ackloo S, Krämer A, Nakka K, Lima-Fernandes E, Deblois G, Duan S, Vellanki RN, Li F, Vedadi M, Dilworth J, Lupien M, Brennan PE, Arrowsmith CH, Müller S, Fedorov O, Filippakopoulos P, Knapp S.

Nat Commun. 2019 Apr 23;10(1):1915. doi: 10.1038/s41467-019-09672-2.

38.

Leveraging Compound Promiscuity to Identify Targetable Cysteines within the Kinome.

Rao S, Gurbani D, Du G, Everley RA, Browne CM, Chaikuad A, Tan L, Schröder M, Gondi S, Ficarro SB, Sim T, Kim ND, Berberich MJ, Knapp S, Marto JA, Westover KD, Sorger PK, Gray NS.

Cell Chem Biol. 2019 Jun 20;26(6):818-829.e9. doi: 10.1016/j.chembiol.2019.02.021. Epub 2019 Apr 11.

PMID:
30982749
39.

Microbial Metabolites in Cystic Fibrosis: A Target for Future Therapy?

Widder S, Knapp S.

Am J Respir Cell Mol Biol. 2019 Aug;61(2):132-133. doi: 10.1165/rcmb.2019-0081ED. No abstract available.

40.

Grey mould of strawberry, a devastating disease caused by the ubiquitous necrotrophic fungal pathogen Botrytis cinerea.

Petrasch S, Knapp SJ, van Kan JAL, Blanco-Ulate B.

Mol Plant Pathol. 2019 Jun;20(6):877-892. doi: 10.1111/mpp.12794. Epub 2019 Apr 4. Review.

41.

Extent and Predictors of Potentially Inappropriate Antidepressant Use Among Older Adults With Dementia and Major Depressive Disorder.

Bhattacharjee S, Lee JK, Patanwala AE, Vadiei N, Malone DC, Knapp SM, Lo-Ciganic WH, Burke WJ.

Am J Geriatr Psychiatry. 2019 Aug;27(8):794-805. doi: 10.1016/j.jagp.2019.02.002. Epub 2019 Feb 7.

PMID:
30926273
42.

Infection Strategies Deployed by Botrytis cinerea, Fusarium acuminatum, and Rhizopus stolonifer as a Function of Tomato Fruit Ripening Stage.

Petrasch S, Silva CJ, Mesquida-Pesci SD, Gallegos K, van den Abeele C, Papin V, Fernandez-Acero FJ, Knapp SJ, Blanco-Ulate B.

Front Plant Sci. 2019 Mar 1;10:223. doi: 10.3389/fpls.2019.00223. eCollection 2019.

43.

Solanummedusae (Solanaceae), a new wolf-fruit from Brazil, and a key to the extra-Amazonian Brazilian Androceras/Crinitum Clade species.

Gouvêa YF, Tehmann JR, Knapp S.

PhytoKeys. 2019 Feb 27;(118):15-32. doi: 10.3897/phytokeys.118.31598. eCollection 2019.

44.

Author Correction: Origin and evolution of the octoploid strawberry genome.

Edger PP, Poorten TJ, VanBuren R, Hardigan MA, Colle M, McKain MR, Smith RD, Teresi SJ, Nelson ADL, Wai CM, Alger EI, Bird KA, Yocca AE, Pumplin N, Ou S, Ben-Zvi G, Brodt A, Baruch K, Swale T, Shiue L, Acharya CB, Cole GS, Mower JP, Childs KL, Jiang N, Lyons E, Freeling M, Puzey JR, Knapp SJ.

Nat Genet. 2019 Apr;51(4):765. doi: 10.1038/s41588-019-0380-4.

PMID:
30842601
45.

Origin and evolution of the octoploid strawberry genome.

Edger PP, Poorten TJ, VanBuren R, Hardigan MA, Colle M, McKain MR, Smith RD, Teresi SJ, Nelson ADL, Wai CM, Alger EI, Bird KA, Yocca AE, Pumplin N, Ou S, Ben-Zvi G, Brodt A, Baruch K, Swale T, Shiue L, Acharya CB, Cole GS, Mower JP, Childs KL, Jiang N, Lyons E, Freeling M, Puzey JR, Knapp SJ.

Nat Genet. 2019 Mar;51(3):541-547. doi: 10.1038/s41588-019-0356-4. Epub 2019 Feb 25. Erratum in: Nat Genet. 2019 Apr;51(4):765.

46.

Designing Dual Inhibitors of Anaplastic Lymphoma Kinase (ALK) and Bromodomain-4 (BRD4) by Tuning Kinase Selectivity.

Watts E, Heidenreich D, Tucker E, Raab M, Strebhardt K, Chesler L, Knapp S, Bellenie B, Hoelder S.

J Med Chem. 2019 Mar 14;62(5):2618-2637. doi: 10.1021/acs.jmedchem.8b01947. Epub 2019 Feb 21.

47.

Conservation of structure, function and inhibitor binding in UNC-51-like kinase 1 and 2 (ULK1/2).

Chaikuad A, Koschade SE, Stolz A, Zivkovic K, Pohl C, Shaid S, Ren H, Lambert LJ, Cosford NDP, Brandts CH, Knapp S.

Biochem J. 2019 Mar 12;476(5):875-887. doi: 10.1042/BCJ20190038.

PMID:
30782972
48.

SGC-GAK-1: A Chemical Probe for Cyclin G Associated Kinase (GAK).

Asquith CRM, Berger BT, Wan J, Bennett JM, Capuzzi SJ, Crona DJ, Drewry DH, East MP, Elkins JM, Fedorov O, Godoi PH, Hunter DM, Knapp S, Müller S, Torrice CD, Wells CI, Earp HS, Willson TM, Zuercher WJ.

J Med Chem. 2019 Mar 14;62(5):2830-2836. doi: 10.1021/acs.jmedchem.8b01213. Epub 2019 Feb 26.

49.

New pyrido[3,4-g]quinazoline derivatives as CLK1 and DYRK1A inhibitors: synthesis, biological evaluation and binding mode analysis.

Tazarki H, Zeinyeh W, Esvan YJ, Knapp S, Chatterjee D, Schröder M, Joerger AC, Khiari J, Josselin B, Baratte B, Bach S, Ruchaud S, Anizon F, Giraud F, Moreau P.

Eur J Med Chem. 2019 Mar 15;166:304-317. doi: 10.1016/j.ejmech.2019.01.052. Epub 2019 Jan 26.

PMID:
30731399
50.

An Activity-Based Probe Targeting Non-Catalytic, Highly Conserved Amino Acid Residues within Bromodomains.

D'Ascenzio M, Pugh KM, Konietzny R, Berridge G, Tallant C, Hashem S, Monteiro O, Thomas JR, Schirle M, Knapp S, Marsden B, Fedorov O, Bountra C, Kessler BM, Brennan PE.

Angew Chem Int Ed Engl. 2019 Jan 21;58(4):1007-1012. doi: 10.1002/anie.201807825. Epub 2018 Dec 27.

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