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Items: 10

1.

The dynamic switch mechanism that leads to activation of LRRK2 is embedded in the DFGψ motif in the kinase domain.

Schmidt SH, Knape MJ, Boassa D, Mumdey N, Kornev AP, Ellisman MH, Taylor SS, Herberg FW.

Proc Natl Acad Sci U S A. 2019 Jul 23;116(30):14979-14988. doi: 10.1073/pnas.1900289116. Epub 2019 Jul 10.

2.

A Stapled Peptide Mimic of the Pseudosubstrate Inhibitor PKI Inhibits Protein Kinase A.

Manschwetus JT, Bendzunas GN, Limaye AJ, Knape MJ, Herberg FW, Kennedy EJ.

Molecules. 2019 Apr 20;24(8). pii: E1567. doi: 10.3390/molecules24081567.

3.

Activating PRKACB somatic mutation in cortisol-producing adenomas.

Espiard S, Knape MJ, Bathon K, Assié G, Rizk-Rabin M, Faillot S, Luscap-Rondof W, Abid D, Guignat L, Calebiro D, Herberg FW, Stratakis CA, Bertherat J.

JCI Insight. 2018 Apr 19;3(8). pii: 98296. doi: 10.1172/jci.insight.98296. eCollection 2018 Apr 19.

4.

PKA-RII subunit phosphorylation precedes activation by cAMP and regulates activity termination.

Isensee J, Kaufholz M, Knape MJ, Hasenauer J, Hammerich H, Gonczarowska-Jorge H, Zahedi RP, Schwede F, Herberg FW, Hucho T.

J Cell Biol. 2018 Jun 4;217(6):2167-2184. doi: 10.1083/jcb.201708053. Epub 2018 Apr 3.

5.

cGMP Binding Domain D Mediates a Unique Activation Mechanism in Plasmodium falciparum PKG.

Franz E, Knape MJ, Herberg FW.

ACS Infect Dis. 2018 Mar 9;4(3):415-423. doi: 10.1021/acsinfecdis.7b00222. Epub 2017 Dec 26.

PMID:
29251493
6.

Divalent metal ions control activity and inhibition of protein kinases.

Knape MJ, Ballez M, Burghardt NC, Zimmermann B, Bertinetti D, Kornev AP, Herberg FW.

Metallomics. 2017 Nov 15;9(11):1576-1584. doi: 10.1039/c7mt00204a.

PMID:
29043344
7.

Metal coordination in kinases and pseudokinases.

Knape MJ, Herberg FW.

Biochem Soc Trans. 2017 Jun 15;45(3):653-663. doi: 10.1042/BST20160327. Review.

PMID:
28620027
8.

Utilisation of antibody microarrays for the selection of specific and informative antibodies from recombinant library binders of unknown quality.

Kibat J, Schirrmann T, Knape MJ, Helmsing S, Meier D, Hust M, Schröder C, Bertinetti D, Winter G, Pardes K, Funk M, Vala A, Giese N, Herberg FW, Dübel S, Hoheisel JD.

N Biotechnol. 2016 Sep 25;33(5 Pt A):574-81. doi: 10.1016/j.nbt.2015.12.003. Epub 2015 Dec 17.

9.

Divalent Metal Ions Mg²⁺ and Ca²⁺ Have Distinct Effects on Protein Kinase A Activity and Regulation.

Knape MJ, Ahuja LG, Bertinetti D, Burghardt NC, Zimmermann B, Taylor SS, Herberg FW.

ACS Chem Biol. 2015 Oct 16;10(10):2303-15. doi: 10.1021/acschembio.5b00271. Epub 2015 Aug 5.

10.

Single Turnover Autophosphorylation Cycle of the PKA RIIβ Holoenzyme.

Zhang P, Knape MJ, Ahuja LG, Keshwani MM, King CC, Sastri M, Herberg FW, Taylor SS.

PLoS Biol. 2015 Jul 9;13(7):e1002192. doi: 10.1371/journal.pbio.1002192. eCollection 2015 Jul.

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