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Items: 43

1.

Prevalence of at-risk genotypes for genotoxic effects decreases with age in a randomly selected population in Flanders: a cross sectional study.

Ketelslegers HB, Godschalk RW, Gottschalk RW, Knaapen AM, Koppen G, Schoeters G, Baeyens WF, Nelen V, Geraedts JP, van Delft JH, Kleinjans JC, van Larebeke NA.

Environ Health. 2011 Oct 5;10:85. doi: 10.1186/1476-069X-10-85.

2.

Diesel engine exhaust initiates a sequence of pulmonary and cardiovascular effects in rats.

Kooter IM, Gerlofs-Nijland ME, Boere AJ, Leseman DL, Fokkens PH, Spronk HM, Frederix K, Ten Cate H, Knaapen AM, Vreman HJ, Cassee FR.

J Toxicol. 2010;2010:206057. doi: 10.1155/2010/206057. Epub 2010 Oct 31.

3.

NF-kappaB dependent and independent mechanisms of quartz-induced proinflammatory activation of lung epithelial cells.

van Berlo D, Knaapen AM, van Schooten FJ, Schins RP, Albrecht C.

Part Fibre Toxicol. 2010 May 21;7:13. doi: 10.1186/1743-8977-7-13.

4.

Comparative evaluation of the effects of short-term inhalation exposure to diesel engine exhaust on rat lung and brain.

van Berlo D, Albrecht C, Knaapen AM, Cassee FR, Gerlofs-Nijland ME, Kooter IM, Palomero-Gallagher N, Bidmon HJ, van Schooten FJ, Krutmann J, Schins RP.

Arch Toxicol. 2010 Jul;84(7):553-62. doi: 10.1007/s00204-010-0551-7. Epub 2010 May 14.

5.

Transcriptional profiling of the acute pulmonary inflammatory response induced by LPS: role of neutrophils.

Güngör N, Pennings JL, Knaapen AM, Chiu RK, Peluso M, Godschalk RW, Van Schooten FJ.

Respir Res. 2010 Feb 25;11:24. doi: 10.1186/1465-9921-11-24.

6.

Lung inflammation is associated with reduced pulmonary nucleotide excision repair in vivo.

Güngör N, Haegens A, Knaapen AM, Godschalk RW, Chiu RK, Wouters EF, van Schooten FJ.

Mutagenesis. 2010 Jan;25(1):77-82. doi: 10.1093/mutage/gep049. Epub 2009 Nov 16.

PMID:
19917589
7.

Genotoxic effects of neutrophils and hypochlorous acid.

Güngör N, Knaapen AM, Munnia A, Peluso M, Haenen GR, Chiu RK, Godschalk RW, van Schooten FJ.

Mutagenesis. 2010 Mar;25(2):149-54. doi: 10.1093/mutage/gep053. Epub 2009 Nov 5.

PMID:
19892774
8.

Genetic variation as a predictor of smoking cessation success. A promising preventive and intervention tool for chronic respiratory diseases?

Quaak M, van Schayck CP, Knaapen AM, van Schooten FJ.

Eur Respir J. 2009 Mar;33(3):468-80. doi: 10.1183/09031936.00056908. Review.

9.

Implications of gene-drug interactions in smoking cessation for improving the prevention of chronic degenerative diseases.

Quaak M, van Schayck CP, Knaapen AM, van Schooten FJ.

Mutat Res. 2009 Jul 10;667(1-2):44-57. doi: 10.1016/j.mrfmmm.2008.10.015. Epub 2008 Nov 5. Review.

PMID:
19028511
10.

Beta-carotene metabolites enhance inflammation-induced oxidative DNA damage in lung epithelial cells.

van Helden YG, Keijer J, Knaapen AM, Heil SG, Briedé JJ, van Schooten FJ, Godschalk RW.

Free Radic Biol Med. 2009 Jan 15;46(2):299-304. doi: 10.1016/j.freeradbiomed.2008.10.038. Epub 2008 Oct 31.

PMID:
19026740
11.

Curcumin protects against cytotoxic and inflammatory effects of quartz particles but causes oxidative DNA damage in a rat lung epithelial cell line.

Li H, van Berlo D, Shi T, Speit G, Knaapen AM, Borm PJ, Albrecht C, Schins RP.

Toxicol Appl Pharmacol. 2008 Feb 15;227(1):115-24. Epub 2007 Oct 11.

PMID:
18001810
12.

Genotoxicity of poorly soluble particles.

Schins RP, Knaapen AM.

Inhal Toxicol. 2007;19 Suppl 1:189-98. Review.

PMID:
17886067
13.

Toenails: an easily accessible and long-term stable source of DNA for genetic analyses in large-scale epidemiological studies.

van Breda SG, Hogervorst JG, Schouten LJ, Knaapen AM, van Delft JH, Goldbohm RA, van Schooten FJ, van den Brandt PA.

Clin Chem. 2007 Jun;53(6):1168-70. No abstract available.

14.

Activated neutrophils inhibit nucleotide excision repair in human pulmonary epithelial cells: role of myeloperoxidase.

Güngör N, Godschalk RW, Pachen DM, Van Schooten FJ, Knaapen AM.

FASEB J. 2007 Aug;21(10):2359-67. Epub 2007 Apr 17.

PMID:
17440118
15.

DNA damage, mutagenesis and cardiovascular disease.

van Schooten FJ, Knaapen AM, Izzotti A.

Mutat Res. 2007 Aug 1;621(1-2):1-4. Epub 2007 Feb 28. No abstract available.

PMID:
17397879
16.

Formation of lysine 63-linked poly-ubiquitin chains protects human lung cells against benzo[a]pyrene-diol-epoxide-induced mutagenicity.

Langie SA, Knaapen AM, Ramaekers CH, Theys J, Brun J, Godschalk RW, van Schooten FJ, Lambin P, Gray DA, Wouters BG, Chiu RK.

DNA Repair (Amst). 2007 Jun 1;6(6):852-62. Epub 2007 Mar 28.

PMID:
17395554
17.

The environmental carcinogen benzo[a]pyrene induces expression of monocyte-chemoattractant protein-1 in vascular tissue: a possible role in atherogenesis.

Knaapen AM, Curfs DM, Pachen DM, Gottschalk RW, de Winther MP, Daemen MJ, Van Schooten FJ.

Mutat Res. 2007 Aug 1;621(1-2):31-41. Epub 2007 Feb 28.

PMID:
17376491
18.

Inhibition of the mitochondrial respiratory chain function abrogates quartz induced DNA damage in lung epithelial cells.

Li H, Haberzettl P, Albrecht C, Höhr D, Knaapen AM, Borm PJ, Schins RP.

Mutat Res. 2007 Apr 1;617(1-2):46-57. Epub 2006 Dec 22.

PMID:
17239409
19.

The role of glutathione in the regulation of nucleotide excision repair during oxidative stress.

Langie SA, Knaapen AM, Houben JM, van Kempen FC, de Hoon JP, Gottschalk RW, Godschalk RW, van Schooten FJ.

Toxicol Lett. 2007 Feb 5;168(3):302-9. Epub 2006 Nov 16.

PMID:
17207589
20.

Neutrophils and respiratory tract DNA damage and mutagenesis: a review.

Knaapen AM, Güngör N, Schins RP, Borm PJ, Van Schooten FJ.

Mutagenesis. 2006 Jul;21(4):225-36. Epub 2006 Jul 26. Review.

PMID:
16870698
21.

Interindividual variations in DNA adduct levels assessed by analysis of multiple genetic polymorphisms in smokers.

Ketelslegers HB, Gottschalk RW, Godschalk RW, Knaapen AM, van Schooten FJ, Vlietinck RF, Kleinjans JC, van Delft JH.

Cancer Epidemiol Biomarkers Prev. 2006 Apr;15(4):624-9.

22.

Development and validation of a modified comet assay to phenotypically assess nucleotide excision repair.

Langie SA, Knaapen AM, Brauers KJ, van Berlo D, van Schooten FJ, Godschalk RW.

Mutagenesis. 2006 Mar;21(2):153-8. Epub 2006 Mar 23.

PMID:
16556641
23.

Induction of CYP1A1 in rat lung cells following in vivo and in vitro exposure to quartz.

Becker A, Albrecht C, Knaapen AM, Schins RP, Höhr D, Ledermann K, Borm PJ.

Arch Toxicol. 2006 May;80(5):258-68. Epub 2006 Mar 18.

PMID:
16547697
24.

The crucial role of particle surface reactivity in respirable quartz-induced reactive oxygen/nitrogen species formation and APE/Ref-1 induction in rat lung.

Albrecht C, Knaapen AM, Becker A, Höhr D, Haberzettl P, van Schooten FJ, Borm PJ, Schins RP.

Respir Res. 2005 Nov 2;6:129.

25.

Polycyclic aromatic hydrocarbons induce an inflammatory atherosclerotic plaque phenotype irrespective of their DNA binding properties.

Curfs DM, Knaapen AM, Pachen DM, Gijbels MJ, Lutgens E, Smook ML, Kockx MM, Daemen MJ, van Schooten FJ.

FASEB J. 2005 Aug;19(10):1290-2. Epub 2005 Jun 6.

PMID:
15939734
26.

Nitrite enhances neutrophil-induced DNA strand breakage in pulmonary epithelial cells by inhibition of myeloperoxidase.

Knaapen AM, Schins RP, Borm PJ, van Schooten FJ.

Carcinogenesis. 2005 Sep;26(9):1642-8. Epub 2005 May 5.

PMID:
15878909
27.

Simultaneous genotyping of nine polymorphisms in xenobiotic-metabolizing enzymes by multiplex PCR amplification and single base extension.

Knaapen AM, Ketelslegers HB, Gottschalk RW, Janssen RG, Paulussen AD, Smeets HJ, Godschalk RW, Van Schooten FJ, Kleinjans JC, Van Delft JH.

Clin Chem. 2004 Sep;50(9):1664-8. No abstract available.

28.

Inflammatory time course after quartz instillation: role of tumor necrosis factor-alpha and particle surface.

Albrecht C, Schins RP, Höhr D, Becker A, Shi T, Knaapen AM, Borm PJ.

Am J Respir Cell Mol Biol. 2004 Sep;31(3):292-301. Epub 2004 Jun 10.

PMID:
15191911
29.

Myeloperoxidase (MPO) -463G->A reduces MPO activity and DNA adduct levels in bronchoalveolar lavages of smokers.

Van Schooten FJ, Boots AW, Knaapen AM, Godschalk RW, Maas LM, Borm PJ, Drent M, Jacobs JA.

Cancer Epidemiol Biomarkers Prev. 2004 May;13(5):828-33.

30.

Inhaled particles and lung cancer. Part A: Mechanisms.

Knaapen AM, Borm PJ, Albrecht C, Schins RP.

Int J Cancer. 2004 May 10;109(6):799-809. Review.

31.

Hydroxyl radical generation by electron paramagnetic resonance as a new method to monitor ambient particulate matter composition.

Shi T, Schins RP, Knaapen AM, Kuhlbusch T, Pitz M, Heinrich J, Borm PJ.

J Environ Monit. 2003 Aug;5(4):550-6.

PMID:
12948226
32.

Oxidative stress and calcium signaling in the adverse effects of environmental particles (PM10).

Donaldson K, Stone V, Borm PJ, Jimenez LA, Gilmour PS, Schins RP, Knaapen AM, Rahman I, Faux SP, Brown DM, MacNee W.

Free Radic Biol Med. 2003 Jun 1;34(11):1369-82. Review.

PMID:
12757847
33.

Temporal variation of hydroxyl radical generation and 8-hydroxy-2'-deoxyguanosine formation by coarse and fine particulate matter.

Shi T, Knaapen AM, Begerow J, Birmili W, Borm PJ, Schins RP.

Occup Environ Med. 2003 May;60(5):315-21.

34.

Surface modification of quartz inhibits toxicity, particle uptake, and oxidative DNA damage in human lung epithelial cells.

Schins RP, Duffin R, Höhr D, Knaapen AM, Shi T, Weishaupt C, Stone V, Donaldson K, Borm PJ.

Chem Res Toxicol. 2002 Sep;15(9):1166-73.

PMID:
12230410
35.

Soluble metals as well as the insoluble particle fraction are involved in cellular DNA damage induced by particulate matter.

Knaapen AM, Shi T, Borm PJ, Schins RP.

Mol Cell Biochem. 2002 May-Jun;234-235(1-2):317-26.

PMID:
12162450
36.

Mechanisms of neutrophil-induced DNA damage in respiratory tract epithelial cells.

Knaapen AM, Schins RP, Polat D, Becker A, Borm PJ.

Mol Cell Biochem. 2002 May-Jun;234-235(1-2):143-51.

PMID:
12162427
37.

DNA damage in lung epithelial cells isolated from rats exposed to quartz: role of surface reactivity and neutrophilic inflammation.

Knaapen AM, Albrecht C, Becker A, Höhr D, Winzer A, Haenen GR, Borm PJ, Schins RP.

Carcinogenesis. 2002 Jul;23(7):1111-20.

PMID:
12117767
38.

The surface area rather than the surface coating determines the acute inflammatory response after instillation of fine and ultrafine TiO2 in the rat.

Höhr D, Steinfartz Y, Schins RP, Knaapen AM, Martra G, Fubini B, Borm PJ.

Int J Hyg Environ Health. 2002 Apr;205(3):239-44.

PMID:
12040922
39.

Oxidant-induced DNA damage by quartz in alveolar epithelial cells.

Schins RP, Knaapen AM, Cakmak GD, Shi T, Weishaupt C, Borm PJ.

Mutat Res. 2002 May 27;517(1-2):77-86.

PMID:
12034310
40.

Ambient particulate matter induces relaxation of rat aortic rings in vitro.

Knaapen AM, den Hartog GJ, Bast A, Borm PJ.

Hum Exp Toxicol. 2001 May;20(5):259-65.

PMID:
11476159
41.

Ambient Particulate Matter Induces Oxidative Dna Damage in Lung Epithelial Cells.

Knaapen AM, Schins RP, Steinfartz Y, Doris H, Dunemann L, Borm PJ.

Inhal Toxicol. 2000 Jan;12 Suppl 3:125-32. doi: 10.1080/08958378.2000.11463238.

PMID:
26368608
42.

Neutrophils cause oxidative DNA damage in alveolar epithelial cells.

Knaapen AM, Seiler F, Schilderman PA, Nehls P, Bruch J, Schins RP, Borm PJ.

Free Radic Biol Med. 1999 Jul;27(1-2):234-40.

PMID:
10443941
43.

Neutrophils amplify the formation of DNA adducts by benzo[a]pyrene in lung target cells.

Borm PJ, Knaapen AM, Schins RP, Godschalk RW, Schooten FJ.

Environ Health Perspect. 1997 Sep;105 Suppl 5:1089-93.

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