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Optical voltage imaging in neurons: moving from technology development to practical tool.

Knöpfel T, Song C.

Nat Rev Neurosci. 2019 Dec;20(12):719-727. doi: 10.1038/s41583-019-0231-4. Epub 2019 Nov 8. Review.


Genetically Encoded Fluorescent Calcium and Voltage Indicators.

Mollinedo-Gajate I, Song C, Knöpfel T.

Handb Exp Pharmacol. 2019 Oct 9. doi: 10.1007/164_2019_299. [Epub ahead of print]


Paracellular transport of phosphate along the intestine.

Knöpfel T, Himmerkus N, Günzel D, Bleich M, Hernando N, Wagner CA.

Am J Physiol Gastrointest Liver Physiol. 2019 Aug 1;317(2):G233-G241. doi: 10.1152/ajpgi.00032.2019. Epub 2019 Jun 6.


Corrigendum: Single-Neuron Level One-Photon Voltage Imaging With Sparsely Targeted Genetically Encoded Voltage Indicators.

Quicke P, Song C, McKimm EJ, Milosevic MM, Howe CL, Neil M, Schultz SR, Antic SD, Foust AJ, Knöpfel T.

Front Cell Neurosci. 2019 May 7;13:202. doi: 10.3389/fncel.2019.00202. eCollection 2019.


Assessing spatiotemporal variability of brain spontaneous activity by multiscale entropy and functional connectivity.

Liu M, Song C, Liang Y, Knöpfel T, Zhou C.

Neuroimage. 2019 Sep;198:198-220. doi: 10.1016/j.neuroimage.2019.05.022. Epub 2019 May 12.


Single-Neuron Level One-Photon Voltage Imaging With Sparsely Targeted Genetically Encoded Voltage Indicators.

Quicke P, Song C, McKimm EJ, Milosevic MM, Howe CL, Neil M, Schultz SR, Antic SD, Foust AJ, Knöpfel T.

Front Cell Neurosci. 2019 Feb 14;13:39. doi: 10.3389/fncel.2019.00039. eCollection 2019. Erratum in: Front Cell Neurosci. 2019 May 07;13:202.


Gene panel sequencing identifies a likely monogenic cause in 7% of 235 Pakistani families with nephrolithiasis.

Amar A, Majmundar AJ, Ullah I, Afzal A, Braun DA, Shril S, Daga A, Jobst-Schwan T, Ahmad M, Sayer JA, Gee HY, Halbritter J, Knöpfel T, Hernando N, Werner A, Wagner C, Khaliq S, Hildebrandt F.

Hum Genet. 2019 Mar;138(3):211-219. doi: 10.1007/s00439-019-01978-x. Epub 2019 Feb 18.


Scale-Change Symmetry in the Rules Governing Neural Systems.

Agrawal V, Chakraborty S, Knöpfel T, Shew WL.

iScience. 2019 Feb 22;12:121-131. doi: 10.1016/j.isci.2019.01.009. Epub 2019 Jan 8.


High speed functional imaging with source localized multifocal two-photon microscopy.

Quicke P, Reynolds S, Neil M, Knöpfel T, Schultz SR, Foust AJ.

Biomed Opt Express. 2018 Jul 12;9(8):3678-3693. doi: 10.1364/BOE.9.003678. eCollection 2018 Aug 1.


Optogenetic sensors in the zebrafish heart: a novel in vivo electrophysiological tool to study cardiac arrhythmogenesis.

van Opbergen CJM, Koopman CD, Kok BJM, Knöpfel T, Renninger SL, Orger MB, Vos MA, van Veen TAB, Bakkers J, de Boer TP.

Theranostics. 2018 Sep 9;8(17):4750-4764. doi: 10.7150/thno.26108. eCollection 2018.


Inhibition of sodium/hydrogen exchanger 3 in the gastrointestinal tract by tenapanor reduces paracellular phosphate permeability.

King AJ, Siegel M, He Y, Nie B, Wang J, Koo-McCoy S, Minassian NA, Jafri Q, Pan D, Kohler J, Kumaraswamy P, Kozuka K, Lewis JG, Dragoli D, Rosenbaum DP, O'Neill D, Plain A, Greasley PJ, Jönsson-Rylander AC, Karlsson D, Behrendt M, Strömstedt M, Ryden-Bergsten T, Knöpfel T, Pastor Arroyo EM, Hernando N, Marks J, Donowitz M, Wagner CA, Alexander RT, Caldwell JS.

Sci Transl Med. 2018 Aug 29;10(456). pii: eaam6474. doi: 10.1126/scitranslmed.aam6474.


Cortical signatures of wakeful somatosensory processing.

Song C, Piscopo DM, Niell CM, Knöpfel T.

Sci Rep. 2018 Aug 10;8(1):11977. doi: 10.1038/s41598-018-30422-9.


Neurotechnology to address big questions.

Knöpfel T.

Science. 2018 Jul 27;361(6400):328-329. doi: 10.1126/science.aau4705. No abstract available.


The characteristic patterns of neuronal avalanches in mice under anesthesia and at rest: An investigation using constrained artificial neural networks.

Fagerholm ED, Dinov M, Knöpfel T, Leech R.

PLoS One. 2018 May 24;13(5):e0197893. doi: 10.1371/journal.pone.0197893. eCollection 2018.


The elevation of circulating fibroblast growth factor 23 without kidney disease does not increase cardiovascular disease risk.

Pastor-Arroyo EM, Gehring N, Krudewig C, Costantino S, Bettoni C, Knöpfel T, Sabrautzki S, Lorenz-Depiereux B, Pastor J, Strom TM, Hrabě de Angelis M, Camici GG, Paneni F, Wagner CA, Rubio-Aliaga I.

Kidney Int. 2018 Jul;94(1):49-59. doi: 10.1016/j.kint.2018.02.017. Epub 2018 May 5.


Tolerance and Tachyphylaxis to Head Twitches Induced by the 5-HT2A Agonist 25CN-NBOH in Mice.

Buchborn T, Lyons T, Knöpfel T.

Front Pharmacol. 2018 Feb 6;9:17. doi: 10.3389/fphar.2018.00017. eCollection 2018.


Optogenetic targeting of cardiac myocytes and non-myocytes: Tools, challenges and utility.

Johnston CM, Rog-Zielinska EA, Wülfers EM, Houwaart T, Siedlecka U, Naumann A, Nitschke R, Knöpfel T, Kohl P, Schneider-Warme F.

Prog Biophys Mol Biol. 2017 Nov;130(Pt B):140-149. doi: 10.1016/j.pbiomolbio.2017.09.014. Epub 2017 Sep 15.


The intestinal phosphate transporter NaPi-IIb (Slc34a2) is required to protect bone during dietary phosphate restriction.

Knöpfel T, Pastor-Arroyo EM, Schnitzbauer U, Kratschmar DV, Odermatt A, Pellegrini G, Hernando N, Wagner CA.

Sci Rep. 2017 Sep 8;7(1):11018. doi: 10.1038/s41598-017-10390-2.


Cardiac optogenetics: using light to monitor cardiac physiology.

Koopman CD, Zimmermann WH, Knöpfel T, de Boer TP.

Basic Res Cardiol. 2017 Aug 31;112(5):56. doi: 10.1007/s00395-017-0645-y. Review.


Transgenic Strategies for Sparse but Strong Expression of Genetically Encoded Voltage and Calcium Indicators.

Song C, Do QB, Antic SD, Knöpfel T.

Int J Mol Sci. 2017 Jul 7;18(7). pii: E1461. doi: 10.3390/ijms18071461.


Renal localization and regulation by dietary phosphate of the MCT14 orphan transporter.

Knöpfel T, Atanassoff A, Hernando N, Biber J, Wagner CA.

PLoS One. 2017 Jun 29;12(6):e0177942. doi: 10.1371/journal.pone.0177942. eCollection 2017.


Mammalian cortical voltage imaging using genetically encoded voltage indicators: a review honoring professor Amiram Grinvald.

Song C, Barnes S, Knöpfel T.

Neurophotonics. 2017 Jul;4(3):031214. doi: 10.1117/1.NPh.4.3.031214. Epub 2017 May 4. Review.


State-Dependent Modulation of Slow Wave Motifs towards Awakening.

Shimaoka D, Song C, Knöpfel T.

Front Cell Neurosci. 2017 Apr 24;11:108. doi: 10.3389/fncel.2017.00108. eCollection 2017.


Roadmap on neurophotonics.

Cho YK, Zheng G, Augustine GJ, Hochbaum D, Cohen A, Knöpfel T, Pisanello F, Pavone FS, Vellekoop IM, Booth MJ, Hu S, Zhu J, Chen Z, Hoshi Y.

J Opt. 2016 Sep;18(9). pii: 093007. doi: 10.1088/2040-8978/18/9/093007. Epub 2016 Aug 18.


Imaging of Brain Slices with a Genetically Encoded Voltage Indicator.

Quicke P, Barnes SJ, Knöpfel T.

Methods Mol Biol. 2017;1563:73-84. doi: 10.1007/978-1-4939-6810-7_5.


Acute Adaption to Oral or Intravenous Phosphate Requires Parathyroid Hormone.

Thomas L, Bettoni C, Knöpfel T, Hernando N, Biber J, Wagner CA.

J Am Soc Nephrol. 2017 Mar;28(3):903-914. doi: 10.1681/ASN.2016010082. Epub 2016 Oct 6.


Electrotonic coupling of excitable and nonexcitable cells in the heart revealed by optogenetics.

Quinn TA, Camelliti P, Rog-Zielinska EA, Siedlecka U, Poggioli T, O'Toole ET, Knöpfel T, Kohl P.

Proc Natl Acad Sci U S A. 2016 Dec 20;113(51):14852-14857. doi: 10.1073/pnas.1611184114. Epub 2016 Dec 7.


Cortical Entropy, Mutual Information and Scale-Free Dynamics in Waking Mice.

Fagerholm ED, Scott G, Shew WL, Song C, Leech R, Knöpfel T, Sharp DJ.

Cereb Cortex. 2016 Oct;26(10):3945-52. doi: 10.1093/cercor/bhw200. Epub 2016 Jul 6.


Voltage imaging to understand connections and functions of neuronal circuits.

Antic SD, Empson RM, Knöpfel T.

J Neurophysiol. 2016 Jul 1;116(1):135-52. doi: 10.1152/jn.00226.2016. Epub 2016 Apr 13. Review.


Optical Imaging of Brain Activity In Vivo Using Genetically Encoded Probes.

Wachowiak M, Knöpfel T.

In: Frostig RD, editor. In Vivo Optical Imaging of Brain Function. 2nd edition. Boca Raton (FL): CRC Press/Taylor & Francis; 2009. Chapter 1.


Facilitated Anion Transport Induces Hyperpolarization of the Cell Membrane That Triggers Differentiation and Cell Death in Cancer Stem Cells.

Soto-Cerrato V, Manuel-Manresa P, Hernando E, Calabuig-Fariñas S, Martínez-Romero A, Fernández-Dueñas V, Sahlholm K, Knöpfel T, García-Valverde M, Rodilla AM, Jantus-Lewintre E, Farràs R, Ciruela F, Pérez-Tomás R, Quesada R.

J Am Chem Soc. 2015 Dec 23;137(50):15892-8. doi: 10.1021/jacs.5b09970. Epub 2015 Dec 17.


Optogenetics enlightens neuroscience drug discovery.

Song C, Knöpfel T.

Nat Rev Drug Discov. 2016 Feb;15(2):97-109. doi: 10.1038/nrd.2015.15. Epub 2015 Nov 27. Review.


Validation of optical voltage reporting by the genetically encoded voltage indicator VSFP-Butterfly from cortical layer 2/3 pyramidal neurons in mouse brain slices.

Empson RM, Goulton C, Scholtz D, Gallero-Salas Y, Zeng H, Knöpfel T.

Physiol Rep. 2015 Jul 29;3(7). pii: e12468. doi: 10.14814/phy2.12468. Epub 2015 Jul 29.


Genetically encoded voltage indicators for large scale cortical imaging come of age.

Knöpfel T, Gallero-Salas Y, Song C.

Curr Opin Chem Biol. 2015 Aug;27:75-83. doi: 10.1016/j.cbpa.2015.06.006. Epub 2015 Jun 24. Review.


Sensing Cardiac Electrical Activity With a Cardiac Myocyte--Targeted Optogenetic Voltage Indicator.

Chang Liao ML, de Boer TP, Mutoh H, Raad N, Richter C, Wagner E, Downie BR, Unsöld B, Arooj I, Streckfuss-Bömeke K, Döker S, Luther S, Guan K, Wagner S, Lehnart SE, Maier LS, Stühmer W, Wettwer E, van Veen T, Morlock MM, Knöpfel T, Zimmermann WH.

Circ Res. 2015 Aug 14;117(5):401-12. doi: 10.1161/CIRCRESAHA.117.306143. Epub 2015 Jun 15.


Comparative performance of a genetically-encoded voltage indicator and a blue voltage sensitive dye for large scale cortical voltage imaging.

Mutoh H, Mishina Y, Gallero-Salas Y, Knöpfel T.

Front Cell Neurosci. 2015 Apr 24;9:147. doi: 10.3389/fncel.2015.00147. eCollection 2015.


Intestinal Depletion of NaPi-IIb/Slc34a2 in Mice: Renal and Hormonal Adaptation.

Hernando N, Myakala K, Simona F, Knöpfel T, Thomas L, Murer H, Wagner CA, Biber J.

J Bone Miner Res. 2015 Oct;30(10):1925-37. doi: 10.1002/jbmr.2523. Epub 2015 May 7.


Transgenic mice for intersectional targeting of neural sensors and effectors with high specificity and performance.

Madisen L, Garner AR, Shimaoka D, Chuong AS, Klapoetke NC, Li L, van der Bourg A, Niino Y, Egolf L, Monetti C, Gu H, Mills M, Cheng A, Tasic B, Nguyen TN, Sunkin SM, Benucci A, Nagy A, Miyawaki A, Helmchen F, Empson RM, Knöpfel T, Boyden ES, Reid RC, Carandini M, Zeng H.

Neuron. 2015 Mar 4;85(5):942-58. doi: 10.1016/j.neuron.2015.02.022.


Imaging the awake visual cortex with a genetically encoded voltage indicator.

Carandini M, Shimaoka D, Rossi LF, Sato TK, Benucci A, Knöpfel T.

J Neurosci. 2015 Jan 7;35(1):53-63. doi: 10.1523/JNEUROSCI.0594-14.2015.


Voltage imaging of waking mouse cortex reveals emergence of critical neuronal dynamics.

Scott G, Fagerholm ED, Mutoh H, Leech R, Sharp DJ, Shew WL, Knöpfel T.

J Neurosci. 2014 Dec 10;34(50):16611-20. doi: 10.1523/JNEUROSCI.3474-14.2014.


Exploration of genetically encoded voltage indicators based on a chimeric voltage sensing domain.

Mishina Y, Mutoh H, Song C, Knöpfel T.

Front Mol Neurosci. 2014 Sep 29;7:78. doi: 10.3389/fnmol.2014.00078. eCollection 2014.


Structural fold and binding sites of the human Na⁺-phosphate cotransporter NaPi-II.

Fenollar-Ferrer C, Patti M, Knöpfel T, Werner A, Forster IC, Forrest LR.

Biophys J. 2014 Mar 18;106(6):1268-79. doi: 10.1016/j.bpj.2014.01.043.


Quantification of the density of cooperative neighboring synapses required to evoke endocannabinoid signaling.

Pachoud B, Sharma P, Bergerot A, Knöpfel T, Marcaggi P.

Neuroscience. 2014 Jan 3;256:412-25. doi: 10.1016/j.neuroscience.2013.10.041. Epub 2013 Oct 30.


Delivery of differentiation factors by mesoporous silica particles assists advanced differentiation of transplanted murine embryonic stem cells.

Garcia-Bennett AE, Kozhevnikova M, König N, Zhou C, Leao R, Knöpfel T, Pankratova S, Trolle C, Berezin V, Bock E, Aldskogius H, Kozlova EN.

Stem Cells Transl Med. 2013 Nov;2(11):906-15. doi: 10.5966/sctm.2013-0072. Epub 2013 Oct 2.


Two-photon voltage imaging using a genetically encoded voltage indicator.

Akemann W, Sasaki M, Mutoh H, Imamura T, Honkura N, Knöpfel T.

Sci Rep. 2013;3:2231. doi: 10.1038/srep02231.


Enhanced synaptic inhibition in the cerebellar cortex of the ataxic PMCA2(-/-) knockout mouse.

Empson RM, Huang H, Nagaraja RY, Roome CJ, Knöpfel T.

Cerebellum. 2013 Oct;12(5):667-75. doi: 10.1007/s12311-013-0472-0.


Distinct spatiotemporal activity in principal neurons of the mouse olfactory bulb in anesthetized and awake states.

Blauvelt DG, Sato TF, Wienisch M, Knöpfel T, Murthy VN.

Front Neural Circuits. 2013 Mar 28;7:46. doi: 10.3389/fncir.2013.00046. eCollection 2013. Erratum in: Front Neural Circuits. 2013;7:114. Knöpfel, Thomas [added].


Probing neuronal activities with genetically encoded optical indicators: from a historical to a forward-looking perspective.

Mutoh H, Knöpfel T.

Pflugers Arch. 2013 Mar;465(3):361-71. doi: 10.1007/s00424-012-1202-z. Epub 2012 Dec 28. Review.


A macrocyclic approach to tetracycline natural products. Investigation of transannular alkylations and Michael additions.

Wzorek JS, Knöpfel TF, Sapountzis I, Evans DA.

Org Lett. 2012 Dec 7;14(23):5840-3. doi: 10.1021/ol302691j. Epub 2012 Nov 12.


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