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Items: 1 to 50 of 140

1.

CRISPR-Directed Gene Editing Catalyzes Precise Gene Segment Replacement In Vitro Enabling a Novel Method for Multiplex Site-Directed Mutagenesis.

Sansbury BM, Wagner AM, Tarcic G, Barth S, Nitzan E, Goldfus R, Vidne M, Kmiec EB.

CRISPR J. 2019 Apr;2:121-132. doi: 10.1089/crispr.2018.0054.

PMID:
30998096
2.

CRISPR-Directed In Vitro Gene Editing of Plasmid DNA Catalyzed by Cpf1 (Cas12a) Nuclease and a Mammalian Cell-Free Extract.

Sansbury BM, Wagner AM, Nitzan E, Tarcic G, Kmiec EB.

CRISPR J. 2018 Apr 1;1(2):191-202. doi: 10.1089/crispr.2018.0006.

3.

Functional Gene Knockout of NRF2 Increases Chemosensitivity of Human Lung Cancer A549 Cells In Vitro and in a Xenograft Mouse Model.

Bialk P, Wang Y, Banas K, Kmiec EB.

Mol Ther Oncolytics. 2018 Oct 18;11:75-89. doi: 10.1016/j.omto.2018.10.002. eCollection 2018 Dec 21.

4.

Efficient Delivery and Nuclear Uptake Is Not Sufficient to Detect Gene Editing in CD34+ Cells Directed by a Ribonucleoprotein Complex.

Modarai SR, Man D, Bialk P, Rivera-Torres N, Bloh K, Kmiec EB.

Mol Ther Nucleic Acids. 2018 Jun 1;11:116-129. doi: 10.1016/j.omtn.2018.01.013. Epub 2018 Feb 7.

6.

CRISPR/Cas9-Directed Reassignment of the GATA1 Initiation Codon in K562 Cells to Recapitulate AML in Down Syndrome.

Bloh KM, Bialk PA, Gopalakrishnapillai A, Kolb EA, Kmiec EB.

Mol Ther Nucleic Acids. 2017 Jun 16;7:288-298. doi: 10.1016/j.omtn.2017.04.009. Epub 2017 Apr 13.

7.

To cleave or not to cleave: therapeutic gene editing with and without programmable nucleases.

Woolf TM, Gurumurthy CB, Boyce F, Kmiec EB.

Nat Rev Drug Discov. 2017 Apr;16(4):296. doi: 10.1038/nrd.2017.42. Epub 2017 Mar 17. No abstract available.

PMID:
28303022
8.

Insertional Mutagenesis by CRISPR/Cas9 Ribonucleoprotein Gene Editing in Cells Targeted for Point Mutation Repair Directed by Short Single-Stranded DNA Oligonucleotides.

Rivera-Torres N, Banas K, Bialk P, Bloh KM, Kmiec EB.

PLoS One. 2017 Jan 4;12(1):e0169350. doi: 10.1371/journal.pone.0169350. eCollection 2017.

9.

Analyses of point mutation repair and allelic heterogeneity generated by CRISPR/Cas9 and single-stranded DNA oligonucleotides.

Bialk P, Sansbury B, Rivera-Torres N, Bloh K, Man D, Kmiec EB.

Sci Rep. 2016 Sep 9;6:32681. doi: 10.1038/srep32681.

10.

Genetic spell-checking: gene editing using single-stranded DNA oligonucleotides.

Rivera-Torres N, Kmiec EB.

Plant Biotechnol J. 2016 Feb;14(2):463-70. doi: 10.1111/pbi.12473. Epub 2015 Sep 24. Review.

11.

Regulation of Gene Editing Activity Directed by Single-Stranded Oligonucleotides and CRISPR/Cas9 Systems.

Bialk P, Rivera-Torres N, Strouse B, Kmiec EB.

PLoS One. 2015 Jun 8;10(6):e0129308. doi: 10.1371/journal.pone.0129308. eCollection 2015.

12.

Is the age of genetic surgery finally upon us?

Kmiec EB.

Surg Oncol. 2015 Jun;24(2):95-9. doi: 10.1016/j.suronc.2015.04.002. Epub 2015 Apr 13. Review.

PMID:
25936245
13.

The position of DNA cleavage by TALENs and cell synchronization influences the frequency of gene editing directed by single-stranded oligonucleotides.

Rivera-Torres N, Strouse B, Bialk P, Niamat RA, Kmiec EB.

PLoS One. 2014 May 1;9(5):e96483. doi: 10.1371/journal.pone.0096483. eCollection 2014.

14.

Enrichment of breast cancer stem-like cells by growth on electrospun polycaprolactone-chitosan nanofiber scaffolds.

Sims-Mourtada J, Niamat RA, Samuel S, Eskridge C, Kmiec EB.

Int J Nanomedicine. 2014 Feb 19;9:995-1003. doi: 10.2147/IJN.S55720. eCollection 2014.

15.

Combinatorial gene editing in mammalian cells using ssODNs and TALENs.

Strouse B, Bialk P, Niamat RA, Rivera-Torres N, Kmiec EB.

Sci Rep. 2014 Jan 21;4:3791. doi: 10.1038/srep03791.

16.

Electrospun fiber membranes enable proliferation of genetically modified cells.

Borjigin M, Eskridge C, Niamat R, Strouse B, Bialk P, Kmiec EB.

Int J Nanomedicine. 2013;8:855-64. doi: 10.2147/IJN.S40117. Epub 2013 Feb 27.

17.

DNA damage response pathway and replication fork stress during oligonucleotide directed gene editing.

Bonner M, Strouse B, Applegate M, Livingston P, Kmiec EB.

Mol Ther Nucleic Acids. 2012 Apr 3;1:e18. doi: 10.1038/mtna.2012.9.

18.

Proliferation of genetically modified human cells on electrospun nanofiber scaffolds.

Borjigin M, Strouse B, Niamat RA, Bialk P, Eskridge C, Xie J, Kmiec EB.

Mol Ther Nucleic Acids. 2012 Dec 4;1:e59. doi: 10.1038/mtna.2012.51.

19.

Oligonucleotide delivery by nucleofection does not rescue the reduced proliferation phenotype of gene-edited cells.

Livingston P, Strouse B, Perry H, Borjigin M, Bialk P, Kmiec EB.

Nucleic Acid Ther. 2012 Dec;22(6):405-13. doi: 10.1089/nat.2012.0374. Epub 2012 Oct 16.

20.

Modifications of p53 and the DNA damage response in cells expressing mutant form of the protein huntingtin.

Illuzzi JL, Vickers CA, Kmiec EB.

J Mol Neurosci. 2011 Oct;45(2):256-68. doi: 10.1007/s12031-011-9516-4. Epub 2011 Apr 5.

PMID:
21465263
21.

Strand bias influences the mechanism of gene editing directed by single-stranded DNA oligonucleotides.

Falgowski K, Falgowski C, York-Vickers C, Kmiec EB.

Nucleic Acids Res. 2011 Jun;39(11):4783-94. doi: 10.1093/nar/gkr061. Epub 2011 Feb 22.

22.

Gene editing activity on extrachromosomal arrays in C. elegans transgenics.

Falgowski KA, Kmiec EB.

Gene. 2011 Apr 15;475(2):87-93. doi: 10.1016/j.gene.2010.12.014. Epub 2011 Jan 15.

PMID:
21241788
23.

A stable G-quartet binds to a huntingtin protein fragment containing expanded polyglutamine tracks.

Yerkes S, Vesenka J, Kmiec EB.

J Neurosci Res. 2010 Feb 1;88(2):335-45. doi: 10.1002/jnr.22210.

PMID:
19705452
24.

DNA breakage associated with targeted gene alteration directed by DNA oligonucleotides.

Bonner M, Kmiec EB.

Mutat Res. 2009 Oct 2;669(1-2):85-94. doi: 10.1016/j.mrfmmm.2009.05.004. Epub 2009 May 20.

25.

Regulation of targeted gene repair by intrinsic cellular processes.

Engstrom JU, Suzuki T, Kmiec EB.

Bioessays. 2009 Feb;31(2):159-68. doi: 10.1002/bies.200800119. Review.

PMID:
19204988
26.

DNA breakage and induction of DNA damage response proteins precede the appearance of visible mutant huntingtin aggregates.

Illuzzi J, Yerkes S, Parekh-Olmedo H, Kmiec EB.

J Neurosci Res. 2009 Feb 15;87(3):733-47. doi: 10.1002/jnr.21881.

PMID:
18831068
27.

DNA replication, cell cycle progression and the targeted gene repair reaction.

Engstrom JU, Kmiec EB.

Cell Cycle. 2008 May 15;7(10):1402-14. Epub 2008 Feb 28.

PMID:
18424915
28.

G-rich oligonucleotides alter cell cycle progression and induce apoptosis specifically in OE19 esophageal tumor cells.

Schwartz TR, Vasta CA, Bauer TL, Parekh-Olmedo H, Kmiec EB.

Oligonucleotides. 2008 Spring;18(1):51-63. doi: 10.1089/oli.2007.0109.

PMID:
18321162
29.

Genetic conversion of an SMN2 gene to SMN1: a novel approach to the treatment of spinal muscular atrophy.

DiMatteo D, Callahan S, Kmiec EB.

Exp Cell Res. 2008 Feb 15;314(4):878-86. Epub 2007 Oct 24.

PMID:
18078930
30.

Progress and prospects: targeted gene alteration (TGA).

Parekh-Olmedo H, Kmiec EB.

Gene Ther. 2007 Dec;14(24):1675-80. Epub 2007 Nov 1. Review.

PMID:
17972921
31.

Recovery of cell cycle delay following targeted gene repair by oligonucleotides.

Ferrara L, Engstrom JU, Schwartz T, Parekh-Olmedo H, Kmiec EB.

DNA Repair (Amst). 2007 Oct 1;6(10):1529-35. Epub 2007 Jun 11.

33.
34.
35.

Targeted gene repair activates Chk1 and Chk2 and stalls replication in corrected cells.

Ferrara L, Kmiec EB.

DNA Repair (Amst). 2006 Apr 8;5(4):422-31. Epub 2006 Jan 18.

PMID:
16414312
36.

A tolerance of DNA heterology in the mammalian targeted gene repair reaction.

Drury MD, Skogen MJ, Kmiec EB.

Oligonucleotides. 2005 Fall;15(3):155-71.

PMID:
16201904
37.

Gene therapy progress and prospects: targeted gene repair.

Parekh-Olmedo H, Ferrara L, Brachman E, Kmiec EB.

Gene Ther. 2005 Apr;12(8):639-46. Review.

PMID:
15815682
38.

Reaction parameters of targeted gene repair in mammalian cells.

Hu Y, Parekh-Olmedo H, Drury M, Skogen M, Kmiec EB.

Mol Biotechnol. 2005 Mar;29(3):197-210.

PMID:
15767697
39.

Gene repair in mammalian cells is stimulated by the elongation of S phase and transient stalling of replication forks.

Brachman EE, Kmiec EB.

DNA Repair (Amst). 2005 Apr 4;4(4):445-57. Epub 2005 Jan 15.

PMID:
15725625
40.
42.

Modified single-stranded oligonucleotides inhibit aggregate formation and toxicity induced by expanded polyglutamine.

Parekh-Olmedo H, Wang J, Gusella JF, Kmiec EB.

J Mol Neurosci. 2004;24(2):257-67.

PMID:
15456939
43.

Enhanced oligonucleotide-directed gene targeting in mammalian cells following treatment with DNA damaging agents.

Ferrara L, Parekh-Olmedo H, Kmiec EB.

Exp Cell Res. 2004 Oct 15;300(1):170-9.

PMID:
15383324
44.

DNA replication and transcription direct a DNA strand bias in the process of targeted gene repair in mammalian cells.

Brachman EE, Kmiec EB.

J Cell Sci. 2004 Aug 1;117(Pt 17):3867-74. Epub 2004 Jul 20.

45.
46.
47.

Gene editing of a human gene in yeast artificial chromosomes using modified single-stranded DNA and dual targeting.

van Brabant AJ, Williams JK, Parekh-Olmedo H, Kmiec EB.

Pharmacogenomics J. 2004;4(3):175-83.

PMID:
15007372
48.

Enhancement of in vivo targeted nucleotide exchange by nonspecific carrier DNA.

Maguire KK, Kmiec EB.

Methods Mol Biol. 2004;262:209-19.

PMID:
14769964
49.

The effect of hydroxyurea and trichostatin a on targeted nucleotide exchange in yeast and Mammalian cells.

Parekh-Olmedo H, Engstrom JU, Kmiec EB.

Ann N Y Acad Sci. 2003 Dec;1002:43-55.

PMID:
14751821
50.

Fluorescent detection and isolation of DNA variants using stabilized RecA-coated oligonucleotides.

Rice MC, Heckman BM, Liu Y, Kmiec EB.

Genome Res. 2004 Jan;14(1):116-25. Epub 2003 Dec 12.

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