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Items: 1 to 50 of 96

1.

CCL2/MCP-1 and CXCL12/SDF-1 blockade by L-aptamers improve pancreatic islet engraftment and survival in mouse.

Citro A, Pellegrini S, Dugnani E, Eulberg D, Klussmann S, Piemonti L.

Am J Transplant. 2019 Jul 3. doi: 10.1111/ajt.15518. [Epub ahead of print]

PMID:
31267721
2.

CXCL12 blockade preferentially regenerates lost podocytes in cortical nephrons by targeting an intrinsic podocyte-progenitor feedback mechanism.

Romoli S, Angelotti ML, Antonelli G, Kumar Vr S, Mulay SR, Desai J, Anguiano Gomez L, Thomasova D, Eulberg D, Klussmann S, Melica ME, Conte C, Lombardi D, Lasagni L, Anders HJ, Romagnani P.

Kidney Int. 2018 Dec;94(6):1111-1126. doi: 10.1016/j.kint.2018.08.013. Epub 2018 Oct 29.

3.

Nonenzymatic Polymerization into Long Linear RNA Templated by Liquid Crystal Self-Assembly.

Todisco M, Fraccia TP, Smith GP, Corno A, Bethge L, Klussmann S, Paraboschi EM, Asselta R, Colombo D, Zanchetta G, Clark NA, Bellini T.

ACS Nano. 2018 Oct 23;12(10):9750-9762. doi: 10.1021/acsnano.8b05821. Epub 2018 Oct 3.

4.

Newtonian to non-newtonian fluid transition of a model transient network.

Nava G, Yang T, Vitali V, Minzioni P, Cristiani I, Bragheri F, Osellame R, Bethge L, Klussmann S, Paraboschi EM, Asselta R, Bellini T.

Soft Matter. 2018 May 2;14(17):3288-3295. doi: 10.1039/c8sm00373d.

PMID:
29691545
5.

Effect of a calcitonin gene-related peptide-binding L-RNA aptamer on neuronal activity in the rat spinal trigeminal nucleus.

Fischer MJM, Schmidt J, Koulchitsky S, Klussmann S, Vater A, Messlinger K.

J Headache Pain. 2018 Jan 15;19(1):3. doi: 10.1186/s10194-018-0832-8.

6.

Reprint of "Dual blockade of the pro-inflammatory chemokine CCL2 and the homeostatic chemokine CXCL12 is as effective as high dose cyclophosphamide in murine proliferative lupus nephritis".

Devarapu SK, Kumar Vr S, Rupanagudi KV, Kulkarni OP, Eulberg D, Klussmann S, Anders HJ.

Clin Immunol. 2017 Dec;185:119-127. doi: 10.1016/j.clim.2017.10.011. Epub 2017 Oct 28.

PMID:
29111236
7.

Novel Tumor Pretargeting System Based on Complementary l-Configured Oligonucleotides.

Schubert M, Bergmann R, Förster C, Sihver W, Vonhoff S, Klussmann S, Bethge L, Walther M, Schlesinger J, Pietzsch J, Steinbach J, Pietzsch HJ.

Bioconjug Chem. 2017 Apr 19;28(4):1176-1188. doi: 10.1021/acs.bioconjchem.7b00045. Epub 2017 Mar 22.

PMID:
28222590
8.

A thermostable d-polymerase for mirror-image PCR.

Pech A, Achenbach J, Jahnz M, Schülzchen S, Jarosch F, Bordusa F, Klussmann S.

Nucleic Acids Res. 2017 Apr 20;45(7):3997-4005. doi: 10.1093/nar/gkx079.

9.

Liquid Crystal Ordering and Isotropic Gelation in Solutions of Four-Base-Long DNA Oligomers.

Fraccia TP, Smith GP, Bethge L, Zanchetta G, Nava G, Klussmann S, Clark NA, Bellini T.

ACS Nano. 2016 Sep 27;10(9):8508-16. doi: 10.1021/acsnano.6b03622. Epub 2016 Sep 1.

PMID:
27571250
10.

Dual blockade of the pro-inflammatory chemokine CCL2 and the homeostatic chemokine CXCL12 is as effective as high dose cyclophosphamide in murine proliferative lupus nephritis.

Devarapu SK, Kumar Vr S, Rupanagudi KV, Kulkarni OP, Eulberg D, Klussmann S, Anders HJ.

Clin Immunol. 2016 Aug;169:139-147. doi: 10.1016/j.clim.2016.07.003. Epub 2016 Jul 5.

PMID:
27392463
11.

Expanding biohybrid-mediated asymmetric catalysis into the realm of RNA.

Duchemin N, Benedetti E, Bethge L, Vonhoff S, Klussmann S, Vasseur JJ, Cossy J, Smietana M, Arseniyadis S.

Chem Commun (Camb). 2016 Jun 30;52(55):8604-7. doi: 10.1039/c6cc03540j.

PMID:
27327242
12.

Noncompetitive affinity assays of glucagon and amylin using mirror-image aptamers as affinity probes.

Yi L, Wang X, Bethge L, Klussmann S, Roper MG.

Analyst. 2016 Mar 21;141(6):1939-46. doi: 10.1039/c5an02468d.

13.

SDF-1/CXCR4/CXCR7 is pivotal for vascular smooth muscle cell proliferation and chronic allograft vasculopathy.

Thomas MN, Kalnins A, Andrassy M, Wagner A, Klussmann S, Rentsch M, Habicht A, Pratschke S, Stangl M, Bazhin AV, Meiser B, Fischereder M, Werner J, Guba M, Andrassy J.

Transpl Int. 2015 Dec;28(12):1426-35. doi: 10.1111/tri.12651. Epub 2015 Sep 1.

14.

Outwitting EF-Tu and the ribosome: translation with d-amino acids.

Achenbach J, Jahnz M, Bethge L, Paal K, Jung M, Schuster M, Albrecht R, Jarosch F, Nierhaus KH, Klussmann S.

Nucleic Acids Res. 2015 Jul 13;43(12):5687-98. doi: 10.1093/nar/gkv566. Epub 2015 May 30.

15.

Intravitreal inhibition of complement C5a reduces choroidal neovascularization in mice.

Brockmann C, Brockmann T, Dege S, Busch C, Kociok N, Vater A, Klussmann S, Strauß O, Joussen AM.

Graefes Arch Clin Exp Ophthalmol. 2015 Oct;253(10):1695-704. doi: 10.1007/s00417-015-3041-z. Epub 2015 May 16.

PMID:
25981118
16.

Spiegelmer Inhibition of MCP-1/CCR2--Potential as an Adjunct Immunosuppressive Therapy in Transplantation.

Kalnins A, Thomas MN, Andrassy M, Müller S, Wagner A, Pratschke S, Rentsch M, Klussmann S, Kauke T, Angele MK, Bazhin AV, Fischereder M, Werner J, Guba M, Andrassy J.

Scand J Immunol. 2015 Aug;82(2):102-9. doi: 10.1111/sji.12310.

17.

Structural basis for the targeting of complement anaphylatoxin C5a using a mixed L-RNA/L-DNA aptamer.

Yatime L, Maasch C, Hoehlig K, Klussmann S, Andersen GR, Vater A.

Nat Commun. 2015 Apr 22;6:6481. doi: 10.1038/ncomms7481.

18.

Crystal structure of a mirror-image L-RNA aptamer (Spiegelmer) in complex with the natural L-protein target CCL2.

Oberthür D, Achenbach J, Gabdulkhakov A, Buchner K, Maasch C, Falke S, Rehders D, Klussmann S, Betzel C.

Nat Commun. 2015 Apr 22;6:6923. doi: 10.1038/ncomms7923.

19.

Stereospecificity of oligonucleotide interactions revisited: no evidence for heterochiral hybridization and ribozyme/DNAzyme activity.

Hoehlig K, Bethge L, Klussmann S.

PLoS One. 2015 Feb 13;10(2):e0115328. doi: 10.1371/journal.pone.0115328. eCollection 2015.

20.

A novel CGRP-neutralizing Spiegelmer attenuates neurogenic plasma protein extravasation.

Hoehlig K, Johnson KW, Pryazhnikov E, Maasch C, Clemens-Smith A, Purschke WG, Vauléon S, Buchner K, Jarosch F, Khiroug L, Vater A, Klussmann S.

Br J Pharmacol. 2015 Jun;172(12):3086-98. doi: 10.1111/bph.13110. Epub 2015 Mar 27.

21.

DNA-cellulose: an economical, fully recyclable and highly effective chiral biomaterial for asymmetric catalysis.

Benedetti E, Duchemin N, Bethge L, Vonhoff S, Klussmann S, Vasseur JJ, Cossy J, Smietana M, Arseniyadis S.

Chem Commun (Camb). 2015 Apr 11;51(28):6076-9. doi: 10.1039/c4cc10190a.

PMID:
25613918
22.

Neonatal ghrelin programs development of hypothalamic feeding circuits.

Steculorum SM, Collden G, Coupe B, Croizier S, Lockie S, Andrews ZB, Jarosch F, Klussmann S, Bouret SG.

J Clin Invest. 2015 Feb;125(2):846-58. doi: 10.1172/JCI73688. Epub 2015 Jan 20.

23.

SDF-1 inhibition targets the bone marrow niche for cancer therapy.

Roccaro AM, Sacco A, Purschke WG, Moschetta M, Buchner K, Maasch C, Zboralski D, Zöllner S, Vonhoff S, Mishima Y, Maiso P, Reagan MR, Lonardi S, Ungari M, Facchetti F, Eulberg D, Kruschinski A, Vater A, Rossi G, Klussmann S, Ghobrial IM.

Cell Rep. 2014 Oct 9;9(1):118-128. doi: 10.1016/j.celrep.2014.08.042. Epub 2014 Sep 25.

24.

Turning mirror-image oligonucleotides into drugs: the evolution of Spiegelmer(®) therapeutics.

Vater A, Klussmann S.

Drug Discov Today. 2015 Jan;20(1):147-55. doi: 10.1016/j.drudis.2014.09.004. Epub 2014 Sep 16. Review.

25.

In vivo interrogation of central nervous system translatome by polyribosome fractionation.

Lou WP, Baser A, Klußmann S, Martin-Villalba A.

J Vis Exp. 2014 Apr 30;(86). doi: 10.3791/51255.

26.

Identification and characterization of a mirror-image oligonucleotide that binds and neutralizes sphingosine 1-phosphate, a central mediator of angiogenesis.

Purschke WG, Hoehlig K, Buchner K, Zboralski D, Schwoebel F, Vater A, Klussmann S.

Biochem J. 2014 Aug 15;462(1):153-62. doi: 10.1042/BJ20131422.

27.

Blockade of SDF-1 after irradiation inhibits tumor recurrences of autochthonous brain tumors in rats.

Liu SC, Alomran R, Chernikova SB, Lartey F, Stafford J, Jang T, Merchant M, Zboralski D, Zöllner S, Kruschinski A, Klussmann S, Recht L, Brown JM.

Neuro Oncol. 2014 Jan;16(1):21-8. doi: 10.1093/neuonc/not149. Epub 2013 Dec 10.

28.

DNA vs. mirror-image DNA: a universal approach to tune the absolute configuration in DNA-based asymmetric catalysis.

Wang J, Benedetti E, Bethge L, Vonhoff S, Klussmann S, Vasseur JJ, Cossy J, Smietana M, Arseniyadis S.

Angew Chem Int Ed Engl. 2013 Oct 25;52(44):11546-9. doi: 10.1002/anie.201306232. Epub 2013 Sep 12.

PMID:
24030985
29.

A novel C5a-neutralizing mirror-image (l-)aptamer prevents organ failure and improves survival in experimental sepsis.

Hoehlig K, Maasch C, Shushakova N, Buchner K, Huber-Lang M, Purschke WG, Vater A, Klussmann S.

Mol Ther. 2013 Dec;21(12):2236-46. doi: 10.1038/mt.2013.178. Epub 2013 Jul 26.

30.

A mixed mirror-image DNA/RNA aptamer inhibits glucagon and acutely improves glucose tolerance in models of type 1 and type 2 diabetes.

Vater A, Sell S, Kaczmarek P, Maasch C, Buchner K, Pruszynska-Oszmalek E, Kolodziejski P, Purschke WG, Nowak KW, Strowski MZ, Klussmann S.

J Biol Chem. 2013 Jul 19;288(29):21136-47. doi: 10.1074/jbc.M112.444414. Epub 2013 Jun 6.

31.

Bioactive lipids S1P and C1P are prometastatic factors in human rhabdomyosarcoma, and their tissue levels increase in response to radio/chemotherapy.

Schneider G, Bryndza E, Abdel-Latif A, Ratajczak J, Maj M, Tarnowski M, Klyachkin YM, Houghton P, Morris AJ, Vater A, Klussmann S, Kucia M, Ratajczak MZ.

Mol Cancer Res. 2013 Jul;11(7):793-807. doi: 10.1158/1541-7786.MCR-12-0600. Epub 2013 Apr 24.

32.

Hematopoietic stem and progenitor cell mobilization in mice and humans by a first-in-class mirror-image oligonucleotide inhibitor of CXCL12.

Vater A, Sahlmann J, Kröger N, Zöllner S, Lioznov M, Maasch C, Buchner K, Vossmeyer D, Schwoebel F, Purschke WG, Vonhoff S, Kruschinski A, Hübel K, Humphrey M, Klussmann S, Fliegert F.

Clin Pharmacol Ther. 2013 Jul;94(1):150-7. doi: 10.1038/clpt.2013.58. Epub 2013 Mar 19.

PMID:
23588307
33.

Targeting complement component 5a promotes vascular integrity and limits airway remodeling.

Khan MA, Maasch C, Vater A, Klussmann S, Morser J, Leung LL, Atkinson C, Tomlinson S, Heeger PS, Nicolls MR.

Proc Natl Acad Sci U S A. 2013 Apr 9;110(15):6061-6. doi: 10.1073/pnas.1217991110. Epub 2013 Mar 25.

34.

Propagation of chirality in mixtures of natural and enantiomeric DNA oligomers.

Rossi M, Zanchetta G, Klussmann S, Clark NA, Bellini T.

Phys Rev Lett. 2013 Mar 8;110(10):107801. Epub 2013 Mar 7.

35.

The effects of the anti-hepcidin Spiegelmer NOX-H94 on inflammation-induced anemia in cynomolgus monkeys.

Schwoebel F, van Eijk LT, Zboralski D, Sell S, Buchner K, Maasch C, Purschke WG, Humphrey M, Zöllner S, Eulberg D, Morich F, Pickkers P, Klussmann S.

Blood. 2013 Mar 21;121(12):2311-5. doi: 10.1182/blood-2012-09-456756. Epub 2013 Jan 24.

36.

Immune and inflammatory cell involvement in the pathology of idiopathic pulmonary arterial hypertension.

Savai R, Pullamsetti SS, Kolbe J, Bieniek E, Voswinckel R, Fink L, Scheed A, Ritter C, Dahal BK, Vater A, Klussmann S, Ghofrani HA, Weissmann N, Klepetko W, Banat GA, Seeger W, Grimminger F, Schermuly RT.

Am J Respir Crit Care Med. 2012 Nov 1;186(9):897-908. doi: 10.1164/rccm.201202-0335OC. Epub 2012 Sep 6.

PMID:
22955318
37.

Methods for L-ribooligonucleotide sequence determination using LCMS.

Turner JJ, Hoos JS, Vonhoff S, Klussmann S.

Nucleic Acids Res. 2011 Nov;39(21):e147. doi: 10.1093/nar/gkr776. Epub 2011 Sep 24.

38.

RNA aptamers and spiegelmers: synthesis, purification, and post-synthetic PEG conjugation.

Hoffmann S, Hoos J, Klussmann S, Vonhoff S.

Curr Protoc Nucleic Acid Chem. 2011 Sep;Chapter 4:Unit 4.46.1-30. doi: 10.1002/0471142700.nc0446s46.

PMID:
21901672
39.

Pharmacological inhibition of the chemokine CCL2 (MCP-1) diminishes liver macrophage infiltration and steatohepatitis in chronic hepatic injury.

Baeck C, Wehr A, Karlmark KR, Heymann F, Vucur M, Gassler N, Huss S, Klussmann S, Eulberg D, Luedde T, Trautwein C, Tacke F.

Gut. 2012 Mar;61(3):416-26. doi: 10.1136/gutjnl-2011-300304. Epub 2011 Aug 3.

PMID:
21813474
40.

Dual blockade of the homeostatic chemokine CXCL12 and the proinflammatory chemokine CCL2 has additive protective effects on diabetic kidney disease.

Darisipudi MN, Kulkarni OP, Sayyed SG, Ryu M, Migliorini A, Sagrinati C, Parente E, Vater A, Eulberg D, Klussmann S, Romagnani P, Anders HJ.

Am J Pathol. 2011 Jul;179(1):116-24. doi: 10.1016/j.ajpath.2011.03.004. Epub 2011 Apr 30.

41.

Ghrelin neutralization during fasting-refeeding cycle impairs the recuperation of body weight and alters hepatic energy metabolism.

Sangiao-Alvarellos S, Helmling S, Vázquez MJ, Klussmann S, Cordido F.

Mol Cell Endocrinol. 2011 Mar 30;335(2):177-88. doi: 10.1016/j.mce.2011.01.010. Epub 2011 Jan 15.

PMID:
21241769
42.

Polyetheylenimine-polyplexes of Spiegelmer NOX-A50 directed against intracellular high mobility group protein A1 (HMGA1) reduce tumor growth in vivo.

Maasch C, Vater A, Buchner K, Purschke WG, Eulberg D, Vonhoff S, Klussmann S.

J Biol Chem. 2010 Dec 17;285(51):40012-8. doi: 10.1074/jbc.M110.178533. Epub 2010 Oct 20.

43.

The hematopoietic factor granulocyte-colony stimulating factor improves outcome in experimental spinal cord injury.

Pitzer C, Klussmann S, Krüger C, Letellier E, Plaas C, Dittgen T, Kirsch F, Stieltjes B, Weber D, Laage R, Martin-Villalba A, Schneider A.

J Neurochem. 2010 May;113(4):930-42. doi: 10.1111/j.1471-4159.2010.06659.x. Epub 2010 Feb 25.

44.

CD95-ligand on peripheral myeloid cells activates Syk kinase to trigger their recruitment to the inflammatory site.

Letellier E, Kumar S, Sancho-Martinez I, Krauth S, Funke-Kaiser A, Laudenklos S, Konecki K, Klussmann S, Corsini NS, Kleber S, Drost N, Neumann A, Lévi-Strauss M, Brors B, Gretz N, Edler L, Fischer C, Hill O, Thiemann M, Biglari B, Karray S, Martin-Villalba A.

Immunity. 2010 Feb 26;32(2):240-52. doi: 10.1016/j.immuni.2010.01.011. Epub 2010 Feb 11.

45.

Progressive glomerulosclerosis in type 2 diabetes is associated with renal histone H3K9 and H3K23 acetylation, H3K4 dimethylation and phosphorylation at serine 10.

Sayyed SG, Gaikwad AB, Lichtnekert J, Kulkarni O, Eulberg D, Klussmann S, Tikoo K, Anders HJ.

Nephrol Dial Transplant. 2010 Jun;25(6):1811-7. doi: 10.1093/ndt/gfp730. Epub 2010 Jan 12.

46.

Podocytes produce homeostatic chemokine stromal cell-derived factor-1/CXCL12, which contributes to glomerulosclerosis, podocyte loss and albuminuria in a mouse model of type 2 diabetes.

Sayyed SG, Hägele H, Kulkarni OP, Endlich K, Segerer S, Eulberg D, Klussmann S, Anders HJ.

Diabetologia. 2009 Nov;52(11):2445-54. doi: 10.1007/s00125-009-1493-6. Epub 2009 Aug 26.

PMID:
19707743
47.

The death receptor CD95 activates adult neural stem cells for working memory formation and brain repair.

Corsini NS, Sancho-Martinez I, Laudenklos S, Glagow D, Kumar S, Letellier E, Koch P, Teodorczyk M, Kleber S, Klussmann S, Wiestler B, Brüstle O, Mueller W, Gieffers C, Hill O, Thiemann M, Seedorf M, Gretz N, Sprengel R, Celikel T, Martin-Villalba A.

Cell Stem Cell. 2009 Aug 7;5(2):178-90. doi: 10.1016/j.stem.2009.05.004.

48.

Radiosynthesis of new [90Y]-DOTA-based maleimide reagents suitable for the prelabeling of thiol-bearing L-oligonucleotides and peptides.

Schlesinger J, Fischer C, Koezle I, Vonhoff S, Klussmann S, Bergmann R, Pietzsch HJ, Steinbach J.

Bioconjug Chem. 2009 Jul;20(7):1340-8. doi: 10.1021/bc900095k.

PMID:
19552458
49.

Ccl2/Mcp-1 blockade reduces glomerular and interstitial macrophages but does not ameliorate renal pathology in collagen4A3-deficient mice with autosomal recessive Alport nephropathy.

Clauss S, Gross O, Kulkarni O, Avila-Ferrufino A, Radomska E, Segerer S, Eulberg D, Klussmann S, Anders HJ.

J Pathol. 2009 May;218(1):40-7. doi: 10.1002/path.2505.

PMID:
19156777
50.

Anti-Ccl2 Spiegelmer permits 75% dose reduction of cyclophosphamide to control diffuse proliferative lupus nephritis and pneumonitis in MRL-Fas(lpr) mice.

Kulkarni O, Eulberg D, Selve N, Zöllner S, Allam R, Pawar RD, Pfeiffer S, Segerer S, Klussmann S, Anders HJ.

J Pharmacol Exp Ther. 2009 Feb;328(2):371-7. doi: 10.1124/jpet.108.142711. Epub 2008 Nov 7.

PMID:
18997060

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