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Items: 1 to 50 of 116

1.

Function of the Nonconserved N-Terminal Domain of Pseudorabies Virus pUL31 in Nuclear Egress.

Klupp BG, Hellberg T, Rönfeldt S, Franzke K, Fuchs W, Mettenleiter TC.

J Virol. 2018 Jul 17;92(15). pii: e00566-18. doi: 10.1128/JVI.00566-18. Print 2018 Aug 1.

2.

Functional Relevance of the Transmembrane Domain and Cytoplasmic Tail of the Pseudorabies Virus Glycoprotein H for Membrane Fusion.

Vallbracht M, Fuchs W, Klupp BG, Mettenleiter TC.

J Virol. 2018 May 29;92(12). pii: e00376-18. doi: 10.1128/JVI.00376-18. Print 2018 Jun 15.

3.

Functional Role of N-Linked Glycosylation in Pseudorabies Virus Glycoprotein gH.

Vallbracht M, Rehwaldt S, Klupp BG, Mettenleiter TC, Fuchs W.

J Virol. 2018 Apr 13;92(9). pii: e00084-18. doi: 10.1128/JVI.00084-18. Print 2018 May 1.

4.

Structure-Function Dissection of Pseudorabies Virus Glycoprotein B Fusion Loops.

Vallbracht M, Brun D, Tassinari M, Vaney MC, Pehau-Arnaudet G, Guardado-Calvo P, Haouz A, Klupp BG, Mettenleiter TC, Rey FA, Backovic M.

J Virol. 2017 Dec 14;92(1). pii: e01203-17. doi: 10.1128/JVI.01203-17. Print 2018 Jan 1.

5.

Lysine 242 within Helix 10 of the Pseudorabies Virus Nuclear Egress Complex pUL31 Component Is Critical for Primary Envelopment of Nucleocapsids.

Rönfeldt S, Klupp BG, Franzke K, Mettenleiter TC.

J Virol. 2017 Oct 27;91(22). pii: e01182-17. doi: 10.1128/JVI.01182-17. Print 2017 Nov 15.

6.

Integrity of the Linker of Nucleoskeleton and Cytoskeleton Is Required for Efficient Herpesvirus Nuclear Egress.

Klupp BG, Hellberg T, Granzow H, Franzke K, Dominguez Gonzalez B, Goodchild RE, Mettenleiter TC.

J Virol. 2017 Sep 12;91(19). pii: e00330-17. doi: 10.1128/JVI.00330-17. Print 2017 Oct 1.

7.

Functional Relevance of the N-Terminal Domain of Pseudorabies Virus Envelope Glycoprotein H and Its Interaction with Glycoprotein L.

Vallbracht M, Rehwaldt S, Klupp BG, Mettenleiter TC, Fuchs W.

J Virol. 2017 Apr 13;91(9). pii: e00061-17. doi: 10.1128/JVI.00061-17. Print 2017 May 1.

8.

Nuclear Egress of Herpesviruses: The Prototypic Vesicular Nucleocytoplasmic Transport.

Hellberg T, Paßvogel L, Schulz KS, Klupp BG, Mettenleiter TC.

Adv Virus Res. 2016;94:81-140. doi: 10.1016/bs.aivir.2015.10.002. Epub 2016 Jan 29. Review.

PMID:
26997591
9.

Correction: Dimerization-Induced Allosteric Changes of the Oxyanion-Hole Loop Activate the Pseudorabies Virus Assemblin pUL26N, a Herpesvirus Serine Protease.

Zühlsdorf M, Werten S, Klupp BG, Palm GJ, Mettenleiter TC, Hinrichs W.

PLoS Pathog. 2016 Mar 11;12(3):e1005506. doi: 10.1371/journal.ppat.1005506. eCollection 2016 Mar. No abstract available.

10.

Crystal Structure of the Herpesvirus Nuclear Egress Complex Provides Insights into Inner Nuclear Membrane Remodeling.

Zeev-Ben-Mordehai T, Weberruß M, Lorenz M, Cheleski J, Hellberg T, Whittle C, El Omari K, Vasishtan D, Dent KC, Harlos K, Franzke K, Hagen C, Klupp BG, Antonin W, Mettenleiter TC, Grünewald K.

Cell Rep. 2015 Dec 29;13(12):2645-52. doi: 10.1016/j.celrep.2015.11.008. Epub 2015 Dec 17.

11.

Structural Basis of Vesicle Formation at the Inner Nuclear Membrane.

Hagen C, Dent KC, Zeev-Ben-Mordehai T, Grange M, Bosse JB, Whittle C, Klupp BG, Siebert CA, Vasishtan D, Bäuerlein FJ, Cheleski J, Werner S, Guttmann P, Rehbein S, Henzler K, Demmerle J, Adler B, Koszinowski U, Schermelleh L, Schneider G, Enquist LW, Plitzko JM, Mettenleiter TC, Grünewald K.

Cell. 2015 Dec 17;163(7):1692-701. doi: 10.1016/j.cell.2015.11.029.

12.

Mutations in Pseudorabies Virus Glycoproteins gB, gD, and gH Functionally Compensate for the Absence of gL.

Schröter C, Vallbracht M, Altenschmidt J, Kargoll S, Fuchs W, Klupp BG, Mettenleiter TC.

J Virol. 2015 Dec 9;90(5):2264-72. doi: 10.1128/JVI.02739-15.

13.

Comparative Mutagenesis of Pseudorabies Virus and Epstein-Barr Virus gH Identifies a Structural Determinant within Domain III of gH Required for Surface Expression and Entry Function.

Möhl BS, Schröter C, Klupp BG, Fuchs W, Mettenleiter TC, Jardetzky TS, Longnecker R.

J Virol. 2015 Dec 9;90(5):2285-93. doi: 10.1128/JVI.03032-15.

14.

Functional Characterization of Glycoprotein H Chimeras Composed of Conserved Domains of the Pseudorabies Virus and Herpes Simplex Virus 1 Homologs.

Böhm SW, Backovic M, Klupp BG, Rey FA, Mettenleiter TC, Fuchs W.

J Virol. 2015 Oct 21;90(1):421-32. doi: 10.1128/JVI.01985-15. Print 2016 Jan 1.

15.

Dimerization-Induced Allosteric Changes of the Oxyanion-Hole Loop Activate the Pseudorabies Virus Assemblin pUL26N, a Herpesvirus Serine Protease.

Zühlsdorf M, Werten S, Klupp BG, Palm GJ, Mettenleiter TC, Hinrichs W.

PLoS Pathog. 2015 Jul 10;11(7):e1005045. doi: 10.1371/journal.ppat.1005045. eCollection 2015 Jul. Erratum in: PLoS Pathog. 2016 Mar;12(3):e1005506.

16.

A replication defect of pseudorabies virus induced by targeted α-helix distortion in the syntaxin-like bundle of glycoprotein H (V275P) is corrected by an adjacent compensatory mutation (V271A).

Böhm SW, Backovic M, Klupp BG, Rey FA, Mettenleiter TC, Fuchs W.

J Gen Virol. 2015 Aug;96(8):2349-54. doi: 10.1099/vir.0.000161. Epub 2015 Apr 23.

PMID:
25908778
17.

Herpesvirus nuclear egress: Pseudorabies Virus can simultaneously induce nuclear envelope breakdown and exit the nucleus via the envelopment-deenvelopment-pathway.

Schulz KS, Klupp BG, Granzow H, Passvogel L, Mettenleiter TC.

Virus Res. 2015 Nov 2;209:76-86. doi: 10.1016/j.virusres.2015.02.001. Epub 2015 Feb 9.

PMID:
25678269
18.

A single herpesvirus protein can mediate vesicle formation in the nuclear envelope.

Lorenz M, Vollmer B, Unsay JD, Klupp BG, García-Sáez AJ, Mettenleiter TC, Antonin W.

J Biol Chem. 2015 Mar 13;290(11):6962-74. doi: 10.1074/jbc.M114.627521. Epub 2015 Jan 20.

19.

Functional characterization of nuclear trafficking signals in pseudorabies virus pUL31.

Paßvogel L, Klupp BG, Granzow H, Fuchs W, Mettenleiter TC.

J Virol. 2015 Feb;89(4):2002-12. doi: 10.1128/JVI.03143-14. Epub 2014 Dec 10.

20.

Structure-based functional analyses of domains II and III of pseudorabies virus glycoprotein H.

Böhm SW, Eckroth E, Backovic M, Klupp BG, Rey FA, Mettenleiter TC, Fuchs W.

J Virol. 2015 Jan 15;89(2):1364-76. doi: 10.1128/JVI.02765-14. Epub 2014 Nov 12.

21.

The highly conserved proline at position 438 in pseudorabies virus gH is important for regulation of membrane fusion.

Schröter C, Klupp BG, Fuchs W, Gerhard M, Backovic M, Rey FA, Mettenleiter TC.

J Virol. 2014 Nov;88(22):13064-72. doi: 10.1128/JVI.01204-14. Epub 2014 Sep 3.

22.

Identification of conserved amino acids in pUL34 which are critical for function of the pseudorabies virus nuclear egress complex.

Paßvogel L, Janke U, Klupp BG, Granzow H, Mettenleiter TC.

J Virol. 2014 Jun;88(11):6224-31. doi: 10.1128/JVI.00595-14. Epub 2014 Mar 19.

23.

Pseudorabies virus pUL46 induces activation of ERK1/2 and regulates herpesvirus-induced nuclear envelope breakdown.

Schulz KS, Liu X, Klupp BG, Granzow H, Cohen JI, Mettenleiter TC.

J Virol. 2014 Jun;88(11):6003-11. doi: 10.1128/JVI.00501-14. Epub 2014 Mar 12.

24.

Glycoproteins gB and gH are required for syncytium formation but not for herpesvirus-induced nuclear envelope breakdown.

Schulz KS, Klupp BG, Granzow H, Mettenleiter TC.

J Virol. 2013 Sep;87(17):9733-41. doi: 10.1128/JVI.01401-13. Epub 2013 Jul 3.

25.

Mapping of sequences in Pseudorabies virus pUL34 that are required for formation and function of the nuclear egress complex.

Paßvogel L, Trübe P, Schuster F, Klupp BG, Mettenleiter TC.

J Virol. 2013 Apr;87(8):4475-85. doi: 10.1128/JVI.00021-13. Epub 2013 Feb 6.

26.

The way out: what we know and do not know about herpesvirus nuclear egress.

Mettenleiter TC, Müller F, Granzow H, Klupp BG.

Cell Microbiol. 2013 Feb;15(2):170-8. doi: 10.1111/cmi.12044. Epub 2012 Nov 7. Review.

PMID:
23057731
27.

Structure-based mutational analysis of the highly conserved domain IV of glycoprotein H of pseudorabies virus.

Fuchs W, Backovic M, Klupp BG, Rey FA, Mettenleiter TC.

J Virol. 2012 Aug;86(15):8002-13. doi: 10.1128/JVI.00690-12. Epub 2012 May 23.

28.

Analysis of viral and cellular factors influencing herpesvirus-induced nuclear envelope breakdown.

Grimm KS, Klupp BG, Granzow H, Müller FM, Fuchs W, Mettenleiter TC.

J Virol. 2012 Jun;86(12):6512-21. doi: 10.1128/JVI.00068-12. Epub 2012 Apr 4.

29.

Structural determinants for nuclear envelope localization and function of pseudorabies virus pUL34.

Schuster F, Klupp BG, Granzow H, Mettenleiter TC.

J Virol. 2012 Feb;86(4):2079-88. doi: 10.1128/JVI.05484-11. Epub 2011 Dec 7. Erratum in: J Virol. 2012 Apr;86(7):4042.

30.

Pseudorabies virus in wild swine: a global perspective.

Müller T, Hahn EC, Tottewitz F, Kramer M, Klupp BG, Mettenleiter TC, Freuling C.

Arch Virol. 2011 Oct;156(10):1691-705. doi: 10.1007/s00705-011-1080-2. Epub 2011 Aug 12. Review.

PMID:
21837416
31.

Nuclear envelope breakdown can substitute for primary envelopment-mediated nuclear egress of herpesviruses.

Klupp BG, Granzow H, Mettenleiter TC.

J Virol. 2011 Aug;85(16):8285-92. doi: 10.1128/JVI.00741-11. Epub 2011 Jun 15.

32.

Structure of a core fragment of glycoprotein H from pseudorabies virus in complex with antibody.

Backovic M, DuBois RM, Cockburn JJ, Sharff AJ, Vaney MC, Granzow H, Klupp BG, Bricogne G, Mettenleiter TC, Rey FA.

Proc Natl Acad Sci U S A. 2010 Dec 28;107(52):22635-40. doi: 10.1073/pnas.1011507107. Epub 2010 Dec 13.

33.

Ultrastructural analysis of virion formation and intraaxonal transport of herpes simplex virus type 1 in primary rat neurons.

Negatsch A, Granzow H, Maresch C, Klupp BG, Fuchs W, Teifke JP, Mettenleiter TC.

J Virol. 2010 Dec;84(24):13031-5. doi: 10.1128/JVI.01784-10. Epub 2010 Oct 13.

34.

Analysis of pseudorabies and herpes simplex virus recombinants simultaneously lacking the pUL17 and pUL25 components of the C-capsid specific component.

Kuhn J, Leege T, Granzow H, Fuchs W, Mettenleiter TC, Klupp BG.

Virus Res. 2010 Oct;153(1):20-8. doi: 10.1016/j.virusres.2010.06.022. Epub 2010 Jul 13.

PMID:
20603164
35.

Random transposon-mediated mutagenesis of the essential large tegument protein pUL36 of pseudorabies virus.

Möhl BS, Böttcher S, Granzow H, Fuchs W, Klupp BG, Mettenleiter TC.

J Virol. 2010 Aug;84(16):8153-62. doi: 10.1128/JVI.00953-10. Epub 2010 Jun 9.

36.

Ultrastructural analysis of virion formation and anterograde intraaxonal transport of the alphaherpesvirus pseudorabies virus in primary neurons.

Maresch C, Granzow H, Negatsch A, Klupp BG, Fuchs W, Teifke JP, Mettenleiter TC.

J Virol. 2010 Jun;84(11):5528-39. doi: 10.1128/JVI.00067-10. Epub 2010 Mar 17.

37.

Characterization of pseudorabies virus of wild boar origin from Europe.

Müller T, Klupp BG, Freuling C, Hoffmann B, Mojcicz M, Capua I, Palfi V, Toma B, Lutz W, Ruiz-Fon F, Gortárzar C, Hlinak A, Schaarschmidt U, Zimmer K, Conraths FJ, Hahn EC, Mettenleiter TC.

Epidemiol Infect. 2010 Nov;138(11):1590-600. doi: 10.1017/S0950268810000361. Epub 2010 Mar 12.

PMID:
20223047
38.

Advanced tracing tools: functional neuronal expression of virally encoded fluorescent calcium indicator proteins.

Rothermel M, Brunert D, Klupp BG, Luebbert M, Mettenleiter TC, Hatt H.

J Neurovirol. 2009 Sep;15(5-6):458-64. doi: 10.3109/13550280903473460.

PMID:
20105103
39.

Efficient method for production of high yields of Fab fragments in Drosophila S2 cells.

Backovic M, Johansson DX, Klupp BG, Mettenleiter TC, Persson MA, Rey FA.

Protein Eng Des Sel. 2010 Apr;23(4):169-74. doi: 10.1093/protein/gzp088. Epub 2010 Jan 24.

PMID:
20100703
40.

Herpesvirus assembly: an update.

Mettenleiter TC, Klupp BG, Granzow H.

Virus Res. 2009 Aug;143(2):222-34. doi: 10.1016/j.virusres.2009.03.018. Epub 2009 Apr 7. Review.

PMID:
19651457
41.

Intracellular localization of the pseudorabies virus large tegument protein pUL36.

Möhl BS, Böttcher S, Granzow H, Kuhn J, Klupp BG, Mettenleiter TC.

J Virol. 2009 Oct;83(19):9641-51. doi: 10.1128/JVI.01045-09. Epub 2009 Jul 29.

42.

Phenotypic similarities and differences between UL37-deleted pseudorabies virus and herpes simplex virus type 1.

Leege T, Granzow H, Fuchs W, Klupp BG, Mettenleiter TC.

J Gen Virol. 2009 Jul;90(Pt 7):1560-8. doi: 10.1099/vir.0.010322-0. Epub 2009 Mar 18.

PMID:
19297610
43.

Characterization of pseudorabies virus (PrV) cleavage-encapsidation proteins and functional complementation of PrV pUL32 by the homologous protein of herpes simplex virus type 1.

Fuchs W, Klupp BG, Granzow H, Leege T, Mettenleiter TC.

J Virol. 2009 Apr;83(8):3930-43. doi: 10.1128/JVI.02636-08. Epub 2009 Feb 4.

44.

Translocation of incoming pseudorabies virus capsids to the cell nucleus is delayed in the absence of tegument protein pUL37.

Krautwald M, Fuchs W, Klupp BG, Mettenleiter TC.

J Virol. 2009 Apr;83(7):3389-96. doi: 10.1128/JVI.02090-08. Epub 2009 Jan 14.

45.

Effects of simultaneous deletion of pUL11 and glycoprotein M on virion maturation of herpes simplex virus type 1.

Leege T, Fuchs W, Granzow H, Kopp M, Klupp BG, Mettenleiter TC.

J Virol. 2009 Jan;83(2):896-907. doi: 10.1128/JVI.01842-08. Epub 2008 Nov 12.

46.

Deletion or green fluorescent protein tagging of the pUL35 capsid component of pseudorabies virus impairs virus replication in cell culture and neuroinvasion in mice.

Krautwald M, Maresch C, Klupp BG, Fuchs W, Mettenleiter TC.

J Gen Virol. 2008 Jun;89(Pt 6):1346-51. doi: 10.1099/vir.0.83652-0.

PMID:
18474549
47.

Partial functional complementation of a pseudorabies virus UL25 deletion mutant by herpes simplex virus type 1 pUL25 indicates overlapping functions of alphaherpesvirus pUL25 proteins.

Kuhn J, Leege T, Klupp BG, Granzow H, Fuchs W, Mettenleiter TC.

J Virol. 2008 Jun;82(12):5725-34. doi: 10.1128/JVI.02441-07. Epub 2008 Apr 9.

48.

Mutagenesis of the active-site cysteine in the ubiquitin-specific protease contained in large tegument protein pUL36 of pseudorabies virus impairs viral replication in vitro and neuroinvasion in vivo.

Böttcher S, Maresch C, Granzow H, Klupp BG, Teifke JP, Mettenleiter TC.

J Virol. 2008 Jun;82(12):6009-16. doi: 10.1128/JVI.00280-08. Epub 2008 Apr 9.

49.

Identification of envelope protein pORF81 of koi herpesvirus.

Rosenkranz D, Klupp BG, Teifke JP, Granzow H, Fichtner D, Mettenleiter TC, Fuchs W.

J Gen Virol. 2008 Apr;89(Pt 4):896-900. doi: 10.1099/vir.0.83565-0.

PMID:
18343829
50.

Anterograde transsynaptic tracing in the murine somatosensory system using Pseudorabies virus (PrV): a "live-cell"-tracing tool for analysis of identified neurons in vitro.

Rothermel M, Schöbel N, Damann N, Klupp BG, Mettenleiter TC, Hatt H, Wetzel CH.

J Neurovirol. 2007 Dec;13(6):579-85.

PMID:
18097889

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