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Items: 1 to 50 of 126

1.

Excision of uracil from DNA by hSMUG1 includes strand incision and processing.

Alexeeva M, Moen MN, Grøsvik K, Tesfahun AN, Xu XM, Muruzábal-Lecumberri I, Olsen KM, Rasmussen A, Ruoff P, Kirpekar F, Klungland A, Bjelland S.

Nucleic Acids Res. 2019 Jan 25;47(2):779-793. doi: 10.1093/nar/gky1184.

2.

STIM1 R304W causes muscle degeneration and impaired platelet activation in mice.

Gamage TH, Gunnes G, Lee RH, Louch WE, Holmgren A, Bruton JD, Lengle E, Kolstad TRS, Revold T, Amundsen SS, Dalen KT, Holme PA, Tjønnfjord GE, Christensen G, Westerblad H, Klungland A, Bergmeier W, Misceo D, Frengen E.

Cell Calcium. 2018 Dec;76:87-100. doi: 10.1016/j.ceca.2018.10.001. Epub 2018 Oct 5.

PMID:
30390422
3.

A transgenic minipig model of Huntington's disease shows early signs of behavioral and molecular pathologies.

Askeland G, Rodinova M, Štufková H, Dosoudilova Z, Baxa M, Smatlikova P, Bohuslavova B, Klempir J, Nguyen TD, Kuśnierczyk A, Bjørås M, Klungland A, Hansikova H, Ellederova Z, Eide L.

Dis Model Mech. 2018 Oct 24;11(10). pii: dmm035949. doi: 10.1242/dmm.035949.

4.

Differential m6A, m6Am, and m1A Demethylation Mediated by FTO in the Cell Nucleus and Cytoplasm.

Wei J, Liu F, Lu Z, Fei Q, Ai Y, He PC, Shi H, Cui X, Su R, Klungland A, Jia G, Chen J, He C.

Mol Cell. 2018 Sep 20;71(6):973-985.e5. doi: 10.1016/j.molcel.2018.08.011. Epub 2018 Sep 6.

PMID:
30197295
5.

Increased nuclear DNA damage precedes mitochondrial dysfunction in peripheral blood mononuclear cells from Huntington's disease patients.

Askeland G, Dosoudilova Z, Rodinova M, Klempir J, Liskova I, Kuśnierczyk A, Bjørås M, Nesse G, Klungland A, Hansikova H, Eide L.

Sci Rep. 2018 Jun 29;8(1):9817. doi: 10.1038/s41598-018-27985-y.

6.

RNA m6A methylation participates in regulation of postnatal development of the mouse cerebellum.

Ma C, Chang M, Lv H, Zhang ZW, Zhang W, He X, Wu G, Zhao S, Zhang Y, Wang D, Teng X, Liu C, Li Q, Klungland A, Niu Y, Song S, Tong WM.

Genome Biol. 2018 May 31;19(1):68. doi: 10.1186/s13059-018-1435-z.

7.

Ythdf2-mediated m6A mRNA clearance modulates neural development in mice.

Li M, Zhao X, Wang W, Shi H, Pan Q, Lu Z, Perez SP, Suganthan R, He C, Bjørås M, Klungland A.

Genome Biol. 2018 May 31;19(1):69. doi: 10.1186/s13059-018-1436-y.

8.

Excision of the doubly methylated base N4,5-dimethylcytosine from DNA by Escherichia coli Nei and Fpg proteins.

Alexeeva M, Guragain P, Tesfahun AN, Tomkuvienė M, Arshad A, Gerasimaitė R, Rukšėnaitė A, Urbanavičiūtė G, Bjørås M, Laerdahl JK, Klungland A, Klimašauskas S, Bjelland S.

Philos Trans R Soc Lond B Biol Sci. 2018 Jun 5;373(1748). pii: 20170337. doi: 10.1098/rstb.2017.0337.

PMID:
29685966
9.

Positioning Europe for the EPITRANSCRIPTOMICS challenge.

Jantsch MF, Quattrone A, O'Connell M, Helm M, Frye M, Macias-Gonzales M, Ohman M, Ameres S, Willems L, Fuks F, Oulas A, Vanacova S, Nielsen H, Bousquet-Antonelli C, Motorin Y, Roignant JY, Balatsos N, Dinnyes A, Baranov P, Kelly V, Lamm A, Rechavi G, Pelizzola M, Liepins J, Holodnuka Kholodnyuk I, Zammit V, Ayers D, Drablos F, Dahl JA, Bujnicki J, Jeronimo C, Almeida R, Neagu M, Costache M, Bankovic J, Banovic B, Kyselovic J, Valor LM, Selbert S, Pir P, Demircan T, Cowling V, Schäfer M, Rossmanith W, Lafontaine D, David A, Carre C, Lyko F, Schaffrath R, Schwartz S, Verdel A, Klungland A, Purta E, Timotijevic G, Cardona F, Davalos A, Ballana E, O Carroll D, Ule J, Fray R.

RNA Biol. 2018;15(6):829-831. doi: 10.1080/15476286.2018.1460996. Epub 2018 May 9.

10.

ALKBH5-dependent m6A demethylation controls splicing and stability of long 3'-UTR mRNAs in male germ cells.

Tang C, Klukovich R, Peng H, Wang Z, Yu T, Zhang Y, Zheng H, Klungland A, Yan W.

Proc Natl Acad Sci U S A. 2018 Jan 9;115(2):E325-E333. doi: 10.1073/pnas.1717794115. Epub 2017 Dec 26.

11.

Metabolism and DNA repair shape a specific modification pattern in mitochondrial DNA.

Pawar T, Bjørås M, Klungland A, Eide L.

Mitochondrion. 2018 May;40:16-28. doi: 10.1016/j.mito.2017.09.002. Epub 2017 Sep 8.

PMID:
28893634
12.

Role of the DNA repair glycosylase OGG1 in the activation of murine splenocytes.

Seifermann M, Ulges A, Bopp T, Melcea S, Schäfer A, Oka S, Nakabeppu Y, Klungland A, Niehrs C, Epe B.

DNA Repair (Amst). 2017 Oct;58:13-20. doi: 10.1016/j.dnarep.2017.08.005. Epub 2017 Aug 12.

PMID:
28843610
13.

ALKBH7 drives a tissue and sex-specific necrotic cell death response following alkylation-induced damage.

Jordan JJ, Chhim S, Margulies CM, Allocca M, Bronson RT, Klungland A, Samson LD, Fu D.

Cell Death Dis. 2017 Jul 20;8(7):e2947. doi: 10.1038/cddis.2017.343.

14.

No cancer predisposition or increased spontaneous mutation frequencies in NEIL DNA glycosylases-deficient mice.

Rolseth V, Luna L, Olsen AK, Suganthan R, Scheffler K, Neurauter CG, Esbensen Y, Kuśnierczyk A, Hildrestrand GA, Graupner A, Andersen JM, Slupphaug G, Klungland A, Nilsen H, Bjørås M.

Sci Rep. 2017 Jun 29;7(1):4384. doi: 10.1038/s41598-017-04472-4.

15.

Genome-wide profiling of DNA 5-hydroxymethylcytosine during rat Sertoli cell maturation.

Landfors M, Johansen J, Aronsen JM, Vågbø CB, Doré LC, He C, Sjaastad I, Sætrom P, Fedorcsák P, Dahl JA, Aanes H, Fußer M, Klungland A.

Cell Discov. 2017 May 9;3:17013. doi: 10.1038/celldisc.2017.13. eCollection 2017.

16.

Nucleocytoplasmic Shuttling of FTO Does Not Affect Starvation-Induced Autophagy.

Aas A, Isakson P, Bindesbøll C, Alemu EA, Klungland A, Simonsen A.

PLoS One. 2017 Mar 13;12(3):e0168182. doi: 10.1371/journal.pone.0168182. eCollection 2017.

17.

Gene expression profiles in preterm infants on continuous long‑term oxygen therapy suggest reduced oxidative stress‑dependent signaling during hypoxia.

Kalikstad B, Kultima HG, Andersstuen TK, Klungland A, Isaksson A.

Mol Med Rep. 2017 Apr;15(4):1513-1526. doi: 10.3892/mmr.2017.6185. Epub 2017 Feb 8.

18.

Corrigendum: Sumoylation of Rap1 mediates the recruitment of TFIID to promote transcription of ribosomal protein genes.

Chymkowitch P, P AN, Aanes H, Koehler CJ, Thiede B, Lorenz S, Meza-Zepeda LA, Klungland A, Enserink JM.

Genome Res. 2017 Feb;27(2):334. doi: 10.1101/gr.218370.116. No abstract available.

19.

TORC1-dependent sumoylation of Rpc82 promotes RNA polymerase III assembly and activity.

Chymkowitch P, Nguéa P A, Aanes H, Robertson J, Klungland A, Enserink JM.

Proc Natl Acad Sci U S A. 2017 Jan 31;114(5):1039-1044. doi: 10.1073/pnas.1615093114. Epub 2017 Jan 17.

20.

NEIL3-Dependent Regulation of Cardiac Fibroblast Proliferation Prevents Myocardial Rupture.

Olsen MB, Hildrestrand GA, Scheffler K, Vinge LE, Alfsnes K, Palibrk V, Wang J, Neurauter CG, Luna L, Johansen J, Øgaard JDS, Ohm IK, Slupphaug G, Kuśnierczyk A, Fiane AE, Brorson SH, Zhang L, Gullestad L, Louch WE, Iversen PO, Østlie I, Klungland A, Christensen G, Sjaastad I, Sætrom P, Yndestad A, Aukrust P, Bjørås M, Finsen AV.

Cell Rep. 2017 Jan 3;18(1):82-92. doi: 10.1016/j.celrep.2016.12.009.

21.

Reversible RNA modifications in meiosis and pluripotency.

Klungland A, Dahl JA, Greggains G, Fedorcsak P, Filipczyk A.

Nat Methods. 2016 Dec 29;14(1):18-22. doi: 10.1038/nmeth.4111.

PMID:
28032624
22.

ALKBH1-Mediated tRNA Demethylation Regulates Translation.

Liu F, Clark W, Luo G, Wang X, Fu Y, Wei J, Wang X, Hao Z, Dai Q, Zheng G, Ma H, Han D, Evans M, Klungland A, Pan T, He C.

Cell. 2016 Dec 15;167(7):1897. doi: 10.1016/j.cell.2016.11.045. No abstract available.

23.

Oxidized C5-methyl cytosine bases in DNA: 5-Hydroxymethylcytosine; 5-formylcytosine; and 5-carboxycytosine.

Klungland A, Robertson AB.

Free Radic Biol Med. 2017 Jun;107:62-68. doi: 10.1016/j.freeradbiomed.2016.11.038. Epub 2016 Nov 24. Review.

24.

Removal of aquaporin-4 from glial and ependymal membranes causes brain water accumulation.

Vindedal GF, Thoren AE, Jensen V, Klungland A, Zhang Y, Holtzman MJ, Ottersen OP, Nagelhus EA.

Mol Cell Neurosci. 2016 Dec;77:47-52. doi: 10.1016/j.mcn.2016.10.004. Epub 2016 Oct 14.

25.

ALKBH1-Mediated tRNA Demethylation Regulates Translation.

Liu F, Clark W, Luo G, Wang X, Fu Y, Wei J, Wang X, Hao Z, Dai Q, Zheng G, Ma H, Han D, Evans M, Klungland A, Pan T, He C.

Cell. 2016 Oct 20;167(3):816-828.e16. doi: 10.1016/j.cell.2016.09.038. Epub 2016 Oct 13.

26.

A ketogenic diet accelerates neurodegeneration in mice with induced mitochondrial DNA toxicity in the forebrain.

Lauritzen KH, Hasan-Olive MM, Regnell CE, Kleppa L, Scheibye-Knudsen M, Gjedde A, Klungland A, Bohr VA, Storm-Mathisen J, Bergersen LH.

Neurobiol Aging. 2016 Dec;48:34-47. doi: 10.1016/j.neurobiolaging.2016.08.005. Epub 2016 Aug 18.

27.

Broad histone H3K4me3 domains in mouse oocytes modulate maternal-to-zygotic transition.

Dahl JA, Jung I, Aanes H, Greggains GD, Manaf A, Lerdrup M, Li G, Kuan S, Li B, Lee AY, Preissl S, Jermstad I, Haugen MH, Suganthan R, Bjørås M, Hansen K, Dalen KT, Fedorcsak P, Ren B, Klungland A.

Nature. 2016 Sep 22;537(7621):548-552. doi: 10.1038/nature19360. Epub 2016 Sep 14.

28.

Effects of Anthocyanins on CAG Repeat Instability and Behaviour in Huntington's Disease R6/1 Mice.

Møllersen L, Moldestad O, Rowe AD, Bjølgerud A, Holm I, Tveterås L, Klungland A, Retterstøl L.

PLoS Curr. 2016 Jul 5;8. pii: ecurrents.hd.58d04209ab6d5de0844db7ef5628ff67. doi: 10.1371/currents.hd.58d04209ab6d5de0844db7ef5628ff67.

29.

Changes of 5-hydroxymethylcytosine distribution during myeloid and lymphoid differentiation of CD34+ cells.

Tekpli X, Urbanucci A, Hashim A, Vågbø CB, Lyle R, Kringen MK, Staff AC, Dybedal I, Mills IG, Klungland A, Staerk J.

Epigenetics Chromatin. 2016 May 31;9:21. doi: 10.1186/s13072-016-0070-8. eCollection 2016.

30.

ALKBHs-facilitated RNA modifications and de-modifications.

A Alemu E, He C, Klungland A.

DNA Repair (Amst). 2016 Aug;44:87-91. doi: 10.1016/j.dnarep.2016.05.026. Epub 2016 May 17. Review.

31.

Biochemical reconstitution of TET1-TDG-BER-dependent active DNA demethylation reveals a highly coordinated mechanism.

Weber AR, Krawczyk C, Robertson AB, Kuśnierczyk A, Vågbø CB, Schuermann D, Klungland A, Schär P.

Nat Commun. 2016 Mar 2;7:10806. doi: 10.1038/ncomms10806.

32.

DNA base modifications in honey bee and fruit fly genomes suggest an active demethylation machinery with species- and tissue-specific turnover rates.

Rasmussen EMK, Vågbø CB, Münch D, Krokan HE, Klungland A, Amdam GV, Dahl JA.

Biochem Biophys Rep. 2016 Feb 22;6:9-15. doi: 10.1016/j.bbrep.2016.02.011. eCollection 2016 Jul.

33.

Sequencing of FTO and ALKBH5 in men undergoing infertility work-up identifies an infertility-associated variant and two missense mutations.

Landfors M, Nakken S, Fusser M, Dahl JA, Klungland A, Fedorcsak P.

Fertil Steril. 2016 May;105(5):1170-1179.e5. doi: 10.1016/j.fertnstert.2016.01.002. Epub 2016 Jan 25.

34.

Role of ALKBH1 in the Core Transcriptional Network of Embryonic Stem Cells.

Ougland R, Jonson I, Moen MN, Nesse G, Asker G, Klungland A, Larsen E.

Cell Physiol Biochem. 2016;38(1):173-84. doi: 10.1159/000438619. Epub 2016 Jan 15.

35.

Synergistic Actions of Ogg1 and Mutyh DNA Glycosylases Modulate Anxiety-like Behavior in Mice.

Bjørge MD, Hildrestrand GA, Scheffler K, Suganthan R, Rolseth V, Kuśnierczyk A, Rowe AD, Vågbø CB, Vetlesen S, Eide L, Slupphaug G, Nakabeppu Y, Bredy TW, Klungland A, Bjørås M.

Cell Rep. 2015 Dec 29;13(12):2671-8. doi: 10.1016/j.celrep.2015.12.001. Epub 2015 Dec 17.

36.

Endogenous DNA Damage and Repair Enzymes: -A short summary of the scientific achievements of Tomas Lindahl, Nobel Laureate in Chemistry 2015.

Klungland A, Yang YG.

Genomics Proteomics Bioinformatics. 2016 Jun;14(3):122-125. doi: 10.1016/j.gpb.2015.11.001. Epub 2015 Dec 12.

37.

Base-excision repair and beyond --A short summary attributed to scientific achievements of Tomas Lindahl, Nobel Prize Laureate in Chemistry 2015.

Mi S, Klungland A, Yang YG.

Sci China Life Sci. 2016 Jan;59(1):89-92. doi: 10.1007/s11427-015-4983-4. Epub 2015 Dec 16. No abstract available.

PMID:
26676642
38.

Lysine Methylation of the Valosin-Containing Protein (VCP) Is Dispensable for Development and Survival of Mice.

Fusser M, Kernstock S, Aileni VK, Egge-Jacobsen W, Falnes PØ, Klungland A.

PLoS One. 2015 Nov 6;10(11):e0141472. doi: 10.1371/journal.pone.0141472. eCollection 2015.

39.

A majority of m6A residues are in the last exons, allowing the potential for 3' UTR regulation.

Ke S, Alemu EA, Mertens C, Gantman EC, Fak JJ, Mele A, Haripal B, Zucker-Scharff I, Moore MJ, Park CY, Vågbø CB, Kusśnierczyk A, Klungland A, Darnell JE Jr, Darnell RB.

Genes Dev. 2015 Oct 1;29(19):2037-53. doi: 10.1101/gad.269415.115. Epub 2015 Sep 24.

40.

Impaired dynamics and function of mitochondria caused by mtDNA toxicity leads to heart failure.

Lauritzen KH, Kleppa L, Aronsen JM, Eide L, Carlsen H, Haugen ØP, Sjaastad I, Klungland A, Rasmussen LJ, Attramadal H, Storm-Mathisen J, Bergersen LH.

Am J Physiol Heart Circ Physiol. 2015 Aug 1;309(3):H434-49. doi: 10.1152/ajpheart.00253.2014. Epub 2015 Jun 8.

41.

Non-homologous functions of the AlkB homologs.

Ougland R, Rognes T, Klungland A, Larsen E.

J Mol Cell Biol. 2015 Dec;7(6):494-504. doi: 10.1093/jmcb/mjv029. Epub 2015 May 23. Review.

PMID:
26003568
42.

Sumoylation of Rap1 mediates the recruitment of TFIID to promote transcription of ribosomal protein genes.

Chymkowitch P, Nguéa AP, Aanes H, Koehler CJ, Thiede B, Lorenz S, Meza-Zepeda LA, Klungland A, Enserink JM.

Genome Res. 2015 Jun;25(6):897-906. doi: 10.1101/gr.185793.114. Epub 2015 Mar 23. Erratum in: Genome Res. 2017 Feb;27(2):334.

43.

Endonuclease G preferentially cleaves 5-hydroxymethylcytosine-modified DNA creating a substrate for recombination.

Robertson AB, Robertson J, Fusser M, Klungland A.

Nucleic Acids Res. 2014 Dec 1;42(21):13280-93. doi: 10.1093/nar/gku1032. Epub 2014 Oct 29.

44.

Micro chromatin immunoprecipitation (μChIP) from early mammalian embryos.

Dahl JA, Klungland A.

Methods Mol Biol. 2015;1222:227-45. doi: 10.1007/978-1-4939-1594-1_17.

PMID:
25287350
45.

ALKBH4 depletion in mice leads to spermatogenic defects.

Nilsen A, Fusser M, Greggains G, Fedorcsak P, Klungland A.

PLoS One. 2014 Aug 25;9(8):e105113. doi: 10.1371/journal.pone.0105113. eCollection 2014.

46.

Dynamic RNA modifications in disease.

Klungland A, Dahl JA.

Curr Opin Genet Dev. 2014 Jun;26:47-52. doi: 10.1016/j.gde.2014.05.006. Epub 2014 Jul 5. Review.

PMID:
25005745
47.

DNA metabolism: bases of DNA repair and regulation.

Robertson AB, Dahl JA, Klungland A.

Nat Chem Biol. 2014 Jul;10(7):487-8. doi: 10.1038/nchembio.1553. No abstract available. Erratum in: Nat Chem Biol. 2014 Dec;10(12);1074.

PMID:
24937064
48.

Protozoan ALKBH8 oxygenases display both DNA repair and tRNA modification activities.

Zdżalik D, Vågbø CB, Kirpekar F, Davydova E, Puścian A, Maciejewska AM, Krokan HE, Klungland A, Tudek B, van den Born E, Falnes PØ.

PLoS One. 2014 Jun 10;9(6):e98729. doi: 10.1371/journal.pone.0098729. eCollection 2014.

49.

Oxidative stress causes DNA triplet expansion in Huntington's disease mouse embryonic stem cells.

Jonson I, Ougland R, Klungland A, Larsen E.

Stem Cell Res. 2013 Nov;11(3):1264-71. doi: 10.1016/j.scr.2013.08.010. Epub 2013 Aug 27.

50.

ALKBH4-dependent demethylation of actin regulates actomyosin dynamics.

Li MM, Nilsen A, Shi Y, Fusser M, Ding YH, Fu Y, Liu B, Niu Y, Wu YS, Huang CM, Olofsson M, Jin KX, Lv Y, Xu XZ, He C, Dong MQ, Rendtlew Danielsen JM, Klungland A, Yang YG.

Nat Commun. 2013;4:1832. doi: 10.1038/ncomms2863.

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