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Antiviral Activity, Safety, and Pharmacokinetics of Capsid Assembly Modulator NVR 3-778 in Patients with Chronic HBV Infection.

Yuen MF, Gane EJ, Kim DJ, Weilert F, Chan HLY, Lalezari J, Hwang SG, Nguyen T, Flores O, Hartman G, Liaw S, Lenz O, Kakuda TN, Talloen W, Schwabe C, Klumpp K, Brown N.

Gastroenterology. 2019 Jan 5. pii: S0016-5085(18)35438-6. doi: 10.1053/j.gastro.2018.12.023. [Epub ahead of print]


Preclinical Characterization of NVR 3-778, a First-in-Class Capsid Assembly Modulator against Hepatitis B Virus.

Lam AM, Espiritu C, Vogel R, Ren S, Lau V, Kelly M, Kuduk SD, Hartman GD, Flores OA, Klumpp K.

Antimicrob Agents Chemother. 2018 Dec 21;63(1). pii: e01734-18. doi: 10.1128/AAC.01734-18. Print 2019 Jan.


The use of biogeochemical models to evaluate mitigation of greenhouse gas emissions from managed grasslands.

Sándor R, Ehrhardt F, Brilli L, Carozzi M, Recous S, Smith P, Snow V, Soussana JF, Dorich CD, Fuchs K, Fitton N, Gongadze K, Klumpp K, Liebig M, Martin R, Merbold L, Newton PCD, Rees RM, Rolinski S, Bellocchi G.

Sci Total Environ. 2018 Nov 15;642:292-306. doi: 10.1016/j.scitotenv.2018.06.020. Epub 2018 Jun 12.


Structure-Guided Combinatorial Engineering Facilitates Affinity and Specificity Optimization of Anti-CD81 Antibodies.

Nelson B, Adams J, Kuglstatter A, Li Z, Harris SF, Liu Y, Bohini S, Ma H, Klumpp K, Gao J, Sidhu SS.

J Mol Biol. 2018 Jul 6;430(14):2139-2152. doi: 10.1016/j.jmb.2018.05.018. Epub 2018 May 17.


Greenhouse gas fluxes over managed grasslands in Central Europe.

Hörtnagl L, Barthel M, Buchmann N, Eugster W, Butterbach-Bahl K, Díaz-Pinés E, Zeeman M, Klumpp K, Kiese R, Bahn M, Hammerle A, Lu H, Ladreiter-Knauss T, Burri S, Merbold L.

Glob Chang Biol. 2018 May;24(5):1843-1872. doi: 10.1111/gcb.14079. Epub 2018 Mar 8.


Response to Editor to the comment by Schipper & Smith to our paper entitled "Continuous soil carbon storage of old permanent pastures in Amazonia".

Fontaine S, Stahl C, Klumpp K, Picon-Cochard C, Grise MM, Dezécache C, Ponchant L, Freycon V, Blanc L, Bonal D, Burban B, Soussana JF, Blanfort V, Alvarez G.

Glob Chang Biol. 2018 Mar;24(3):e732-e733. doi: 10.1111/gcb.14028. Epub 2018 Jan 15. No abstract available.


Assessing uncertainties in crop and pasture ensemble model simulations of productivity and N2 O emissions.

Ehrhardt F, Soussana JF, Bellocchi G, Grace P, McAuliffe R, Recous S, Sándor R, Smith P, Snow V, de Antoni Migliorati M, Basso B, Bhatia A, Brilli L, Doltra J, Dorich CD, Doro L, Fitton N, Giacomini SJ, Grant B, Harrison MT, Jones SK, Kirschbaum MUF, Klumpp K, Laville P, Léonard J, Liebig M, Lieffering M, Martin R, Massad RS, Meier E, Merbold L, Moore AD, Myrgiotis V, Newton P, Pattey E, Rolinski S, Sharp J, Smith WN, Wu L, Zhang Q.

Glob Chang Biol. 2018 Feb;24(2):e603-e616. doi: 10.1111/gcb.13965. Epub 2017 Nov 24.


Efficacy of NVR 3-778, Alone and In Combination With Pegylated Interferon, vs Entecavir In uPA/SCID Mice With Humanized Livers and HBV Infection.

Klumpp K, Shimada T, Allweiss L, Volz T, Lütgehetmann M, Hartman G, Flores OA, Lam AM, Dandri M.

Gastroenterology. 2018 Feb;154(3):652-662.e8. doi: 10.1053/j.gastro.2017.10.017. Epub 2017 Oct 24.


Potential and limitations of inferring ecosystem photosynthetic capacity from leaf functional traits.

Musavi T, Migliavacca M, van de Weg MJ, Kattge J, Wohlfahrt G, van Bodegom PM, Reichstein M, Bahn M, Carrara A, Domingues TF, Gavazzi M, Gianelle D, Gimeno C, Granier A, Gruening C, Havránková K, Herbst M, Hrynkiw C, Kalhori A, Kaminski T, Klumpp K, Kolari P, Longdoz B, Minerbi S, Montagnani L, Moors E, Oechel WC, Reich PB, Rohatyn S, Rossi A, Rotenberg E, Varlagin A, Wilkinson M, Wirth C, Mahecha MD.

Ecol Evol. 2016 Sep 22;6(20):7352-7366. doi: 10.1002/ece3.2479. eCollection 2016 Oct.


Hepatitis B Virus Capsid Assembly Modulators, but Not Nucleoside Analogs, Inhibit the Production of Extracellular Pregenomic RNA and Spliced RNA Variants.

Lam AM, Ren S, Espiritu C, Kelly M, Lau V, Zheng L, Hartman GD, Flores OA, Klumpp K.

Antimicrob Agents Chemother. 2017 Jul 25;61(8). pii: e00680-17. doi: 10.1128/AAC.00680-17. Print 2017 Aug.


Future productivity and phenology changes in European grasslands for different warming levels: implications for grassland management and carbon balance.

Chang J, Ciais P, Viovy N, Soussana JF, Klumpp K, Sultan B.

Carbon Balance Manag. 2017 Dec;12(1):11. doi: 10.1186/s13021-017-0079-8. Epub 2017 May 4.


Review and analysis of strengths and weaknesses of agro-ecosystem models for simulating C and N fluxes.

Brilli L, Bechini L, Bindi M, Carozzi M, Cavalli D, Conant R, Dorich CD, Doro L, Ehrhardt F, Farina R, Ferrise R, Fitton N, Francaviglia R, Grace P, Iocola I, Klumpp K, Léonard J, Martin R, Massad RS, Recous S, Seddaiu G, Sharp J, Smith P, Smith WN, Soussana JF, Bellocchi G.

Sci Total Environ. 2017 Nov 15;598:445-470. doi: 10.1016/j.scitotenv.2017.03.208. Epub 2017 Apr 25. Review.


Continuous soil carbon storage of old permanent pastures in Amazonia.

Stahl C, Fontaine S, Klumpp K, Picon-Cochard C, Grise MM, Dezécache C, Ponchant L, Freycon V, Blanc L, Bonal D, Burban B, Soussana JF, Blanfort V.

Glob Chang Biol. 2017 Aug;23(8):3382-3392. doi: 10.1111/gcb.13573. Epub 2016 Dec 14.


Reconstitution and Functional Analysis of a Full-Length Hepatitis C Virus NS5B Polymerase on a Supported Lipid Bilayer.

Cho NJ, Pham EA, Hagey RJ, Lévêque VJ, Ma H, Klumpp K, Glenn JS.

ACS Cent Sci. 2016 Jul 27;2(7):456-66. doi: 10.1021/acscentsci.6b00112. Epub 2016 Jun 13.


High-resolution crystal structure of a hepatitis B virus replication inhibitor bound to the viral core protein.

Klumpp K, Lam AM, Lukacs C, Vogel R, Ren S, Espiritu C, Baydo R, Atkins K, Abendroth J, Liao G, Efimov A, Hartman G, Flores OA.

Proc Natl Acad Sci U S A. 2015 Dec 8;112(49):15196-201. doi: 10.1073/pnas.1513803112. Epub 2015 Nov 23.


Quality Control Measures over 30 Years in a Multicenter Clinical Study: Results from the Diabetes Control and Complications Trial / Epidemiology of Diabetes Interventions and Complications (DCCT/EDIC) Study.

Lorenzi GM, Braffett BH, Arends VL, Danis RP, Diminick L, Klumpp KA, Morrison AD, Soliman EZ, Steffes MW, Cleary PA; DCCT/EDIC Research Group.

PLoS One. 2015 Nov 3;10(11):e0141286. doi: 10.1371/journal.pone.0141286. eCollection 2015.


Modeled Changes in Potential Grassland Productivity and in Grass-Fed Ruminant Livestock Density in Europe over 1961-2010.

Chang J, Viovy N, Vuichard N, Ciais P, Campioli M, Klumpp K, Martin R, Leip A, Soussana JF.

PLoS One. 2015 May 27;10(5):e0127554. doi: 10.1371/journal.pone.0127554. eCollection 2015.


Prevention of hepatitis C virus infection and spread in human liver chimeric mice by an anti-CD81 monoclonal antibody.

Ji C, Liu Y, Pamulapati C, Bohini S, Fertig G, Schraeml M, Rubas W, Brandt M, Ries S, Ma H, Klumpp K.

Hepatology. 2015 Apr;61(4):1136-44. doi: 10.1002/hep.27603. Epub 2015 Feb 10.


Reply to Magnani et al.: Linking large-scale chlorophyll fluorescence observations with cropland gross primary production.

Guanter L, Zhang Y, Jung M, Joiner J, Voigt M, Berry JA, Frankenberg C, Huete AR, Zarco-Tejada P, Lee JE, Moran MS, Ponce-Campos G, Beer C, Camps-Valls G, Buchmann N, Gianelle D, Klumpp K, Cescatti A, Baker JM, Griffis TJ.

Proc Natl Acad Sci U S A. 2014 Jun 24;111(25):E2511. No abstract available.


A novel immuno-competitive capture mass spectrometry strategy for protein-protein interaction profiling reveals that LATS kinases regulate HCV replication through NS5A phosphorylation.

Meistermann H, Gao J, Golling S, Lamerz J, Le Pogam S, Tzouros M, Sankabathula S, Gruenbaum L, Nájera I, Langen H, Klumpp K, Augustin A.

Mol Cell Proteomics. 2014 Nov;13(11):3040-8. doi: 10.1074/mcp.M113.028977. Epub 2014 Jul 20.


Global and time-resolved monitoring of crop photosynthesis with chlorophyll fluorescence.

Guanter L, Zhang Y, Jung M, Joiner J, Voigt M, Berry JA, Frankenberg C, Huete AR, Zarco-Tejada P, Lee JE, Moran MS, Ponce-Campos G, Beer C, Camps-Valls G, Buchmann N, Gianelle D, Klumpp K, Cescatti A, Baker JM, Griffis TJ.

Proc Natl Acad Sci U S A. 2014 Apr 8;111(14):E1327-33. doi: 10.1073/pnas.1320008111. Epub 2014 Mar 25.


Capsid proteins of enveloped viruses as antiviral drug targets.

Klumpp K, Crépin T.

Curr Opin Virol. 2014 Apr;5:63-71. doi: 10.1016/j.coviro.2014.02.002. Epub 2014 Mar 5. Review.


Intracellular effects of the Hepatitis C virus nucleoside polymerase inhibitor RO5855 (Mericitabine Parent) and Ribavirin in combination.

Ma H, Le Pogam S, Fletcher S, Hinojosa-Kirschenbaum F, Javanbakht H, Yan JM, Jiang WR, Inocencio N, Klumpp K, Nájera I.

Antimicrob Agents Chemother. 2014 May;58(5):2614-25. doi: 10.1128/AAC.02250-13. Epub 2014 Feb 18.


Inhibition of hepatitis C virus in chimeric mice by short synthetic hairpin RNAs: sequence analysis of surviving virus shows added selective pressure of combination therapy.

Dallas A, Ilves H, Ma H, Chin DJ, Maclachlan I, Klumpp K, Johnston BH.

J Virol. 2014 May;88(9):4647-56. doi: 10.1128/JVI.00105-14. Epub 2014 Jan 29.


Immune cell responses are not required to induce substantial hepatitis B virus antigen decline during pegylated interferon-alpha administration.

Allweiss L, Volz T, Lütgehetmann M, Giersch K, Bornscheuer T, Lohse AW, Petersen J, Ma H, Klumpp K, Fletcher SP, Dandri M.

J Hepatol. 2014 Mar;60(3):500-7. doi: 10.1016/j.jhep.2013.10.021. Epub 2013 Oct 26.


Priming effect and microbial diversity in ecosystem functioning and response to global change: a modeling approach using the SYMPHONY model.

Perveen N, Barot S, Alvarez G, Klumpp K, Martin R, Rapaport A, Herfurth D, Louault F, Fontaine S.

Glob Chang Biol. 2014 Apr;20(4):1174-90. doi: 10.1111/gcb.12493. Epub 2014 Feb 7.


In vivo emergence of a novel mutant L159F/L320F in the NS5B polymerase confers low-level resistance to the HCV polymerase inhibitors mericitabine and sofosbuvir.

Tong X, Le Pogam S, Li L, Haines K, Piso K, Baronas V, Yan JM, So SS, Klumpp K, Nájera I.

J Infect Dis. 2014 Mar 1;209(5):668-75. doi: 10.1093/infdis/jit562. Epub 2013 Oct 23.


Formulated minimal-length synthetic small hairpin RNAs are potent inhibitors of hepatitis C virus in mice with humanized livers.

Ma H, Dallas A, Ilves H, Shorenstein J, MacLachlan I, Klumpp K, Johnston BH.

Gastroenterology. 2014 Jan;146(1):63-6.e5. doi: 10.1053/j.gastro.2013.09.049. Epub 2013 Sep 27.


Successes and challenges in the antiviral field.

Shaw ML, Klumpp K.

Curr Opin Virol. 2013 Oct;3(5):483-6. doi: 10.1016/j.coviro.2013.08.015. Epub 2013 Sep 12. No abstract available.


Determination of neuraminidase kinetic constants using whole influenza virus preparations and correction for spectroscopic interference by a fluorogenic substrate.

Marathe BM, Lévêque V, Klumpp K, Webster RG, Govorkova EA.

PLoS One. 2013 Aug 15;8(8):e71401. doi: 10.1371/journal.pone.0071401. eCollection 2013.


Target-mediated drug disposition and prolonged liver accumulation of a novel humanized anti-CD81 monoclonal antibody in cynomolgus monkeys.

Vexler V, Yu L, Pamulapati C, Garrido R, Grimm HP, Sriraman P, Bohini S, Schraeml M, Singh U, Brandt M, Ries S, Ma H, Klumpp K, Ji C.

MAbs. 2013 Sep-Oct;5(5):776-86. doi: 10.4161/mabs.25642. Epub 2013 Jul 8.


Characterization of PA-N terminal domain of Influenza A polymerase reveals sequence specific RNA cleavage.

Datta K, Wolkerstorfer A, Szolar OH, Cusack S, Klumpp K.

Nucleic Acids Res. 2013 Sep;41(17):8289-99. doi: 10.1093/nar/gkt603. Epub 2013 Jul 11.


A serine palmitoyltransferase inhibitor blocks hepatitis C virus replication in human hepatocytes.

Katsume A, Tokunaga Y, Hirata Y, Munakata T, Saito M, Hayashi H, Okamoto K, Ohmori Y, Kusanagi I, Fujiwara S, Tsukuda T, Aoki Y, Klumpp K, Tsukiyama-Kohara K, El-Gohary A, Sudoh M, Kohara M.

Gastroenterology. 2013 Oct;145(4):865-73. doi: 10.1053/j.gastro.2013.06.012. Epub 2013 Jun 18.


NTP-mediated nucleotide excision activity of hepatitis C virus RNA-dependent RNA polymerase.

Jin Z, Leveque V, Ma H, Johnson KA, Klumpp K.

Proc Natl Acad Sci U S A. 2013 Jan 29;110(5):E348-57. doi: 10.1073/pnas.1214924110. Epub 2013 Jan 10.


Characterization of hepatitis C virus (HCV) quasispecies dynamics upon short-term dual therapy with the HCV NS5B nucleoside polymerase inhibitor mericitabine and the NS3/4 protease inhibitor danoprevir.

Le Pogam S, Yan JM, Chhabra M, Ilnicka M, Kang H, Kosaka A, Ali S, Chin DJ, Shulman NS, Smith P, Klumpp K, Nájera I.

Antimicrob Agents Chemother. 2012 Nov;56(11):5494-502. doi: 10.1128/AAC.01035-12. Epub 2012 Aug 6.


A randomized, double-blind placebo controlled trial of balapiravir, a polymerase inhibitor, in adult dengue patients.

Nguyen NM, Tran CN, Phung LK, Duong KT, Huynh Hle A, Farrar J, Nguyen QT, Tran HT, Nguyen CV, Merson L, Hoang LT, Hibberd ML, Aw PP, Wilm A, Nagarajan N, Nguyen DT, Pham MP, Nguyen TT, Javanbakht H, Klumpp K, Hammond J, Petric R, Wolbers M, Nguyen CT, Simmons CP.

J Infect Dis. 2013 May 1;207(9):1442-50. doi: 10.1093/infdis/jis470. Epub 2012 Jul 17.


Identification of an intrahepatic transcriptional signature associated with self-limiting infection in the woodchuck model of hepatitis B.

Fletcher SP, Chin DJ, Cheng DT, Ravindran P, Bitter H, Gruenbaum L, Cote PJ, Ma H, Klumpp K, Menne S.

Hepatology. 2013 Jan;57(1):13-22. doi: 10.1002/hep.25954.


Targeted delivery of interferon-α to hepatitis B virus-infected cells using T-cell receptor-like antibodies.

Ji C, Sastry KS, Tiefenthaler G, Cano J, Tang T, Ho ZZ, Teoh D, Bohini S, Chen A, Sankuratri S, Macary PA, Kennedy P, Ma H, Ries S, Klumpp K, Kopetzki E, Bertoletti A.

Hepatology. 2012 Dec;56(6):2027-38. doi: 10.1002/hep.25875. Epub 2012 Jul 12.


Discovery of 4'-azido-2'-deoxy-2'-C-methyl cytidine and prodrugs thereof: a potent inhibitor of Hepatitis C virus replication.

Nilsson M, Kalayanov G, Winqvist A, Pinho P, Sund C, Zhou XX, Wähling H, Belfrage AK, Pelcman M, Agback T, Benckestock K, Wikström K, Boothee M, Lindqvist A, Rydegård C, Jonckers TH, Vandyck K, Raboisson P, Lin TI, Lachau-Durand S, de Kock H, Smith DB, Martin JA, Klumpp K, Simmen K, Vrang L, Terelius Y, Samuelsson B, Rosenquist S, Johansson NG.

Bioorg Med Chem Lett. 2012 May 1;22(9):3265-8. doi: 10.1016/j.bmcl.2012.03.021. Epub 2012 Mar 16.


Transcriptomic analysis of the woodchuck model of chronic hepatitis B.

Fletcher SP, Chin DJ, Ji Y, Iniguez AL, Taillon B, Swinney DC, Ravindran P, Cheng DT, Bitter H, Lopatin U, Ma H, Klumpp K, Menne S.

Hepatology. 2012 Sep;56(3):820-30. doi: 10.1002/hep.25730. Epub 2012 Jul 12.


Assembly, purification, and pre-steady-state kinetic analysis of active RNA-dependent RNA polymerase elongation complex.

Jin Z, Leveque V, Ma H, Johnson KA, Klumpp K.

J Biol Chem. 2012 Mar 23;287(13):10674-83. doi: 10.1074/jbc.M111.325530. Epub 2012 Feb 2.


Ground-based optical measurements at European flux sites: a review of methods, instruments and current controversies.

Balzarolo M, Anderson K, Nichol C, Rossini M, Vescovo L, Arriga N, Wohlfahrt G, Calvet JC, Carrara A, Cerasoli S, Cogliati S, Daumard F, Eklundh L, Elbers JA, Evrendilek F, Handcock RN, Kaduk J, Klumpp K, Longdoz B, Matteucci G, Meroni M, Montagnani L, Ourcival JM, Sánchez-Cañete EP, Pontailler JY, Juszczak R, Scholes B, Martín MP.

Sensors (Basel). 2011;11(8):7954-81. doi: 10.3390/s11087954. Epub 2011 Aug 12. Review.


Oseltamivir in seasonal, pandemic, and avian influenza: a comprehensive review of 10-years clinical experience.

Smith JR, Rayner CR, Donner B, Wollenhaupt M, Klumpp K, Dutkowski R.

Adv Ther. 2011 Nov;28(11):927-59. doi: 10.1007/s12325-011-0072-7. Epub 2011 Nov 1. Review.


H5N1 influenza virus pathogenesis in genetically diverse mice is mediated at the level of viral load.

Boon AC, Finkelstein D, Zheng M, Liao G, Allard J, Klumpp K, Webster R, Peltz G, Webby RJ.

MBio. 2011 Sep 6;2(5). pii: e00171-11. doi: 10.1128/mBio.00171-11. Print 2011.


The hepatitis C virus NS5A inhibitor (BMS-790052) alters the subcellular localization of the NS5A non-structural viral protein.

Lee C, Ma H, Hang JQ, Leveque V, Sklan EH, Elazar M, Klumpp K, Glenn JS.

Virology. 2011 May 25;414(1):10-8. doi: 10.1016/j.virol.2011.03.026. Epub 2011 Apr 22.


Exploration of piperidine-4-yl-aminopyrimidines as HIV-1 reverse transcriptase inhibitors. N-Phenyl derivatives with broad potency against resistant mutant viruses.

Tang G, Kertesz DJ, Yang M, Lin X, Wang Z, Li W, Qiu Z, Chen J, Mei J, Chen L, Mirzadegan T, Harris SF, Villaseñor AG, Fretland J, Fitch WL, Hang JQ, Heilek G, Klumpp K.

Bioorg Med Chem Lett. 2010 Oct 15;20(20):6020-3. doi: 10.1016/j.bmcl.2010.08.068. Epub 2010 Aug 19.


Combinations of oseltamivir and peramivir for the treatment of influenza A (H1N1) virus infections in cell culture and in mice.

Smee DF, Hurst BL, Wong MH, Tarbet EB, Babu YS, Klumpp K, Morrey JD.

Antiviral Res. 2010 Oct;88(1):38-44. doi: 10.1016/j.antiviral.2010.07.003. Epub 2010 Jul 13.


Discovery of piperidin-4-yl-aminopyrimidines as HIV-1 reverse transcriptase inhibitors. N-benzyl derivatives with broad potency against resistant mutant viruses.

Kertesz DJ, Brotherton-Pleiss C, Yang M, Wang Z, Lin X, Qiu Z, Hirschfeld DR, Gleason S, Mirzadegan T, Dunten PW, Harris SF, Villaseñor AG, Hang JQ, Heilek GM, Klumpp K.

Bioorg Med Chem Lett. 2010 Jul 15;20(14):4215-8. doi: 10.1016/j.bmcl.2010.05.040. Epub 2010 May 16.


Biochemical characterization of the inhibition of the dengue virus RNA polymerase by beta-d-2'-ethynyl-7-deaza-adenosine triphosphate.

Latour DR, Jekle A, Javanbakht H, Henningsen R, Gee P, Lee I, Tran P, Ren S, Kutach AK, Harris SF, Wang SM, Lok SJ, Shaw D, Li J, Heilek G, Klumpp K, Swinney DC, Deval J.

Antiviral Res. 2010 Aug;87(2):213-22. doi: 10.1016/j.antiviral.2010.05.003. Epub 2010 May 12.


In vitro resistance development for RO-0335, a novel diphenylether nonnucleoside reverse transcriptase inhibitor.

Javanbakht H, Ptak RG, Chow E, Yan JM, Russell JD, Mankowski MK, Hogan PA, Hogg JH, Vora H, Hang JQ, Li Y, Su G, Paul A, Cammack N, Klumpp K, Heilek G.

Antiviral Res. 2010 May;86(2):212-9. doi: 10.1016/j.antiviral.2010.02.323. Epub 2010 Feb 26.


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