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Items: 1 to 50 of 153

1.

The ubiquitin-conjugating enzyme UBE2QL1 coordinates lysophagy in response to endolysosomal damage.

Koerver L, Papadopoulos C, Liu B, Kravic B, Rota G, Brecht L, Veenendaal T, Polajnar M, Bluemke A, Ehrmann M, Klumperman J, Jäättelä M, Behrends C, Meyer H.

EMBO Rep. 2019 Oct 4;20(10):e48014. doi: 10.15252/embr.201948014. Epub 2019 Aug 21.

2.

DGAT2 partially compensates for lipid-induced ER stress in human DGAT1-deficient intestinal stem cells.

van Rijn JM, van Hoesel M, de Heus C, van Vugt AHM, Klumperman J, Nieuwenhuis EES, Houwen RHJ, Middendorp S.

J Lipid Res. 2019 Oct;60(10):1787-1800. doi: 10.1194/jlr.M094201. Epub 2019 Jul 17.

PMID:
31315900
3.

The hepatic WASH complex is required for efficient plasma LDL and HDL cholesterol clearance.

Wijers M, Zanoni P, Liv N, Vos DY, Jäckstein MY, Smit M, Wilbrink S, Wolters JC, van der Veen YT, Huijkman N, Dekker D, Kloosterhuis N, van Dijk TH, Billadeau DD, Kuipers F, Klumperman J, von Eckardstein A, Kuivenhoven JA, van de Sluis B.

JCI Insight. 2019 Jun 6;4(11). pii: 126462. doi: 10.1172/jci.insight.126462. eCollection 2019 Jun 6.

4.

CORVET, CHEVI and HOPS - multisubunit tethers of the endo-lysosomal system in health and disease.

van der Beek J, Jonker C, van der Welle R, Liv N, Klumperman J.

J Cell Sci. 2019 May 15;132(10). pii: jcs189134. doi: 10.1242/jcs.189134. Review.

PMID:
31092635
5.

Visualizing the cellular route of entry of a cystine-knot peptide with Xfect transfection reagent by electron microscopy.

Gao X, De Mazière A, Iaea DB, Arthur CP, Klumperman J, Ciferri C, Hannoush RN.

Sci Rep. 2019 May 6;9(1):6907. doi: 10.1038/s41598-019-43285-5.

6.

A mouse model for SPG48 reveals a block of autophagic flux upon disruption of adaptor protein complex five.

Khundadze M, Ribaudo F, Hussain A, Rosentreter J, Nietzsche S, Thelen M, Winter D, Hoffmann B, Afzal MA, Hermann T, de Heus C, Piskor EM, Kosan C, Franzka P, von Kleist L, Stauber T, Klumperman J, Damme M, Proikas-Cezanne T, Hübner CA.

Neurobiol Dis. 2019 Jul;127:419-431. doi: 10.1016/j.nbd.2019.03.026. Epub 2019 Mar 28.

PMID:
30930081
7.

High accuracy, fiducial marker-based image registration of correlative microscopy images.

Mohammadian S, Fokkema J, Agronskaia AV, Liv N, de Heus C, van Donselaar E, Blab GA, Klumperman J, Gerritsen HC.

Sci Rep. 2019 Mar 1;9(1):3211. doi: 10.1038/s41598-019-40098-4.

8.

Changes in the Synaptic Proteome in Tauopathy and Rescue of Tau-Induced Synapse Loss by C1q Antibodies.

Dejanovic B, Huntley MA, De Mazière A, Meilandt WJ, Wu T, Srinivasan K, Jiang Z, Gandham V, Friedman BA, Ngu H, Foreman O, Carano RAD, Chih B, Klumperman J, Bakalarski C, Hanson JE, Sheng M.

Neuron. 2018 Dec 19;100(6):1322-1336.e7. doi: 10.1016/j.neuron.2018.10.014. Epub 2018 Nov 1.

PMID:
30392797
9.

Fluorescently Labelled Silica Coated Gold Nanoparticles as Fiducial Markers for Correlative Light and Electron Microscopy.

Fokkema J, Fermie J, Liv N, van den Heuvel DJ, Konings TOM, Blab GA, Meijerink A, Klumperman J, Gerritsen HC.

Sci Rep. 2018 Sep 11;8(1):13625. doi: 10.1038/s41598-018-31836-1.

10.

Transcriptional and epigenetic profiling of nutrient-deprived cells to identify novel regulators of autophagy.

Peeters JGC, Picavet LW, Coenen SGJM, Mauthe M, Vervoort SJ, Mocholi E, de Heus C, Klumperman J, Vastert SJ, Reggiori F, Coffer PJ, Mokry M, van Loosdregt J.

Autophagy. 2019 Jan;15(1):98-112. doi: 10.1080/15548627.2018.1509608. Epub 2018 Sep 11.

11.

Dynamic kinetochore size regulation promotes microtubule capture and chromosome biorientation in mitosis.

Sacristan C, Ahmad MUD, Keller J, Fermie J, Groenewold V, Tromer E, Fish A, Melero R, Carazo JM, Klumperman J, Musacchio A, Perrakis A, Kops GJ.

Nat Cell Biol. 2018 Jul;20(7):800-810. doi: 10.1038/s41556-018-0130-3. Epub 2018 Jun 18.

12.

Vps3 and Vps8 control integrin trafficking from early to recycling endosomes and regulate integrin-dependent functions.

Jonker CTH, Galmes R, Veenendaal T, Ten Brink C, van der Welle REN, Liv N, de Rooij J, Peden AA, van der Sluijs P, Margadant C, Klumperman J.

Nat Commun. 2018 Feb 23;9(1):792. doi: 10.1038/s41467-018-03226-8.

13.

Mesenchymal Stromal/stem Cell-derived Extracellular Vesicles Promote Human Cartilage Regeneration In Vitro.

Vonk LA, van Dooremalen SFJ, Liv N, Klumperman J, Coffer PJ, Saris DBF, Lorenowicz MJ.

Theranostics. 2018 Jan 1;8(4):906-920. doi: 10.7150/thno.20746. eCollection 2018.

14.

HEPES activates a MiT/TFE-dependent lysosomal-autophagic gene network in cultured cells: A call for caution.

Tol MJ, van der Lienden MJC, Gabriel TL, Hagen JJ, Scheij S, Veenendaal T, Klumperman J, Donker-Koopman WE, Verhoeven AJ, Overkleeft H, Aerts JM, Argmann CA, van Eijk M.

Autophagy. 2018;14(3):437-449. doi: 10.1080/15548627.2017.1419118. Epub 2018 Feb 17.

15.

Single organelle dynamics linked to 3D structure by correlative live-cell imaging and 3D electron microscopy.

Fermie J, Liv N, Ten Brink C, van Donselaar EG, Müller WH, Schieber NL, Schwab Y, Gerritsen HC, Klumperman J.

Traffic. 2018 May;19(5):354-369. doi: 10.1111/tra.12557. Epub 2018 Mar 25.

16.

Ultrastructural Characterization of Membrane Rearrangements Induced by Porcine Epidemic Diarrhea Virus Infection.

Zhou X, Cong Y, Veenendaal T, Klumperman J, Shi D, Mari M, Reggiori F.

Viruses. 2017 Sep 5;9(9). pii: E251. doi: 10.3390/v9090251.

17.

Improving Comprehension Efficiency of High Content Screening Data Through Interactive Visualizations.

Omta WA, Nobel J, Klumperman J, Egan DA, Spruit MR, Brinkhuis MJS.

Assay Drug Dev Technol. 2017 Aug/Sep;15(6):247-256. doi: 10.1089/adt.2017.794.

PMID:
28837357
18.

EB1 and EB3 regulate microtubule minus end organization and Golgi morphology.

Yang C, Wu J, de Heus C, Grigoriev I, Liv N, Yao Y, Smal I, Meijering E, Klumperman J, Qi RZ, Akhmanova A.

J Cell Biol. 2017 Oct 2;216(10):3179-3198. doi: 10.1083/jcb.201701024. Epub 2017 Aug 16.

19.

Discovery of Small Molecules That Induce Lysosomal Cell Death in Cancer Cell Lines Using an Image-Based Screening Platform.

Pagliero RJ, D'Astolfo DS, Lelieveld D, Pratiwi RD, Aits S, Jaattela M, Martin NI, Klumperman J, Egan DA.

Assay Drug Dev Technol. 2016 Oct;14(8):489-510. Epub 2016 Sep 22.

PMID:
27732064
20.

Molecular Pathway of Microtubule Organization at the Golgi Apparatus.

Wu J, de Heus C, Liu Q, Bouchet BP, Noordstra I, Jiang K, Hua S, Martin M, Yang C, Grigoriev I, Katrukha EA, Altelaar AFM, Hoogenraad CC, Qi RZ, Klumperman J, Akhmanova A.

Dev Cell. 2016 Oct 10;39(1):44-60. doi: 10.1016/j.devcel.2016.08.009. Epub 2016 Sep 22.

21.

HC StratoMineR: A Web-Based Tool for the Rapid Analysis of High-Content Datasets.

Omta WA, van Heesbeen RG, Pagliero RJ, van der Velden LM, Lelieveld D, Nellen M, Kramer M, Yeong M, Saeidi AM, Medema RH, Spruit M, Brinkkemper S, Klumperman J, Egan DA.

Assay Drug Dev Technol. 2016 Oct;14(8):439-452. Epub 2016 Sep 16.

PMID:
27636821
22.

Cathepsin D and its newly identified transport receptor SEZ6L2 can modulate neurite outgrowth.

Boonen M, Staudt C, Gilis F, Oorschot V, Klumperman J, Jadot M.

J Cell Sci. 2016 Feb 1;129(3):557-68. doi: 10.1242/jcs.179374. Epub 2015 Dec 23.

23.

Lysosome associated membrane proteins maintain pancreatic acinar cell homeostasis: LAMP-2 deficient mice develop pancreatitis.

Mareninova OA, Sendler M, Malla SR, Yakubov I, French SW, Tokhtaeva E, Vagin O, Oorschot V, Lüllmann-Rauch R, Blanz J, Dawson D, Klumperman J, Lerch MM, Mayerle J, Gukovsky I, Gukovskaya AS.

Cell Mol Gastroenterol Hepatol. 2015 Nov 1;1(6):678-694.

24.

Characterization of the Mammalian CORVET and HOPS Complexes and Their Modular Restructuring for Endosome Specificity.

van der Kant R, Jonker CT, Wijdeven RH, Bakker J, Janssen L, Klumperman J, Neefjes J.

J Biol Chem. 2015 Dec 18;290(51):30280-90. doi: 10.1074/jbc.M115.688440. Epub 2015 Oct 13.

25.

Vps33B is required for delivery of endocytosed cargo to lysosomes.

Galmes R, ten Brink C, Oorschot V, Veenendaal T, Jonker C, van der Sluijs P, Klumperman J.

Traffic. 2015 Dec;16(12):1288-305. doi: 10.1111/tra.12334. Epub 2015 Oct 21.

26.

An inducible mouse model for microvillus inclusion disease reveals a role for myosin Vb in apical and basolateral trafficking.

Schneeberger K, Vogel GF, Teunissen H, van Ommen DD, Begthel H, El Bouazzaoui L, van Vugt AH, Beekman JM, Klumperman J, Müller T, Janecke A, Gerner P, Huber LA, Hess MW, Clevers H, van Es JH, Nieuwenhuis EE, Middendorp S.

Proc Natl Acad Sci U S A. 2015 Oct 6;112(40):12408-13. doi: 10.1073/pnas.1516672112. Epub 2015 Sep 21.

27.

TGN exit of the cation-independent mannose 6-phosphate receptor does not require acid hydrolase binding.

van Meel E, Klumperman J.

Cell Logist. 2014 Jul 3;4(3):e954441. eCollection 2014 Jul-Sep.

28.

Lysosomal capturing of cytoplasmic injected nanoparticles by autophagy: an additional barrier to non viral gene delivery.

Remaut K, Oorschot V, Braeckmans K, Klumperman J, De Smedt SC.

J Control Release. 2014 Dec 10;195:29-36. doi: 10.1016/j.jconrel.2014.08.002. Epub 2014 Aug 11. Erratum in: J Control Release. 2015 Feb 10;199:179.

PMID:
25125327
29.

Apoptosis-linked gene-2 (ALG-2)/Sec31 interactions regulate endoplasmic reticulum (ER)-to-Golgi transport: a potential effector pathway for luminal calcium.

Helm JR, Bentley M, Thorsen KD, Wang T, Foltz L, Oorschot V, Klumperman J, Hay JC.

J Biol Chem. 2014 Aug 22;289(34):23609-28. doi: 10.1074/jbc.M114.561829. Epub 2014 Jul 8.

30.

The complex ultrastructure of the endolysosomal system.

Klumperman J, Raposo G.

Cold Spring Harb Perspect Biol. 2014 May 22;6(10):a016857. doi: 10.1101/cshperspect.a016857. Review.

31.

Loss of syntaxin 3 causes variant microvillus inclusion disease.

Wiegerinck CL, Janecke AR, Schneeberger K, Vogel GF, van Haaften-Visser DY, Escher JC, Adam R, Thöni CE, Pfaller K, Jordan AJ, Weis CA, Nijman IJ, Monroe GR, van Hasselt PM, Cutz E, Klumperman J, Clevers H, Nieuwenhuis EE, Houwen RH, van Haaften G, Hess MW, Huber LA, Stapelbroek JM, Müller T, Middendorp S.

Gastroenterology. 2014 Jul;147(1):65-68.e10. doi: 10.1053/j.gastro.2014.04.002. Epub 2014 Apr 12.

PMID:
24726755
32.

Endosomes are specialized platforms for bacterial sensing and NOD2 signalling.

Nakamura N, Lill JR, Phung Q, Jiang Z, Bakalarski C, de Mazière A, Klumperman J, Schlatter M, Delamarre L, Mellman I.

Nature. 2014 May 8;509(7499):240-4. doi: 10.1038/nature13133. Epub 2014 Mar 30.

PMID:
24695226
33.

Anti-EGFL7 antibodies enhance stress-induced endothelial cell death and anti-VEGF efficacy.

Johnson L, Huseni M, Smyczek T, Lima A, Yeung S, Cheng JH, Molina R, Kan D, De Mazière A, Klumperman J, Kasman I, Zhang Y, Dennis MS, Eastham-Anderson J, Jubb AM, Hwang O, Desai R, Schmidt M, Nannini MA, Barck KH, Carano RA, Forrest WF, Song Q, Chen DS, Naumovski L, Singh M, Ye W, Hegde PS.

J Clin Invest. 2013 Sep;123(9):3997-4009. doi: 10.1172/JCI67892. Epub 2013 Aug 15.

34.

Sunitinib and SU11652 inhibit acid sphingomyelinase, destabilize lysosomes, and inhibit multidrug resistance.

Ellegaard AM, Groth-Pedersen L, Oorschot V, Klumperman J, Kirkegaard T, Nylandsted J, Jäättelä M.

Mol Cancer Ther. 2013 Oct;12(10):2018-30. doi: 10.1158/1535-7163.MCT-13-0084. Epub 2013 Aug 6.

35.

Rasip1 regulates vertebrate vascular endothelial junction stability through Epac1-Rap1 signaling.

Wilson CW, Parker LH, Hall CJ, Smyczek T, Mak J, Crow A, Posthuma G, De Mazière A, Sagolla M, Chalouni C, Vitorino P, Roose-Girma M, Warming S, Klumperman J, Crosier PS, Ye W.

Blood. 2013 Nov 21;122(22):3678-90. doi: 10.1182/blood-2013-02-483156. Epub 2013 Jul 25.

36.

The Sec7 guanine nucleotide exchange factor GBF1 regulates membrane recruitment of BIG1 and BIG2 guanine nucleotide exchange factors to the trans-Golgi network (TGN).

Lowery J, Szul T, Styers M, Holloway Z, Oorschot V, Klumperman J, Sztul E.

J Biol Chem. 2013 Apr 19;288(16):11532-45. doi: 10.1074/jbc.M112.438481. Epub 2013 Feb 5.

37.

hVps41 and VAMP7 function in direct TGN to late endosome transport of lysosomal membrane proteins.

Pols MS, van Meel E, Oorschot V, ten Brink C, Fukuda M, Swetha MG, Mayor S, Klumperman J.

Nat Commun. 2013;4:1361. doi: 10.1038/ncomms2360.

PMID:
23322049
38.

Identification of the ubiquitin ligase Triad1 as a regulator of endosomal transport.

Hassink G, Slotman J, Oorschot V, Van Der Reijden BA, Monteferrario D, Noordermeer SM, Van Kerkhof P, Klumperman J, Strous GJ.

Biol Open. 2012 Jun 15;1(6):607-14. doi: 10.1242/bio.2012778. Epub 2012 May 9.

39.

The HOPS proteins hVps41 and hVps39 are required for homotypic and heterotypic late endosome fusion.

Pols MS, ten Brink C, Gosavi P, Oorschot V, Klumperman J.

Traffic. 2013 Feb;14(2):219-32. doi: 10.1111/tra.12027. Epub 2012 Dec 12.

40.

AP-3 and Rabip4' coordinately regulate spatial distribution of lysosomes.

Ivan V, Martinez-Sanchez E, Sima LE, Oorschot V, Klumperman J, Petrescu SM, van der Sluijs P.

PLoS One. 2012;7(10):e48142. doi: 10.1371/journal.pone.0048142. Epub 2012 Oct 29.

41.

Associations among genotype, clinical phenotype, and intracellular localization of trafficking proteins in ARC syndrome.

Smith H, Galmes R, Gogolina E, Straatman-Iwanowska A, Reay K, Banushi B, Bruce CK, Cullinane AR, Romero R, Chang R, Ackermann O, Baumann C, Cangul H, Cakmak Celik F, Aygun C, Coward R, Dionisi-Vici C, Sibbles B, Inward C, Kim CA, Klumperman J, Knisely AS, Watson SP, Gissen P.

Hum Mutat. 2012 Dec;33(12):1656-64. doi: 10.1002/humu.22155. Epub 2012 Aug 6.

42.

R-SNARE ykt6 resides in membrane-associated protease-resistant protein particles and modulates cell cycle progression when over-expressed.

Thayanidhi N, Liang Y, Hasegawa H, Nycz DC, Oorschot V, Klumperman J, Hay JC.

Biol Cell. 2012 Jul;104(7):397-417. doi: 10.1111/boc.201100048. Epub 2012 May 29.

PMID:
22443861
43.

Autophagy proteins regulate the secretory component of osteoclastic bone resorption.

DeSelm CJ, Miller BC, Zou W, Beatty WL, van Meel E, Takahata Y, Klumperman J, Tooze SA, Teitelbaum SL, Virgin HW.

Dev Cell. 2011 Nov 15;21(5):966-74. doi: 10.1016/j.devcel.2011.08.016. Epub 2011 Nov 4. Erratum in: Dev Cell. 2011 Dec 13;21(6):1179.

44.

A novel type of macrothrombocytopenia associated with a defect in α2,3-sialylation.

Jones C, Denecke J, Sträter R, Stölting T, Schunicht Y, Zeuschner D, Klumperman J, Lefeber DJ, Spelten O, Zarbock A, Kelm S, Strenge K, Haslam SM, Lühn K, Stahl D, Gentile L, Schreiter T, Hilgard P, Beck-Sickinger AG, Marquardt T, Wild MK.

Am J Pathol. 2011 Oct;179(4):1969-77. doi: 10.1016/j.ajpath.2011.06.012. Epub 2011 Aug 22.

45.

Lysosomal membrane protein composition, acidic pH and sterol content are regulated via a light-dependent pathway in metazoan cells.

Swetha MG, Sriram V, Krishnan KS, Oorschot VM, ten Brink C, Klumperman J, Mayor S.

Traffic. 2011 Aug;12(8):1037-55. doi: 10.1111/j.1600-0854.2011.01214.x. Epub 2011 May 30.

46.

Architecture of the mammalian Golgi.

Klumperman J.

Cold Spring Harb Perspect Biol. 2011 Jul 1;3(7). pii: a005181. doi: 10.1101/cshperspect.a005181. Review.

47.

Disruption of the Man-6-P targeting pathway in mice impairs osteoclast secretory lysosome biogenesis.

van Meel E, Boonen M, Zhao H, Oorschot V, Ross FP, Kornfeld S, Klumperman J.

Traffic. 2011 Jul;12(7):912-24. doi: 10.1111/j.1600-0854.2011.01203.x. Epub 2011 May 5.

48.

Vacuolization of mucolipidosis type II mouse exocrine gland cells represents accumulation of autolysosomes.

Boonen M, van Meel E, Oorschot V, Klumperman J, Kornfeld S.

Mol Biol Cell. 2011 Apr 15;22(8):1135-47. doi: 10.1091/mbc.E10-07-0584. Epub 2011 Feb 16.

49.

Spatial regulation of Golgi phosphatidylinositol-4-phosphate is required for enzyme localization and glycosylation fidelity.

Cheong FY, Sharma V, Blagoveshchenskaya A, Oorschot VM, Brankatschk B, Klumperman J, Freeze HH, Mayinger P.

Traffic. 2010 Sep;11(9):1180-90. doi: 10.1111/j.1600-0854.2010.01092.x. Epub 2010 Jun 21.

50.

Termination of autophagy and reformation of lysosomes regulated by mTOR.

Yu L, McPhee CK, Zheng L, Mardones GA, Rong Y, Peng J, Mi N, Zhao Y, Liu Z, Wan F, Hailey DW, Oorschot V, Klumperman J, Baehrecke EH, Lenardo MJ.

Nature. 2010 Jun 17;465(7300):942-6. doi: 10.1038/nature09076. Epub 2010 Jun 6.

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