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Items: 1 to 50 of 92

1.

Neurotrophin gene augmentation by electrotransfer to improve cochlear implant hearing outcomes.

Pinyon JL, von Jonquieres G, Crawford EN, Duxbury M, Al Abed A, Lovell NH, Klugmann M, Wise AK, Fallon JB, Shepherd RK, Birman CS, Lai W, McAlpine D, McMahon C, Carter PM, Enke YL, Patrick JF, Schilder AGM, Marie C, Scherman D, Housley GD.

Hear Res. 2019 Sep 1;380:137-149. doi: 10.1016/j.heares.2019.06.002. Epub 2019 Jun 21. Review.

PMID:
31301514
2.

Adeno-associated virus-based Alzheimer's disease mouse models and potential new therapeutic avenues.

Ittner LM, Klugmann M, Ke YD.

Br J Pharmacol. 2019 Sep;176(18):3649-3665. doi: 10.1111/bph.14637. Epub 2019 Apr 23. Review.

PMID:
30817847
3.

Increased Alcohol-Drinking Induced by Manipulations of mGlu5 Phosphorylation within the Bed Nucleus of the Stria Terminalis.

Campbell RR, Domingo RD, Williams AR, Wroten MG, McGregor HA, Waltermire RS, Greentree DI, Goulding SP, Thompson AB, Lee KM, Quadir SG, Jimenez Chavez CL, Coelho MA, Gould AT, von Jonquieres G, Klugmann M, Worley PF, Kippin TE, Szumlinski KK.

J Neurosci. 2019 Apr 3;39(14):2745-2761. doi: 10.1523/JNEUROSCI.1909-18.2018. Epub 2019 Feb 8.

4.

Dual-Plasmid Bionic Array-Directed Gene Electrotransfer in HEK293 Cells and Cochlear Mesenchymal Cells Probes Transgene Expression and Cell Fate.

Pinyon JL, Klugmann M, Lovell NH, Housley GD.

Hum Gene Ther. 2019 Feb;30(2):211-224. doi: 10.1089/hum.2018.062. Epub 2018 Oct 2.

PMID:
30032660
5.

Targeted overexpression of CRH receptor subtype 1 in central amygdala neurons: effect on alcohol-seeking behavior.

Broccoli L, Uhrig S, von Jonquieres G, Schönig K, Bartsch D, Justice NJ, Spanagel R, Sommer WH, Klugmann M, Hansson AC.

Psychopharmacology (Berl). 2018 Jun;235(6):1821-1833. doi: 10.1007/s00213-018-4908-6. Epub 2018 Apr 26.

PMID:
29700576
6.

Expression Pattern of the Aspartyl-tRNA Synthetase DARS in the Human Brain.

Fröhlich D, Suchowerska AK, Voss C, He R, Wolvetang E, von Jonquieres G, Simons C, Fath T, Housley GD, Klugmann M.

Front Mol Neurosci. 2018 Mar 20;11:81. doi: 10.3389/fnmol.2018.00081. eCollection 2018.

7.

Gene therapy mediated seizure suppression in Genetic Generalised Epilepsy: Neuropeptide Y overexpression in a rat model.

Powell KL, Fitzgerald X, Shallue C, Jovanovska V, Klugmann M, Von Jonquieres G, O'Brien TJ, Morris MJ.

Neurobiol Dis. 2018 May;113:23-32. doi: 10.1016/j.nbd.2018.01.016. Epub 2018 Feb 4.

PMID:
29414380
8.

Behavioral and Neurochemical Phenotyping of Mice Incapable of Homer1a Induction.

Datko MC, Hu JH, Williams M, Reyes CM, Lominac KD, von Jonquieres G, Klugmann M, Worley PF, Szumlinski KK.

Front Behav Neurosci. 2017 Nov 1;11:208. doi: 10.3389/fnbeh.2017.00208. eCollection 2017.

9.

Uncoupling N-acetylaspartate from brain pathology: implications for Canavan disease gene therapy.

von Jonquieres G, Spencer ZHT, Rowlands BD, Klugmann CB, Bongers A, Harasta AE, Parley KE, Cederholm J, Teahan O, Pickford R, Delerue F, Ittner LM, Fröhlich D, McLean CA, Don AS, Schneider M, Housley GD, Rae CD, Klugmann M.

Acta Neuropathol. 2018 Jan;135(1):95-113. doi: 10.1007/s00401-017-1784-9. Epub 2017 Nov 7.

10.

Tau exacerbates excitotoxic brain damage in an animal model of stroke.

Bi M, Gladbach A, van Eersel J, Ittner A, Przybyla M, van Hummel A, Chua SW, van der Hoven J, Lee WS, Müller J, Parmar J, Jonquieres GV, Stefen H, Guccione E, Fath T, Housley GD, Klugmann M, Ke YD, Ittner LM.

Nat Commun. 2017 Sep 7;8(1):473. doi: 10.1038/s41467-017-00618-0.

11.

Viral-mediated oligodendroglial alpha-synuclein expression models multiple system atrophy.

Bassil F, Guerin PA, Dutheil N, Li Q, Klugmann M, Meissner WG, Bezard E, Fernagut PO.

Mov Disord. 2017 Aug;32(8):1230-1239. doi: 10.1002/mds.27041. Epub 2017 May 29.

PMID:
28556404
12.

Gene therapy targeting oligodendrocytes provides therapeutic benefit in a leukodystrophy model.

Georgiou E, Sidiropoulou K, Richter J, Papaneophytou C, Sargiannidou I, Kagiava A, von Jonquieres G, Christodoulou C, Klugmann M, Kleopa KA.

Brain. 2017 Mar 1;140(3):599-616. doi: 10.1093/brain/aww351.

13.

Acetate metabolism does not reflect astrocytic activity, contributes directly to GABA synthesis, and is increased by silent information regulator 1 activation.

Rowlands BD, Klugmann M, Rae CD.

J Neurochem. 2017 Mar;140(6):903-918. doi: 10.1111/jnc.13916. Epub 2017 Jan 23.

14.

Methamphetamine Addiction Vulnerability: The Glutamate, the Bad, and the Ugly.

Szumlinski KK, Lominac KD, Campbell RR, Cohen M, Fultz EK, Brown CN, Miller BW, Quadir SG, Martin D, Thompson AB, von Jonquieres G, Klugmann M, Phillips TJ, Kippin TE.

Biol Psychiatry. 2017 Jun 1;81(11):959-970. doi: 10.1016/j.biopsych.2016.10.005. Epub 2016 Oct 13.

15.

In vivocharacterization of the aspartyl-tRNA synthetase DARS: Homing in on the leukodystrophy HBSL.

Fröhlich D, Suchowerska AK, Spencer ZH, von Jonquieres G, Klugmann CB, Bongers A, Delerue F, Stefen H, Ittner LM, Fath T, Housley GD, Klugmann M.

Neurobiol Dis. 2017 Jan;97(Pt A):24-35. doi: 10.1016/j.nbd.2016.10.008. Epub 2016 Nov 2.

16.

Recombinant Human Myelin-Associated Glycoprotein Promoter Drives Selective AAV-Mediated Transgene Expression in Oligodendrocytes.

von Jonquieres G, Fröhlich D, Klugmann CB, Wen X, Harasta AE, Ramkumar R, Spencer ZH, Housley GD, Klugmann M.

Front Mol Neurosci. 2016 Feb 23;9:13. doi: 10.3389/fnmol.2016.00013. eCollection 2016.

17.

Mapping of bionic array electric field focusing in plasmid DNA-based gene electrotransfer.

Browne CJ, Pinyon JL, Housley DM, Crawford EN, Lovell NH, Klugmann M, Housley GD.

Gene Ther. 2016 Apr;23(4):369-79. doi: 10.1038/gt.2016.8. Epub 2016 Jan 30.

18.

Homer2 within the nucleus accumbens core bidirectionally regulates alcohol intake by both P and Wistar rats.

Haider A, Woodward NC, Lominac KD, Sacramento AD, Klugmann M, Bell RL, Szumlinski KK.

Alcohol. 2015 Sep;49(6):533-42. doi: 10.1016/j.alcohol.2015.03.009. Epub 2015 Jul 21.

19.

Impaired 2-AG Signaling in Hippocampal Glutamatergic Neurons: Aggravation of Anxiety-Like Behavior and Unaltered Seizure Susceptibility.

Guggenhuber S, Romo-Parra H, Bindila L, Leschik J, Lomazzo E, Remmers F, Zimmermann T, Lerner R, Klugmann M, Pape HC, Lutz B.

Int J Neuropsychopharmacol. 2015 Aug 1;19(2). pii: pyv091. doi: 10.1093/ijnp/pyv091.

20.

Type II spiral ganglion afferent neurons drive medial olivocochlear reflex suppression of the cochlear amplifier.

Froud KE, Wong AC, Cederholm JM, Klugmann M, Sandow SL, Julien JP, Ryan AF, Housley GD.

Nat Commun. 2015 May 12;6:7115. doi: 10.1038/ncomms8115.

21.

Cannabinoid receptor-interacting protein Crip1a modulates CB1 receptor signaling in mouse hippocampus.

Guggenhuber S, Alpar A, Chen R, Schmitz N, Wickert M, Mattheus T, Harasta AE, Purrio M, Kaiser N, Elphick MR, Monory K, Kilb W, Luhmann HJ, Harkany T, Lutz B, Klugmann M.

Brain Struct Funct. 2016 May;221(4):2061-74. doi: 10.1007/s00429-015-1027-6. Epub 2015 Mar 15.

PMID:
25772509
22.

Silent information regulator 1 modulator resveratrol increases brain lactate production and inhibits mitochondrial metabolism, whereas SRT1720 increases oxidative metabolism.

Rowlands BD, Lau CL, Ryall JG, Thomas DS, Klugmann M, Beart PM, Rae CD.

J Neurosci Res. 2015 Jul;93(7):1147-56. doi: 10.1002/jnr.23570. Epub 2015 Feb 9.

PMID:
25677687
23.

Septal Glucagon-Like Peptide 1 Receptor Expression Determines Suppression of Cocaine-Induced Behavior.

Harasta AE, Power JM, von Jonquieres G, Karl T, Drucker DJ, Housley GD, Schneider M, Klugmann M.

Neuropsychopharmacology. 2015 Jul;40(8):1969-78. doi: 10.1038/npp.2015.47. Epub 2015 Feb 11.

24.

An Immunological Approach to Increase the Brain's Resilience to Insults.

Lin EJ, Symes CW, Townsend-Nicholson A, Klugmann M, Klugmann CB, Lehnert K, Fong D, Young D, During MJ.

ISRN Neurosci. 2014 Apr 24;2014:103213. doi: 10.1155/2014/103213. eCollection 2014.

25.

Loss of central auditory processing in a mouse model of Canavan disease.

von Jonquieres G, Froud KE, Klugmann CB, Wong AC, Housley GD, Klugmann M.

PLoS One. 2014 May 14;9(5):e97374. doi: 10.1371/journal.pone.0097374. eCollection 2014.

26.

Close-field electroporation gene delivery using the cochlear implant electrode array enhances the bionic ear.

Pinyon JL, Tadros SF, Froud KE, Y Wong AC, Tompson IT, Crawford EN, Ko M, Morris R, Klugmann M, Housley GD.

Sci Transl Med. 2014 Apr 23;6(233):233ra54. doi: 10.1126/scitranslmed.3008177.

27.

Cocaine-elicited imbalances in ventromedial prefrontal cortex Homer1 versus Homer2 expression: implications for relapse.

Gould AT, Sacramento AD, Wroten MG, Miller BW, von Jonquieres G, Klugmann M, Ben-Shahar O, Szumlinski KK.

Addict Biol. 2015 Jan;20(1):148-57. doi: 10.1111/adb.12088. Epub 2013 Sep 30.

28.

KIBRA (KIdney/BRAin protein) regulates learning and memory and stabilizes Protein kinase Mζ.

Vogt-Eisele A, Krüger C, Duning K, Weber D, Spoelgen R, Pitzer C, Plaas C, Eisenhardt G, Meyer A, Vogt G, Krieger M, Handwerker E, Wennmann DO, Weide T, Skryabin BV, Klugmann M, Pavenstädt H, Huentelmann MJ, Kremerskothen J, Schneider A.

J Neurochem. 2014 Mar;128(5):686-700. doi: 10.1111/jnc.12480. Epub 2013 Oct 28.

29.

Binge alcohol drinking by mice requires intact group 1 metabotropic glutamate receptor signaling within the central nucleus of the amygdala.

Cozzoli DK, Courson J, Wroten MG, Greentree DI, Lum EN, Campbell RR, Thompson AB, Maliniak D, Worley PF, Jonquieres G, Klugmann M, Finn DA, Szumlinski KK.

Neuropsychopharmacology. 2014 Jan;39(2):435-44. doi: 10.1038/npp.2013.214. Epub 2013 Aug 21.

30.

Neurotransmitter-triggered transfer of exosomes mediates oligodendrocyte-neuron communication.

Frühbeis C, Fröhlich D, Kuo WP, Amphornrat J, Thilemann S, Saab AS, Kirchhoff F, Möbius W, Goebbels S, Nave KA, Schneider A, Simons M, Klugmann M, Trotter J, Krämer-Albers EM.

PLoS Biol. 2013 Jul;11(7):e1001604. doi: 10.1371/journal.pbio.1001604. Epub 2013 Jul 9.

31.

Glial promoter selectivity following AAV-delivery to the immature brain.

von Jonquieres G, Mersmann N, Klugmann CB, Harasta AE, Lutz B, Teahan O, Housley GD, Fröhlich D, Krämer-Albers EM, Klugmann M.

PLoS One. 2013 Jun 14;8(6):e65646. doi: 10.1371/journal.pone.0065646. Print 2013.

32.

Homers at the Interface between Reward and Pain.

Obara I, Goulding SP, Gould AT, Lominac KD, Hu JH, Zhang PW, von Jonquieres G, Dehoff M, Xiao B, Seeburg PH, Worley PF, Klugmann M, Szumlinski KK.

Front Psychiatry. 2013 Jun 7;4:39. doi: 10.3389/fpsyt.2013.00039. eCollection 2013.

33.

Nerve injury-induced changes in Homer/glutamate receptor signaling contribute to the development and maintenance of neuropathic pain.

Obara I, Goulding SP, Hu JH, Klugmann M, Worley PF, Szumlinski KK.

Pain. 2013 Oct;154(10):1932-45. doi: 10.1016/j.pain.2013.03.035. Epub 2013 Apr 2.

34.

Imbalances in prefrontal cortex CC-Homer1 versus CC-Homer2 expression promote cocaine preference.

Ary AW, Lominac KD, Wroten MG, Williams AR, Campbell RR, Ben-Shahar O, von Jonquieres G, Klugmann M, Szumlinski KK.

J Neurosci. 2013 May 8;33(19):8101-13. doi: 10.1523/JNEUROSCI.1727-12.2013.

35.

A single gene defect causing claustrophobia.

El-Kordi A, Kästner A, Grube S, Klugmann M, Begemann M, Sperling S, Hammerschmidt K, Hammer C, Stepniak B, Patzig J, de Monasterio-Schrader P, Strenzke N, Flügge G, Werner HB, Pawlak R, Nave KA, Ehrenreich H.

Transl Psychiatry. 2013 Apr 30;3:e254. doi: 10.1038/tp.2013.28.

36.

GluA1 and its PDZ-interaction: a role in experience-dependent behavioral plasticity in the forced swim test.

Freudenberg F, Marx V, Mack V, Layer LE, Klugmann M, Seeburg PH, Sprengel R, Celikel T.

Neurobiol Dis. 2013 Apr;52:160-7. doi: 10.1016/j.nbd.2012.12.003. Epub 2012 Dec 20.

PMID:
23262314
37.

The hematopoietic cytokine granulocyte-macrophage colony stimulating factor is important for cognitive functions.

Krieger M, Both M, Kranig SA, Pitzer C, Klugmann M, Vogt G, Draguhn A, Schneider A.

Sci Rep. 2012;2:697. Epub 2012 Sep 26.

38.

Alternative splicing of the TRPC3 ion channel calmodulin/IP3 receptor-binding domain in the hindbrain enhances cation flux.

Kim Y, Wong AC, Power JM, Tadros SF, Klugmann M, Moorhouse AJ, Bertrand PP, Housley GD.

J Neurosci. 2012 Aug 15;32(33):11414-23. doi: 10.1523/JNEUROSCI.6446-11.2012.

39.

Hypothalamic CB1 cannabinoid receptors regulate energy balance in mice.

Cardinal P, Bellocchio L, Clark S, Cannich A, Klugmann M, Lutz B, Marsicano G, Cota D.

Endocrinology. 2012 Sep;153(9):4136-43. doi: 10.1210/en.2012-1405. Epub 2012 Jul 9.

PMID:
22778221
40.

Volatile meets versatile: does isoflurane strike a new path to neuroprotection?

Klugmann M.

Crit Care Med. 2012 Jun;40(6):1992-3. doi: 10.1097/CCM.0b013e31824c9034. No abstract available.

PMID:
22610220
41.

Nucleus accumbens mGluR5-associated signaling regulates binge alcohol drinking under drinking-in-the-dark procedures.

Cozzoli DK, Courson J, Caruana AL, Miller BW, Greentree DI, Thompson AB, Wroten MG, Zhang PW, Xiao B, Hu JH, Klugmann M, Metten P, Worley PF, Crabbe JC, Szumlinski KK.

Alcohol Clin Exp Res. 2012 Sep;36(9):1623-33. doi: 10.1111/j.1530-0277.2012.01776.x. Epub 2012 Mar 20.

42.

Mitochondrial CB₁ receptors regulate neuronal energy metabolism.

Bénard G, Massa F, Puente N, Lourenço J, Bellocchio L, Soria-Gómez E, Matias I, Delamarre A, Metna-Laurent M, Cannich A, Hebert-Chatelain E, Mulle C, Ortega-Gutiérrez S, Martín-Fontecha M, Klugmann M, Guggenhuber S, Lutz B, Gertsch J, Chaouloff F, López-Rodríguez ML, Grandes P, Rossignol R, Marsicano G.

Nat Neurosci. 2012 Mar 4;15(4):558-64. doi: 10.1038/nn.3053.

PMID:
22388959
43.

Production and titering of recombinant adeno-associated viral vectors.

McClure C, Cole KL, Wulff P, Klugmann M, Murray AJ.

J Vis Exp. 2011 Nov 27;(57):e3348. doi: 10.3791/3348.

44.

Optogenetic release of ACh induces rhythmic bursts of perisomatic IPSCs in hippocampus.

Nagode DA, Tang AH, Karson MA, Klugmann M, Alger BE.

PLoS One. 2011;6(11):e27691. doi: 10.1371/journal.pone.0027691. Epub 2011 Nov 16.

45.

Nerve terminal nicotinic acetylcholine receptors initiate quantal GABA release from perisomatic interneurons by activating axonal T-type (Cav3) Ca²⁺ channels and Ca²⁺ release from stores.

Tang AH, Karson MA, Nagode DA, McIntosh JM, Uebele VN, Renger JJ, Klugmann M, Milner TA, Alger BE.

J Neurosci. 2011 Sep 21;31(38):13546-61. doi: 10.1523/JNEUROSCI.2781-11.2011.

46.

AAV-Mediated Overexpression of the CB1 Receptor in the mPFC of Adult Rats Alters Cognitive Flexibility, Social Behavior, and Emotional Reactivity.

Klugmann M, Goepfrich A, Friemel CM, Schneider M.

Front Behav Neurosci. 2011 Jul 13;5:37. doi: 10.3389/fnbeh.2011.00037. eCollection 2011.

47.

Aspartoacylase-lacZ knockin mice: an engineered model of Canavan disease.

Mersmann N, Tkachev D, Jelinek R, Röth PT, Möbius W, Ruhwedel T, Rühle S, Weber-Fahr W, Sartorius A, Klugmann M.

PLoS One. 2011;6(5):e20336. doi: 10.1371/journal.pone.0020336. Epub 2011 May 20.

48.

Cannabinoid exposure in pubertal rats increases spontaneous ethanol consumption and NMDA receptor associated protein levels.

Klugmann M, Klippenstein V, Leweke FM, Spanagel R, Schneider M.

Int J Neuropsychopharmacol. 2011 May;14(4):505-17. doi: 10.1017/S1461145710001562. Epub 2011 Jan 7. Erratum in: Int J Neuropsychopharmacol. 2011 May;14(4):519.

PMID:
21211107
49.

AAV vector-mediated overexpression of CB1 cannabinoid receptor in pyramidal neurons of the hippocampus protects against seizure-induced excitoxicity.

Guggenhuber S, Monory K, Lutz B, Klugmann M.

PLoS One. 2010 Dec 21;5(12):e15707. doi: 10.1371/journal.pone.0015707.

50.

CNS-targeted viral delivery of G-CSF in an animal model for ALS: improved efficacy and preservation of the neuromuscular unit.

Henriques A, Pitzer C, Dittgen T, Klugmann M, Dupuis L, Schneider A.

Mol Ther. 2011 Feb;19(2):284-92. doi: 10.1038/mt.2010.271. Epub 2010 Dec 7.

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