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Grina/TMBIM3 modulates voltage-gated CaV2.2 Ca2+ channels in a G-protein-like manner.

Mallmann RT, Moravcikova L, Ondacova K, Lacinova L, Klugbauer N.

Cell Calcium. 2019 Jun;80:71-78. doi: 10.1016/j.ceca.2019.04.002. Epub 2019 Apr 8.


Correction to: Four novel interaction partners demonstrate diverse modulatory effects on voltage-gated CaV2.2 Ca2+ channels.

Mallmann R, Ondacova K, Moravcikova L, Jurkovicova-Tarabova B, Pavlovicova M, Moravcik R, Lichvarova L, Kominkova V, Klugbauer N, Lacinova L.

Pflugers Arch. 2019 Jun;471(6):875. doi: 10.1007/s00424-019-02265-4.


Four novel interaction partners demonstrate diverse modulatory effects on voltage-gated CaV2.2 Ca2+ channels.

Mallmann R, Ondacova K, Moravcikova L, Jurkovicova-Tarabova B, Pavlovicova M, Moravcik R, Lichvarova L, Kominkova V, Klugbauer N, Lacinova L.

Pflugers Arch. 2019 Jun;471(6):861-874. doi: 10.1007/s00424-018-02248-x. Epub 2019 Jan 5. Erratum in: Pflugers Arch. 2019 Feb 22;:.


Antidepressants Rescue Stress-Induced Disruption of Synaptic Plasticity via Serotonin Transporter-Independent Inhibition of L-Type Calcium Channels.

Normann C, Frase S, Haug V, von Wolff G, Clark K, Münzer P, Dorner A, Scholliers J, Horn M, Vo Van T, Seifert G, Serchov T, Biber K, Nissen C, Klugbauer N, Bischofberger J.

Biol Psychiatry. 2018 Jul 1;84(1):55-64. doi: 10.1016/j.biopsych.2017.10.008. Epub 2017 Oct 19.


The two-pore channel TPC1 is required for efficient protein processing through early and recycling endosomes.

Castonguay J, Orth JHC, Müller T, Sleman F, Grimm C, Wahl-Schott C, Biel M, Mallmann RT, Bildl W, Schulte U, Klugbauer N.

Sci Rep. 2017 Aug 30;7(1):10038. doi: 10.1038/s41598-017-10607-4.


New clues on Sidt2 being a cation conducting protein in lysosomal membranes.

Klugbauer N.

FEBS Lett. 2017 Jan;591(1):3-4. doi: 10.1002/1873-3468.12541. Epub 2017 Jan 8. No abstract available.


Ebola virus. Two-pore channels control Ebola virus host cell entry and are drug targets for disease treatment.

Sakurai Y, Kolokoltsov AA, Chen CC, Tidwell MW, Bauta WE, Klugbauer N, Grimm C, Wahl-Schott C, Biel M, Davey RA.

Science. 2015 Feb 27;347(6225):995-8. doi: 10.1126/science.1258758.


High susceptibility to fatty liver disease in two-pore channel 2-deficient mice.

Grimm C, Holdt LM, Chen CC, Hassan S, Müller C, Jörs S, Cuny H, Kissing S, Schröder B, Butz E, Northoff B, Castonguay J, Luber CA, Moser M, Spahn S, Lüllmann-Rauch R, Fendel C, Klugbauer N, Griesbeck O, Haas A, Mann M, Bracher F, Teupser D, Saftig P, Biel M, Wahl-Schott C.

Nat Commun. 2014 Aug 21;5:4699. doi: 10.1038/ncomms5699.


NAADP and the two-pore channel protein 1 participate in the acrosome reaction in mammalian spermatozoa.

Arndt L, Castonguay J, Arlt E, Meyer D, Hassan S, Borth H, Zierler S, Wennemuth G, Breit A, Biel M, Wahl-Schott C, Gudermann T, Klugbauer N, Boekhoff I.

Mol Biol Cell. 2014 Mar;25(6):948-64. doi: 10.1091/mbc.E13-09-0523. Epub 2014 Jan 22.


Ablation of Ca(V)2.1 voltage-gated Ca²⁺ channels in mouse forebrain generates multiple cognitive impairments.

Mallmann RT, Elgueta C, Sleman F, Castonguay J, Wilmes T, van den Maagdenberg A, Klugbauer N.

PLoS One. 2013 Oct 31;8(10):e78598. doi: 10.1371/journal.pone.0078598. eCollection 2013. Erratum in: PLoS One. 2013;8(12). doi:10.1371/annotation/d8de7f3c-6be2-44b6-b835-3cfd1518d7f5.


Tetraspanin-13 modulates voltage-gated CaV2.2 Ca2+ channels.

Mallmann RT, Wilmes T, Lichvarova L, Bührer A, Lohmüller B, Castonguay J, Lacinova L, Klugbauer N.

Sci Rep. 2013;3:1777. doi: 10.1038/srep01777.


Lavender oil-potent anxiolytic properties via modulating voltage dependent calcium channels.

Schuwald AM, Nöldner M, Wilmes T, Klugbauer N, Leuner K, Müller WE.

PLoS One. 2013 Apr 29;8(4):e59998. doi: 10.1371/journal.pone.0059998. Print 2013.


Phosphoinositide-3-kinases p110α and p110β mediate S phase entry in astroglial cells in the marginal zone of rat neocortex.

Müller R, Fischer C, Wilmes T, Heimrich B, Distel V, Klugbauer N, Meyer DK.

Front Cell Neurosci. 2013 Mar 14;7:24. doi: 10.3389/fncel.2013.00024. eCollection 2013.


Cysteines in the loop between IS5 and the pore helix of Ca(V)3.1 are essential for channel gating.

Karmazinova M, Beyl S, Stary-Weinzinger A, Suwattanasophon C, Klugbauer N, Hering S, Lacinova L.

Pflugers Arch. 2010 Nov;460(6):1015-28. doi: 10.1007/s00424-010-0874-5. Epub 2010 Sep 9.


The nuclear import of the small GTPase Rac1 is mediated by the direct interaction with karyopherin alpha2.

Sandrock K, Bielek H, Schradi K, Schmidt G, Klugbauer N.

Traffic. 2010 Feb;11(2):198-209. doi: 10.1111/j.1600-0854.2009.01015.x. Epub 2009 Dec 5.


The effect of the outermost basic residues in the S4 segments of the Ca(V)3.1 T-type calcium channel on channel gating.

Kurejová M, Lacinová L, Pavlovicová M, Eschbach M, Klugbauer N.

Pflugers Arch. 2007 Dec;455(3):527-39. Epub 2007 Jul 19. Erratum in: Pflugers Arch. 2008 Mar;455(6):1173-4.


SCN9A mutations in paroxysmal extreme pain disorder: allelic variants underlie distinct channel defects and phenotypes.

Fertleman CR, Baker MD, Parker KA, Moffatt S, Elmslie FV, Abrahamsen B, Ostman J, Klugbauer N, Wood JN, Gardiner RM, Rees M.

Neuron. 2006 Dec 7;52(5):767-74.


BKCa-Cav channel complexes mediate rapid and localized Ca2+-activated K+ signaling.

Berkefeld H, Sailer CA, Bildl W, Rohde V, Thumfart JO, Eble S, Klugbauer N, Reisinger E, Bischofberger J, Oliver D, Knaus HG, Schulte U, Fakler B.

Science. 2006 Oct 27;314(5799):615-20.


Calmodulin kinase II is involved in voltage-dependent facilitation of the L-type Cav1.2 calcium channel: Identification of the phosphorylation sites.

Lee TS, Karl R, Moosmang S, Lenhardt P, Klugbauer N, Hofmann F, Kleppisch T, Welling A.

J Biol Chem. 2006 Sep 1;281(35):25560-7. Epub 2006 Jul 4.


Control of intestinal motility by the Ca(v)1.2 L-type calcium channel in mice.

Wegener JW, Schulla V, Koller A, Klugbauer N, Feil R, Hofmann F.

FASEB J. 2006 Jun;20(8):1260-2. Epub 2006 Apr 24.


Gating of the expressed T-type Cav3.1 calcium channels is modulated by Ca2+.

Lacinová L, Kurejová M, Klugbauer N, Hofmann F.

Acta Physiol (Oxf). 2006 Apr;186(4):249-60.


Role of hippocampal Cav1.2 Ca2+ channels in NMDA receptor-independent synaptic plasticity and spatial memory.

Moosmang S, Haider N, Klugbauer N, Adelsberger H, Langwieser N, Müller J, Stiess M, Marais E, Schulla V, Lacinova L, Goebbels S, Nave KA, Storm DR, Hofmann F, Kleppisch T.

J Neurosci. 2005 Oct 26;25(43):9883-92.


Pituitary adenylyl cyclase-activating polypeptide 38 reduces astroglial proliferation by inhibiting the GTPase RhoA.

Meyer DK, Fischer C, Becker U, Göttsching I, Boutillier S, Baermann C, Schmidt G, Klugbauer N, Leemhuis J.

J Biol Chem. 2005 Jul 1;280(26):25258-66. Epub 2005 May 3.


An essential role of Cav1.2 L-type calcium channel for urinary bladder function.

Wegener JW, Schulla V, Lee TS, Koller A, Feil S, Feil R, Kleppisch T, Klugbauer N, Moosmang S, Welling A, Hofmann F.

FASEB J. 2004 Jul;18(10):1159-61. Epub 2004 May 7.


Modulation of gating currents of the Ca(v)3.1 calcium channel by alpha 2 delta 2 and gamma 5 subunits.

Lacinová L, Klugbauer N.

Arch Biochem Biophys. 2004 May 15;425(2):207-13.


Roles of molecular regions in determining differences between voltage dependence of activation of CaV3.1 and CaV1.2 calcium channels.

Li J, Stevens L, Klugbauer N, Wray D.

J Biol Chem. 2004 Jun 25;279(26):26858-67. Epub 2004 Apr 20.


Calcium channel alpha2delta subunits: differential expression, function, and drug binding.

Klugbauer N, Marais E, Hofmann F.

J Bioenerg Biomembr. 2003 Dec;35(6):639-47. Review.


entla, a novel epileptic and ataxic Cacna2d2 mutant of the mouse.

Brill J, Klocke R, Paul D, Boison D, Gouder N, Klugbauer N, Hofmann F, Becker CM, Becker K.

J Biol Chem. 2004 Feb 20;279(8):7322-30. Epub 2003 Dec 2.


Dominant role of smooth muscle L-type calcium channel Cav1.2 for blood pressure regulation.

Moosmang S, Schulla V, Welling A, Feil R, Feil S, Wegener JW, Hofmann F, Klugbauer N.

EMBO J. 2003 Nov 17;22(22):6027-34.


Enhanced expression of L-type Cav1.3 calcium channels in murine embryonic hearts from Cav1.2-deficient mice.

Xu M, Welling A, Paparisto S, Hofmann F, Klugbauer N.

J Biol Chem. 2003 Oct 17;278(42):40837-41. Epub 2003 Aug 4.


Impaired insulin secretion and glucose tolerance in beta cell-selective Ca(v)1.2 Ca2+ channel null mice.

Schulla V, Renström E, Feil R, Feil S, Franklin I, Gjinovci A, Jing XJ, Laux D, Lundquist I, Magnuson MA, Obermüller S, Olofsson CS, Salehi A, Wendt A, Klugbauer N, Wollheim CB, Rorsman P, Hofmann F.

EMBO J. 2003 Aug 1;22(15):3844-54.


Extracellular Ca2+ modulates the effects of protons on gating and conduction properties of the T-type Ca2+ channel alpha1G (CaV3.1).

Talavera K, Janssens A, Klugbauer N, Droogmans G, Nilius B.

J Gen Physiol. 2003 Jun;121(6):511-28. Epub 2003 May 12.


Pore structure influences gating properties of the T-type Ca2+ channel alpha1G.

Talavera K, Janssens A, Klugbauer N, Droogmans G, Nilius B.

J Gen Physiol. 2003 Jun;121(6):529-40. Epub 2003 May 12.


Laboratory acquired infection with recombinant vaccinia virus containing an immunomodulating construct.

Mempel M, Isa G, Klugbauer N, Meyer H, Wildi G, Ring J, Hofmann F, Hofmann H.

J Invest Dermatol. 2003 Mar;120(3):356-8.


Gating of the expressed Cav3.1 calcium channel.

Lacinová L, Klugbauer N, Hofmann F.

FEBS Lett. 2002 Nov 6;531(2):235-40.


L-type Ca2+ channels of the embryonic mouse heart.

Klugbauer N, Welling A, Specht V, Seisenberger C, Hofmann F.

Eur J Pharmacol. 2002 Jul 5;447(2-3):279-84. Review.


Cilnidipine is a novel slow-acting blocker of vascular L-type calcium channels that does not target protein kinase C.

Löhn M, Muzzulini U, Essin K, Tsang SY, Kirsch T, Litteral J, Waldron P, Conrad H, Klugbauer N, Hofmann F, Haller H, Luft FC, Huang Y, Gollasch M.

J Hypertens. 2002 May;20(5):885-93.


Aspartate residues of the Glu-Glu-Asp-Asp (EEDD) pore locus control selectivity and permeation of the T-type Ca(2+) channel alpha(1G).

Talavera K, Staes M, Janssens A, Klugbauer N, Droogmans G, Hofmann F, Nilius B.

J Biol Chem. 2001 Dec 7;276(49):45628-35. Epub 2001 Aug 28.


Calcium channel alpha(2)delta subunits-structure and Gabapentin binding.

Marais E, Klugbauer N, Hofmann F.

Mol Pharmacol. 2001 May;59(5):1243-8.


Functional coupling between 'R-type' Ca2+ channels and insulin secretion in the insulinoma cell line INS-1.

Vajna R, Klöckner U, Pereverzev A, Weiergräber M, Chen X, Miljanich G, Klugbauer N, Hescheler J, Perez-Reyes E, Schneider T.

Eur J Biochem. 2001 Feb;268(4):1066-75.


Low voltage activated calcium channels: from genes to function.

Lacinová L, Klugbauer N, Hofmann F.

Gen Physiol Biophys. 2000 Jun;19(2):121-36. Review.


The amino side of the C-terminus determines fast inactivation of the T-type calcium channel alpha1G.

Staes M, Talavera K, Klugbauer N, Prenen J, Lacinova L, Droogmans G, Hofmann F, Nilius B.

J Physiol. 2001 Jan 1;530(Pt 1):35-45.


Expression of T- and L-type calcium channel mRNA in murine sinoatrial node.

Bohn G, Moosmang S, Conrad H, Ludwig A, Hofmann F, Klugbauer N.

FEBS Lett. 2000 Sep 8;481(1):73-6.


Functional embryonic cardiomyocytes after disruption of the L-type alpha1C (Cav1.2) calcium channel gene in the mouse.

Seisenberger C, Specht V, Welling A, Platzer J, Pfeifer A, Kühbandner S, Striessnig J, Klugbauer N, Feil R, Hofmann F.

J Biol Chem. 2000 Dec 15;275(50):39193-9.


The alpha 1-subunit of smooth muscle Ca(2+) channel preserves multiple open states induced by depolarization.

Nakayama S, Klugbauer N, Kabeya Y, Smith LM, Hofmann F, Kuzuya M.

J Physiol. 2000 Jul 1;526 Pt 1:47-56.


State- and isoform-dependent interaction of isradipine with the alpha1C L-type calcium channel.

Lacinová L, Klugbauer N, Hofmann F.

Pflugers Arch. 2000 May;440(1):50-60.


Neuronal distribution and functional characterization of the calcium channel alpha2delta-2 subunit.

Hobom M, Dai S, Marais E, Lacinova L, Hofmann F, Klugbauer N.

Eur J Neurosci. 2000 Apr;12(4):1217-26.


Regulation of the calcium channel alpha(1G) subunit by divalent cations and organic blockers.

Lacinová L, Klugbauer N, Hofmann F.

Neuropharmacology. 2000 Apr 27;39(7):1254-66.


A family of gamma-like calcium channel subunits.

Klugbauer N, Dai S, Specht V, Lacinová L, Marais E, Bohn G, Hofmann F.

FEBS Lett. 2000 Mar 24;470(2):189-97.

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