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Items: 1 to 50 of 113

1.

Physiotherapy improves motor function in patients with the Parkinson variant of multiple system atrophy: A prospective trial.

Raccagni C, Goebel G, Gaßner H, Granata R, Ndayisaba JP, Seebacher B, Schoenherr G, Mitterhuber J, Hendriks P, Kaindlstorfer C, Eschlboeck S, Fanciulli A, Krismer F, Seppi K, Poewe W, Bloem BR, Klucken J, Wenning GK.

Parkinsonism Relat Disord. 2019 Oct;67:60-65. doi: 10.1016/j.parkreldis.2019.09.026. Epub 2019 Sep 24.

PMID:
31621609
2.

Silhouette-Length-Scaled Gait Parameters for Motor Functional Analysis in Mice and Rats.

Timotius IK, Moceri S, Plank AC, Habermeyer J, Canneva F, Winkler J, Klucken J, Casadei N, Riess O, Eskofier B, von Hörsten S.

eNeuro. 2019 Nov 1;6(6). pii: ENEURO.0100-19.2019. doi: 10.1523/ENEURO.0100-19.2019. Print 2019 Nov/Dec.

3.

Interindividual Balance Adaptations in Response to Perturbation Treadmill Training in Persons With Parkinson Disease.

Klamroth S, Gaßner H, Winkler J, Eskofier B, Klucken J, Pfeifer K, Steib S.

J Neurol Phys Ther. 2019 Oct;43(4):224-232. doi: 10.1097/NPT.0000000000000291.

PMID:
31517749
4.

The Use of Digital Technology and Media in German Parkinson's Disease Patients.

Marxreiter F, Buttler U, Gassner H, Gandor F, Gladow T, Winkler J, Ebersbach G, Klucken J.

J Parkinsons Dis. 2019 Aug 9. doi: 10.3233/JPD-191698. [Epub ahead of print]

PMID:
31424420
5.

Systematic data analysis and data mining in CatWalk gait analysis by heat mapping exemplified in rodent models for neurodegenerative diseases.

Timotius IK, Canneva F, Minakaki G, Moceri S, Plank AC, Casadei N, Riess O, Winkler J, Klucken J, Eskofier B, von Hörsten S.

J Neurosci Methods. 2019 Oct 1;326:108367. doi: 10.1016/j.jneumeth.2019.108367. Epub 2019 Jul 24. Review.

PMID:
31351096
6.

Correction to: Development and clinical validation of inertial sensor-based gait-clustering methods in Parkinson's disease.

Nguyen A, Roth N, Ghassemi NH, Hannink J, Seel T, Klucken J, Gassner H, Eskofier BM.

J Neuroeng Rehabil. 2019 Jul 26;16(1):98. doi: 10.1186/s12984-019-0567-z.

7.

Turning Analysis during Standardized Test Using On-Shoe Wearable Sensors in Parkinson's Disease.

Haji Ghassemi N, Hannink J, Roth N, Gaßner H, Marxreiter F, Klucken J, Eskofier BM.

Sensors (Basel). 2019 Jul 13;19(14). pii: E3103. doi: 10.3390/s19143103.

8.

[Wearables in the treatment of neurological diseases-where do we stand today?]

Klucken J, Gladow T, Hilgert JG, Stamminger M, Weigand C, Eskofier B.

Nervenarzt. 2019 Aug;90(8):787-795. doi: 10.1007/s00115-019-0753-z. Review. German.

PMID:
31309270
9.

Development and clinical validation of inertial sensor-based gait-clustering methods in Parkinson's disease.

Nguyen A, Roth N, Ghassemi NH, Hannink J, Seel T, Klucken J, Gassner H, Eskofier BM.

J Neuroeng Rehabil. 2019 Jun 26;16(1):77. doi: 10.1186/s12984-019-0548-2. Erratum in: J Neuroeng Rehabil. 2019 Jul 26;16(1):98.

10.

Balance and mobility in geriatric patients : Assessment and treatment of neurological aspects.

Jahn K, Freiberger E, Eskofier BM, Bollheimer C, Klucken J.

Z Gerontol Geriatr. 2019 Jul;52(4):316-323. doi: 10.1007/s00391-019-01561-z. Epub 2019 Jun 3. Review.

PMID:
31161336
11.

Perturbation Treadmill Training Improves Clinical Characteristics of Gait and Balance in Parkinson's Disease.

Gaßner H, Steib S, Klamroth S, Pasluosta CF, Adler W, Eskofier BM, Pfeifer K, Winkler J, Klucken J.

J Parkinsons Dis. 2019;9(2):413-426. doi: 10.3233/JPD-181534.

PMID:
30958316
12.

A roadmap for implementation of patient-centered digital outcome measures in Parkinson's disease obtained using mobile health technologies.

Espay AJ, Hausdorff JM, Sánchez-Ferro Á, Klucken J, Merola A, Bonato P, Paul SS, Horak FB, Vizcarra JA, Mestre TA, Reilmann R, Nieuwboer A, Dorsey ER, Rochester L, Bloem BR, Maetzler W; Movement Disorder Society Task Force on Technology.

Mov Disord. 2019 May;34(5):657-663. doi: 10.1002/mds.27671. Epub 2019 Mar 22. Review.

PMID:
30901495
13.

The Parkinson's disease e-diary: Developing a clinical and research tool for the digital age.

Vizcarra JA, Sánchez-Ferro Á, Maetzler W, Marsili L, Zavala L, Lang AE, Martinez-Martin P, Mestre TA, Reilmann R, Hausdorff JM, Dorsey ER, Paul SS, Dexheimer JW, Wissel BD, Fuller RLM, Bonato P, Tan AH, Bloem BR, Kopil C, Daeschler M, Bataille L, Kleiner G, Cedarbaum JM, Klucken J, Merola A, Goetz CG, Stebbins GT, Espay AJ; MDS Technology Task Force and the MDS Rating Scales Program Electronic Development Ad-Hoc Committee.

Mov Disord. 2019 May;34(5):676-681. doi: 10.1002/mds.27673. Epub 2019 Mar 22. No abstract available.

PMID:
30901492
14.

The Diagnostic Scope of Sensor-Based Gait Analysis in Atypical Parkinsonism: Further Observations.

Gaßner H, Raccagni C, Eskofier BM, Klucken J, Wenning GK.

Front Neurol. 2019 Jan 22;10:5. doi: 10.3389/fneur.2019.00005. eCollection 2019.

15.

Exploring gait adaptations to perturbed and conventional treadmill training in Parkinson's disease: Time-course, sustainability, and transfer.

Steib S, Klamroth S, Gaßner H, Pasluosta C, Eskofier B, Winkler J, Klucken J, Pfeifer K.

Hum Mov Sci. 2019 Apr;64:123-132. doi: 10.1016/j.humov.2019.01.007. Epub 2019 Feb 1.

PMID:
30711905
16.

Extracellular aggregated alpha synuclein primarily triggers lysosomal dysfunction in neural cells prevented by trehalose.

Hoffmann AC, Minakaki G, Menges S, Salvi R, Savitskiy S, Kazman A, Vicente Miranda H, Mielenz D, Klucken J, Winkler J, Xiang W.

Sci Rep. 2019 Jan 24;9(1):544. doi: 10.1038/s41598-018-35811-8.

17.

Treadmill exercise intervention improves gait and postural control in alpha-synuclein mouse models without inducing cerebral autophagy.

Minakaki G, Canneva F, Chevessier F, Bode F, Menges S, Timotius IK, Kalinichenko LS, Meixner H, Müller CP, Eskofier BM, Casadei N, Riess O, Schröder R, Winkler J, Xiang W, von Hörsten S, Klucken J.

Behav Brain Res. 2019 May 2;363:199-215. doi: 10.1016/j.bbr.2018.11.035. Epub 2018 Dec 30.

PMID:
30599154
18.

Management of Parkinson's Disease 20 Years from Now: Towards Digital Health Pathways.

Klucken J, Krüger R, Schmidt P, Bloem BR.

J Parkinsons Dis. 2018;8(s1):S85-S94. doi: 10.3233/JPD-181519. Review.

19.

The Luxembourg Parkinson's Study: A Comprehensive Approach for Stratification and Early Diagnosis.

Hipp G, Vaillant M, Diederich NJ, Roomp K, Satagopam VP, Banda P, Sandt E, Mommaerts K, Schmitz SK, Longhino L, Schweicher A, Hanff AM, Nicolai B, Kolber P, Reiter D, Pavelka L, Binck S, Pauly C, Geffers L, Betsou F, Gantenbein M, Klucken J, Gasser T, Hu MT, Balling R, Krüger R.

Front Aging Neurosci. 2018 Oct 29;10:326. doi: 10.3389/fnagi.2018.00326. eCollection 2018.

20.

A Single Bout of Aerobic Exercise Improves Motor Skill Consolidation in Parkinson's Disease.

Steib S, Wanner P, Adler W, Winkler J, Klucken J, Pfeifer K.

Front Aging Neurosci. 2018 Oct 22;10:328. doi: 10.3389/fnagi.2018.00328. eCollection 2018.

21.

Thigh-Derived Inertial Sensor Metrics to Assess the Sit-to-Stand and Stand-to-Sit Transitions in the Timed Up and Go (TUG) Task for Quantifying Mobility Impairment in Multiple Sclerosis.

Witchel HJ, Oberndorfer C, Needham R, Healy A, Westling CEI, Guppy JH, Bush J, Barth J, Herberz C, Roggen D, Eskofier BM, Rashid W, Chockalingam N, Klucken J.

Front Neurol. 2018 Sep 14;9:684. doi: 10.3389/fneur.2018.00684. eCollection 2018.

22.

Pre-operative sensor-based gait parameters predict functional outcome after total knee arthroplasty.

Kluge F, Hannink J, Pasluosta C, Klucken J, Gaßner H, Gelse K, Eskofier BM, Krinner S.

Gait Posture. 2018 Oct;66:194-200. doi: 10.1016/j.gaitpost.2018.08.026. Epub 2018 Aug 24.

PMID:
30199778
23.

FoxO Function Is Essential for Maintenance of Autophagic Flux and Neuronal Morphogenesis in Adult Neurogenesis.

Schäffner I, Minakaki G, Khan MA, Balta EA, Schlötzer-Schrehardt U, Schwarz TJ, Beckervordersandforth R, Winner B, Webb AE, DePinho RA, Paik J, Wurst W, Klucken J, Lie DC.

Neuron. 2018 Sep 19;99(6):1188-1203.e6. doi: 10.1016/j.neuron.2018.08.017. Epub 2018 Sep 6.

24.

Sensor-based gait analysis of individualized improvement during apomorphine titration in Parkinson's disease.

Marxreiter F, Gaßner H, Borozdina O, Barth J, Kohl Z, Schlachetzki JCM, Thun-Hohenstein C, Volc D, Eskofier BM, Winkler J, Klucken J.

J Neurol. 2018 Nov;265(11):2656-2665. doi: 10.1007/s00415-018-9012-7. Epub 2018 Sep 8.

PMID:
30196324
25.

Multimodal Assessment of Parkinson's Disease: A Deep Learning Approach.

Vasquez-Correa JC, Arias-Vergara T, Orozco-Arroyave JR, Eskofier B, Klucken J, Noth E.

IEEE J Biomed Health Inform. 2019 Jul;23(4):1618-1630. doi: 10.1109/JBHI.2018.2866873. Epub 2018 Aug 23.

PMID:
30137018
26.

Dynamic footprints of α-synucleinopathic mice recorded by CatWalk gait analysis.

Timotius IK, Canneva F, Minakaki G, Pasluosta C, Moceri S, Casadei N, Riess O, Winkler J, Klucken J, von Hörsten S, Eskofier B.

Data Brief. 2018 Jan 3;17:189-193. doi: 10.1016/j.dib.2017.12.067. eCollection 2018 Apr.

27.

Sensor-based gait analysis in atypical parkinsonian disorders.

Raccagni C, Gaßner H, Eschlboeck S, Boesch S, Krismer F, Seppi K, Poewe W, Eskofier BM, Winkler J, Wenning G, Klucken J.

Brain Behav. 2018 Jun;8(6):e00977. doi: 10.1002/brb3.977. Epub 2018 May 7.

28.

Motor output complexity in Parkinson's disease during quiet standing and walking: Analysis of short-term correlations using the entropic half-life.

Pasluosta C, Hannink J, Gaßner H, Von Tscharner V, Winkler J, Klucken J, Eskofier BM.

Hum Mov Sci. 2018 Apr;58:185-194. doi: 10.1016/j.humov.2018.02.005. Epub 2018 Mar 12.

PMID:
29459326
29.

Segmentation of Gait Sequences in Sensor-Based Movement Analysis: A Comparison of Methods in Parkinson's Disease.

Haji Ghassemi N, Hannink J, Martindale CF, Gaßner H, Müller M, Klucken J, Eskofier BM.

Sensors (Basel). 2018 Jan 6;18(1). pii: E145. doi: 10.3390/s18010145.

30.

Dynamic footprint based locomotion sway assessment in α-synucleinopathic mice using Fast Fourier Transform and Low Pass Filter.

Timotius IK, Canneva F, Minakaki G, Pasluosta C, Moceri S, Casadei N, Riess O, Winkler J, Klucken J, von Hörsten S, Eskofier B.

J Neurosci Methods. 2018 Feb 15;296:1-11. doi: 10.1016/j.jneumeth.2017.12.004. Epub 2017 Dec 16.

PMID:
29253577
31.

Autophagy inhibition promotes SNCA/alpha-synuclein release and transfer via extracellular vesicles with a hybrid autophagosome-exosome-like phenotype.

Minakaki G, Menges S, Kittel A, Emmanouilidou E, Schaeffner I, Barkovits K, Bergmann A, Rockenstein E, Adame A, Marxreiter F, Mollenhauer B, Galasko D, Buzás EI, Schlötzer-Schrehardt U, Marcus K, Xiang W, Lie DC, Vekrellis K, Masliah E, Winkler J, Klucken J.

Autophagy. 2018;14(1):98-119. doi: 10.1080/15548627.2017.1395992. Epub 2018 Jan 15.

32.

Gait and Cognition in Parkinson's Disease: Cognitive Impairment Is Inadequately Reflected by Gait Performance during Dual Task.

Gaßner H, Marxreiter F, Steib S, Kohl Z, Schlachetzki JCM, Adler W, Eskofier BM, Pfeifer K, Winkler J, Klucken J.

Front Neurol. 2017 Oct 26;8:550. doi: 10.3389/fneur.2017.00550. eCollection 2017.

33.

Segmentation of gait sequences using inertial sensor data in hereditary spastic paraplegia.

Martindale CF, Strauss M, Gassner H, List J, Muller M, Klucken J, Kohl Z, Eskofier BM.

Conf Proc IEEE Eng Med Biol Soc. 2017 Jul;2017:1266-1269. doi: 10.1109/EMBC.2017.8037062.

PMID:
29060107
34.

Acute Neuromuscular Adaptations in the Postural Control of Patients with Parkinson's Disease after Perturbed Walking.

Pasluosta CF, Steib S, Klamroth S, Gaßner H, Goßler J, Hannink J, von Tscharner V, Pfeifer K, Winkler J, Klucken J, Eskofier BM.

Front Aging Neurosci. 2017 Sep 27;9:316. doi: 10.3389/fnagi.2017.00316. eCollection 2017.

35.

Wearable sensors objectively measure gait parameters in Parkinson's disease.

Schlachetzki JCM, Barth J, Marxreiter F, Gossler J, Kohl Z, Reinfelder S, Gassner H, Aminian K, Eskofier BM, Winkler J, Klucken J.

PLoS One. 2017 Oct 11;12(10):e0183989. doi: 10.1371/journal.pone.0183989. eCollection 2017.

36.

Increase of Reproductive Life Span Delays Age of Onset of Parkinson's Disease.

Frentzel D, Judanin G, Borozdina O, Klucken J, Winkler J, Schlachetzki JCM.

Front Neurol. 2017 Aug 21;8:397. doi: 10.3389/fneur.2017.00397. eCollection 2017.

37.

Benchmarking Foot Trajectory Estimation Methods for Mobile Gait Analysis.

Hannink J, Ollenschläger M, Kluge F, Roth N, Klucken J, Eskofier BM.

Sensors (Basel). 2017 Aug 23;17(9). pii: E1940. doi: 10.3390/s17091940.

38.

Perturbation During Treadmill Training Improves Dynamic Balance and Gait in Parkinson's Disease: A Single-Blind Randomized Controlled Pilot Trial.

Steib S, Klamroth S, Gaßner H, Pasluosta C, Eskofier B, Winkler J, Klucken J, Pfeifer K.

Neurorehabil Neural Repair. 2017 Aug;31(8):758-768. doi: 10.1177/1545968317721976. Epub 2017 Jul 31.

PMID:
28758519
39.

Towards Mobile Gait Analysis: Concurrent Validity and Test-Retest Reliability of an Inertial Measurement System for the Assessment of Spatio-Temporal Gait Parameters.

Kluge F, Gaßner H, Hannink J, Pasluosta C, Klucken J, Eskofier BM.

Sensors (Basel). 2017 Jun 28;17(7). pii: E1522. doi: 10.3390/s17071522.

40.

Glycation potentiates α-synuclein-associated neurodegeneration in synucleinopathies.

Vicente Miranda H, Szego ÉM, Oliveira LMA, Breda C, Darendelioglu E, de Oliveira RM, Ferreira DG, Gomes MA, Rott R, Oliveira M, Munari F, Enguita FJ, Simões T, Rodrigues EF, Heinrich M, Martins IC, Zamolo I, Riess O, Cordeiro C, Ponces-Freire A, Lashuel HA, Santos NC, Lopes LV, Xiang W, Jovin TM, Penque D, Engelender S, Zweckstetter M, Klucken J, Giorgini F, Quintas A, Outeiro TF.

Brain. 2017 May 1;140(5):1399-1419. doi: 10.1093/brain/awx056.

PMID:
28398476
41.

Classification of advanced stages of Parkinson's disease: translation into stratified treatments.

Krüger R, Klucken J, Weiss D, Tönges L, Kolber P, Unterecker S, Lorrain M, Baas H, Müller T, Riederer P.

J Neural Transm (Vienna). 2017 Aug;124(8):1015-1027. doi: 10.1007/s00702-017-1707-x. Epub 2017 Mar 24. Review.

42.

Mobile Stride Length Estimation With Deep Convolutional Neural Networks.

Hannink J, Kautz T, Pasluosta CF, Barth J, Schulein S, GaBmann KG, Klucken J, Eskofier BM.

IEEE J Biomed Health Inform. 2018 Mar;22(2):354-362. doi: 10.1109/JBHI.2017.2679486. Epub 2017 Mar 9.

PMID:
28333648
43.

Inertial sensor based gait analysis discriminates subjects with and without visual impairment caused by simulated macular degeneration.

Kanzler CM, Barth J, Klucken J, Eskofier BM.

Conf Proc IEEE Eng Med Biol Soc. 2016 Aug;2016:4979-4982. doi: 10.1109/EMBC.2016.7591845.

PMID:
28269386
44.

Combined accelerometer and EMG analysis to differentiate essential tremor from Parkinson's disease.

Ghassemi NH, Marxreiter F, Pasluosta CF, Kugler P, Schlachetzki J, Schramm A, Eskofier BM, Klucken J.

Conf Proc IEEE Eng Med Biol Soc. 2016 Aug;2016:672-675. doi: 10.1109/EMBC.2016.7590791.

PMID:
28268417
45.

Recent machine learning advancements in sensor-based mobility analysis: Deep learning for Parkinson's disease assessment.

Eskofier BM, Lee SI, Daneault JF, Golabchi FN, Ferreira-Carvalho G, Vergara-Diaz G, Sapienza S, Costante G, Klucken J, Kautz T, Bonato P.

Conf Proc IEEE Eng Med Biol Soc. 2016 Aug;2016:655-658. doi: 10.1109/EMBC.2016.7590787.

PMID:
28268413
46.

Instrumented gait analysis: a measure of gait improvement by a wheeled walker in hospitalized geriatric patients.

Schülein S, Barth J, Rampp A, Rupprecht R, Eskofier BM, Winkler J, Gaßmann KG, Klucken J.

J Neuroeng Rehabil. 2017 Feb 27;14(1):18. doi: 10.1186/s12984-017-0228-z.

47.

Alpha-synuclein prevents the formation of spherical mitochondria and apoptosis under oxidative stress.

Menges S, Minakaki G, Schaefer PM, Meixner H, Prots I, Schlötzer-Schrehardt U, Friedland K, Winner B, Outeiro TF, Winklhofer KF, von Arnim CA, Xiang W, Winkler J, Klucken J.

Sci Rep. 2017 Feb 22;7:42942. doi: 10.1038/srep42942.

48.

Sensor-Based Gait Parameter Extraction With Deep Convolutional Neural Networks.

Hannink J, Kautz T, Pasluosta CF, Gasmann KG, Klucken J, Eskofier BM.

IEEE J Biomed Health Inform. 2017 Jan;21(1):85-93. doi: 10.1109/JBHI.2016.2636456. Epub 2016 Dec 8.

PMID:
28103196
49.

Academic Freedom Should Be Redefined: Point and Counterpoint.

Woods TM, Acosta WR, Chung EP, Cox AG, Garcia GA, Klucken JR, Chisholm-Burns M.

Am J Pharm Educ. 2016 Nov 25;80(9):146. doi: 10.5688/ajpe809146.

50.

Immediate effects of perturbation treadmill training on gait and postural control in patients with Parkinson's disease.

Klamroth S, Steib S, Gaßner H, Goßler J, Winkler J, Eskofier B, Klucken J, Pfeifer K.

Gait Posture. 2016 Oct;50:102-108. doi: 10.1016/j.gaitpost.2016.08.020. Epub 2016 Aug 26.

PMID:
27591395

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