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Items: 1 to 50 of 58

1.

Avoiding adsorption of Bcl-2 proteins to plasticware is important for accurate quantitation.

Hockings C, Iyer S, Uren RT, Kluck RM.

Cell Death Differ. 2019 May;26(5):794-795. doi: 10.1038/s41418-019-0284-y. Epub 2019 Feb 13. No abstract available.

PMID:
30760874
2.

Probing BAK and BAX Activation and Pore Assembly with Cytochrome c Release, Limited Proteolysis, and Oxidant-Induced Linkage.

Iyer S, Uren RT, Kluck RM.

Methods Mol Biol. 2019;1877:201-216. doi: 10.1007/978-1-4939-8861-7_14.

PMID:
30536008
3.

VDAC2 enables BAX to mediate apoptosis and limit tumor development.

Chin HS, Li MX, Tan IKL, Ninnis RL, Reljic B, Scicluna K, Dagley LF, Sandow JJ, Kelly GL, Samson AL, Chappaz S, Khaw SL, Chang C, Morokoff A, Brinkmann K, Webb A, Hockings C, Hall CM, Kueh AJ, Ryan MT, Kluck RM, Bouillet P, Herold MJ, Gray DHD, Huang DCS, van Delft MF, Dewson G.

Nat Commun. 2018 Nov 26;9(1):4976. doi: 10.1038/s41467-018-07309-4.

4.

Ensemble Properties of Bax Determine Its Function.

Robin AY, Iyer S, Birkinshaw RW, Sandow J, Wardak A, Luo CS, Shi M, Webb AI, Czabotar PE, Kluck RM, Colman PM.

Structure. 2018 Oct 2;26(10):1346-1359.e5. doi: 10.1016/j.str.2018.07.006. Epub 2018 Aug 16.

PMID:
30122452
5.

Mcl-1 and Bcl-xL sequestration of Bak confers differential resistance to BH3-only proteins.

Hockings C, Alsop AE, Fennell SC, Lee EF, Fairlie WD, Dewson G, Kluck RM.

Cell Death Differ. 2018 Mar;25(4):721-734. doi: 10.1038/s41418-017-0010-6. Epub 2018 Feb 19.

6.

BAK α6 permits activation by BH3-only proteins and homooligomerization via the canonical hydrophobic groove.

Li MX, Tan IKL, Ma SB, Hockings C, Kratina T, Dengler MA, Alsop AE, Kluck RM, Dewson G.

Proc Natl Acad Sci U S A. 2017 Jul 18;114(29):7629-7634. doi: 10.1073/pnas.1702453114. Epub 2017 Jul 3.

7.

Pore formation by dimeric Bak and Bax: an unusual pore?

Uren RT, Iyer S, Kluck RM.

Philos Trans R Soc Lond B Biol Sci. 2017 Aug 5;372(1726). pii: 20160218. doi: 10.1098/rstb.2016.0218. Review.

8.

Disordered clusters of Bak dimers rupture mitochondria during apoptosis.

Uren RT, O'Hely M, Iyer S, Bartolo R, Shi MX, Brouwer JM, Alsop AE, Dewson G, Kluck RM.

Elife. 2017 Feb 6;6. pii: e19944. doi: 10.7554/eLife.19944.

9.

Epigenetic control of mitochondrial cell death through PACS1-mediated regulation of BAX/BAK oligomerization.

Brasacchio D, Alsop AE, Noori T, Lufti M, Iyer S, Simpson KJ, Bird PI, Kluck RM, Johnstone RW, Trapani JA.

Cell Death Differ. 2017 Jun;24(6):961-970. doi: 10.1038/cdd.2016.119. Epub 2017 Jan 6.

10.

Identification of an activation site in Bak and mitochondrial Bax triggered by antibodies.

Iyer S, Anwari K, Alsop AE, Yuen WS, Huang DC, Carroll J, Smith NA, Smith BJ, Dewson G, Kluck RM.

Nat Commun. 2016 May 24;7:11734. doi: 10.1038/ncomms11734.

11.

Physiological restraint of Bak by Bcl-xL is essential for cell survival.

Lee EF, Grabow S, Chappaz S, Dewson G, Hockings C, Kluck RM, Debrincat MA, Gray DH, Witkowski MT, Evangelista M, Pettikiriarachchi A, Bouillet P, Lane RM, Czabotar PE, Colman PM, Smith BJ, Kile BT, Fairlie WD.

Genes Dev. 2016 May 15;30(10):1240-50. doi: 10.1101/gad.279414.116. Epub 2016 May 19.

12.

A Role for the Mitochondrial Protein Mrpl44 in Maintaining OXPHOS Capacity.

Yeo JH, Skinner JP, Bird MJ, Formosa LE, Zhang JG, Kluck RM, Belz GT, Chong MM.

PLoS One. 2015 Jul 29;10(7):e0134326. doi: 10.1371/journal.pone.0134326. eCollection 2015.

13.

Bid chimeras indicate that most BH3-only proteins can directly activate Bak and Bax, and show no preference for Bak versus Bax.

Hockings C, Anwari K, Ninnis RL, Brouwer J, O'Hely M, Evangelista M, Hinds MG, Czabotar PE, Lee EF, Fairlie WD, Dewson G, Kluck RM.

Cell Death Dis. 2015 Apr 23;6:e1735. doi: 10.1038/cddis.2015.105.

14.

Dissociation of Bak α1 helix from the core and latch domains is required for apoptosis.

Alsop AE, Fennell SC, Bartolo RC, Tan IK, Dewson G, Kluck RM.

Nat Commun. 2015 Apr 16;6:6841. doi: 10.1038/ncomms7841.

PMID:
25880232
15.

Bak apoptotic pores involve a flexible C-terminal region and juxtaposition of the C-terminal transmembrane domains.

Iyer S, Bell F, Westphal D, Anwari K, Gulbis J, Smith BJ, Dewson G, Kluck RM.

Cell Death Differ. 2015 Oct;22(10):1665-75. doi: 10.1038/cdd.2015.15. Epub 2015 Mar 6.

16.

Apoptotic pore formation is associated with in-plane insertion of Bak or Bax central helices into the mitochondrial outer membrane.

Westphal D, Dewson G, Menard M, Frederick P, Iyer S, Bartolo R, Gibson L, Czabotar PE, Smith BJ, Adams JM, Kluck RM.

Proc Natl Acad Sci U S A. 2014 Sep 30;111(39):E4076-85. doi: 10.1073/pnas.1415142111. Epub 2014 Sep 16.

17.

Bak core and latch domains separate during activation, and freed core domains form symmetric homodimers.

Brouwer JM, Westphal D, Dewson G, Robin AY, Uren RT, Bartolo R, Thompson GV, Colman PM, Kluck RM, Czabotar PE.

Mol Cell. 2014 Sep 18;55(6):938-946. doi: 10.1016/j.molcel.2014.07.016. Epub 2014 Aug 28.

18.

Bax targets mitochondria by distinct mechanisms before or during apoptotic cell death: a requirement for VDAC2 or Bak for efficient Bax apoptotic function.

Ma SB, Nguyen TN, Tan I, Ninnis R, Iyer S, Stroud DA, Menard M, Kluck RM, Ryan MT, Dewson G.

Cell Death Differ. 2014 Dec;21(12):1925-35. doi: 10.1038/cdd.2014.119. Epub 2014 Aug 22.

19.

Building blocks of the apoptotic pore: how Bax and Bak are activated and oligomerize during apoptosis.

Westphal D, Kluck RM, Dewson G.

Cell Death Differ. 2014 Feb;21(2):196-205. doi: 10.1038/cdd.2013.139. Epub 2013 Oct 25. Review.

20.

Assembly of the Bak apoptotic pore: a critical role for the Bak protein α6 helix in the multimerization of homodimers during apoptosis.

Ma S, Hockings C, Anwari K, Kratina T, Fennell S, Lazarou M, Ryan MT, Kluck RM, Dewson G.

J Biol Chem. 2013 Sep 6;288(36):26027-38. doi: 10.1074/jbc.M113.490094. Epub 2013 Jul 26.

21.

MCMV-mediated inhibition of the pro-apoptotic Bak protein is required for optimal in vivo replication.

Fleming P, Kvansakul M, Voigt V, Kile BT, Kluck RM, Huang DC, Degli-Esposti MA, Andoniou CE.

PLoS Pathog. 2013 Feb;9(2):e1003192. doi: 10.1371/journal.ppat.1003192. Epub 2013 Feb 28.

22.

Bax crystal structures reveal how BH3 domains activate Bax and nucleate its oligomerization to induce apoptosis.

Czabotar PE, Westphal D, Dewson G, Ma S, Hockings C, Fairlie WD, Lee EF, Yao S, Robin AY, Smith BJ, Huang DC, Kluck RM, Adams JM, Colman PM.

Cell. 2013 Jan 31;152(3):519-31. doi: 10.1016/j.cell.2012.12.031.

23.

Bak apoptotic function is not directly regulated by phosphorylation.

Tran VH, Bartolo R, Westphal D, Alsop A, Dewson G, Kluck RM.

Cell Death Dis. 2013 Jan 10;4:e452. doi: 10.1038/cddis.2012.191.

24.

Granzyme B triggers a prolonged pressure to die in Bcl-2 overexpressing cells, defining a window of opportunity for effective treatment with ABT-737.

Sutton VR, Sedelies K, Dewson G, Christensen ME, Bird PI, Johnstone RW, Kluck RM, Trapani JA, Waterhouse NJ.

Cell Death Dis. 2012 Jul 5;3:e344. doi: 10.1038/cddis.2012.73.

25.

Translocation of a Bak C-terminus mutant from cytosol to mitochondria to mediate cytochrome C release: implications for Bak and Bax apoptotic function.

Ferrer PE, Frederick P, Gulbis JM, Dewson G, Kluck RM.

PLoS One. 2012;7(3):e31510. doi: 10.1371/journal.pone.0031510. Epub 2012 Mar 19.

26.

Bax dimerizes via a symmetric BH3:groove interface during apoptosis.

Dewson G, Ma S, Frederick P, Hockings C, Tan I, Kratina T, Kluck RM.

Cell Death Differ. 2012 Apr;19(4):661-70. doi: 10.1038/cdd.2011.138. Epub 2011 Oct 21.

27.

Molecular biology of Bax and Bak activation and action.

Westphal D, Dewson G, Czabotar PE, Kluck RM.

Biochim Biophys Acta. 2011 Apr;1813(4):521-31. doi: 10.1016/j.bbamcr.2010.12.019. Epub 2010 Dec 30. Review.

28.

Inhibition of Bak activation by VDAC2 is dependent on the Bak transmembrane anchor.

Lazarou M, Stojanovski D, Frazier AE, Kotevski A, Dewson G, Craigen WJ, Kluck RM, Vaux DL, Ryan MT.

J Biol Chem. 2010 Nov 19;285(47):36876-83. doi: 10.1074/jbc.M110.159301. Epub 2010 Sep 17.

29.

Bak activation for apoptosis involves oligomerization of dimers via their alpha6 helices.

Dewson G, Kratina T, Czabotar P, Day CL, Adams JM, Kluck RM.

Mol Cell. 2009 Nov 25;36(4):696-703. doi: 10.1016/j.molcel.2009.11.008.

30.

Mechanisms by which Bak and Bax permeabilise mitochondria during apoptosis.

Dewson G, Kluck RM.

J Cell Sci. 2009 Aug 15;122(Pt 16):2801-8.

31.

To trigger apoptosis, Bak exposes its BH3 domain and homodimerizes via BH3:groove interactions.

Dewson G, Kratina T, Sim HW, Puthalakath H, Adams JM, Colman PM, Kluck RM.

Mol Cell. 2008 May 9;30(3):369-80. doi: 10.1016/j.molcel.2008.04.005.

32.

The mitochondrial gateway to cell death.

Smith DJ, Ng H, Kluck RM, Nagley P.

IUBMB Life. 2008 Jun;60(6):383-9. doi: 10.1002/iub.44. Review.

33.

Mitochondrial permeabilization relies on BH3 ligands engaging multiple prosurvival Bcl-2 relatives, not Bak.

Uren RT, Dewson G, Chen L, Coyne SC, Huang DC, Adams JM, Kluck RM.

J Cell Biol. 2007 Apr 23;177(2):277-87.

34.

Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or Bak.

Willis SN, Fletcher JI, Kaufmann T, van Delft MF, Chen L, Czabotar PE, Ierino H, Lee EF, Fairlie WD, Bouillet P, Strasser A, Kluck RM, Adams JM, Huang DC.

Science. 2007 Feb 9;315(5813):856-9.

35.

Mitochondrial release of pro-apoptotic proteins: electrostatic interactions can hold cytochrome c but not Smac/DIABLO to mitochondrial membranes.

Uren RT, Dewson G, Bonzon C, Lithgow T, Newmeyer DD, Kluck RM.

J Biol Chem. 2005 Jan 21;280(3):2266-74. Epub 2004 Nov 9.

36.

A cytochrome c mutant with high electron transfer and antioxidant activities but devoid of apoptogenic effect.

Abdullaev ZKh, Bodrova ME, Chernyak BV, Dolgikh DA, Kluck RM, Pereverzev MO, Arseniev AS, Efremov RG, Kirpichnikov MP, Mokhova EN, Newmeyer DD, Roder H, Skulachev VP.

Biochem J. 2002 Mar 15;362(Pt 3):749-54.

37.

A distinct pathway of cell-mediated apoptosis initiated by granulysin.

Kaspar AA, Okada S, Kumar J, Poulain FR, Drouvalakis KA, Kelekar A, Hanson DA, Kluck RM, Hitoshi Y, Johnson DE, Froelich CJ, Thompson CB, Newmeyer DD, Anel A, Clayberger C, Krensky AM.

J Immunol. 2001 Jul 1;167(1):350-6.

38.

The (Holey) study of mitochondria in apoptosis.

Waterhouse NJ, Goldstein JC, Kluck RM, Newmeyer DD, Green DR.

Methods Cell Biol. 2001;66:365-91. No abstract available.

PMID:
11396012
39.

A single cell analysis of apoptosis. Ordering the apoptotic phenotype.

Goldstein JC, Kluck RM, Green DR.

Ann N Y Acad Sci. 2000;926:132-41.

PMID:
11193030
40.

Preservation of mitochondrial structure and function after Bid- or Bax-mediated cytochrome c release.

von Ahsen O, Renken C, Perkins G, Kluck RM, Bossy-Wetzel E, Newmeyer DD.

J Cell Biol. 2000 Sep 4;150(5):1027-36.

41.

Determinants of cytochrome c pro-apoptotic activity. The role of lysine 72 trimethylation.

Kluck RM, Ellerby LM, Ellerby HM, Naiem S, Yaffe MP, Margoliash E, Bredesen D, Mauk AG, Sherman F, Newmeyer DD.

J Biol Chem. 2000 May 26;275(21):16127-33.

42.

Bcl-xL does not inhibit the function of Apaf-1.

Newmeyer DD, Bossy-Wetzel E, Kluck RM, Wolf BB, Beere HM, Green DR.

Cell Death Differ. 2000 Apr;7(4):402-7.

43.

The pro-apoptotic proteins, Bid and Bax, cause a limited permeabilization of the mitochondrial outer membrane that is enhanced by cytosol.

Kluck RM, Esposti MD, Perkins G, Renken C, Kuwana T, Bossy-Wetzel E, Goldberg M, Allen T, Barber MJ, Green DR, Newmeyer DD.

J Cell Biol. 1999 Nov 15;147(4):809-22.

44.

Ordering the cytochrome c-initiated caspase cascade: hierarchical activation of caspases-2, -3, -6, -7, -8, and -10 in a caspase-9-dependent manner.

Slee EA, Harte MT, Kluck RM, Wolf BB, Casiano CA, Newmeyer DD, Wang HG, Reed JC, Nicholson DW, Alnemri ES, Green DR, Martin SJ.

J Cell Biol. 1999 Jan 25;144(2):281-92.

45.

Cytochrome c activation of CPP32-like proteolysis plays a critical role in a Xenopus cell-free apoptosis system.

Kluck RM, Martin SJ, Hoffman BM, Zhou JS, Green DR, Newmeyer DD.

EMBO J. 1997 Aug 1;16(15):4639-49.

46.

The release of cytochrome c from mitochondria: a primary site for Bcl-2 regulation of apoptosis.

Kluck RM, Bossy-Wetzel E, Green DR, Newmeyer DD.

Science. 1997 Feb 21;275(5303):1132-6.

47.

A lively meeting on a deathly topic.

Kluck RM, Kasibhatla S.

Apoptosis. 1997;2(3):337-42. No abstract available.

PMID:
14692410
48.
49.

Calcium chelators induce apoptosis--evidence that raised intracellular ionised calcium is not essential for apoptosis.

Kluck RM, McDougall CA, Harmon BV, Halliday JW.

Biochim Biophys Acta. 1994 Sep 8;1223(2):247-54.

PMID:
8086495
50.

Induction of cell surface peptidase activity: a global response to cell stress correlated with apoptosis.

Brown SB, Kluck RM, Ellem KA.

J Cell Biochem. 1994 Mar;54(3):320-31.

PMID:
8200912

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