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Items: 1 to 50 of 71

1.

Evaluation of the Possibility to Detect Circulating Tumor DNA From Pituitary Adenoma.

Megnis K, Peculis R, Rovite V, Laksa P, Niedra H, Balcere I, Caune O, Breiksa A, Nazarovs J, Stukens J, Konrade I, Pirags V, Klovins J.

Front Endocrinol (Lausanne). 2019 Sep 18;10:615. doi: 10.3389/fendo.2019.00615. eCollection 2019.

2.

Control of Acinetobacter baumannii outbreak in the neonatal intensive care unit in Latvia: whole-genome sequencing powered investigation and closure of the ward.

Gramatniece A, Silamikelis I, Zahare I, Urtans V, Zahare I, Dimina E, Saule M, Balode A, Radovica-Spalvina I, Klovins J, Fridmanis D, Dumpis U.

Antimicrob Resist Infect Control. 2019 May 22;8:84. doi: 10.1186/s13756-019-0537-z. eCollection 2019.

3.

Significantly altered peripheral blood cell DNA methylation profile as a result of immediate effect of metformin use in healthy individuals.

Elbere I, Silamikelis I, Ustinova M, Kalnina I, Zaharenko L, Peculis R, Konrade I, Ciuculete DM, Zhukovsky C, Gudra D, Radovica-Spalvina I, Fridmanis D, Pirags V, Schiöth HB, Klovins J.

Clin Epigenetics. 2018 Dec 13;10(1):156. doi: 10.1186/s13148-018-0593-x.

4.

Hydroxycarboxylic Acid Receptor Ligands Modulate Proinflammatory Cytokine Expression in Human Macrophages and Adipocytes without Affecting Adipose Differentiation.

Mandrika I, Tilgase A, Petrovska R, Klovins J.

Biol Pharm Bull. 2018;41(10):1574-1580. doi: 10.1248/bpb.b18-00301.

5.

Association of metformin administration with gut microbiome dysbiosis in healthy volunteers.

Elbere I, Kalnina I, Silamikelis I, Konrade I, Zaharenko L, Sekace K, Radovica-Spalvina I, Fridmanis D, Gudra D, Pirags V, Klovins J.

PLoS One. 2018 Sep 27;13(9):e0204317. doi: 10.1371/journal.pone.0204317. eCollection 2018.

6.

A widely used sampling device in colorectal cancer screening programmes allows for large-scale microbiome studies.

Gudra D, Shoaie S, Fridmanis D, Klovins J, Wefer H, Silamikelis I, Peculis R, Kalnina I, Elbere I, Radovica-Spalvina I, Hultcrantz R, Šķenders Ģ, Leja M, Engstrand L.

Gut. 2019 Sep;68(9):1723-1725. doi: 10.1136/gutjnl-2018-316225. Epub 2018 Sep 21. No abstract available.

7.

Genes reveal traces of common recent demographic history for most of the Uralic-speaking populations.

Tambets K, Yunusbayev B, Hudjashov G, Ilumäe AM, Rootsi S, Honkola T, Vesakoski O, Atkinson Q, Skoglund P, Kushniarevich A, Litvinov S, Reidla M, Metspalu E, Saag L, Rantanen T, Karmin M, Parik J, Zhadanov SI, Gubina M, Damba LD, Bermisheva M, Reisberg T, Dibirova K, Evseeva I, Nelis M, Klovins J, Metspalu A, Esko T, Balanovsky O, Balanovska E, Khusnutdinova EK, Osipova LP, Voevoda M, Villems R, Kivisild T, Metspalu M.

Genome Biol. 2018 Sep 21;19(1):139. doi: 10.1186/s13059-018-1522-1.

8.

Analysis of shared heritability in common disorders of the brain.

Brainstorm Consortium, Anttila V, Bulik-Sullivan B, Finucane HK, Walters RK, Bras J, Duncan L, Escott-Price V, Falcone GJ, Gormley P, Malik R, Patsopoulos NA, Ripke S, Wei Z, Yu D, Lee PH, Turley P, Grenier-Boley B, Chouraki V, Kamatani Y, Berr C, Letenneur L, Hannequin D, Amouyel P, Boland A, Deleuze JF, Duron E, Vardarajan BN, Reitz C, Goate AM, Huentelman MJ, Kamboh MI, Larson EB, Rogaeva E, St George-Hyslop P, Hakonarson H, Kukull WA, Farrer LA, Barnes LL, Beach TG, Demirci FY, Head E, Hulette CM, Jicha GA, Kauwe JSK, Kaye JA, Leverenz JB, Levey AI, Lieberman AP, Pankratz VS, Poon WW, Quinn JF, Saykin AJ, Schneider LS, Smith AG, Sonnen JA, Stern RA, Van Deerlin VM, Van Eldik LJ, Harold D, Russo G, Rubinsztein DC, Bayer A, Tsolaki M, Proitsi P, Fox NC, Hampel H, Owen MJ, Mead S, Passmore P, Morgan K, Nöthen MM, Rossor M, Lupton MK, Hoffmann P, Kornhuber J, Lawlor B, McQuillin A, Al-Chalabi A, Bis JC, Ruiz A, Boada M, Seshadri S, Beiser A, Rice K, van der Lee SJ, De Jager PL, Geschwind DH, Riemenschneider M, Riedel-Heller S, Rotter JI, Ransmayr G, Hyman BT, Cruchaga C, Alegret M, Winsvold B, Palta P, Farh KH, Cuenca-Leon E, Furlotte N, Kurth T, Ligthart L, Terwindt GM, Freilinger T, Ran C, Gordon SD, Borck G, Adams HHH, Lehtimäki T, Wedenoja J, Buring JE, Schürks M, Hrafnsdottir M, Hottenga JJ, Penninx B, Artto V, Kaunisto M, Vepsäläinen S, Martin NG, Montgomery GW, Kurki MI, Hämäläinen E, Huang H, Huang J, Sandor C, Webber C, Muller-Myhsok B, Schreiber S, Salomaa V, Loehrer E, Göbel H, Macaya A, Pozo-Rosich P, Hansen T, Werge T, Kaprio J, Metspalu A, Kubisch C, Ferrari MD, Belin AC, van den Maagdenberg AMJM, Zwart JA, Boomsma D, Eriksson N, Olesen J, Chasman DI, Nyholt DR, Avbersek A, Baum L, Berkovic S, Bradfield J, Buono RJ, Catarino CB, Cossette P, De Jonghe P, Depondt C, Dlugos D, Ferraro TN, French J, Hjalgrim H, Jamnadas-Khoda J, Kälviäinen R, Kunz WS, Lerche H, Leu C, Lindhout D, Lo W, Lowenstein D, McCormack M, Møller RS, Molloy A, Ng PW, Oliver K, Privitera M, Radtke R, Ruppert AK, Sander T, Schachter S, Schankin C, Scheffer I, Schoch S, Sisodiya SM, Smith P, Sperling M, Striano P, Surges R, Thomas GN, Visscher F, Whelan CD, Zara F, Heinzen EL, Marson A, Becker F, Stroink H, Zimprich F, Gasser T, Gibbs R, Heutink P, Martinez M, Morris HR, Sharma M, Ryten M, Mok KY, Pulit S, Bevan S, Holliday E, Attia J, Battey T, Boncoraglio G, Thijs V, Chen WM, Mitchell B, Rothwell P, Sharma P, Sudlow C, Vicente A, Markus H, Kourkoulis C, Pera J, Raffeld M, Silliman S, Boraska Perica V, Thornton LM, Huckins LM, William Rayner N, Lewis CM, Gratacos M, Rybakowski F, Keski-Rahkonen A, Raevuori A, Hudson JI, Reichborn-Kjennerud T, Monteleone P, Karwautz A, Mannik K, Baker JH, O'Toole JK, Trace SE, Davis OSP, Helder SG, Ehrlich S, Herpertz-Dahlmann B, Danner UN, van Elburg AA, Clementi M, Forzan M, Docampo E, Lissowska J, Hauser J, Tortorella A, Maj M, Gonidakis F, Tziouvas K, Papezova H, Yilmaz Z, Wagner G, Cohen-Woods S, Herms S, Julià A, Rabionet R, Dick DM, Ripatti S, Andreassen OA, Espeseth T, Lundervold AJ, Steen VM, Pinto D, Scherer SW, Aschauer H, Schosser A, Alfredsson L, Padyukov L, Halmi KA, Mitchell J, Strober M, Bergen AW, Kaye W, Szatkiewicz JP, Cormand B, Ramos-Quiroga JA, Sánchez-Mora C, Ribasés M, Casas M, Hervas A, Arranz MJ, Haavik J, Zayats T, Johansson S, Williams N, Dempfle A, Rothenberger A, Kuntsi J, Oades RD, Banaschewski T, Franke B, Buitelaar JK, Arias Vasquez A, Doyle AE, Reif A, Lesch KP, Freitag C, Rivero O, Palmason H, Romanos M, Langley K, Rietschel M, Witt SH, Dalsgaard S, Børglum AD, Waldman I, Wilmot B, Molly N, Bau CHD, Crosbie J, Schachar R, Loo SK, McGough JJ, Grevet EH, Medland SE, Robinson E, Weiss LA, Bacchelli E, Bailey A, Bal V, Battaglia A, Betancur C, Bolton P, Cantor R, Celestino-Soper P, Dawson G, De Rubeis S, Duque F, Green A, Klauck SM, Leboyer M, Levitt P, Maestrini E, Mane S, De-Luca DM, Parr J, Regan R, Reichenberg A, Sandin S, Vorstman J, Wassink T, Wijsman E, Cook E, Santangelo S, Delorme R, Rogé B, Magalhaes T, Arking D, Schulze TG, Thompson RC, Strohmaier J, Matthews K, Melle I, Morris D, Blackwood D, McIntosh A, Bergen SE, Schalling M, Jamain S, Maaser A, Fischer SB, Reinbold CS, Fullerton JM, Guzman-Parra J, Mayoral F, Schofield PR, Cichon S, Mühleisen TW, Degenhardt F, Schumacher J, Bauer M, Mitchell PB, Gershon ES, Rice J, Potash JB, Zandi PP, Craddock N, Ferrier IN, Alda M, Rouleau GA, Turecki G, Ophoff R, Pato C, Anjorin A, Stahl E, Leber M, Czerski PM, Cruceanu C, Jones IR, Posthuma D, Andlauer TFM, Forstner AJ, Streit F, Baune BT, Air T, Sinnamon G, Wray NR, MacIntyre DJ, Porteous D, Homuth G, Rivera M, Grove J, Middeldorp CM, Hickie I, Pergadia M, Mehta D, Smit JH, Jansen R, de Geus E, Dunn E, Li QS, Nauck M, Schoevers RA, Beekman AT, Knowles JA, Viktorin A, Arnold P, Barr CL, Bedoya-Berrio G, Bienvenu OJ, Brentani H, Burton C, Camarena B, Cappi C, Cath D, Cavallini M, Cusi D, Darrow S, Denys D, Derks EM, Dietrich A, Fernandez T, Figee M, Freimer N, Gerber G, Grados M, Greenberg E, Hanna GL, Hartmann A, Hirschtritt ME, Hoekstra PJ, Huang A, Huyser C, Illmann C, Jenike M, Kuperman S, Leventhal B, Lochner C, Lyon GJ, Macciardi F, Madruga-Garrido M, Malaty IA, Maras A, McGrath L, Miguel EC, Mir P, Nestadt G, Nicolini H, Okun MS, Pakstis A, Paschou P, Piacentini J, Pittenger C, Plessen K, Ramensky V, Ramos EM, Reus V, Richter MA, Riddle MA, Robertson MM, Roessner V, Rosário M, Samuels JF, Sandor P, Stein DJ, Tsetsos F, Van Nieuwerburgh F, Weatherall S, Wendland JR, Wolanczyk T, Worbe Y, Zai G, Goes FS, McLaughlin N, Nestadt PS, Grabe HJ, Depienne C, Konkashbaev A, Lanzagorta N, Valencia-Duarte A, Bramon E, Buccola N, Cahn W, Cairns M, Chong SA, Cohen D, Crespo-Facorro B, Crowley J, Davidson M, DeLisi L, Dinan T, Donohoe G, Drapeau E, Duan J, Haan L, Hougaard D, Karachanak-Yankova S, Khrunin A, Klovins J, Kučinskas V, Lee Chee Keong J, Limborska S, Loughland C, Lönnqvist J, Maher B, Mattheisen M, McDonald C, Murphy KC, Nenadic I, van Os J, Pantelis C, Pato M, Petryshen T, Quested D, Roussos P, Sanders AR, Schall U, Schwab SG, Sim K, So HC, Stögmann E, Subramaniam M, Toncheva D, Waddington J, Walters J, Weiser M, Cheng W, Cloninger R, Curtis D, Gejman PV, Henskens F, Mattingsdal M, Oh SY, Scott R, Webb B, Breen G, Churchhouse C, Bulik CM, Daly M, Dichgans M, Faraone SV, Guerreiro R, Holmans P, Kendler KS, Koeleman B, Mathews CA, Price A, Scharf J, Sklar P, Williams J, Wood NW, Cotsapas C, Palotie A, Smoller JW, Sullivan P, Rosand J, Corvin A, Neale BM, Schott JM, Anney R, Elia J, Grigoroiu-Serbanescu M, Edenberg HJ, Murray R.

Science. 2018 Jun 22;360(6395). pii: eaap8757. doi: 10.1126/science.aap8757.

9.

Genome Database of the Latvian Population (LGDB): Design, Goals, and Primary Results.

Rovite V, Wolff-Sagi Y, Zaharenko L, Nikitina-Zake L, Grens E, Klovins J.

J Epidemiol. 2018 Aug 5;28(8):353-360. doi: 10.2188/jea.JE20170079. Epub 2018 Mar 24.

10.

Synthesis and evaluation of (E)-2-(5-phenylpent-2-en-4-ynamido)cyclohex-1-ene-1-carboxylate derivatives as HCA2 receptor agonists.

Bobileva O, Ikaunieks M, Duburs G, Mandrika I, Petrovska R, Klovins J, Loza E.

Bioorg Med Chem. 2017 Aug 15;25(16):4314-4329. doi: 10.1016/j.bmc.2017.06.028. Epub 2017 Jun 21.

PMID:
28668361
11.

ACTH Receptor (MC2R) Specificity: What Do We Know About Underlying Molecular Mechanisms?

Fridmanis D, Roga A, Klovins J.

Front Endocrinol (Lausanne). 2017 Feb 6;8:13. doi: 10.3389/fendo.2017.00013. eCollection 2017. Review.

12.

Variants in Pharmacokinetic Transporters and Glycemic Response to Metformin: A Metgen Meta-Analysis.

Dujic T, Zhou K, Yee SW, van Leeuwen N, de Keyser CE, Javorský M, Goswami S, Zaharenko L, Hougaard Christensen MM, Out M, Tavendale R, Kubo M, Hedderson MM, van der Heijden AA, Klimčáková L, Pirags V, Kooy A, Brøsen K, Klovins J, Semiz S, Tkáč I, Stricker BH, Palmer C, 't Hart LM, Giacomini KM, Pearson ER.

Clin Pharmacol Ther. 2017 Jun;101(6):763-772. doi: 10.1002/cpt.567. Epub 2017 Feb 3.

13.

Single nucleotide polymorphisms in the intergenic region between metformin transporter OCT2 and OCT3 coding genes are associated with short-term response to metformin monotherapy in type 2 diabetes mellitus patients.

Zaharenko L, Kalnina I, Geldnere K, Konrade I, Grinberga S, Židzik J, Javorský M, Lejnieks A, Nikitina-Zake L, Fridmanis D, Peculis R, Radovica-Spalvina I, Hartmane D, Pugovics O, Tkáč I, Klimčáková L, Pīrāgs V, Klovins J.

Eur J Endocrinol. 2016 Dec;175(6):531-540. Epub 2016 Sep 8.

PMID:
27609360
14.

Variation in the glucose transporter gene SLC2A2 is associated with glycemic response to metformin.

Zhou K, Yee SW, Seiser EL, van Leeuwen N, Tavendale R, Bennett AJ, Groves CJ, Coleman RL, van der Heijden AA, Beulens JW, de Keyser CE, Zaharenko L, Rotroff DM, Out M, Jablonski KA, Chen L, Javorský M, Židzik J, Levin AM, Williams LK, Dujic T, Semiz S, Kubo M, Chien HC, Maeda S, Witte JS, Wu L, Tkáč I, Kooy A, van Schaik RHN, Stehouwer CDA, Logie L; MetGen Investigators; DPP Investigators; ACCORD Investigators, Sutherland C, Klovins J, Pirags V, Hofman A, Stricker BH, Motsinger-Reif AA, Wagner MJ, Innocenti F, 't Hart LM, Holman RR, McCarthy MI, Hedderson MM, Palmer CNA, Florez JC, Giacomini KM, Pearson ER.

Nat Genet. 2016 Sep;48(9):1055-1059. doi: 10.1038/ng.3632. Epub 2016 Aug 8.

15.

Functional Characteristics of Multipotent Mesenchymal Stromal Cells from Pituitary Adenomas.

Megnis K, Mandrika I, Petrovska R, Stukens J, Rovite V, Balcere I, Jansone LS, Peculis R, Pirags V, Klovins J.

Stem Cells Int. 2016;2016:7103720. doi: 10.1155/2016/7103720. Epub 2016 Jun 2.

16.

Polymorphisms in MEN1 and DRD2 genes are associated with the occurrence and characteristics of pituitary adenomas.

Peculis R, Balcere I, Rovite V, Megnis K, Valtere A, Stukens J, Arnicane L, Nikitina-Zake L, Lejnieks A, Pirags V, Klovins J.

Eur J Endocrinol. 2016 Aug;175(2):145-53. doi: 10.1530/EJE-15-0879. Epub 2016 May 16.

PMID:
27185868
17.

Many obesity-associated SNPs strongly associate with DNA methylation changes at proximal promoters and enhancers.

Voisin S, Almén MS, Zheleznyakova GY, Lundberg L, Zarei S, Castillo S, Eriksson FE, Nilsson EK, Blüher M, Böttcher Y, Kovacs P, Klovins J, Rask-Andersen M, Schiöth HB.

Genome Med. 2015 Oct 8;7:103. doi: 10.1186/s13073-015-0225-4.

18.

Next-generation-sequencing-based identification of familial hypercholesterolemia-related mutations in subjects with increased LDL-C levels in a latvian population.

Radovica-Spalvina I, Latkovskis G, Silamikelis I, Fridmanis D, Elbere I, Ventins K, Ozola G, Erglis A, Klovins J.

BMC Med Genet. 2015 Sep 28;16:86. doi: 10.1186/s12881-015-0230-x.

19.

Harmonising and linking biomedical and clinical data across disparate data archives to enable integrative cross-biobank research.

Spjuth O, Krestyaninova M, Hastings J, Shen HY, Heikkinen J, Waldenberger M, Langhammer A, Ladenvall C, Esko T, Persson MÅ, Heggland J, Dietrich J, Ose S, Gieger C, Ried JS, Peters A, Fortier I, de Geus EJ, Klovins J, Zaharenko L, Willemsen G, Hottenga JJ, Litton JE, Karvanen J, Boomsma DI, Groop L, Rung J, Palmgren J, Pedersen NL, McCarthy MI, van Duijn CM, Hveem K, Metspalu A, Ripatti S, Prokopenko I, Harris JR.

Eur J Hum Genet. 2016 Apr;24(4):521-8. doi: 10.1038/ejhg.2015.165. Epub 2015 Aug 26.

20.

Prevalence estimation of celiac disease in the general adult population of Latvia using serology and HLA genotyping.

Leja M, Shums Z, Nikitina-Zake L, Gavars M, Kikuste I, Milo J, Daugule I, Pahomova J, Pirags V, Dzerve V, Klovins J, Erglis A, Norman GL.

United European Gastroenterol J. 2015 Apr;3(2):190-9. doi: 10.1177/2050640615569379.

21.

Association between CETP, MLXIPL, and TOMM40 polymorphisms and serum lipid levels in a Latvian population.

Radovica I, Fridmanis D, Silamikelis I, Nikitina-Zake L, Klovins J.

Meta Gene. 2014 Aug 20;2:565-78. doi: 10.1016/j.mgene.2014.07.006. eCollection 2014 Dec.

22.

Association of F11 polymorphism rs2289252 with deep vein thrombosis and related phenotypes in population of Latvia.

Rovite V, Maurins U, Megnis K, Vaivade I, Pečulis R, Rits J, Prave S, Klovins J.

Thromb Res. 2014 Sep;134(3):659-63. doi: 10.1016/j.thromres.2014.07.011. Epub 2014 Jul 18.

PMID:
25091233
23.

Replacement of short segments within transmembrane domains of MC2R disrupts retention signal.

Fridmanis D, Petrovska R, Pjanova D, Schiöth HB, Klovins J.

J Mol Endocrinol. 2014 Oct;53(2):201-15. doi: 10.1530/JME-14-0169. Epub 2014 Jul 29.

PMID:
25074265
24.

Role of genetic factors on the effect of additional loading doses and two maintenance doses used to overcome clopidogrel hyporesponsiveness.

Latkovskis G, Urtane I, Knipse A, Peculis R, Cakstina I, Klovins J, Erglis A.

Medicina (Kaunas). 2014;50(1):19-27. doi: 10.1016/j.medici.2014.05.004. Epub 2014 Jun 6.

25.

HFE-related hemochromatosis risk mutations in Latvian population.

Peculis R, Lace B, Putnina A, Nikitina-Zake L, Klovins J.

Ann Hematol. 2015 Feb;94(2):343-4. No abstract available.

PMID:
25015053
26.

Genome-wide analysis reveals DNA methylation markers that vary with both age and obesity.

Almén MS, Nilsson EK, Jacobsson JA, Kalnina I, Klovins J, Fredriksson R, Schiöth HB.

Gene. 2014 Sep 10;548(1):61-7. doi: 10.1016/j.gene.2014.07.009. Epub 2014 Jul 8.

27.

Synthesis and evaluation of (E)-2-(acrylamido)cyclohex-1-enecarboxylic acid derivatives as HCA1, HCA2, and HCA3 receptor agonists.

Bobileva O, Bokaldere R, Gailite V, Kaula I, Ikaunieks M, Duburs G, Petrovska R, Mandrika I, Klovins J, Loza E.

Bioorg Med Chem. 2014 Jul 15;22(14):3654-69. doi: 10.1016/j.bmc.2014.05.011. Epub 2014 May 17.

PMID:
24864041
28.

The role of common and rare MC4R variants and FTO polymorphisms in extreme form of obesity.

Rovite V, Petrovska R, Vaivade I, Kalnina I, Fridmanis D, Zaharenko L, Peculis R, Pirags V, Schioth HB, Klovins J.

Mol Biol Rep. 2014 Mar;41(3):1491-500. doi: 10.1007/s11033-013-2994-4. Epub 2014 Jan 3.

PMID:
24385306
29.

Polymorphisms in FTO and near TMEM18 associate with type 2 diabetes and predispose to younger age at diagnosis of diabetes.

Kalnina I, Zaharenko L, Vaivade I, Rovite V, Nikitina-Zake L, Peculis R, Fridmanis D, Geldnere K, Jacobsson JA, Almen MS, Pirags V, Schiöth HB, Klovins J.

Gene. 2013 Sep 25;527(2):462-8. doi: 10.1016/j.gene.2013.06.079. Epub 2013 Jul 13.

PMID:
23860325
30.

The association of common SNPs and haplotypes in CETP gene with HDL cholesterol levels in Latvian population.

Radovica I, Fridmanis D, Vaivade I, Nikitina-Zake L, Klovins J.

PLoS One. 2013 May 13;8(5):e64191. doi: 10.1371/journal.pone.0064191. Print 2013.

31.

A genome-wide analysis of populations from European Russia reveals a new pole of genetic diversity in northern Europe.

Khrunin AV, Khokhrin DV, Filippova IN, Esko T, Nelis M, Bebyakova NA, Bolotova NL, Klovins J, Nikitina-Zake L, Rehnström K, Ripatti S, Schreiber S, Franke A, Macek M, Krulišová V, Lubinski J, Metspalu A, Limborska SA.

PLoS One. 2013;8(3):e58552. doi: 10.1371/journal.pone.0058552. Epub 2013 Mar 7.

32.

Genetic characterization of northeastern Italian population isolates in the context of broader European genetic diversity.

Esko T, Mezzavilla M, Nelis M, Borel C, Debniak T, Jakkula E, Julia A, Karachanak S, Khrunin A, Kisfali P, Krulisova V, Aušrelé Kučinskiené Z, Rehnström K, Traglia M, Nikitina-Zake L, Zimprich F, Antonarakis SE, Estivill X, Glavač D, Gut I, Klovins J, Krawczak M, Kučinskas V, Lathrop M, Macek M, Marsal S, Meitinger T, Melegh B, Limborska S, Lubinski J, Paolotie A, Schreiber S, Toncheva D, Toniolo D, Wichmann HE, Zimprich A, Metspalu M, Gasparini P, Metspalu A, D'Adamo P.

Eur J Hum Genet. 2013 Jun;21(6):659-65. doi: 10.1038/ejhg.2012.229. Epub 2012 Dec 19.

33.

Identification of glyoxalase 1 polymorphisms associated with enzyme activity.

Peculis R, Konrade I, Skapare E, Fridmanis D, Nikitina-Zake L, Lejnieks A, Pirags V, Dambrova M, Klovins J.

Gene. 2013 Feb 15;515(1):140-3. doi: 10.1016/j.gene.2012.11.009. Epub 2012 Nov 29.

PMID:
23201419
34.

BCL3 gene role in facial morphology.

Lace B, Kempa I, Klovins J, Stavusis J, Krumina A, Akota I, Barkane B, Vieira AR, Nagle E, Grinfelde I, Maulina I.

Birth Defects Res A Clin Mol Teratol. 2012 Nov;94(11):918-24. doi: 10.1002/bdra.23085. Epub 2012 Nov 1.

PMID:
23115114
35.

Association of genetic variation in the organic cation transporters OCT1, OCT2 and multidrug and toxin extrusion 1 transporter protein genes with the gastrointestinal side effects and lower BMI in metformin-treated type 2 diabetes patients.

Tarasova L, Kalnina I, Geldnere K, Bumbure A, Ritenberga R, Nikitina-Zake L, Fridmanis D, Vaivade I, Pirags V, Klovins J.

Pharmacogenet Genomics. 2012 Sep;22(9):659-66. doi: 10.1097/FPC.0b013e3283561666.

PMID:
22735389
36.

Determination of the obesity-associated gene variants within the entire FTO gene by ultra-deep targeted sequencing in obese and lean children.

Sällman Almén M, Rask-Andersen M, Jacobsson JA, Ameur A, Kalnina I, Moschonis G, Juhlin S, Bringeland N, Hedberg LA, Ignatovica V, Chrousos GP, Manios Y, Klovins J, Marcus C, Gyllensten U, Fredriksson R, Schiöth HB.

Int J Obes (Lond). 2013 Mar;37(3):424-31. doi: 10.1038/ijo.2012.57. Epub 2012 Apr 24.

37.

Stronger association of common variants in TCF7L2 gene with nonobese type 2 diabetes in the Latvian population.

Kalnina I, Geldnere K, Tarasova L, Nikitina-Zake L, Peculis R, Fridmanis D, Pirags V, Klovins J.

Exp Clin Endocrinol Diabetes. 2012 Sep;120(8):466-8. doi: 10.1055/s-0032-1306298. Epub 2012 Mar 22.

PMID:
22441719
38.

Association of protein tyrosine phosphatase non-receptor 22 (PTPN22) rs2476601 and Kruppel-like factor 12 (KLF12) rs1324913 single nucleotide polymorphisms with rheumatoid arthritis in a Latvian population.

Mihailova A, Mikazane H, Klovins J, Nikitina-Zake L.

Scand J Rheumatol. 2011 Nov;40(6):491-2. doi: 10.3109/03009742.2011.608715. No abstract available.

PMID:
22150086
39.

Association studies of candidate genes and cleft lip and palate taking into consideration geographical origin.

Lace B, Kempa I, Piekuse L, Grinfelde I, Klovins J, Pliss L, Krumina A, Vieira AR.

Eur J Oral Sci. 2011 Dec;119(6):413-7. doi: 10.1111/j.1600-0722.2011.00877.x. Epub 2011 Oct 15.

PMID:
22112025
40.

Identification and analysis of functionally important amino acids in human purinergic 12 receptor using a Saccharomyces cerevisiae expression system.

Ignatovica V, Megnis K, Lapins M, Schiöth HB, Klovins J.

FEBS J. 2012 Jan;279(1):180-91. doi: 10.1111/j.1742-4658.2011.08410.x. Epub 2011 Nov 23.

41.

Identification of somatostatin receptor type 5 gene polymorphisms associated with acromegaly.

Ciganoka D, Balcere I, Kapa I, Peculis R, Valtere A, Nikitina-Zake L, Lase I, Schiöth HB, Pirags V, Klovins J.

Eur J Endocrinol. 2011 Oct;165(4):517-25. doi: 10.1530/EJE-11-0416. Epub 2011 Aug 2.

42.

A nonsynonymous variant I248L of the adenosine A3 receptor is associated with coronary heart disease in a Latvian population.

Peculis R, Latkovskis G, Tarasova L, Pirags V, Erglis A, Klovins J.

DNA Cell Biol. 2011 Nov;30(11):907-11. doi: 10.1089/dna.2011.1230. Epub 2011 Jun 15.

PMID:
21675873
43.

Single nucleotide polymorphisms of the purinergic 1 receptor are not associated with myocardial infarction in a Latvian population.

Ignatovica V, Latkovskis G, Peculis R, Megnis K, Schioth HB, Vaivade I, Fridmanis D, Pirags V, Erglis A, Klovins J.

Mol Biol Rep. 2012 Feb;39(2):1917-25. doi: 10.1007/s11033-011-0938-4. Epub 2011 Jun 4.

PMID:
21643756
44.

Variation in FGF1, FOXE1, and TIMP2 genes is associated with nonsyndromic cleft lip with or without cleft palate.

Nikopensius T, Kempa I, Ambrozaitytė L, Jagomägi T, Saag M, Matulevičienė A, Utkus A, Krjutškov K, Tammekivi V, Piekuse L, Akota I, Barkane B, Krumina A, Klovins J, Lace B, Kučinskas V, Metspalu A.

Birth Defects Res A Clin Mol Teratol. 2011 Apr;91(4):218-25. doi: 10.1002/bdra.20791. Epub 2011 Apr 1.

PMID:
21462296
45.

Evidence for constitutive dimerization of niacin receptor subtypes.

Mandrika I, Petrovska R, Klovins J.

Biochem Biophys Res Commun. 2010 Apr 30;395(2):281-7. doi: 10.1016/j.bbrc.2010.04.011. Epub 2010 Apr 7.

PMID:
20380810
46.

Identification of domains responsible for specific membrane transport and ligand specificity of the ACTH receptor (MC2R).

Fridmanis D, Petrovska R, Kalnina I, Slaidina M, Peculis R, Schiöth HB, Klovins J.

Mol Cell Endocrinol. 2010 Jun 10;321(2):175-83. doi: 10.1016/j.mce.2010.02.032. Epub 2010 Mar 3.

PMID:
20206229
47.

Association between a rare SNP in the second intron of human Agouti related protein gene and increased BMI.

Kalnina I, Kapa I, Pirags V, Ignatovica V, Schiöth HB, Klovins J.

BMC Med Genet. 2009 Jul 14;10:63. doi: 10.1186/1471-2350-10-63.

48.

Genetic structure of Europeans: a view from the North-East.

Nelis M, Esko T, Mägi R, Zimprich F, Zimprich A, Toncheva D, Karachanak S, Piskácková T, Balascák I, Peltonen L, Jakkula E, Rehnström K, Lathrop M, Heath S, Galan P, Schreiber S, Meitinger T, Pfeufer A, Wichmann HE, Melegh B, Polgár N, Toniolo D, Gasparini P, D'Adamo P, Klovins J, Nikitina-Zake L, Kucinskas V, Kasnauskiene J, Lubinski J, Debniak T, Limborska S, Khrunin A, Estivill X, Rabionet R, Marsal S, Julià A, Antonarakis SE, Deutsch S, Borel C, Attar H, Gagnebin M, Macek M, Krawczak M, Remm M, Metspalu A.

PLoS One. 2009;4(5):e5472. doi: 10.1371/journal.pone.0005472. Epub 2009 May 8. Erratum in: PLoS One. 2010;5(3). doi: 10.1371/annotation/2849e182-aef5-4e2b-a5ac-0b74b30e5f48.

49.

Novel genetic variant in FTO influences insulin levels and insulin resistance in severely obese children and adolescents.

Jacobsson JA, Klovins J, Kapa I, Danielsson P, Svensson V, Ridderstråle M, Gyllensten U, Marcus C, Fredriksson R, Schiöth HB.

Int J Obes (Lond). 2008 Nov;32(11):1730-5. doi: 10.1038/ijo.2008.168. Epub 2008 Sep 16.

PMID:
18794893
50.

Major gender difference in association of FTO gene variant among severely obese children with obesity and obesity related phenotypes.

Jacobsson JA, Danielsson P, Svensson V, Klovins J, Gyllensten U, Marcus C, Schiöth HB, Fredriksson R.

Biochem Biophys Res Commun. 2008 Apr 11;368(3):476-82. doi: 10.1016/j.bbrc.2008.01.087. Epub 2008 Feb 4.

PMID:
18249188

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