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Items: 1 to 50 of 299

1.

Efficacy and Tolerance of Synthetic Cannabidiol for Treatment of Drug Resistant Epilepsy.

Klotz KA, Grob D, Hirsch M, Metternich B, Schulze-Bonhage A, Jacobs J.

Front Neurol. 2019 Dec 10;10:1313. doi: 10.3389/fneur.2019.01313. eCollection 2019.

2.

Trends in pediatric epilepsy surgery in Europe between 2008 and 2015: Country-, center-, and age-specific variation.

Barba C, Cross JH, Braun K, Cossu M, Klotz KA, De Masi S, Perez Jiménez MA, Gaily E, Specchio N, Cabral P, Toulouse J, Dimova P, Battaglia D, Freri E, Consales A, Cesaroni E, Tarta-Arsene O, Gil-Nagel A, Mindruta I, Di Gennaro G, Giulioni M, Tisdall MM, Eltze C, Tahir MZ, Jansen F, van Rijen P, Sanders M, Tassi L, Francione S, Lo Russo G, Jacobs J, Bast T, Matta G, Budke M, Fournier Del Castillo C, Metsahonkala EL, Karppinen A, Ferreira JC, Minkin K, Marras CE; European Survey Group, Arzimanoglou A, Guerrini R.

Epilepsia. 2019 Dec 26. doi: 10.1111/epi.16414. [Epub ahead of print]

PMID:
31876960
3.

Structure-Based Optimization of Coumarin hA3 Adenosine Receptor Antagonists.

Matos MJ, Vilar S, Vazquez-Rodriguez S, Kachler S, Klotz KN, Buccioni M, Delogu G, Santana L, Uriarte E, Borges F.

J Med Chem. 2019 Dec 4. doi: 10.1021/acs.jmedchem.9b01572. [Epub ahead of print]

PMID:
31738058
4.

Design, Synthesis and Evaluation of New Indolylpyrimidylpiperazines for Gastrointestinal Cancer Therapy.

Tan A, Babak MV, Venkatesan G, Lim C, Klotz KN, Herr DR, Cheong SL, Federico S, Spalluto G, Ong WY, Chen YZ, Loo JSE, Pastorin G.

Molecules. 2019 Oct 11;24(20). pii: E3661. doi: 10.3390/molecules24203661.

5.

Complete Genome Sequence of Escherichia coli Myophage Mansfield.

D'Souza GM, Klotz K, Moreland R, Liu M, Ramsey J.

Microbiol Resour Announc. 2019 Sep 19;8(38). pii: e01038-19. doi: 10.1128/MRA.01038-19.

6.

Systemic availability of lipophilic organic UV filters through dermal sunscreen exposure.

Hiller J, Klotz K, Meyer S, Uter W, Hof K, Greiner A, Göen T, Drexler H.

Environ Int. 2019 Nov;132:105068. doi: 10.1016/j.envint.2019.105068. Epub 2019 Aug 27.

7.

New A2A adenosine receptor antagonists: a structure-based upside-down interaction in the receptor cavity.

Lambertucci C, Spinaci A, Buccioni M, Dal Ben D, Ngouadjeu Ngnintedem MA, Kachler S, Marucci G, Klotz KN, Volpini R.

Bioorg Chem. 2019 Nov;92:103183. doi: 10.1016/j.bioorg.2019.103183. Epub 2019 Aug 5.

PMID:
31446240
8.

Toxicokinetics of urinary 2-ethylhexyl salicylate and its metabolite 2-ethyl-hydroxyhexyl salicylate in humans after simulating real-life dermal sunscreen exposure.

Hiller J, Klotz K, Meyer S, Uter W, Hof K, Greiner A, Göen T, Drexler H.

Arch Toxicol. 2019 Sep;93(9):2565-2574. doi: 10.1007/s00204-019-02537-z. Epub 2019 Aug 22.

PMID:
31435713
9.

A novel small molecule A2A adenosine receptor agonist, indirubin-3'-monoxime, alleviates lipid-induced inflammation and insulin resistance in 3T3-L1 adipocytes.

Choudhary SA, Bora N, Banerjee D, Arora L, Das AS, Yadav R, Klotz KN, Pal D, Jha AN, Dasgupta S.

Biochem J. 2019 Aug 30;476(16):2371-2391. doi: 10.1042/BCJ20190251.

PMID:
31409652
10.

Pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidines to develop functionalized ligands to target adenosine receptors: fluorescent ligands as an example.

Federico S, Margiotta E, Paoletta S, Kachler S, Klotz KN, Jacobson KA, Pastorin G, Moro S, Spalluto G.

Medchemcomm. 2019 Feb 18;10(7):1094-1108. doi: 10.1039/c9md00014c. eCollection 2019 Jul 1.

PMID:
31391881
11.

Agonists activate different A2B adenosine receptor signaling pathways in MBA-MD-231 breast cancer cells with distinct potencies.

Koussémou M, Klotz KN.

Naunyn Schmiedebergs Arch Pharmacol. 2019 Dec;392(12):1515-1521. doi: 10.1007/s00210-019-01695-2. Epub 2019 Jul 23.

PMID:
31338535
12.

Medicinal Chemistry and Therapeutic Potential of Agonists, Antagonists and Allosteric Modulators of A1 Adenosine Receptor: Current Status and Perspectives.

Deb PK, Deka S, Borah P, Abed SN, Klotz KN.

Curr Pharm Des. 2019;25(25):2697-2715. doi: 10.2174/1381612825666190716100509.

PMID:
31333094
13.

Complete Genome Sequence of Staphylococcus aureus Siphophage Sebago.

Klotz K, Korn A, Newkirk H, Liu M, Gill JJ, Ramsey J.

Microbiol Resour Announc. 2019 Jul 18;8(29). pii: e00765-19. doi: 10.1128/MRA.00765-19.

14.

Quantification of prominent organic UV filters and their metabolites in human urine and plasma samples.

Klotz K, Hof K, Hiller J, Göen T, Drexler H.

J Chromatogr B Analyt Technol Biomed Life Sci. 2019 Sep 1;1125:121706. doi: 10.1016/j.jchromb.2019.06.033. Epub 2019 Jun 28.

PMID:
31302475
15.

Validity of different biomonitoring parameters in human urine for the assessment of occupational exposure to naphthalene.

Klotz K, Weiß T, Zobel M, Bury D, Breuer D, Werner S, Sucker K, Zschiesche W, Göen T, Brüning T, Drexler H.

Arch Toxicol. 2019 Aug;93(8):2185-2195. doi: 10.1007/s00204-019-02468-9. Epub 2019 Jun 20.

PMID:
31222524
16.

Effects of cannabidiol on brivaracetam plasma levels.

Klotz KA, Hirsch M, Heers M, Schulze-Bonhage A, Jacobs J.

Epilepsia. 2019 Jul;60(7):e74-e77. doi: 10.1111/epi.16071. Epub 2019 Jun 18.

PMID:
31211851
17.

The current status of pharmacotherapy for the treatment of Parkinson's disease: transition from single-target to multitarget therapy.

Cheong SL, Federico S, Spalluto G, Klotz KN, Pastorin G.

Drug Discov Today. 2019 Sep;24(9):1769-1783. doi: 10.1016/j.drudis.2019.05.003. Epub 2019 May 16. Review.

PMID:
31102728
18.

7-Amino-2-aryl/hetero-aryl-5-oxo-5,8-dihydro[1,2,4]triazolo[1,5-a]pyridine-6-carbonitriles: Synthesis and adenosine receptor binding studies.

Shaik K, Deb PK, Mailavaram RP, Chandrasekaran B, Kachler S, Klotz KN, Jaber AMY.

Chem Biol Drug Des. 2019 Aug;94(2):1568-1573. doi: 10.1111/cbdd.13528. Epub 2019 May 15.

PMID:
30985956
19.
20.

Neuroprotective potential of adenosine A1 receptor partial agonists in experimental models of cerebral ischemia.

Martire A, Lambertucci C, Pepponi R, Ferrante A, Benati N, Buccioni M, Dal Ben D, Marucci G, Klotz KN, Volpini R, Popoli P.

J Neurochem. 2019 Apr;149(2):211-230. doi: 10.1111/jnc.14660. Epub 2019 Feb 11.

PMID:
30614535
21.

Cannabidiol for Treatment of Childhood Epilepsy-A Cross-Sectional Survey.

Klotz KA, Schulze-Bonhage A, Antonio-Arce VS, Jacobs J.

Front Neurol. 2018 Sep 7;9:731. doi: 10.3389/fneur.2018.00731. eCollection 2018.

22.

A Quality Improvement Initiative to Decrease Time to Antibiotics for Children with Intestinal Failure, Fever, and a Central Line.

Hariharan S, Mezoff EA, Dandoy CE, Zhang Y, Chiarenzelli J, Troutt ML, Simpkins J, Dewald M, Klotz K, Mezoff AG, Cole CR.

Pediatr Qual Saf. 2018 Jul 20;3(4):e090. doi: 10.1097/pq9.0000000000000090. eCollection 2018 Jul-Aug.

23.

The A2B adenosine receptor in MDA-MB-231 breast cancer cells diminishes ERK1/2 phosphorylation by activation of MAPK-phosphatase-1.

Koussémou M, Lorenz K, Klotz KN.

PLoS One. 2018 Aug 29;13(8):e0202914. doi: 10.1371/journal.pone.0202914. eCollection 2018.

24.

[1,2,4]Triazolo[1,5-c]pyrimidines as adenosine receptor antagonists: Modifications at the 8 position to reach selectivity towards A3 adenosine receptor subtype.

Federico S, Margiotta E, Salmaso V, Pastorin G, Kachler S, Klotz KN, Moro S, Spalluto G.

Eur J Med Chem. 2018 Sep 5;157:837-851. doi: 10.1016/j.ejmech.2018.08.042. Epub 2018 Aug 20.

PMID:
30144700
25.

Discovery of 2-aminoimidazole and 2-amino imidazolyl-thiazoles as non-xanthine human adenosine A3 receptor antagonists: SAR and molecular modeling studies.

Pandya AN, Baraiya AB, Jalani HB, Pandya D, Kaila JC, Kachler S, Salmaso V, Moro S, Klotz KN, Vasu KK.

Medchemcomm. 2018 Mar 13;9(4):676-684. doi: 10.1039/c7md00643h. eCollection 2018 Apr 1.

26.

Suitability of several naphthalene metabolites for their application in biomonitoring studies.

Klotz K, Zobel M, Schäferhenrich A, Hebisch R, Drexler H, Göen T.

Toxicol Lett. 2018 Dec 1;298:91-98. doi: 10.1016/j.toxlet.2018.07.008. Epub 2018 Jul 7.

PMID:
29990563
27.

New potent and selective A1 adenosine receptor antagonists as potential tools for the treatment of gastrointestinal diseases.

Lambertucci C, Marucci G, Dal Ben D, Buccioni M, Spinaci A, Kachler S, Klotz KN, Volpini R.

Eur J Med Chem. 2018 May 10;151:199-213. doi: 10.1016/j.ejmech.2018.03.067. Epub 2018 Mar 27.

PMID:
29614417
28.

Discovery of Novel Adenosine Receptor Antagonists through a Combined Structure- and Ligand-Based Approach Followed by Molecular Dynamics Investigation of Ligand Binding Mode.

Lagarias P, Vrontaki E, Lambrinidis G, Stamatis D, Convertino M, Ortore G, Mavromoustakos T, Klotz KN, Kolocouris A.

J Chem Inf Model. 2018 Apr 23;58(4):794-815. doi: 10.1021/acs.jcim.7b00455. Epub 2018 Mar 19.

PMID:
29485875
29.

LC-MS/MS procedure for the simultaneous determination of N-acetyl-S-(1-naphthyl)cysteine and N-acetyl-S-(2-napthyl)cysteine in human urine.

Zobel M, Klotz K, Göen T.

J Chromatogr B Analyt Technol Biomed Life Sci. 2018 Feb 1;1074-1075:139-145. doi: 10.1016/j.jchromb.2017.12.023. Epub 2017 Dec 16.

PMID:
29413004
30.

Discovery of indolylpiperazinylpyrimidines with dual-target profiles at adenosine A2A and dopamine D2 receptors for Parkinson's disease treatment.

Shao YM, Ma X, Paira P, Tan A, Herr DR, Lim KL, Ng CH, Venkatesan G, Klotz KN, Federico S, Spalluto G, Cheong SL, Chen YZ, Pastorin G.

PLoS One. 2018 Jan 5;13(1):e0188212. doi: 10.1371/journal.pone.0188212. eCollection 2018.

31.

Structure-Based Design, Synthesis, and In Vivo Antinociceptive Effects of Selective A1 Adenosine Receptor Agonists.

Petrelli R, Scortichini M, Belardo C, Boccella S, Luongo L, Capone F, Kachler S, Vita P, Del Bello F, Maione S, Lavecchia A, Klotz KN, Cappellacci L.

J Med Chem. 2018 Jan 11;61(1):305-318. doi: 10.1021/acs.jmedchem.7b01399. Epub 2018 Jan 3.

PMID:
29257884
32.

Synthesis, adenosine receptor binding and molecular modelling studies of novel thieno[2,3-d]pyrimidine derivatives.

Deb PK, Mailavaram R, Chandrasekaran B, Kaki VR, Kaur R, Kachler S, Klotz KN, Akkinepally RR.

Chem Biol Drug Des. 2018 Apr;91(4):962-969. doi: 10.1111/cbdd.13155. Epub 2017 Dec 22.

PMID:
29194979
33.

Exposure to Sublethal Ammonia Concentrations Alters the Duration and Intensity of Agonistic Interactions in the Crayfish, Orconectes rusticus.

Edwards DD, Klotz KL, Moore PA.

Bull Environ Contam Toxicol. 2018 Feb;100(2):189-194. doi: 10.1007/s00128-017-2190-7. Epub 2017 Nov 16.

34.

The Health Effects of Aluminum Exposure.

Klotz K, Weistenhöfer W, Neff F, Hartwig A, van Thriel C, Drexler H.

Dtsch Arztebl Int. 2017 Sep 29;114(39):653-659. doi: 10.3238/arztebl.2017.0653. Review.

35.

Reliable quantification of 1,2-dihydroxynaphthalene in urine using a conjugated reference compound for calibration.

Zobel M, Göen T, Belov V, Klotz K.

Anal Bioanal Chem. 2017 Nov;409(29):6861-6872. doi: 10.1007/s00216-017-0651-9. Epub 2017 Oct 10.

PMID:
29018900
36.

Guanosine exerts antiplatelet and antithrombotic properties through an adenosine-related cAMP-PKA signaling.

Fuentes F, Alarcón M, Badimon L, Fuentes M, Klotz KN, Vilahur G, Kachler S, Padró T, Palomo I, Fuentes E.

Int J Cardiol. 2017 Dec 1;248:294-300. doi: 10.1016/j.ijcard.2017.08.006. Epub 2017 Aug 7.

PMID:
28811090
37.

Coumarins and adenosine receptors: New perceptions in structure-affinity relationships.

Fonseca A, Matos MJ, Vilar S, Kachler S, Klotz KN, Uriarte E, Borges F.

Chem Biol Drug Des. 2018 Jan;91(1):245-256. doi: 10.1111/cbdd.13075. Epub 2017 Sep 4.

PMID:
28734062
38.

Human Biomonitoring of Lead Exposure.

Klotz K, Göen T.

Met Ions Life Sci. 2017 Apr 10;17. pii: /books/9783110434330/9783110434330-006/9783110434330-006.xml. doi: 10.1515/9783110434330-006.

PMID:
28731299
39.

Exploring the Role of N6-Substituents in Potent Dual Acting 5'-C-Ethyltetrazolyladenosine Derivatives: Synthesis, Binding, Functional Assays, and Antinociceptive Effects in Mice ∇.

Petrelli R, Scortichini M, Kachler S, Boccella S, Cerchia C, Torquati I, Del Bello F, Salvemini D, Novellino E, Luongo L, Maione S, Jacobson KA, Lavecchia A, Klotz KN, Cappellacci L.

J Med Chem. 2017 May 25;60(10):4327-4341. doi: 10.1021/acs.jmedchem.7b00291. Epub 2017 May 5.

40.

Vitamin B6-Responsive Epilepsy due to a Novel KCNQ2 Mutation.

Klotz KA, Lemke JR, Korinthenberg R, Jacobs J.

Neuropediatrics. 2017 Jun;48(3):199-204. doi: 10.1055/s-0037-1601857. Epub 2017 Apr 18.

PMID:
28420012
41.

Synthesis and Evaluation of a New Series of 8-(2-Nitroaryl)Xanthines as Adenosine Receptor Ligands.

Bansal R, Kumar G, Rohilla S, Klotz KN, Kachler S, Young LC, Harvey AL.

Drug Dev Res. 2016 Aug;77(5):241-50. doi: 10.1002/ddr.21317. Epub 2016 Jul 12.

PMID:
27404511
42.

Discovery of 7-(Prolinol-N-yl)-2-phenylamino-thiazolo[5,4-d]pyrimidines as Novel Non-Nucleoside Partial Agonists for the A2A Adenosine Receptor: Prediction from Molecular Modeling.

Bharate SB, Singh B, Kachler S, Oliveira A, Kumar V, Bharate SS, Vishwakarma RA, Klotz KN, Gutiérrez de Terán H.

J Med Chem. 2016 Jun 23;59(12):5922-8. doi: 10.1021/acs.jmedchem.6b00552. Epub 2016 Jun 7.

PMID:
27227326
43.

The Length and Flexibility of the 2-Substituent of 9-Ethyladenine Derivatives Modulate Affinity and Selectivity for the Human A2A Adenosine Receptor.

Thomas A, Buccioni M, Dal Ben D, Lambertucci C, Marucci G, Santinelli C, Spinaci A, Kachler S, Klotz KN, Volpini R.

ChemMedChem. 2016 Aug 19;11(16):1829-39. doi: 10.1002/cmdc.201500595. Epub 2016 Apr 1.

PMID:
27037522
44.

Synthesis and pharmacological characterization of novel xanthine carboxylate amides as A2A adenosine receptor ligands exhibiting bronchospasmolytic activity.

Yadav R, Bansal R, Rohilla S, Kachler S, Klotz KN.

Bioorg Chem. 2016 Apr;65:26-37. doi: 10.1016/j.bioorg.2016.01.003. Epub 2016 Jan 21.

PMID:
26851736
45.

Quantification of naphthoquinone mercapturic acids in urine as biomarkers of naphthalene exposure.

Klotz K, Angerer J.

J Chromatogr B Analyt Technol Biomed Life Sci. 2016 Feb 15;1012-1013:89-96. doi: 10.1016/j.jchromb.2015.12.052. Epub 2015 Dec 29.

PMID:
26812176
46.

Ethanol Lock Efficacy and Associated Complications in Children With Intestinal Failure.

Mezoff EA, Fei L, Troutt M, Klotz K, Kocoshis SA, Cole CR.

JPEN J Parenter Enteral Nutr. 2016 Aug;40(6):815-9. doi: 10.1177/0148607115574745. Epub 2015 Feb 23.

47.

5,7-Disubstituted-[1,2,4]triazolo[1,5-a][1,3,5]triazines as pharmacological tools to explore the antagonist selectivity profiles toward adenosine receptors.

Federico S, Ciancetta A, Porta N, Redenti S, Pastorin G, Cacciari B, Klotz KN, Moro S, Spalluto G.

Eur J Med Chem. 2016 Jan 27;108:529-541. doi: 10.1016/j.ejmech.2015.12.019. Epub 2015 Dec 15.

PMID:
26717203
48.

[Tracing for arsenic exposure--a differentiation of arsenic compounds is essential for the health assessment].

Weistenhöfer W, Ochsmann E, Drexler H, Göen T, Klotz K.

Dtsch Med Wochenschr. 2016 Jan;141(1):59-60. doi: 10.1055/s-0041-104370. Epub 2015 Dec 28. German.

PMID:
26710207
49.

Inhibitors of membranous adenylyl cyclases with affinity for adenosine receptors.

Klotz KN, Kachler S.

Naunyn Schmiedebergs Arch Pharmacol. 2016 Mar;389(3):349-52. doi: 10.1007/s00210-015-1197-z. Epub 2015 Dec 14.

PMID:
26660072
50.

The Influence of the 1-(3-Trifluoromethyl-Benzyl)-1H-Pyrazole-4-yl Moiety on the Adenosine Receptors Affinity Profile of Pyrazolo[4,3-e][1,2,4]Triazolo[1,5-c]Pyrimidine Derivatives.

Federico S, Redenti S, Sturlese M, Ciancetta A, Kachler S, Klotz KN, Cacciari B, Moro S, Spalluto G.

PLoS One. 2015 Dec 1;10(12):e0143504. doi: 10.1371/journal.pone.0143504. eCollection 2015.

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