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Items: 1 to 50 of 120

1.

IDLV-HIV-1 Env vaccination in non-human primates induces affinity maturation of antigen-specific memory B cells.

Blasi M, Negri D, LaBranche C, Alam SM, Baker EJ, Brunner EC, Gladden MA, Michelini Z, Vandergrift NA, Wiehe KJ, Parks R, Shen X, Bonsignori M, Tomaras GD, Ferrari G, Montefiori DC, Santra S, Haynes BF, Moody MA, Cara A, Klotman ME.

Commun Biol. 2018 Sep 5;1:134. doi: 10.1038/s42003-018-0131-6. eCollection 2018.

2.

Polyploidy and Mitotic Cell Death Are Two Distinct HIV-1 Vpr-Driven Outcomes in Renal Tubule Epithelial Cells.

Payne EH, Ramalingam D, Fox DT, Klotman ME.

J Virol. 2018 Jan 2;92(2). pii: e01718-17. doi: 10.1128/JVI.01718-17. Print 2018 Jan 15.

3.

Immunization with an SIV-based IDLV Expressing HIV-1 Env 1086 Clade C Elicits Durable Humoral and Cellular Responses in Rhesus Macaques.

Negri D, Blasi M, LaBranche C, Parks R, Balachandran H, Lifton M, Shen X, Denny T, Ferrari G, Vescio MF, Andersen H, Montefiori DC, Tomaras GD, Liao HX, Santra S, Haynes BF, Klotman ME, Cara A.

Mol Ther. 2016 Nov;24(11):2021-2032. doi: 10.1038/mt.2016.123. Epub 2016 Jun 21.

4.

HIV infection-induced transcriptional program in renal tubular epithelial cells activates a CXCR2-driven CD4+ T-cell chemotactic response.

Chen P, Yi Z, Zhang W, Klotman ME, Chen BK.

AIDS. 2016 Jul 31;30(12):1877-88. doi: 10.1097/QAD.0000000000001153.

5.

Identification of HIV-1 genitourinary tract compartmentalization by analyzing the env gene sequences in urine.

Blasi M, Carpenter JH, Balakumaran B, Cara A, Gao F, Klotman ME.

AIDS. 2015 Aug 24;29(13):1651-7. doi: 10.1097/QAD.0000000000000757.

6.

Murine granulocyte-macrophage colony-stimulating factor expressed from a bicistronic simian immunodeficiency virus-based integrase-defective lentiviral vector does not enhance T-cell responses in mice.

Michelini Z, Negri D, Biava M, Baroncelli S, Spada M, Leone P, Bona R, Blasi M, Nègre D, Klotman ME, Cara A.

Viral Immunol. 2014 Dec;27(10):512-20. doi: 10.1089/vim.2014.0062.

PMID:
25343523
7.

Optimization of mucosal responses after intramuscular immunization with integrase defective lentiviral vector.

Rossi A, Michelini Z, Leone P, Borghi M, Blasi M, Bona R, Spada M, Grasso F, Gugliotta A, Klotman ME, Cara A, Negri D.

PLoS One. 2014 Sep 11;9(9):e107377. doi: 10.1371/journal.pone.0107377. eCollection 2014.

8.

The imperative to invest in science has never been greater.

Carethers JM, Coughlin S, Diamond B, Erzurum S, Fried LP, Jameson JL, Kaushansky K, Klotman ME, Lemon S, Mitchell B, Rothman P, Sawyers C, Seidman C, Somlo S.

J Clin Invest. 2014 Sep;124(9):3680-1. doi: 10.1172/JCI77894. Epub 2014 Sep 2. No abstract available.

9.

Renal epithelial cells produce and spread HIV-1 via T-cell contact.

Blasi M, Balakumaran B, Chen P, Negri DR, Cara A, Chen BK, Klotman ME.

AIDS. 2014 Oct 23;28(16):2345-53. doi: 10.1097/QAD.0000000000000398.

10.

Career outcomes of the graduates of the American Board of Internal Medicine Research Pathway, 1995-2007.

Todd RF 3rd, Salata RA, Klotman ME, Weisfeldt ML, Katz JT, Xian SX, Hearn DP, Lipner RS.

Acad Med. 2013 Nov;88(11):1747-53. doi: 10.1097/ACM.0b013e3182a7f627.

PMID:
24072121
11.

Novel small leucine-rich repeat protein podocan is a negative regulator of migration and proliferation of smooth muscle cells, modulates neointima formation, and is expressed in human atheroma.

Hutter R, Huang L, Speidl WS, Giannarelli C, Trubin P, Bauriedel G, Klotman ME, Fuster V, Badimon JJ, Klotman PE.

Circulation. 2013 Nov 26;128(22):2351-63. doi: 10.1161/CIRCULATIONAHA.113.004634. Epub 2013 Sep 16.

12.

Postintegration HIV-1 infection of cervical epithelial cells mediates contact-dependent productive infection of T cells.

Micsenyi AM, Zony C, Alvarez RA, Durham ND, Chen BK, Klotman ME.

J Infect Dis. 2013 Dec 1;208(11):1756-67. doi: 10.1093/infdis/jit362. Epub 2013 Aug 1.

13.

Simian immunodeficiency virus-Vpx for improving integrase defective lentiviral vector-based vaccines.

Negri DR, Rossi A, Blasi M, Michelini Z, Leone P, Chiantore MV, Baroncelli S, Perretta G, Cimarelli A, Klotman ME, Cara A.

Retrovirology. 2012 Aug 22;9:69. doi: 10.1186/1742-4690-9-69.

14.

APOL1 variants increase risk for FSGS and HIVAN but not IgA nephropathy.

Papeta N, Kiryluk K, Patel A, Sterken R, Kacak N, Snyder HJ, Imus PH, Mhatre AN, Lawani AK, Julian BA, Wyatt RJ, Novak J, Wyatt CM, Ross MJ, Winston JA, Klotman ME, Cohen DJ, Appel GB, D'Agati VD, Klotman PE, Gharavi AG.

J Am Soc Nephrol. 2011 Nov;22(11):1991-6. doi: 10.1681/ASN.2011040434. Epub 2011 Oct 13.

15.

Virological synapses allow HIV-1 uptake and gene expression in renal tubular epithelial cells.

Chen P, Chen BK, Mosoian A, Hays T, Ross MJ, Klotman PE, Klotman ME.

J Am Soc Nephrol. 2011 Mar;22(3):496-507. doi: 10.1681/ASN.2010040379. Epub 2011 Feb 18.

16.

Mucosal human defensins 5 and 6 antagonize the anti-HIV activity of candidate polyanion microbicides.

Ding J, Rapista A, Teleshova N, Lu W, Klotman ME, Chang TL.

J Innate Immun. 2011;3(2):208-12. doi: 10.1159/000322355. Epub 2010 Dec 16.

17.
18.

Nonintegrating Lentiviral Vector-Based Vaccine Efficiently Induces Functional and Persistent CD8+ T Cell Responses in Mice.

Negri DR, Michelini Z, Baroncelli S, Spada M, Vendetti S, Bona R, Leone P, Klotman ME, Cara A.

J Biomed Biotechnol. 2010;2010:534501. doi: 10.1155/2010/534501. Epub 2010 May 19.

19.

Prothymosin-alpha inhibits HIV-1 via Toll-like receptor 4-mediated type I interferon induction.

Mosoian A, Teixeira A, Burns CS, Sander LE, Gusella GL, He C, Blander JM, Klotman P, Klotman ME.

Proc Natl Acad Sci U S A. 2010 Jun 1;107(22):10178-83. doi: 10.1073/pnas.0914870107. Epub 2010 May 17.

20.

HIV-1 viral protein r induces ERK and caspase-8-dependent apoptosis in renal tubular epithelial cells.

Snyder A, Alsauskas ZC, Leventhal JS, Rosenstiel PE, Gong P, Chan JJ, Barley K, He JC, Klotman ME, Ross MJ, Klotman PE.

AIDS. 2010 May 15;24(8):1107-19. doi: 10.1097/QAD.0b013e328337b0ab.

21.

Transduction of human antigen-presenting cells with integrase-defective lentiviral vector enables functional expansion of primed antigen-specific CD8(+) T cells.

Negri DR, Bona R, Michelini Z, Leone P, Macchia I, Klotman ME, Salvatore M, Cara A.

Hum Gene Ther. 2010 Aug;21(8):1029-35. doi: 10.1089/hum.2009.200.

22.

Neisseria gonorrhoeae enhances HIV-1 infection of primary resting CD4+ T cells through TLR2 activation.

Ding J, Rapista A, Teleshova N, Mosoyan G, Jarvis GA, Klotman ME, Chang TL.

J Immunol. 2010 Mar 15;184(6):2814-24. doi: 10.4049/jimmunol.0902125. Epub 2010 Feb 10.

23.

Zoonotic infections: an emerging threat to human health.

Factor SH, Klotman ME.

Mt Sinai J Med. 2009 Oct;76(5):419-20. doi: 10.1002/msj.20141. No abstract available.

PMID:
19787651
24.

FAT10: a novel mediator of Vpr-induced apoptosis in human immunodeficiency virus-associated nephropathy.

Snyder A, Alsauskas Z, Gong P, Rosenstiel PE, Klotman ME, Klotman PE, Ross MJ.

J Virol. 2009 Nov;83(22):11983-8. doi: 10.1128/JVI.00034-09. Epub 2009 Sep 2.

25.

A fine line between molecular umbrella transport and ionophoric activity.

Chen WH, Janout V, Kondo M, Mosoian A, Mosoyan G, Petrov RR, Klotman ME, Regen SL.

Bioconjug Chem. 2009 Sep;20(9):1711-5. doi: 10.1021/bc900246u.

26.

HIV-1 Vpr activates the DNA damage response in renal tubule epithelial cells.

Rosenstiel PE, Chan J, Snyder A, Planelles V, D'Agati VD, Klotman PE, Klotman ME.

AIDS. 2009 Sep 24;23(15):2054-6. doi: 10.1097/QAD.0b013e32833088a0.

27.

Development and use of SIV-based Integrase defective lentiviral vector for immunization.

Michelini Z, Negri DR, Baroncelli S, Spada M, Leone P, Bona R, Klotman ME, Cara A.

Vaccine. 2009 Jul 23;27(34):4622-9. doi: 10.1016/j.vaccine.2009.05.070. Epub 2009 Jun 11.

28.

The differential binding and activity of PRO 2000 against diverse HIV-1 envelopes.

Sachdev DD, Zerhouni-Layachi B, Ortigoza M, Profy AT, Tuen M, Hioe CE, Klotman ME.

J Acquir Immune Defic Syndr. 2009 Jun 1;51(2):125-9. doi: 10.1097/QAI.0b013e31819f9e31.

29.

The spectrum of kidney disease in patients with AIDS in the era of antiretroviral therapy.

Wyatt CM, Morgello S, Katz-Malamed R, Wei C, Klotman ME, Klotman PE, D'Agati VD.

Kidney Int. 2009 Feb;75(4):428-34. doi: 10.1038/ki.2008.604. Epub 2008 Dec 3.

30.

Conditionally replicating lentiviral-hybrid episomal vectors for suicide gene therapy.

Vargas J Jr, Klotman ME, Cara A.

Antiviral Res. 2008 Dec;80(3):288-94. doi: 10.1016/j.antiviral.2008.06.015. Epub 2008 Jul 21.

PMID:
18647620
31.

HIV-1 Vpr inhibits cytokinesis in human proximal tubule cells.

Rosenstiel PE, Gruosso T, Letourneau AM, Chan JJ, LeBlanc A, Husain M, Najfeld V, Planelles V, D'Agati VD, Klotman ME, Klotman PE.

Kidney Int. 2008 Oct;74(8):1049-58. doi: 10.1038/ki.2008.303. Epub 2008 Jul 9.

32.

Neisseria gonorrhoeae-induced human defensins 5 and 6 increase HIV infectivity: role in enhanced transmission.

Klotman ME, Rapista A, Teleshova N, Micsenyi A, Jarvis GA, Lu W, Porter E, Chang TL.

J Immunol. 2008 May 1;180(9):6176-85.

33.

Inhibitory effect of PRO 2000, a candidate microbicide, on dendritic cell-mediated human immunodeficiency virus transfer.

Teleshova N, Chang T, Profy A, Klotman ME.

Antimicrob Agents Chemother. 2008 May;52(5):1751-8. doi: 10.1128/AAC.00707-07. Epub 2008 Mar 10.

34.

Human immunodeficiency virus (HIV) infects human arterial smooth muscle cells in vivo and in vitro: implications for the pathogenesis of HIV-mediated vascular disease.

Eugenin EA, Morgello S, Klotman ME, Mosoian A, Lento PA, Berman JW, Schecter AD.

Am J Pathol. 2008 Apr;172(4):1100-11. doi: 10.2353/ajpath.2008.070457. Epub 2008 Feb 29.

35.

Chronic kidney disease in HIV infection: an urban epidemic.

Wyatt CM, Winston JA, Malvestutto CD, Fishbein DA, Barash I, Cohen AJ, Klotman ME, Klotman PE.

AIDS. 2007 Oct 1;21(15):2101-3.

PMID:
17885301
36.

SAMMA, a mandelic acid condensation polymer, inhibits dendritic cell-mediated HIV transmission.

Chang TL, Teleshova N, Rapista A, Paluch M, Anderson RA, Waller DP, Zaneveld LJ, Granelli-Piperno A, Klotman ME.

FEBS Lett. 2007 Oct 2;581(24):4596-602. Epub 2007 Aug 31.

37.

alpha-Defensin inhibits influenza virus replication by cell-mediated mechanism(s).

Salvatore M, Garcia-Sastre A, Ruchala P, Lehrer RI, Chang T, Klotman ME.

J Infect Dis. 2007 Sep 15;196(6):835-43. Epub 2007 Aug 10.

PMID:
17703413
38.

Successful immunization with a single injection of non-integrating lentiviral vector.

Negri DR, Michelini Z, Baroncelli S, Spada M, Vendetti S, Buffa V, Bona R, Leone P, Klotman ME, Cara A.

Mol Ther. 2007 Sep;15(9):1716-23. Epub 2007 Jun 26.

39.

The homophilic adhesion molecule sidekick-1 contributes to augmented podocyte aggregation in HIV-associated nephropathy.

Kaufman L, Yang G, Hayashi K, Ashby JR, Huang L, Ross MJ, Klotman ME, Klotman PE.

FASEB J. 2007 May;21(7):1367-75. Epub 2007 Feb 16.

PMID:
17307840
40.

ACIDFORM inactivates herpes simplex virus and prevents genital herpes in a mouse model: optimal candidate for microbicide combinations.

Tuyama AC, Cheshenko N, Carlucci MJ, Li JH, Goldberg CL, Waller DP, Anderson RA, Profy AT, Klotman ME, Keller MJ, Herold BC.

J Infect Dis. 2006 Sep 15;194(6):795-803. Epub 2006 Aug 16.

PMID:
16941346
41.

Gonococcal lipooligosaccharide suppresses HIV infection in human primary macrophages through induction of innate immunity.

Liu X, Mosoian A, Li-Yun Chang T, Zerhouni-Layachi B, Snyder A, Jarvis GA, Klotman ME.

J Infect Dis. 2006 Sep 15;194(6):751-9. Epub 2006 Aug 8.

PMID:
16941340
42.

Retroviral E-DNA: persistence and gene expression in nondividing immune cells.

Cara A, Klotman ME.

J Leukoc Biol. 2006 Nov;80(5):1013-7. Epub 2006 Aug 21. Review.

PMID:
16923918
43.

HIV-1 infection initiates an inflammatory cascade in human renal tubular epithelial cells.

Ross MJ, Fan C, Ross MD, Chu TH, Shi Y, Kaufman L, Zhang W, Klotman ME, Klotman PE.

J Acquir Immune Defic Syndr. 2006 May;42(1):1-11.

PMID:
16763488
44.

Defensins in innate antiviral immunity.

Klotman ME, Chang TL.

Nat Rev Immunol. 2006 Jun;6(6):447-56. Review.

PMID:
16724099
45.

Topical microbicides: the time has come.

Dhawan D, Keller M, Klotman ME.

AIDS Read. 2006 Mar;16(3):144-8, 155-8, 161; discussion 148, 156-7. Review.

PMID:
16538955
46.

Kidney and central nervous system as reservoirs of HIV infection.

Fierer DS, Klotman ME.

Curr Opin HIV AIDS. 2006 Mar;1(2):115-20. doi: 10.1097/01.COH.0000209581.88166.89.

PMID:
19372794
47.

Role of ubiquitin-like protein FAT10 in epithelial apoptosis in renal disease.

Ross MJ, Wosnitzer MS, Ross MD, Granelli B, Gusella GL, Husain M, Kaufman L, Vasievich M, D'Agati VD, Wilson PD, Klotman ME, Klotman PE.

J Am Soc Nephrol. 2006 Apr;17(4):996-1004. Epub 2006 Feb 22.

48.

Dual tropism of HIV-1 envelopes derived from renal tubular epithelial cells of patients with HIV-associated nephropathy.

Zerhouni-Layachi B, Husain M, Ross MJ, Marras D, Sunamoto M, Liu X, Klotman PE, Klotman ME.

AIDS. 2006 Feb 28;20(4):621-4.

PMID:
16470129
49.

Acute renal failure in hospitalized patients with HIV: risk factors and impact on in-hospital mortality.

Wyatt CM, Arons RR, Klotman PE, Klotman ME.

AIDS. 2006 Feb 28;20(4):561-5.

PMID:
16470120
50.

PRO 2000 gel inhibits HIV and herpes simplex virus infection following vaginal application: a double-blind placebo-controlled trial.

Keller MJ, Zerhouni-Layachi B, Cheshenko N, John M, Hogarty K, Kasowitz A, Goldberg CL, Wallenstein S, Profy AT, Klotman ME, Herold BC.

J Infect Dis. 2006 Jan 1;193(1):27-35. Epub 2005 Nov 17.

PMID:
16323128

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