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Items: 47

1.

KDM2 proteins constrain transcription from CpG island gene promoters independently of their histone demethylase activity.

Turberfield AH, Kondo T, Nakayama M, Koseki Y, King HW, Koseki H, Klose RJ.

Nucleic Acids Res. 2019 Jul 31. pii: gkz607. doi: 10.1093/nar/gkz607. [Epub ahead of print]

PMID:
31363749
2.

Synergy between Variant PRC1 Complexes Defines Polycomb-Mediated Gene Repression.

Fursova NA, Blackledge NP, Nakayama M, Ito S, Koseki Y, Farcas AM, King HW, Koseki H, Klose RJ.

Mol Cell. 2019 Jun 6;74(5):1020-1036.e8. doi: 10.1016/j.molcel.2019.03.024. Epub 2019 Apr 24.

3.

Histone H2A monoubiquitylation and p38-MAPKs regulate immediate-early gene-like reactivation of latent retrovirus HTLV-1.

Kulkarni A, Taylor GP, Klose RJ, Schofield CJ, Bangham CR.

JCI Insight. 2018 Oct 18;3(20). pii: 123196. doi: 10.1172/jci.insight.123196.

4.

Polycomb repressive complex 1 shapes the nucleosome landscape but not accessibility at target genes.

King HW, Fursova NA, Blackledge NP, Klose RJ.

Genome Res. 2018 Oct;28(10):1494-1507. doi: 10.1101/gr.237180.118. Epub 2018 Aug 28.

5.

FBXL19 recruits CDK-Mediator to CpG islands of developmental genes priming them for activation during lineage commitment.

Dimitrova E, Kondo T, Feldmann A, Nakayama M, Koseki Y, Konietzny R, Kessler BM, Koseki H, Klose RJ.

Elife. 2018 May 29;7. pii: e37084. doi: 10.7554/eLife.37084.

6.

Biochemical Identification of Nonmethylated DNA by BioCAP-Seq.

Long HK, Rose NR, Blackledge NP, Klose RJ.

Methods Mol Biol. 2018;1766:15-29. doi: 10.1007/978-1-4939-7768-0_2.

PMID:
29605845
7.

The SET1 Complex Selects Actively Transcribed Target Genes via Multivalent Interaction with CpG Island Chromatin.

Brown DA, Di Cerbo V, Feldmann A, Ahn J, Ito S, Blackledge NP, Nakayama M, McClellan M, Dimitrova E, Turberfield AH, Long HK, King HW, Kriaucionis S, Schermelleh L, Kutateladze TG, Koseki H, Klose RJ.

Cell Rep. 2017 Sep 5;20(10):2313-2327. doi: 10.1016/j.celrep.2017.08.030.

8.

Correction: PCGF6-PRC1 suppresses premature differentiation of mouse embryonic stem cells by regulating germ cell-related genes.

Endoh M, Endo TA, Shinga J, Hayashi K, Farcas A, Ma KW, Ito S, Sharif J, Endoh T, Onaga N, Nakayama M, Ishikura T, Masui O, Kessler BM, Suda T, Ohara O, Okuda A, Klose RJ, Koseki H.

Elife. 2017 Apr 25;6. pii: e27970. doi: 10.7554/eLife.27970. No abstract available.

9.
10.

MLL-AF4 Spreading Identifies Binding Sites that Are Distinct from Super-Enhancers and that Govern Sensitivity to DOT1L Inhibition in Leukemia.

Kerry J, Godfrey L, Repapi E, Tapia M, Blackledge NP, Ma H, Ballabio E, O'Byrne S, Ponthan F, Heidenreich O, Roy A, Roberts I, Konopleva M, Klose RJ, Geng H, Milne TA.

Cell Rep. 2017 Jan 10;18(2):482-495. doi: 10.1016/j.celrep.2016.12.054.

11.

Successful transmission and transcriptional deployment of a human chromosome via mouse male meiosis.

Ernst C, Pike J, Aitken SJ, Long HK, Eling N, Stojic L, Ward MC, Connor F, Rayner TF, Lukk M, Klose RJ, Kutter C, Odom DT.

Elife. 2016 Nov 18;5. pii: e20235. doi: 10.7554/eLife.20235.

12.

RYBP stimulates PRC1 to shape chromatin-based communication between Polycomb repressive complexes.

Rose NR, King HW, Blackledge NP, Fursova NA, Ember KJ, Fischer R, Kessler BM, Klose RJ.

Elife. 2016 Oct 5;5. pii: e18591. doi: 10.7554/eLife.18591.

13.

Protection of CpG islands from DNA methylation is DNA-encoded and evolutionarily conserved.

Long HK, King HW, Patient RK, Odom DT, Klose RJ.

Nucleic Acids Res. 2016 Aug 19;44(14):6693-706. doi: 10.1093/nar/gkw258. Epub 2016 Apr 15.

14.

Histone demethylases in chromatin biology and beyond.

Dimitrova E, Turberfield AH, Klose RJ.

EMBO Rep. 2015 Dec;16(12):1620-39. doi: 10.15252/embr.201541113. Epub 2015 Nov 12. Review.

15.

Targeting Polycomb systems to regulate gene expression: modifications to a complex story.

Blackledge NP, Rose NR, Klose RJ.

Nat Rev Mol Cell Biol. 2015 Nov;16(11):643-649. doi: 10.1038/nrm4067. Epub 2015 Sep 30. Review.

16.

Variant PRC1 complex-dependent H2A ubiquitylation drives PRC2 recruitment and polycomb domain formation.

Blackledge NP, Farcas AM, Kondo T, King HW, McGouran JF, Hanssen LL, Ito S, Cooper S, Kondo K, Koseki Y, Ishikura T, Long HK, Sheahan TW, Brockdorff N, Kessler BM, Koseki H, Klose RJ.

Cell. 2014 Jun 5;157(6):1445-59. doi: 10.1016/j.cell.2014.05.004. Epub 2014 May 22.

17.

Understanding the relationship between DNA methylation and histone lysine methylation.

Rose NR, Klose RJ.

Biochim Biophys Acta. 2014 Dec;1839(12):1362-72. doi: 10.1016/j.bbagrm.2014.02.007. Epub 2014 Feb 19. Review.

18.

Chromatin sampling--an emerging perspective on targeting polycomb repressor proteins.

Klose RJ, Cooper S, Farcas AM, Blackledge NP, Brockdorff N.

PLoS Genet. 2013;9(8):e1003717. doi: 10.1371/journal.pgen.1003717. Epub 2013 Aug 22. No abstract available.

19.

5-Carboxy-8-hydroxyquinoline is a Broad Spectrum 2-Oxoglutarate Oxygenase Inhibitor which Causes Iron Translocation.

Hopkinson RJ, Tumber A, Yapp C, Chowdhury R, Aik W, Che KH, Li XS, Kristensen JBL, King ONF, Chan MC, Yeoh KK, Choi H, Walport LJ, Thinnes CC, Bush JT, Lejeune C, Rydzik AM, Rose NR, Bagg EA, McDonough MA, Krojer T, Yue WW, Ng SS, Olsen L, Brennan PE, Oppermann U, Muller-Knapp S, Klose RJ, Ratcliffe PJ, Schofield CJ, Kawamura A.

Chem Sci. 2013 Aug 1;4(8):3110-3117. doi: 10.1039/C3SC51122G.

20.

ZF-CxxC domain-containing proteins, CpG islands and the chromatin connection.

Long HK, Blackledge NP, Klose RJ.

Biochem Soc Trans. 2013 Jun;41(3):727-40. doi: 10.1042/BST20130028. Review.

21.

Epigenetic conservation at gene regulatory elements revealed by non-methylated DNA profiling in seven vertebrates.

Long HK, Sims D, Heger A, Blackledge NP, Kutter C, Wright ML, Grützner F, Odom DT, Patient R, Ponting CP, Klose RJ.

Elife. 2013 Feb 26;2:e00348. doi: 10.7554/eLife.00348.

22.

KDM2B links the Polycomb Repressive Complex 1 (PRC1) to recognition of CpG islands.

Farcas AM, Blackledge NP, Sudbery I, Long HK, McGouran JF, Rose NR, Lee S, Sims D, Cerase A, Sheahan TW, Koseki H, Brockdorff N, Ponting CP, Kessler BM, Klose RJ.

Elife. 2012 Dec 18;1:e00205. doi: 10.7554/eLife.00205.

23.

Plant growth regulator daminozide is a selective inhibitor of human KDM2/7 histone demethylases.

Rose NR, Woon EC, Tumber A, Walport LJ, Chowdhury R, Li XS, King ON, Lejeune C, Ng SS, Krojer T, Chan MC, Rydzik AM, Hopkinson RJ, Che KH, Daniel M, Strain-Damerell C, Gileadi C, Kochan G, Leung IK, Dunford J, Yeoh KK, Ratcliffe PJ, Burgess-Brown N, von Delft F, Muller S, Marsden B, Brennan PE, McDonough MA, Oppermann U, Klose RJ, Schofield CJ, Kawamura A.

J Med Chem. 2012 Jul 26;55(14):6639-43. doi: 10.1021/jm300677j. Epub 2012 Jul 11.

24.

Bio-CAP: a versatile and highly sensitive technique to purify and characterise regions of non-methylated DNA.

Blackledge NP, Long HK, Zhou JC, Kriaucionis S, Patient R, Klose RJ.

Nucleic Acids Res. 2012 Feb;40(4):e32. doi: 10.1093/nar/gkr1207. Epub 2011 Dec 10.

25.

Recognition of CpG island chromatin by KDM2A requires direct and specific interaction with linker DNA.

Zhou JC, Blackledge NP, Farcas AM, Klose RJ.

Mol Cell Biol. 2012 Jan;32(2):479-89. doi: 10.1128/MCB.06332-11. Epub 2011 Nov 14.

26.

The oncometabolite 2-hydroxyglutarate inhibits histone lysine demethylases.

Chowdhury R, Yeoh KK, Tian YM, Hillringhaus L, Bagg EA, Rose NR, Leung IK, Li XS, Woon EC, Yang M, McDonough MA, King ON, Clifton IJ, Klose RJ, Claridge TD, Ratcliffe PJ, Schofield CJ, Kawamura A.

EMBO Rep. 2011 May;12(5):463-9. doi: 10.1038/embor.2011.43. Epub 2011 Apr 1.

27.

Quantitative high-throughput screening identifies 8-hydroxyquinolines as cell-active histone demethylase inhibitors.

King ON, Li XS, Sakurai M, Kawamura A, Rose NR, Ng SS, Quinn AM, Rai G, Mott BT, Beswick P, Klose RJ, Oppermann U, Jadhav A, Heightman TD, Maloney DJ, Schofield CJ, Simeonov A.

PLoS One. 2010 Nov 23;5(11):e15535. doi: 10.1371/journal.pone.0015535.

28.

Jarid2 is a PRC2 component in embryonic stem cells required for multi-lineage differentiation and recruitment of PRC1 and RNA Polymerase II to developmental regulators.

Landeira D, Sauer S, Poot R, Dvorkina M, Mazzarella L, Jørgensen HF, Pereira CF, Leleu M, Piccolo FM, Spivakov M, Brookes E, Pombo A, Fisher C, Skarnes WC, Snoek T, Bezstarosti K, Demmers J, Klose RJ, Casanova M, Tavares L, Brockdorff N, Merkenschlager M, Fisher AG.

Nat Cell Biol. 2010 Jun;12(6):618-24. doi: 10.1038/ncb2065. Epub 2010 May 16.

29.

CpG islands recruit a histone H3 lysine 36 demethylase.

Blackledge NP, Zhou JC, Tolstorukov MY, Farcas AM, Park PJ, Klose RJ.

Mol Cell. 2010 Apr 23;38(2):179-90. doi: 10.1016/j.molcel.2010.04.009.

30.

Histone lysine methylation: an epigenetic modification?

Blackledge NP, Klose RJ.

Epigenomics. 2010 Feb;2(1):151-61. doi: 10.2217/epi.09.42. Review.

PMID:
22122751
31.

PHF8, a gene associated with cleft lip/palate and mental retardation, encodes for an Nepsilon-dimethyl lysine demethylase.

Loenarz C, Ge W, Coleman ML, Rose NR, Cooper CD, Klose RJ, Ratcliffe PJ, Schofield CJ.

Hum Mol Genet. 2010 Jan 15;19(2):217-22. doi: 10.1093/hmg/ddp480. Epub 2009 Oct 19.

32.

Phosphorylation of MeCP2 at Serine 80 regulates its chromatin association and neurological function.

Tao J, Hu K, Chang Q, Wu H, Sherman NE, Martinowich K, Klose RJ, Schanen C, Jaenisch R, Wang W, Sun YE.

Proc Natl Acad Sci U S A. 2009 Mar 24;106(12):4882-7. doi: 10.1073/pnas.0811648106. Epub 2009 Feb 18.

33.

Dynamic protein methylation in chromatin biology.

Ng SS, Yue WW, Oppermann U, Klose RJ.

Cell Mol Life Sci. 2009 Feb;66(3):407-22. doi: 10.1007/s00018-008-8303-z. Review.

34.

MeCP2 binding to DNA depends upon hydration at methyl-CpG.

Ho KL, McNae IW, Schmiedeberg L, Klose RJ, Bird AP, Walkinshaw MD.

Mol Cell. 2008 Feb 29;29(4):525-31. doi: 10.1016/j.molcel.2007.12.028.

35.

Histone H3 Arg2 methylation provides alternative directions for COMPASS.

Klose RJ, Zhang Y.

Nat Struct Mol Biol. 2007 Nov;14(11):1058-60. No abstract available.

PMID:
17984969
36.

Demethylation of histone H3K36 and H3K9 by Rph1: a vestige of an H3K9 methylation system in Saccharomyces cerevisiae?

Klose RJ, Gardner KE, Liang G, Erdjument-Bromage H, Tempst P, Zhang Y.

Mol Cell Biol. 2007 Jun;27(11):3951-61. Epub 2007 Mar 19.

37.

PLU-1 is an H3K4 demethylase involved in transcriptional repression and breast cancer cell proliferation.

Yamane K, Tateishi K, Klose RJ, Fang J, Fabrizio LA, Erdjument-Bromage H, Taylor-Papadimitriou J, Tempst P, Zhang Y.

Mol Cell. 2007 Mar 23;25(6):801-12. Epub 2007 Mar 15.

38.

The trithorax-group protein Lid is a histone H3 trimethyl-Lys4 demethylase.

Lee N, Zhang J, Klose RJ, Erdjument-Bromage H, Tempst P, Jones RS, Zhang Y.

Nat Struct Mol Biol. 2007 Apr;14(4):341-3. Epub 2007 Mar 11.

PMID:
17351631
39.

Regulation of histone methylation by demethylimination and demethylation.

Klose RJ, Zhang Y.

Nat Rev Mol Cell Biol. 2007 Apr;8(4):307-18. Epub 2007 Mar 7. Review.

PMID:
17342184
40.

The retinoblastoma binding protein RBP2 is an H3K4 demethylase.

Klose RJ, Yan Q, Tothova Z, Yamane K, Erdjument-Bromage H, Tempst P, Gilliland DG, Zhang Y, Kaelin WG Jr.

Cell. 2007 Mar 9;128(5):889-900. Epub 2007 Feb 22.

41.

Yeast Jhd2p is a histone H3 Lys4 trimethyl demethylase.

Liang G, Klose RJ, Gardner KE, Zhang Y.

Nat Struct Mol Biol. 2007 Mar;14(3):243-5. Epub 2007 Feb 18. Erratum in: Nat Struct Mol Biol. 2007 Apr;14(4):351.

PMID:
17310254
42.

JmjC-domain-containing proteins and histone demethylation.

Klose RJ, Kallin EM, Zhang Y.

Nat Rev Genet. 2006 Sep;7(9):715-27. doi: 10.1038/nrg1945.

PMID:
16983801
43.

The transcriptional repressor JHDM3A demethylates trimethyl histone H3 lysine 9 and lysine 36.

Klose RJ, Yamane K, Bae Y, Zhang D, Erdjument-Bromage H, Tempst P, Wong J, Zhang Y.

Nature. 2006 Jul 20;442(7100):312-6. Epub 2006 May 28.

PMID:
16732292
44.

Genomic DNA methylation: the mark and its mediators.

Klose RJ, Bird AP.

Trends Biochem Sci. 2006 Feb;31(2):89-97. Epub 2006 Jan 5. Review.

PMID:
16403636
45.

DNA binding selectivity of MeCP2 due to a requirement for A/T sequences adjacent to methyl-CpG.

Klose RJ, Sarraf SA, Schmiedeberg L, McDermott SM, Stancheva I, Bird AP.

Mol Cell. 2005 Sep 2;19(5):667-78.

46.
47.

Characterization of an overexpressed spindle protein during a baculovirus infection.

Li X, Barrett J, Pang A, Klose RJ, Krell PJ, Arif BM.

Virology. 2000 Mar 1;268(1):56-67.

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