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Items: 1 to 50 of 69

1.

Mild Impairment of Mitochondrial OXPHOS Promotes Fatty Acid Utilization in POMC Neurons and Improves Glucose Homeostasis in Obesity.

Timper K, Paeger L, Sánchez-Lasheras C, Varela L, Jais A, Nolte H, Vogt MC, Hausen AC, Heilinger C, Evers N, Pospisilik JA, Penninger JM, Taylor EB, Horvath TL, Kloppenburg P, Brüning JC.

Cell Rep. 2018 Oct 9;25(2):383-397.e10. doi: 10.1016/j.celrep.2018.09.034.

2.

p53 in AgRP neurons is required for protection against diet-induced obesity via JNK1.

Quiñones M, Al-Massadi O, Folgueira C, Bremser S, Gallego R, Torres-Leal L, Haddad-Tóvolli R, García-Caceres C, Hernandez-Bautista R, Lam BYH, Beiroa D, Sanchez-Rebordelo E, Senra A, Malagon JA, Valerio P, Fondevila MF, Fernø J, Malagon MM, Contreras R, Pfluger P, Brüning JC, Yeo G, Tschöp M, Diéguez C, López M, Claret M, Kloppenburg P, Sabio G, Nogueiras R.

Nat Commun. 2018 Aug 24;9(1):3432. doi: 10.1038/s41467-018-05711-6.

3.

Analysis of Single Neurons by Perforated Patch Clamp Recordings and MALDI-TOF Mass Spectrometry.

Neupert S, Fusca D, Kloppenburg P, Predel R.

ACS Chem Neurosci. 2018 Aug 15;9(8):2089-2096. doi: 10.1021/acschemneuro.8b00163. Epub 2018 Jul 3.

PMID:
29906100
4.

Diet-Induced Growth Is Regulated via Acquired Leptin Resistance and Engages a Pomc-Somatostatin-Growth Hormone Circuit.

Löhr H, Hess S, Pereira MMA, Reinoß P, Leibold S, Schenkel C, Wunderlich CM, Kloppenburg P, Brüning JC, Hammerschmidt M.

Cell Rep. 2018 May 8;23(6):1728-1741. doi: 10.1016/j.celrep.2018.04.018.

5.

Foreword for the special issue on Neural Coding.

Nawrot MP, Kloppenburg P, Deger M.

Biol Cybern. 2018 Apr;112(1-2):11. doi: 10.1007/s00422-018-0754-1. No abstract available.

PMID:
29605832
6.

S-sulfocysteine/NMDA receptor-dependent signaling underlies neurodegeneration in molybdenum cofactor deficiency.

Kumar A, Dejanovic B, Hetsch F, Semtner M, Fusca D, Arjune S, Santamaria-Araujo JA, Winkelmann A, Ayton S, Bush AI, Kloppenburg P, Meier JC, Schwarz G, Belaidi AA.

J Clin Invest. 2017 Dec 1;127(12):4365-4378. doi: 10.1172/JCI89885. Epub 2017 Nov 6.

7.

Energy imbalance alters Ca2+ handling and excitability of POMC neurons.

Paeger L, Pippow A, Hess S, Paehler M, Klein AC, Husch A, Pouzat C, Brüning JC, Kloppenburg P.

Elife. 2017 Aug 1;6. pii: e25641. doi: 10.7554/eLife.25641.

8.

Antagonistic modulation of NPY/AgRP and POMC neurons in the arcuate nucleus by noradrenalin.

Paeger L, Karakasilioti I, Altmüller J, Frommolt P, Brüning J, Kloppenburg P.

Elife. 2017 Jun 20;6. pii: e25770. doi: 10.7554/eLife.25770.

9.

Lower Affinity of Isradipine for L-Type Ca2+ Channels during Substantia Nigra Dopamine Neuron-Like Activity: Implications for Neuroprotection in Parkinson's Disease.

Ortner NJ, Bock G, Dougalis A, Kharitonova M, Duda J, Hess S, Tuluc P, Pomberger T, Stefanova N, Pitterl F, Ciossek T, Oberacher H, Draheim HJ, Kloppenburg P, Liss B, Striessnig J.

J Neurosci. 2017 Jul 12;37(28):6761-6777. doi: 10.1523/JNEUROSCI.2946-16.2017. Epub 2017 Jun 7.

10.

Inhibition of P2Y6 Signaling in AgRP Neurons Reduces Food Intake and Improves Systemic Insulin Sensitivity in Obesity.

Steculorum SM, Timper K, Engström Ruud L, Evers N, Paeger L, Bremser S, Kloppenburg P, Brüning JC.

Cell Rep. 2017 Feb 14;18(7):1587-1597. doi: 10.1016/j.celrep.2017.01.047.

11.

Transient voltage-activated K+ currents in central antennal lobe neurons: cell type-specific functional properties.

Paeger L, Bardos V, Kloppenburg P.

J Neurophysiol. 2017 May 1;117(5):2053-2064. doi: 10.1152/jn.00685.2016. Epub 2017 Feb 8.

12.

Neurocalcin Delta Suppression Protects against Spinal Muscular Atrophy in Humans and across Species by Restoring Impaired Endocytosis.

Riessland M, Kaczmarek A, Schneider S, Swoboda KJ, Löhr H, Bradler C, Grysko V, Dimitriadi M, Hosseinibarkooie S, Torres-Benito L, Peters M, Upadhyay A, Biglari N, Kröber S, Hölker I, Garbes L, Gilissen C, Hoischen A, Nürnberg G, Nürnberg P, Walter M, Rigo F, Bennett CF, Kye MJ, Hart AC, Hammerschmidt M, Kloppenburg P, Wirth B.

Am J Hum Genet. 2017 Feb 2;100(2):297-315. doi: 10.1016/j.ajhg.2017.01.005. Epub 2017 Jan 26.

13.

Insulin-Dependent Activation of MCH Neurons Impairs Locomotor Activity and Insulin Sensitivity in Obesity.

Hausen AC, Ruud J, Jiang H, Hess S, Varbanov H, Kloppenburg P, Brüning JC.

Cell Rep. 2016 Dec 6;17(10):2512-2521. doi: 10.1016/j.celrep.2016.11.030.

14.

Neuronal Actin Dynamics, Spine Density and Neuronal Dendritic Complexity Are Regulated by CAP2.

Kumar A, Paeger L, Kosmas K, Kloppenburg P, Noegel AA, Peche VS.

Front Cell Neurosci. 2016 Jul 26;10:180. doi: 10.3389/fncel.2016.00180. eCollection 2016.

15.

AgRP Neurons Control Systemic Insulin Sensitivity via Myostatin Expression in Brown Adipose Tissue.

Steculorum SM, Ruud J, Karakasilioti I, Backes H, Engström Ruud L, Timper K, Hess ME, Tsaousidou E, Mauer J, Vogt MC, Paeger L, Bremser S, Klein AC, Morgan DA, Frommolt P, Brinkkötter PT, Hammerschmidt P, Benzing T, Rahmouni K, Wunderlich FT, Kloppenburg P, Brüning JC.

Cell. 2016 Mar 24;165(1):125-138. doi: 10.1016/j.cell.2016.02.044.

16.

Properties and physiological function of Ca2+-dependent K+ currents in uniglomerular olfactory projection neurons.

Bradler C, Warren B, Bardos V, Schleicher S, Klein A, Kloppenburg P.

J Neurophysiol. 2016 May 1;115(5):2330-40. doi: 10.1152/jn.00840.2015. Epub 2016 Jan 28.

17.

Hypothalamic UDP Increases in Obesity and Promotes Feeding via P2Y6-Dependent Activation of AgRP Neurons.

Steculorum SM, Paeger L, Bremser S, Evers N, Hinze Y, Idzko M, Kloppenburg P, Brüning JC.

Cell. 2015 Sep 10;162(6):1404-17. doi: 10.1016/j.cell.2015.08.032.

18.
19.

Human neural stem cell intracerebral grafts show spontaneous early neuronal differentiation after several weeks.

Tennstaedt A, Aswendt M, Adamczak J, Collienne U, Selt M, Schneider G, Henn N, Schaefer C, Lagouge M, Wiedermann D, Kloppenburg P, Hoehn M.

Biomaterials. 2015 Mar;44:143-54. doi: 10.1016/j.biomaterials.2014.12.038. Epub 2015 Jan 12.

20.

Distinct Roles for JNK and IKK Activation in Agouti-Related Peptide Neurons in the Development of Obesity and Insulin Resistance.

Tsaousidou E, Paeger L, Belgardt BF, Pal M, Wunderlich CM, Brönneke H, Collienne U, Hampel B, Wunderlich FT, Schmidt-Supprian M, Kloppenburg P, Brüning JC.

Cell Rep. 2014 Nov 20;9(4):1495-506. doi: 10.1016/j.celrep.2014.10.045. Epub 2014 Nov 13.

21.

Neural coding: sparse but on time.

Kloppenburg P, Nawrot MP.

Curr Biol. 2014 Oct 6;24(19):R957-9. doi: 10.1016/j.cub.2014.08.041.

22.

Rapid and slow chemical synaptic interactions of cholinergic projection neurons and GABAergic local interneurons in the insect antennal lobe.

Warren B, Kloppenburg P.

J Neurosci. 2014 Sep 24;34(39):13039-46. doi: 10.1523/JNEUROSCI.0765-14.2014.

23.

Neonatal insulin action impairs hypothalamic neurocircuit formation in response to maternal high-fat feeding.

Vogt MC, Paeger L, Hess S, Steculorum SM, Awazawa M, Hampel B, Neupert S, Nicholls HT, Mauer J, Hausen AC, Predel R, Kloppenburg P, Horvath TL, Brüning JC.

Cell. 2014 Jan 30;156(3):495-509. doi: 10.1016/j.cell.2014.01.008. Epub 2014 Jan 23.

24.

Catecholamine metabolism drives generation of mitochondrial DNA deletions in dopaminergic neurons.

Neuhaus JF, Baris OR, Hess S, Moser N, Schröder H, Chinta SJ, Andersen JK, Kloppenburg P, Wiesner RJ.

Brain. 2014 Feb;137(Pt 2):354-65. doi: 10.1093/brain/awt291. Epub 2013 Oct 24.

PMID:
24163249
25.

K(ATP)-channel-dependent regulation of catecholaminergic neurons controls BAT sympathetic nerve activity and energy homeostasis.

Tovar S, Paeger L, Hess S, Morgan DA, Hausen AC, Brönneke HS, Hampel B, Ackermann PJ, Evers N, Büning H, Wunderlich FT, Rahmouni K, Kloppenburg P, Brüning JC.

Cell Metab. 2013 Sep 3;18(3):445-55. doi: 10.1016/j.cmet.2013.08.006.

26.

The fat mass and obesity associated gene (Fto) regulates activity of the dopaminergic midbrain circuitry.

Hess ME, Hess S, Meyer KD, Verhagen LA, Koch L, Brönneke HS, Dietrich MO, Jordan SD, Saletore Y, Elemento O, Belgardt BF, Franz T, Horvath TL, Rüther U, Jaffrey SR, Kloppenburg P, Brüning JC.

Nat Neurosci. 2013 Aug;16(8):1042-8. doi: 10.1038/nn.3449. Epub 2013 Jun 30.

PMID:
23817550
27.

Estimating background-subtracted fluorescence transients in calcium imaging experiments: a quantitative approach.

Joucla S, Franconville R, Pippow A, Kloppenburg P, Pouzat C.

Cell Calcium. 2013 Aug;54(2):71-85. doi: 10.1016/j.ceca.2013.04.005. Epub 2013 Jun 18.

PMID:
23787148
28.

Choline acetyltransferase-like immunoreactivity in a physiologically distinct subtype of olfactory nonspiking local interneurons in the cockroach (periplaneta americana).

Fusca D, Husch A, Baumann A, Kloppenburg P.

J Comp Neurol. 2013 Oct 15;521(15):3556-69. doi: 10.1002/cne.23371.

PMID:
23749599
29.

CRN2 enhances the invasiveness of glioblastoma cells.

Ziemann A, Hess S, Bhuwania R, Linder S, Kloppenburg P, Noegel AA, Clemen CS.

Neuro Oncol. 2013 May;15(5):548-61. doi: 10.1093/neuonc/nos388. Epub 2013 Feb 14.

30.

AgRP innervation onto POMC neurons increases with age and is accelerated with chronic high-fat feeding in male mice.

Newton AJ, Hess S, Paeger L, Vogt MC, Fleming Lascano J, Nillni EA, Brüning JC, Kloppenburg P, Xu AW.

Endocrinology. 2013 Jan;154(1):172-83. doi: 10.1210/en.2012-1643. Epub 2012 Nov 16.

31.

AFG3L2 supports mitochondrial protein synthesis and Purkinje cell survival.

Almajan ER, Richter R, Paeger L, Martinelli P, Barth E, Decker T, Larsson NG, Kloppenburg P, Langer T, Rugarli EI.

J Clin Invest. 2012 Nov;122(11):4048-58. doi: 10.1172/JCI64604. Epub 2012 Oct 8.

32.

Desensitization of nicotinic acetylcholine receptors in central nervous system neurons of the stick insect (Carausius morosus) by imidacloprid and sulfoximine insecticides.

Oliveira EE, Schleicher S, Büschges A, Schmidt J, Kloppenburg P, Salgado VL.

Insect Biochem Mol Biol. 2011 Nov;41(11):872-80. doi: 10.1016/j.ibmb.2011.08.001. Epub 2011 Aug 23.

PMID:
21878389
33.

Toward a single-cell-based analysis of neuropeptide expression in Periplaneta americana antennal lobe neurons.

Neupert S, Fusca D, Schachtner J, Kloppenburg P, Predel R.

J Comp Neurol. 2012 Mar 1;520(4):694-716. doi: 10.1002/cne.22745.

PMID:
21826660
34.

High-fat feeding promotes obesity via insulin receptor/PI3K-dependent inhibition of SF-1 VMH neurons.

Klöckener T, Hess S, Belgardt BF, Paeger L, Verhagen LA, Husch A, Sohn JW, Hampel B, Dhillon H, Zigman JM, Lowell BB, Williams KW, Elmquist JK, Horvath TL, Kloppenburg P, Brüning JC.

Nat Neurosci. 2011 Jun 5;14(7):911-8. doi: 10.1038/nn.2847.

35.

Role for insulin signaling in catecholaminergic neurons in control of energy homeostasis.

Könner AC, Hess S, Tovar S, Mesaros A, Sánchez-Lasheras C, Evers N, Verhagen LA, Brönneke HS, Kleinridders A, Hampel B, Kloppenburg P, Brüning JC.

Cell Metab. 2011 Jun 8;13(6):720-8. doi: 10.1016/j.cmet.2011.03.021.

36.

Structural long-term changes at mushroom body input synapses.

Kremer MC, Christiansen F, Leiss F, Paehler M, Knapek S, Andlauer TF, Förstner F, Kloppenburg P, Sigrist SJ, Tavosanis G.

Curr Biol. 2010 Nov 9;20(21):1938-44. doi: 10.1016/j.cub.2010.09.060. Epub 2010 Oct 14.

37.

Cholinergic currents in leg motoneurons of Carausius morosus.

Oliveira EE, Pippow A, Salgado VL, Büschges A, Schmidt J, Kloppenburg P.

J Neurophysiol. 2010 May;103(5):2770-82. doi: 10.1152/jn.00963.2009. Epub 2010 Mar 17.

38.

Quantitative estimation of calcium dynamics from ratiometric measurements: a direct, nonratioing method.

Joucla S, Pippow A, Kloppenburg P, Pouzat C.

J Neurophysiol. 2010 Feb;103(2):1130-44. doi: 10.1152/jn.00414.2009. Epub 2009 Dec 2.

39.

Distinct electrophysiological properties in subtypes of nonspiking olfactory local interneurons correlate with their cell type-specific Ca2+ current profiles.

Husch A, Paehler M, Fusca D, Paeger L, Kloppenburg P.

J Neurophysiol. 2009 Nov;102(5):2834-45. doi: 10.1152/jn.00627.2009. Epub 2009 Sep 16.

40.

Enhanced Stat3 activation in POMC neurons provokes negative feedback inhibition of leptin and insulin signaling in obesity.

Ernst MB, Wunderlich CM, Hess S, Paehler M, Mesaros A, Koralov SB, Kleinridders A, Husch A, Münzberg H, Hampel B, Alber J, Kloppenburg P, Brüning JC, Wunderlich FT.

J Neurosci. 2009 Sep 16;29(37):11582-93. doi: 10.1523/JNEUROSCI.5712-08.2009.

41.

Intrinsic membrane properties and inhibitory synaptic input of kenyon cells as mechanisms for sparse coding?

Demmer H, Kloppenburg P.

J Neurophysiol. 2009 Sep;102(3):1538-50. doi: 10.1152/jn.00183.2009. Epub 2009 Jun 24.

42.

Differences of Ca2+ handling properties in identified central olfactory neurons of the antennal lobe.

Pippow A, Husch A, Pouzat C, Kloppenburg P.

Cell Calcium. 2009 Aug;46(2):87-98. doi: 10.1016/j.ceca.2009.05.004. Epub 2009 Jul 9.

PMID:
19545897
43.

Calcium current diversity in physiologically different local interneuron types of the antennal lobe.

Husch A, Paehler M, Fusca D, Paeger L, Kloppenburg P.

J Neurosci. 2009 Jan 21;29(3):716-26. doi: 10.1523/JNEUROSCI.3677-08.2009.

44.

PDK1 deficiency in POMC-expressing cells reveals FOXO1-dependent and -independent pathways in control of energy homeostasis and stress response.

Belgardt BF, Husch A, Rother E, Ernst MB, Wunderlich FT, Hampel B, Klöckener T, Alessi D, Kloppenburg P, Brüning JC.

Cell Metab. 2008 Apr;7(4):291-301. doi: 10.1016/j.cmet.2008.01.006.

45.

Serotonin modulation of moth central olfactory neurons.

Kloppenburg P, Mercer AR.

Annu Rev Entomol. 2008;53:179-90. Review.

PMID:
18067443
46.
47.

Heterogeneous effects of dopamine on highly localized, voltage-induced Ca2+ accumulation in identified motoneurons.

Kloppenburg P, Zipfel WR, Webb WW, Harris-Warrick RM.

J Neurophysiol. 2007 Nov;98(5):2910-7. Epub 2007 Aug 29.

48.

Plateau potentials in developing antennal-lobe neurons of the moth, Manduca sexta.

Mercer AR, Kloppenburg P, Hildebrand JG.

J Neurophysiol. 2005 Apr;93(4):1949-58. Epub 2004 Nov 17.

49.

Dopamine modulation of calcium currents in pyloric neurons of the lobster stomatogastric ganglion.

Johnson BR, Kloppenburg P, Harris-Warrick RM.

J Neurophysiol. 2003 Aug;90(2):631-43.

50.

Spatial profiles of store-dependent calcium release in motoneurones of the nucleus hypoglossus from newborn mouse.

Ladewig T, Kloppenburg P, Lalley PM, Zipfel WR, Webb WW, Keller BU.

J Physiol. 2003 Mar 15;547(Pt 3):775-87. Epub 2003 Jan 24.

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