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Simvastatin increases temozolomide-induced cell death by targeting the fusion of autophagosomes and lysosomes.

Shojaei S, Koleini N, Samiei E, Aghaei M, Cole LK, Alizadeh J, Islam MI, Vosoughi AR, Albokashy M, Butterfield Y, Marzban H, Xu F, Thliveris J, Kardami E, Hatch GM, Eftekharpour E, Akbari M, Hombach-Klonisch S, Klonisch T, Ghavami S.

FEBS J. 2019 Sep 23. doi: 10.1111/febs.15069. [Epub ahead of print]


Editorial to the mini-review series on relaxin, related peptides and receptors?

Klonisch T.

Mol Cell Endocrinol. 2019 May 1;487:1. doi: 10.1016/j.mce.2019.02.021. Epub 2019 Mar 2. No abstract available.


Emerging roles for the relaxin/RXFP1 system in cancer therapy.

Thanasupawat T, Glogowska A, Nivedita-Krishnan S, Wilson B, Klonisch T, Hombach-Klonisch S.

Mol Cell Endocrinol. 2019 May 1;487:85-93. doi: 10.1016/j.mce.2019.02.001. Epub 2019 Feb 11. Review.


Claudin 1 Is Highly Upregulated by PKC in MCF7 Human Breast Cancer Cells and Correlates Positively with PKCε in Patient Biopsies.

Blanchard AA, Ma X, Wang N, Hombach-Klonisch S, Penner C, Ozturk A, Klonisch T, Pitz M, Murphy L, Leygue E, Myal Y.

Transl Oncol. 2019 Mar;12(3):561-575. doi: 10.1016/j.tranon.2018.12.011. Epub 2019 Jan 15.


A radial microfluidic platform for higher throughput chemotaxis studies with individual gradient control.

Wu J, Kumar-Kanojia A, Hombach-Klonisch S, Klonisch T, Lin F.

Lab Chip. 2018 Dec 4;18(24):3855-3864. doi: 10.1039/c8lc00981c.


Statins: a new approach to combat temozolomide chemoresistance in glioblastoma.

Shojaei S, Alizadeh J, Thliveris J, Koleini N, Kardami E, Hatch GM, Xu F, Hombach-Klonisch S, Klonisch T, Ghavami S.

J Investig Med. 2018 Dec;66(8):1083-1087. doi: 10.1136/jim-2018-000874. Epub 2018 Oct 27. Review.


Maternal smoking and high BMI disrupt thyroid gland development.

Filis P, Hombach-Klonisch S, Ayotte P, Nagrath N, Soffientini U, Klonisch T, O'Shaughnessy P, Fowler PA.

BMC Med. 2018 Oct 23;16(1):194. doi: 10.1186/s12916-018-1183-7.


HMGA2 as a functional antagonist of PARP1 inhibitors in tumor cells.

Hombach-Klonisch S, Kalantari F, Medapati MR, Natarajan S, Krishnan SN, Kumar-Kanojia A, Thanasupawat T, Begum F, Xu FY, Hatch GM, Los M, Klonisch T.

Mol Oncol. 2019 Feb;13(2):153-170. doi: 10.1002/1878-0261.12390. Epub 2018 Nov 28.


Inhibitor of DNA Binding 2 Inhibits Epithelial-Mesenchymal Transition via Up-Regulation of Notch3 in Breast Cancer.

Wen XF, Chen M, Wu Y, Chen MN, Glogowska A, Klonisch T, Zhang GJ.

Transl Oncol. 2018 Oct;11(5):1259-1270. doi: 10.1016/j.tranon.2018.07.015. Epub 2018 Aug 14.


C1q/TNF-related peptide 8 (CTRP8) promotes temozolomide resistance in human glioblastoma.

Thanasupawat T, Glogowska A, Burg M, Krcek J, Beiko J, Pitz M, Zhang GJ, Hombach-Klonisch S, Klonisch T.

Mol Oncol. 2018 Sep;12(9):1464-1479. doi: 10.1002/1878-0261.12349. Epub 2018 Aug 2.


Autophagy modulates transforming growth factor beta 1 induced epithelial to mesenchymal transition in non-small cell lung cancer cells.

Alizadeh J, Glogowska A, Thliveris J, Kalantari F, Shojaei S, Hombach-Klonisch S, Klonisch T, Ghavami S.

Biochim Biophys Acta Mol Cell Res. 2018 May;1865(5):749-768. doi: 10.1016/j.bbamcr.2018.02.007. Epub 2018 Feb 24.


Simple, Hackable, Size-Selective, Amine-Functionalized Fe-Oxide Nanoparticles for Biomedical Applications.

Manna PK, Nickel R, Wroczynskyj Y, Yathindranath V, Li J, Liu S, Thliveris JA, Klonisch T, Miller DW, van Lierop J.

Langmuir. 2018 Feb 27;34(8):2748-2757. doi: 10.1021/acs.langmuir.7b02822. Epub 2018 Feb 12.


Ubiquitin C-terminal hydrolase isozyme L1 is associated with shelterin complex at interstitial telomeric sites.

Ilic A, Lu S, Bhatia V, Begum F, Klonisch T, Agarwal P, Xu W, Davie JR.

Epigenetics Chromatin. 2017 Nov 10;10(1):54. doi: 10.1186/s13072-017-0160-2.


Autophagy activation is required for influenza A virus-induced apoptosis and replication.

Yeganeh B, Ghavami S, Rahim MN, Klonisch T, Halayko AJ, Coombs KM.

Biochim Biophys Acta Mol Cell Res. 2018 Feb;1865(2):364-378. doi: 10.1016/j.bbamcr.2017.10.014. Epub 2017 Nov 3.


Glioblastoma and chemoresistance to alkylating agents: Involvement of apoptosis, autophagy, and unfolded protein response.

Hombach-Klonisch S, Mehrpour M, Shojaei S, Harlos C, Pitz M, Hamai A, Siemianowicz K, Likus W, Wiechec E, Toyota BD, Hoshyar R, Seyfoori A, Sepehri Z, Ande SR, Khadem F, Akbari M, Gorman AM, Samali A, Klonisch T, Ghavami S.

Pharmacol Ther. 2018 Apr;184:13-41. doi: 10.1016/j.pharmthera.2017.10.017. Epub 2017 Nov 8. Review.


Autophagy and the unfolded protein response promote profibrotic effects of TGF-β1 in human lung fibroblasts.

Ghavami S, Yeganeh B, Zeki AA, Shojaei S, Kenyon NJ, Ott S, Samali A, Patterson J, Alizadeh J, Moghadam AR, Dixon IMC, Unruh H, Knight DA, Post M, Klonisch T, Halayko AJ.

Am J Physiol Lung Cell Mol Physiol. 2018 Mar 1;314(3):L493-L504. doi: 10.1152/ajplung.00372.2017. Epub 2017 Oct 26.


Characterization of GPCRs in extracellular vesicle (EV).

Medapati MR, Singh A, Korupally RR, Henderson D, Klonisch T, Manda SV, Chelikani P.

Methods Cell Biol. 2017;142:119-132. doi: 10.1016/bs.mcb.2017.07.004. Epub 2017 Sep 11.


C1q/TNF-related protein 6 (CTRP6) links obesity to adipose tissue inflammation and insulin resistance.

Lei X, Seldin MM, Little HC, Choy N, Klonisch T, Wong GW.

J Biol Chem. 2017 Sep 8;292(36):14836-14850. doi: 10.1074/jbc.M116.766808. Epub 2017 Jul 18.


Dovitinib enhances temozolomide efficacy in glioblastoma cells.

Thanasupawat T, Natarajan S, Rommel A, Glogowska A, Bergen H, Krcek J, Pitz M, Beiko J, Krawitz S, Verma IM, Ghavami S, Klonisch T, Hombach-Klonisch S.

Mol Oncol. 2017 Aug;11(8):1078-1098. doi: 10.1002/1878-0261.12076. Epub 2017 Jun 5.


Corrigendum to "Epidermal Growth Factor Cytoplasmic Domain Affects ErbB Protein Degradation by the Lysosomal and Ubiquitin-Proteasome Pathway in Human Cancer Cells" [Neoplasia 14 (2012) 396-409].

Glogowska A, Stetefeld J, Weber E, Ghavami S, Hoang-Vu C, Klonisch T.

Neoplasia. 2017 Apr;19(4):383. doi: 10.1016/j.neo.2017.01.009. No abstract available.


New frontiers in the treatment of colorectal cancer: Autophagy and the unfolded protein response as promising targets.

Mokarram P, Albokashy M, Zarghooni M, Moosavi MA, Sepehri Z, Chen QM, Hudecki A, Sargazi A, Alizadeh J, Moghadam AR, Hashemi M, Movassagh H, Klonisch T, Owji AA, Łos MJ, Ghavami S.

Autophagy. 2017 May 4;13(5):781-819. doi: 10.1080/15548627.2017.1290751. Epub 2017 Feb 23. Review.


Mevalonate Cascade Inhibition by Simvastatin Induces the Intrinsic Apoptosis Pathway via Depletion of Isoprenoids in Tumor Cells.

Alizadeh J, Zeki AA, Mirzaei N, Tewary S, Rezaei Moghadam A, Glogowska A, Nagakannan P, Eftekharpour E, Wiechec E, Gordon JW, Xu FY, Field JT, Yoneda KY, Kenyon NJ, Hashemi M, Hatch GM, Hombach-Klonisch S, Klonisch T, Ghavami S.

Sci Rep. 2017 Mar 27;7:44841. doi: 10.1038/srep44841.


Dynamics of three-dimensional telomere profiles of circulating tumor cells in patients with high-risk prostate cancer who are undergoing androgen deprivation and radiation therapies.

Wark L, Klonisch T, Awe J, LeClerc C, Dyck B, Quon H, Mai S.

Urol Oncol. 2017 Mar;35(3):112.e1-112.e11. doi: 10.1016/j.urolonc.2016.10.018. Epub 2016 Dec 10.


A prospective cohort study to assess the role of FDG-PET in differentiating benign and malignant follicular neoplasms.

Pathak KA, Goertzen AL, Nason RW, Klonisch T, Leslie WD.

Ann Med Surg (Lond). 2016 Oct 31;12:27-31. eCollection 2016 Dec.


Population-based analysis of breast cancer treatment by intrinsic sub-type in Manitoba, Canada.

Hammond E, Shu E, Sawchuk K, Myal Y, Raouf A, Klonisch T, Hombach-Klonisch S, Leygue E, Kung S, Safneck J, Mowat M, Xu W, Murphy L, Pitz M.

Cancer Epidemiol. 2016 Dec;45:82-90. doi: 10.1016/j.canep.2016.10.006. Epub 2016 Oct 19.


Inhibition of autophagy inhibits the conversion of cardiac fibroblasts to cardiac myofibroblasts.

Gupta SS, Zeglinski MR, Rattan SG, Landry NM, Ghavami S, Wigle JT, Klonisch T, Halayko AJ, Dixon IM.

Oncotarget. 2016 Nov 29;7(48):78516-78531. doi: 10.18632/oncotarget.12392.


Photodynamic N-TiO2 Nanoparticle Treatment Induces Controlled ROS-mediated Autophagy and Terminal Differentiation of Leukemia Cells.

Moosavi MA, Sharifi M, Ghafary SM, Mohammadalipour Z, Khataee A, Rahmati M, Hajjaran S, Łos MJ, Klonisch T, Ghavami S.

Sci Rep. 2016 Oct 4;6:34413. doi: 10.1038/srep34413.


Structural commonality of C1q TNF-related proteins and their potential to activate relaxin/insulin-like family peptide receptor 1 signalling pathways in cancer cells.

Klonisch T, Glogowska A, Thanasupawat T, Burg M, Krcek J, Pitz M, Jaggupilli A, Chelikani P, Wong GW, Hombach-Klonisch S.

Br J Pharmacol. 2017 May;174(10):1025-1033. doi: 10.1111/bph.13559. Epub 2016 Aug 11. Review.


Comparing a thyroid prognostic nomogram to the existing staging systems for prediction risk of death from thyroid cancers.

Pathak KA, Lambert P, Nason RW, Klonisch T.

Eur J Surg Oncol. 2016 Oct;42(10):1491-6. doi: 10.1016/j.ejso.2016.05.016. Epub 2016 May 30.


FDG-PET characteristics of Hürthle cell and follicular adenomas.

Pathak KA, Klonisch T, Nason RW, Leslie WD.

Ann Nucl Med. 2016 Aug;30(7):506-9. doi: 10.1007/s12149-016-1087-6. Epub 2016 May 25.


Pelota Regulates Epidermal Differentiation by Modulating BMP and PI3K/AKT Signaling Pathways.

Elkenani M, Nyamsuren G, Raju P, Liakath-Ali K, Hamdaoui A, Kata A, Dressel R, Klonisch T, Watt FM, Engel W, Thliveris JA, Krishna Pantakani DV, Adham IM.

J Invest Dermatol. 2016 Aug;136(8):1664-1671. doi: 10.1016/j.jid.2016.04.020. Epub 2016 May 7.


Biodistribution of negatively charged iron oxide nanoparticles (IONPs) in mice and enhanced brain delivery using lysophosphatidic acid (LPA).

Sun Z, Worden M, Thliveris JA, Hombach-Klonisch S, Klonisch T, van Lierop J, Hegmann T, Miller DW.

Nanomedicine. 2016 Oct;12(7):1775-1784. doi: 10.1016/j.nano.2016.04.008. Epub 2016 Apr 25.


Cancer stem cells, cancer-initiating cells and methods for their detection.

Akbari-Birgani S, Paranjothy T, Zuse A, Janikowski T, Cieślar-Pobuda A, Likus W, Urasińska E, Schweizer F, Ghavami S, Klonisch T, Łos MJ.

Drug Discov Today. 2016 May;21(5):836-42. doi: 10.1016/j.drudis.2016.03.004. Epub 2016 Mar 11. Review.


High Mobility Group A2 protects cancer cells against telomere dysfunction.

Natarajan S, Begum F, Gim J, Wark L, Henderson D, Davie JR, Hombach-Klonisch S, Klonisch T.

Oncotarget. 2016 Mar 15;7(11):12761-82. doi: 10.18632/oncotarget.6938.


Stage II differentiated thyroid cancer: A mixed bag.

Pathak KA, Klonisch TC, Nason RW.

J Surg Oncol. 2016 Jan;113(1):94-7. doi: 10.1002/jso.24089. Epub 2015 Dec 2.


PDK2-mediated alternative splicing switches Bnip3 from cell death to cell survival.

Gang H, Dhingra R, Lin J, Hai Y, Aviv Y, Margulets V, Hamedani M, Thanasupawat T, Leygue E, Klonisch T, Davie JR, Kirshenbaum LA.

J Cell Biol. 2015 Sep 28;210(7):1101-15. doi: 10.1083/jcb.201504047.


RXFP1 is Targeted by Complement C1q Tumor Necrosis Factor-Related Factor 8 in Brain Cancer.

Thanasupawat T, Glogowska A, Burg M, Wong GW, Hoang-Vu C, Hombach-Klonisch S, Klonisch T.

Front Endocrinol (Lausanne). 2015 Aug 13;6:127. doi: 10.3389/fendo.2015.00127. eCollection 2015. Review.


Nuclear localized Akt enhances breast cancer stem-like cells through counter-regulation of p21(Waf1/Cip1) and p27(kip1).

Jain MV, Jangamreddy JR, Grabarek J, Schweizer F, Klonisch T, Cieślar-Pobuda A, Łos MJ.

Cell Cycle. 2015;14(13):2109-20. doi: 10.1080/15384101.2015.1041692. Epub 2015 Jun 1.


Betacellulin transgenic mice develop urothelial hyperplasia and show sex-dependent reduction in urinary major urinary protein content.

Schulz H, Dahlhoff M, Glogowska A, Zhang L, Arnold GJ, Fröhlich T, Schneider MR, Klonisch T.

Exp Mol Pathol. 2015 Aug;99(1):33-8. doi: 10.1016/j.yexmp.2015.05.002. Epub 2015 May 2.


Autophagy is a regulator of TGF-β1-induced fibrogenesis in primary human atrial myofibroblasts.

Ghavami S, Cunnington RH, Gupta S, Yeganeh B, Filomeno KL, Freed DH, Chen S, Klonisch T, Halayko AJ, Ambrose E, Singal R, Dixon IM.

Cell Death Dis. 2015 Mar 19;6:e1696. doi: 10.1038/cddis.2015.36.


RAGE Mediates the Pro-Migratory Response of Extracellular S100A4 in Human Thyroid Cancer Cells.

Medapati MR, Dahlmann M, Ghavami S, Pathak KA, Lucman L, Klonisch T, Hoang-Vu C, Stein U, Hombach-Klonisch S.

Thyroid. 2015 May;25(5):514-27. doi: 10.1089/thy.2014.0257. Epub 2015 Apr 3.


Characterization of the dystrophin-glycoprotein complex in airway smooth muscle: role of δ-sarcoglycan in airway responsiveness.

Sharma P, Jha A, Stelmack GL, Detillieux K, Basu S, Klonisch T, Unruh H, Halayko AJ.

Can J Physiol Pharmacol. 2015 Mar;93(3):195-202. doi: 10.1139/cjpp-2014-0389. Epub 2015 Jan 14.


Platinum (IV) coiled coil nanotubes selectively kill human glioblastoma cells.

Thanasupawat T, Bergen H, Hombach-Klonisch S, Krcek J, Ghavami S, Del Bigio MR, Krawitz S, Stelmack G, Halayko A, McDougall M, Meier M, Stetefeld J, Klonisch T.

Nanomedicine. 2015 May;11(4):913-25. doi: 10.1016/j.nano.2015.01.014. Epub 2015 Feb 11.


Suppression of influenza A virus replication in human lung epithelial cells by noncytotoxic concentrations bafilomycin A1.

Yeganeh B, Ghavami S, Kroeker AL, Mahood TH, Stelmack GL, Klonisch T, Coombs KM, Halayko AJ.

Am J Physiol Lung Cell Mol Physiol. 2015 Feb 1;308(3):L270-86. doi: 10.1152/ajplung.00011.2014. Epub 2014 Oct 31.


Mechanisms of therapeutic resistance in cancer (stem) cells with emphasis on thyroid cancer cells.

Hombach-Klonisch S, Natarajan S, Thanasupawat T, Medapati M, Pathak A, Ghavami S, Klonisch T.

Front Endocrinol (Lausanne). 2014 Mar 25;5:37. doi: 10.3389/fendo.2014.00037. eCollection 2014. Review.


Airway mesenchymal cell death by mevalonate cascade inhibition: integration of autophagy, unfolded protein response and apoptosis focusing on Bcl2 family proteins.

Ghavami S, Sharma P, Yeganeh B, Ojo OO, Jha A, Mutawe MM, Kashani HH, Los MJ, Klonisch T, Unruh H, Halayko AJ.

Biochim Biophys Acta. 2014 Jul;1843(7):1259-71. doi: 10.1016/j.bbamcr.2014.03.006. Epub 2014 Mar 15.


Chaperoning HMGA2 protein protects stalled replication forks in stem and cancer cells.

Yu H, Lim HH, Tjokro NO, Sathiyanathan P, Natarajan S, Chew TW, Klonisch T, Goodman SD, Surana U, Dröge P.

Cell Rep. 2014 Feb 27;6(4):684-97. doi: 10.1016/j.celrep.2014.01.014. Epub 2014 Feb 6.


Membrane potential differences and GABAA receptor expression in hepatic tumor and non-tumor stem cells.

Bautista W, Perez-Alvarez V, Burczynski F, Raouf A, Klonisch T, Minuk G.

Can J Physiol Pharmacol. 2014 Jan;92(1):85-91. doi: 10.1139/cjpp-2013-0226. Epub 2013 Nov 1.


The changing face of thyroid cancer in a population-based cohort.

Pathak KA, Leslie WD, Klonisch TC, Nason RW.

Cancer Med. 2013 Aug;2(4):537-44. doi: 10.1002/cam4.103. Epub 2013 Jun 26.


Prognostic nomograms to predict oncological outcome of thyroid cancers.

Pathak KA, Mazurat A, Lambert P, Klonisch T, Nason RW.

J Clin Endocrinol Metab. 2013 Dec;98(12):4768-75. doi: 10.1210/jc.2013-2318. Epub 2013 Oct 23.


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