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Items: 47

1.

Nanocrystallography measurements of early stage synthetic malaria pigment.

Dilanian RA, Streltsov V, Coughlan HD, Quiney HM, Martin AV, Klonis N, Dogovski C, Boutet S, Messerschmidt M, Williams GJ, Williams S, Phillips NW, Nugent KA, Tilley L, Abbey B.

J Appl Crystallogr. 2017 Sep 28;50(Pt 5):1533-1540. doi: 10.1107/S1600576717012663. eCollection 2017 Oct 1.

2.

A Dynamic Stress Model Explains the Delayed Drug Effect in Artemisinin Treatment of Plasmodium falciparum.

Cao P, Klonis N, Zaloumis S, Dogovski C, Xie SC, Saralamba S, White LJ, Fowkes FJI, Tilley L, Simpson JA, McCaw JM.

Antimicrob Agents Chemother. 2017 Nov 22;61(12). pii: e00618-17. doi: 10.1128/AAC.00618-17. Print 2017 Dec.

3.

A mechanistic model quantifies artemisinin-induced parasite growth retardation in blood-stage Plasmodium falciparum infection.

Cao P, Klonis N, Zaloumis S, Khoury DS, Cromer D, Davenport MP, Tilley L, Simpson JA, McCaw JM.

J Theor Biol. 2017 Oct 7;430:117-127. doi: 10.1016/j.jtbi.2017.07.017. Epub 2017 Jul 18.

PMID:
28728995
4.

Comparison of the Exposure Time Dependence of the Activities of Synthetic Ozonide Antimalarials and Dihydroartemisinin against K13 Wild-Type and Mutant Plasmodium falciparum Strains.

Yang T, Xie SC, Cao P, Giannangelo C, McCaw J, Creek DJ, Charman SA, Klonis N, Tilley L.

Antimicrob Agents Chemother. 2016 Jul 22;60(8):4501-10. doi: 10.1128/AAC.00574-16. Print 2016 Aug.

5.

Reversible host cell remodeling underpins deformability changes in malaria parasite sexual blood stages.

Dearnley M, Chu T, Zhang Y, Looker O, Huang C, Klonis N, Yeoman J, Kenny S, Arora M, Osborne JM, Chandramohanadas R, Zhang S, Dixon MW, Tilley L.

Proc Natl Acad Sci U S A. 2016 Apr 26;113(17):4800-5. doi: 10.1073/pnas.1520194113. Epub 2016 Apr 11.

6.

Haemoglobin degradation underpins the sensitivity of early ring stage Plasmodium falciparum to artemisinins.

Xie SC, Dogovski C, Hanssen E, Chiu F, Yang T, Crespo MP, Stafford C, Batinovic S, Teguh S, Charman S, Klonis N, Tilley L.

J Cell Sci. 2016 Jan 15;129(2):406-16. doi: 10.1242/jcs.178830. Epub 2015 Dec 16.

7.

Targeting the cell stress response of Plasmodium falciparum to overcome artemisinin resistance.

Dogovski C, Xie SC, Burgio G, Bridgford J, Mok S, McCaw JM, Chotivanich K, Kenny S, Gn├Ądig N, Straimer J, Bozdech Z, Fidock DA, Simpson JA, Dondorp AM, Foote S, Klonis N, Tilley L.

PLoS Biol. 2015 Apr 22;13(4):e1002132. doi: 10.1371/journal.pbio.1002132. eCollection 2015 Apr.

8.

Optimal assay design for determining the in vitro sensitivity of ring stage Plasmodium falciparum to artemisinins.

Xie SC, Dogovski C, Kenny S, Tilley L, Klonis N.

Int J Parasitol. 2014 Oct 15;44(12):893-9. doi: 10.1016/j.ijpara.2014.07.008. Epub 2014 Aug 23. Review.

PMID:
25161101
9.

Iron and heme metabolism in Plasmodium falciparum and the mechanism of action of artemisinins.

Klonis N, Creek DJ, Tilley L.

Curr Opin Microbiol. 2013 Dec;16(6):722-7. doi: 10.1016/j.mib.2013.07.005. Epub 2013 Aug 7. Review.

PMID:
23932203
10.

Novel conjugated quinoline-indoles compromise Plasmodium falciparum mitochondrial function and show promising antimalarial activity.

Teguh SC, Klonis N, Duffy S, Lucantoni L, Avery VM, Hutton CA, Baell JB, Tilley L.

J Med Chem. 2013 Aug 8;56(15):6200-15. doi: 10.1021/jm400656s. Epub 2013 Jul 26.

PMID:
23837878
11.

Altered temporal response of malaria parasites determines differential sensitivity to artemisinin.

Klonis N, Xie SC, McCaw JM, Crespo-Ortiz MP, Zaloumis SG, Simpson JA, Tilley L.

Proc Natl Acad Sci U S A. 2013 Mar 26;110(13):5157-62. doi: 10.1073/pnas.1217452110. Epub 2013 Feb 19.

12.

Artemisinin activity against Plasmodium falciparum requires hemoglobin uptake and digestion.

Klonis N, Crespo-Ortiz MP, Bottova I, Abu-Bakar N, Kenny S, Rosenthal PJ, Tilley L.

Proc Natl Acad Sci U S A. 2011 Jul 12;108(28):11405-10. doi: 10.1073/pnas.1104063108. Epub 2011 Jun 27.

13.

Tracking Glideosome-associated protein 50 reveals the development and organization of the inner membrane complex of Plasmodium falciparum.

Yeoman JA, Hanssen E, Maier AG, Klonis N, Maco B, Baum J, Turnbull L, Whitchurch CB, Dixon MW, Tilley L.

Eukaryot Cell. 2011 Apr;10(4):556-64. doi: 10.1128/EC.00244-10. Epub 2011 Jan 14.

14.

Cryo transmission X-ray imaging of the malaria parasite, P. falciparum.

Hanssen E, Knoechel C, Klonis N, Abu-Bakar N, Deed S, LeGros M, Larabell C, Tilley L.

J Struct Biol. 2011 Jan;173(1):161-8. doi: 10.1016/j.jsb.2010.08.013. Epub 2010 Sep 6.

15.

Hematin-hematin self-association states involved in the formation and reactivity of the malaria parasite pigment, hemozoin.

Klonis N, Dilanian R, Hanssen E, Darmanin C, Streltsov V, Deed S, Quiney H, Tilley L.

Biochemistry. 2010 Aug 10;49(31):6804-11. doi: 10.1021/bi100567j.

PMID:
20593810
16.

Solution behavior of hematin under acidic conditions and implications for its interactions with chloroquine.

Crespo MP, Tilley L, Klonis N.

J Biol Inorg Chem. 2010 Sep;15(7):1009-22. doi: 10.1007/s00775-010-0661-y. Epub 2010 Apr 29.

PMID:
20429019
17.

Dual labeling with a far red probe permits analysis of growth and oxidative stress in P. falciparum-infected erythrocytes.

Fu Y, Tilley L, Kenny S, Klonis N.

Cytometry A. 2010 Mar;77(3):253-63. doi: 10.1002/cyto.a.20856.

18.

Digestive-vacuole genesis and endocytic processes in the early intraerythrocytic stages of Plasmodium falciparum.

Abu Bakar N, Klonis N, Hanssen E, Chan C, Tilley L.

J Cell Sci. 2010 Feb 1;123(Pt 3):441-50. doi: 10.1242/jcs.061499. Epub 2010 Jan 12.

19.

Whole cell imaging reveals novel modular features of the exomembrane system of the malaria parasite, Plasmodium falciparum.

Hanssen E, Carlton P, Deed S, Klonis N, Sedat J, DeRisi J, Tilley L.

Int J Parasitol. 2010 Jan;40(1):123-34. doi: 10.1016/j.ijpara.2009.09.004. Epub 2009 Sep 18.

PMID:
19766648
20.

The astrocytic response in early experimental autoimmune encephalomyelitis occurs across both the grey and white matter compartments.

Pham H, Ramp AA, Klonis N, Ng SW, Klopstein A, Ayers MM, Orian JM.

J Neuroimmunol. 2009 Mar 31;208(1-2):30-9. doi: 10.1016/j.jneuroim.2008.12.010. Epub 2009 Feb 4.

PMID:
19195719
21.

A phosphatidylcholine-BODIPY 581/591 conjugate allows mapping of oxidative stress in P. falciparum-infected erythrocytes.

Fu Y, Klonis N, Suarna C, Maghzal GJ, Stocker R, Tilley L.

Cytometry A. 2009 May;75(5):390-404. doi: 10.1002/cyto.a.20704.

22.

Electron tomography of the Maurer's cleft organelles of Plasmodium falciparum-infected erythrocytes reveals novel structural features.

Hanssen E, Sougrat R, Frankland S, Deed S, Klonis N, Lippincott-Schwartz J, Tilley L.

Mol Microbiol. 2008 Feb;67(4):703-18. Epub 2007 Dec 7.

23.

Evaluation of pH during cytostomal endocytosis and vacuolar catabolism of haemoglobin in Plasmodium falciparum.

Klonis N, Tan O, Jackson K, Goldberg D, Klemba M, Tilley L.

Biochem J. 2007 Nov 1;407(3):343-54.

24.

Illuminating Plasmodium falciparum-infected red blood cells.

Tilley L, McFadden G, Cowman A, Klonis N.

Trends Parasitol. 2007 Jun;23(6):268-77. Epub 2007 Apr 16. Review.

PMID:
17434344
25.

Re-assessing the locations of components of the classical vesicle-mediated trafficking machinery in transfected Plasmodium falciparum.

Adisa A, Frankland S, Rug M, Jackson K, Maier AG, Walsh P, Lithgow T, Klonis N, Gilson PR, Cowman AF, Tilley L.

Int J Parasitol. 2007 Aug;37(10):1127-41. Epub 2007 Mar 12.

PMID:
17428488
26.

A cluster of ring stage-specific genes linked to a locus implicated in cytoadherence in Plasmodium falciparum codes for PEXEL-negative and PEXEL-positive proteins exported into the host cell.

Spielmann T, Hawthorne PL, Dixon MW, Hannemann M, Klotz K, Kemp DJ, Klonis N, Tilley L, Trenholme KR, Gardiner DL.

Mol Biol Cell. 2006 Aug;17(8):3613-24. Epub 2006 Jun 7.

27.

Genesis of and trafficking to the Maurer's clefts of Plasmodium falciparum-infected erythrocytes.

Spycher C, Rug M, Klonis N, Ferguson DJ, Cowman AF, Beck HP, Tilley L.

Mol Cell Biol. 2006 Jun;26(11):4074-85.

28.

Trafficking determinants for PfEMP3 export and assembly under the Plasmodium falciparum-infected red blood cell membrane.

Knuepfer E, Rug M, Klonis N, Tilley L, Cowman AF.

Mol Microbiol. 2005 Nov;58(4):1039-53. Erratum in: Mol Microbiol. 2006 Jan;59(2):722.

29.

Structure of glyceraldehyde-3-phosphate dehydrogenase from Plasmodium falciparum.

Satchell JF, Malby RL, Luo CS, Adisa A, Alpyurek AE, Klonis N, Smith BJ, Tilley L, Colman PM.

Acta Crystallogr D Biol Crystallogr. 2005 Sep;61(Pt 9):1213-21. Epub 2005 Aug 16.

PMID:
16131754
30.

Trafficking of the major virulence factor to the surface of transfected P. falciparum-infected erythrocytes.

Knuepfer E, Rug M, Klonis N, Tilley L, Cowman AF.

Blood. 2005 May 15;105(10):4078-87. Epub 2005 Feb 3.

31.

Food vacuole-associated lipid bodies and heterogeneous lipid environments in the malaria parasite, Plasmodium falciparum.

Jackson KE, Klonis N, Ferguson DJ, Adisa A, Dogovski C, Tilley L.

Mol Microbiol. 2004 Oct;54(1):109-22.

32.

Dual-channel photobleaching FRET microscopy for improved resolution of protein association states in living cells.

Clayton AH, Klonis N, Cody SH, Nice EC.

Eur Biophys J. 2005 Feb;34(1):82-90. Epub 2004 Jun 30.

PMID:
15232659
33.

Novel endoperoxide antimalarials: synthesis, heme binding, and antimalarial activity.

Taylor DK, Avery TD, Greatrex BW, Tiekink ER, Macreadie IG, Macreadie PI, Humphries AD, Kalkanidis M, Fox EN, Klonis N, Tilley L.

J Med Chem. 2004 Mar 25;47(7):1833-9.

PMID:
15027875
34.

Synergistic interaction of a chloroquine metabolite with chloroquine against drug-resistant malaria parasites.

Kalkanidis M, Klonis N, Tschan S, Deady LW, Tilley L.

Biochem Pharmacol. 2004 Apr 1;67(7):1347-53.

PMID:
15013850
35.

Plasmodium falciparum induces reorganization of host membrane proteins during intraerythrocytic growth.

Parker PD, Tilley L, Klonis N.

Blood. 2004 Mar 15;103(6):2404-6. Epub 2003 Nov 13.

PMID:
14615371
36.

MAHRP-1, a novel Plasmodium falciparum histidine-rich protein, binds ferriprotoporphyrin IX and localizes to the Maurer's clefts.

Spycher C, Klonis N, Spielmann T, Kump E, Steiger S, Tilley L, Beck HP.

J Biol Chem. 2003 Sep 12;278(37):35373-83. Epub 2003 Jun 18.

37.

The thiourea group modulates the fluorescence emission decay of fluorescein-labeled molecules.

Klonis N, Sawyer WH.

Photochem Photobiol. 2003 May;77(5):502-9.

PMID:
12812292
38.

Identification and characterization of heme-interacting proteins in the malaria parasite, Plasmodium falciparum.

Campanale N, Nickel C, Daubenberger CA, Wehlan DA, Gorman JJ, Klonis N, Becker K, Tilley L.

J Biol Chem. 2003 Jul 25;278(30):27354-61. Epub 2003 May 14.

39.

Characterization of a series of far-red-absorbing thiobarbituric acid oxonol derivatives as fluorescent probes for biological applications.

Klonis N, Quazi NH, Deady LW, Hughes AB, Tilley L.

Anal Biochem. 2003 Jun 1;317(1):47-58.

PMID:
12729600
40.

The signal sequence of exported protein-1 directs the green fluorescent protein to the parasitophorous vacuole of transfected malaria parasites.

Adisa A, Rug M, Klonis N, Foley M, Cowman AF, Tilley L.

J Biol Chem. 2003 Feb 21;278(8):6532-42. Epub 2002 Nov 26.

41.

Fluorescence photobleaching analysis for the study of cellular dynamics.

Klonis N, Rug M, Harper I, Wickham M, Cowman A, Tilley L.

Eur Biophys J. 2002 Mar;31(1):36-51. Review.

PMID:
12046896
42.

Novel phenothiazine antimalarials: synthesis, antimalarial activity, and inhibition of the formation of beta-haematin.

Kalkanidis M, Klonis N, Tilley L, Deady LW.

Biochem Pharmacol. 2002 Mar 1;63(5):833-42.

PMID:
11911834
43.

Trafficking and assembly of the cytoadherence complex in Plasmodium falciparum-infected human erythrocytes.

Wickham ME, Rug M, Ralph SA, Klonis N, McFadden GI, Tilley L, Cowman AF.

EMBO J. 2001 Oct 15;20(20):5636-49.

44.

Independent movement of the regulatory and catalytic domains of myosin heads revealed by phosphorescence anisotropy.

Brown LJ, Klonis N, Sawyer WH, Fajer PG, Hambly BD.

Biochemistry. 2001 Jul 27;40(28):8283-91.

PMID:
11444974
45.
46.
47.

Spectral properties of the prototropic forms of fluorescein in aqueous solution.

Klonis N, Sawyer WH.

J Fluoresc. 1996 Sep;6(3):147-57. doi: 10.1007/BF00732054.

PMID:
24227203

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