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Items: 1 to 50 of 213

1.

Proteasomal adaptations underlying carfilzomib-resistance in human bone marrow plasma cells.

Woodle ES, Tremblay S, Brailey P, Girnita A, Alloway RR, Aronow B, Dasgupta N, Ebstein F, Kloetzel PM, Lee MJ, Kim KB, Singh H, Driscoll JJ.

Am J Transplant. 2019 Oct 8. doi: 10.1111/ajt.15634. [Epub ahead of print]

PMID:
31595669
2.

Analysis of Proteasome-Generated Antigenic Peptides by Mass Spectrometry.

Textoris-Taube K, Kuckelkorn U, Beier C, Kloetzel PM.

Methods Mol Biol. 2019;1988:15-29. doi: 10.1007/978-1-4939-9450-2_2.

PMID:
31147929
3.

ERAP1-Dependent Antigen Cross-Presentation Determines Efficacy of Adoptive T-cell Therapy in Mice.

Schmidt K, Keller C, Kühl AA, Textor A, Seifert U, Blankenstein T, Willimsky G, Kloetzel PM.

Cancer Res. 2018 Jun 15;78(12):3243-3254. doi: 10.1158/0008-5472.CAN-17-1946. Epub 2018 Mar 20.

4.

Multi-level Strategy for Identifying Proteasome-Catalyzed Spliced Epitopes Targeted by CD8+ T Cells during Bacterial Infection.

Platteel ACM, Liepe J, Textoris-Taube K, Keller C, Henklein P, Schalkwijk HH, Cardoso R, Kloetzel PM, Mishto M, Sijts AJAM.

Cell Rep. 2017 Aug 1;20(5):1242-1253. doi: 10.1016/j.celrep.2017.07.026.

5.

Immunoproteasome deficiency alters microglial cytokine response and improves cognitive deficits in Alzheimer's disease-like APPPS1 mice.

Wagner LK, Gilling KE, Schormann E, Kloetzel PM, Heppner FL, Krüger E, Prokop S.

Acta Neuropathol Commun. 2017 Jun 24;5(1):52. doi: 10.1186/s40478-017-0453-5.

6.

De Novo Disruption of the Proteasome Regulatory Subunit PSMD12 Causes a Syndromic Neurodevelopmental Disorder.

Küry S, Besnard T, Ebstein F, Khan TN, Gambin T, Douglas J, Bacino CA, Craigen WJ, Sanders SJ, Lehmann A, Latypova X, Khan K, Pacault M, Sacharow S, Glaser K, Bieth E, Perrin-Sabourin L, Jacquemont ML, Cho MT, Roeder E, Denommé-Pichon AS, Monaghan KG, Yuan B, Xia F, Simon S, Bonneau D, Parent P, Gilbert-Dussardier B, Odent S, Toutain A, Pasquier L, Barbouth D, Shaw CA, Patel A, Smith JL, Bi W, Schmitt S, Deb W, Nizon M, Mercier S, Vincent M, Rooryck C, Malan V, Briceño I, Gómez A, Nugent KM, Gibson JB, Cogné B, Lupski JR, Stessman HA, Eichler EE, Retterer K, Yang Y, Redon R, Katsanis N, Rosenfeld JA, Kloetzel PM, Golzio C, Bézieau S, Stankiewicz P, Isidor B.

Am J Hum Genet. 2017 Apr 6;100(4):689. doi: 10.1016/j.ajhg.2017.03.003. No abstract available.

7.

Biallelic Variants in OTUD6B Cause an Intellectual Disability Syndrome Associated with Seizures and Dysmorphic Features.

Santiago-Sim T, Burrage LC, Ebstein F, Tokita MJ, Miller M, Bi W, Braxton AA, Rosenfeld JA, Shahrour M, Lehmann A, Cogné B, Küry S, Besnard T, Isidor B, Bézieau S, Hazart I, Nagakura H, Immken LL, Littlejohn RO, Roeder E; EuroEPINOMICS RES Consortium Autosomal Recessive working group, S. Hande Caglayan, Kara B, Hardies K, Weckhuysen S, May P, Lemke JR, Elpeleg O, Abu-Libdeh B, James KN, Silhavy JL, Issa MY, Zaki MS, Gleeson JG, Seavitt JR, Dickinson ME, Ljungberg MC, Wells S, Johnson SJ, Teboul L, Eng CM, Yang Y, Kloetzel PM, Heaney JD, Walkiewicz MA.

Am J Hum Genet. 2017 Apr 6;100(4):676-688. doi: 10.1016/j.ajhg.2017.03.001. Epub 2017 Mar 23.

8.

Extracellular proteasome-osteopontin circuit regulates cell migration with implications in multiple sclerosis.

Dianzani C, Bellavista E, Liepe J, Verderio C, Martucci M, Santoro A, Chiocchetti A, Gigliotti CL, Boggio E, Ferrara B, Riganti L, Keller C, Janek K, Niewienda A, Fenoglio C, Sorosina M, Cantello R, Kloetzel PM, Stumpf MP, Paul F, Ruprecht K, Galimberti D, Martinelli Boneschi F, Comi C, Dianzani U, Mishto M.

Sci Rep. 2017 Mar 9;7:43718. doi: 10.1038/srep43718.

9.

De Novo Disruption of the Proteasome Regulatory Subunit PSMD12 Causes a Syndromic Neurodevelopmental Disorder.

Küry S, Besnard T, Ebstein F, Khan TN, Gambin T, Douglas J, Bacino CA, Craigen WJ, Sanders SJ, Lehmann A, Latypova X, Khan K, Pacault M, Sacharow S, Glaser K, Bieth E, Perrin-Sabourin L, Jacquemont ML, Cho MT, Roeder E, Denommé-Pichon AS, Monaghan KG, Yuan B, Xia F, Simon S, Bonneau D, Parent P, Gilbert-Dussardier B, Odent S, Toutain A, Pasquier L, Barbouth D, Shaw CA, Patel A, Smith JL, Bi W, Schmitt S, Deb W, Nizon M, Mercier S, Vincent M, Rooryck C, Malan V, Briceño I, Gómez A, Nugent KM, Gibson JB, Cogné B, Lupski JR, Stessman HAF, Eichler EE, Retterer K, Yang Y, Redon R, Katsanis N, Rosenfeld JA, Kloetzel PM, Golzio C, Bézieau S, Stankiewicz P, Isidor B.

Am J Hum Genet. 2017 Feb 2;100(2):352-363. doi: 10.1016/j.ajhg.2017.01.003. Epub 2017 Jan 26. Erratum in: Am J Hum Genet. 2017 Apr 6;100(4):689.

10.

Correction: Preventing tumor escape by targeting a post-proteasomal trimming independent epitope.

Textor A, Schmidt K, Kloetzel PM, Weißbrich B, Perez C, Charo J, Anders K, Sidney J, Sette A, Schumacher TN, Keller C, Busch DH, Seifert U, Blankenstein T.

J Exp Med. 2017 Feb;214(2):567. doi: 10.1084/jem.2016063601122017c. Epub 2017 Jan 17. No abstract available.

11.

A large fraction of HLA class I ligands are proteasome-generated spliced peptides.

Liepe J, Marino F, Sidney J, Jeko A, Bunting DE, Sette A, Kloetzel PM, Stumpf MP, Heck AJ, Mishto M.

Science. 2016 Oct 21;354(6310):354-358. Epub 2016 Oct 20.

12.

Immunoproteasome induction is suppressed in hepatitis C virus-infected cells in a protein kinase R-dependent manner.

Oh IS, Textoris-Taube K, Sung PS, Kang W, Gorny X, Kähne T, Hong SH, Choi YJ, Cammann C, Naumann M, Kim JH, Park SH, Yoo OJ, Kloetzel PM, Seifert U, Shin EC.

Exp Mol Med. 2016 Nov 11;48(11):e270. doi: 10.1038/emm.2016.98.

13.

Preventing tumor escape by targeting a post-proteasomal trimming independent epitope.

Textor A, Schmidt K, Kloetzel PM, Weißbrich B, Perez C, Charo J, Anders K, Sidney J, Sette A, Schumacher TN, Keller C, Busch DH, Seifert U, Blankenstein T.

J Exp Med. 2016 Oct 17;213(11):2333-2348. Epub 2016 Oct 3. Erratum in: J Exp Med. 2017 Feb;214(2):567.

14.

Strategies to enhance immunogenicity of cDNA vaccine encoded antigens by modulation of antigen processing.

Platteel ACM, Marit de Groot A, Keller C, Andersen P, Ovaa H, Kloetzel PM, Mishto M, Sijts AJAM.

Vaccine. 2016 Sep 30;34(42):5132-5140. doi: 10.1016/j.vaccine.2016.08.039. Epub 2016 Sep 1.

PMID:
27593157
15.

Exposure to Melan-A/MART-126-35 tumor epitope specific CD8(+)T cells reveals immune escape by affecting the ubiquitin-proteasome system (UPS).

Ebstein F, Keller M, Paschen A, Walden P, Seeger M, Bürger E, Krüger E, Schadendorf D, Kloetzel PM, Seifert U.

Sci Rep. 2016 May 4;6:25208. doi: 10.1038/srep25208.

16.

Elastase-like Activity Is Dominant to Chymotrypsin-like Activity in 20S Proteasome's β5 Catalytic Subunit.

Bensinger D, Neumann T, Scholz C, Voss C, Knorr S, Kuckelkorn U, Hamacher K, Kloetzel PM, Schmidt B.

ACS Chem Biol. 2016 Jul 15;11(7):1800-4. doi: 10.1021/acschembio.6b00023. Epub 2016 May 2.

PMID:
27111844
17.

Proteasome β5i Subunit Deficiency Affects Opsonin Synthesis and Aggravates Pneumococcal Pneumonia.

Kirschner F, Reppe K, Andresen N, Witzenrath M, Ebstein F, Kloetzel PM.

PLoS One. 2016 Apr 21;11(4):e0153847. doi: 10.1371/journal.pone.0153847. eCollection 2016.

18.

Proteasomes generate spliced epitopes by two different mechanisms and as efficiently as non-spliced epitopes.

Ebstein F, Textoris-Taube K, Keller C, Golnik R, Vigneron N, Van den Eynde BJ, Schuler-Thurner B, Schadendorf D, Lorenz FK, Uckert W, Urban S, Lehmann A, Albrecht-Koepke N, Janek K, Henklein P, Niewienda A, Kloetzel PM, Mishto M.

Sci Rep. 2016 Apr 6;6:24032. doi: 10.1038/srep24032.

19.

CD8(+) T cells of Listeria monocytogenes-infected mice recognize both linear and spliced proteasome products.

Platteel AC, Mishto M, Textoris-Taube K, Keller C, Liepe J, Busch DH, Kloetzel PM, Sijts AJ.

Eur J Immunol. 2016 May;46(5):1109-18. doi: 10.1002/eji.201545989. Epub 2016 Mar 16.

20.

Major Histocompatibility Complex (MHC) Class I Processing of the NY-ESO-1 Antigen Is Regulated by Rpn10 and Rpn13 Proteins and Immunoproteasomes following Non-lysine Ubiquitination.

Golnik R, Lehmann A, Kloetzel PM, Ebstein F.

J Biol Chem. 2016 Apr 15;291(16):8805-15. doi: 10.1074/jbc.M115.705178. Epub 2016 Feb 22.

21.

The T210M Substitution in the HLA-a*02:01 gp100 Epitope Strongly Affects Overall Proteasomal Cleavage Site Usage and Antigen Processing.

Textoris-Taube K, Keller C, Liepe J, Henklein P, Sidney J, Sette A, Kloetzel PM, Mishto M.

J Biol Chem. 2015 Dec 18;290(51):30417-28. doi: 10.1074/jbc.M115.695189. Epub 2015 Oct 27.

22.

The proteasome immunosubunits, PA28 and ER-aminopeptidase 1 protect melanoma cells from efficient MART-126-35 -specific T-cell recognition.

Keller M, Ebstein F, Bürger E, Textoris-Taube K, Gorny X, Urban S, Zhao F, Dannenberg T, Sucker A, Keller C, Saveanu L, Krüger E, Rothkötter HJ, Dahlmann B, Henklein P, Voigt A, Kuckelkorn U, Paschen A, Kloetzel PM, Seifert U.

Eur J Immunol. 2015 Dec;45(12):3257-68. doi: 10.1002/eji.201445243. Epub 2015 Oct 19.

23.

Quantitative time-resolved analysis reveals intricate, differential regulation of standard- and immuno-proteasomes.

Liepe J, Holzhütter HG, Bellavista E, Kloetzel PM, Stumpf MP, Mishto M.

Elife. 2015 Sep 22;4:e07545. doi: 10.7554/eLife.07545.

24.

Evidence for anti-apoptotic roles of proteasome activator 28γ via inhibiting caspase activity.

Moncsek A, Gruner M, Meyer H, Lehmann A, Kloetzel PM, Stohwasser R.

Apoptosis. 2015 Sep;20(9):1211-28. doi: 10.1007/s10495-015-1149-6.

PMID:
26201457
25.

The immunoproteasome β5i subunit is a key contributor to ictogenesis in a rat model of chronic epilepsy.

Mishto M, Raza ML, de Biase D, Ravizza T, Vasuri F, Martucci M, Keller C, Bellavista E, Buchholz TJ, Kloetzel PM, Pession A, Vezzani A, Heinemann U.

Brain Behav Immun. 2015 Oct;49:188-96. doi: 10.1016/j.bbi.2015.05.007. Epub 2015 Jun 1.

PMID:
26044087
26.

Role of peptide processing predictions in T cell epitope identification: contribution of different prediction programs.

Calis JJ, Reinink P, Keller C, Kloetzel PM, Keşmir C.

Immunogenetics. 2015 Feb;67(2):85-93. doi: 10.1007/s00251-014-0815-0. Epub 2014 Dec 6.

27.

Biodistribution and Efficacy Studies of the Proteasome Inhibitor BSc2118 in a Mouse Melanoma Model.

Mlynarczuk-Bialy I, Doeppner TR, Golab J, Nowis D, Wilczynski GM, Parobczak K, Wigand ME, Hajdamowicz M, Biały LP, Aniolek O, Henklein P, Bähr M, Schmidt B, Kuckelkorn U, Kloetzel PM.

Transl Oncol. 2014 Oct 24;7(5):570-9. doi: 10.1016/j.tranon.2014.07.002. eCollection 2014 Oct.

28.

Proteasome isoforms exhibit only quantitative differences in cleavage and epitope generation.

Mishto M, Liepe J, Textoris-Taube K, Keller C, Henklein P, Weberruß M, Dahlmann B, Enenkel C, Voigt A, Kuckelkorn U, Stumpf MP, Kloetzel PM.

Eur J Immunol. 2014 Dec;44(12):3508-21. doi: 10.1002/eji.201444902. Epub 2014 Nov 20.

29.

α-Keto phenylamides as P1'-extended proteasome inhibitors.

Voss C, Scholz C, Knorr S, Beck P, Stein ML, Zall A, Kuckelkorn U, Kloetzel PM, Groll M, Hamacher K, Schmidt B.

ChemMedChem. 2014 Nov;9(11):2557-64. doi: 10.1002/cmdc.201402244. Epub 2014 Aug 1.

PMID:
25087721
30.

Two inhibitors of the ubiquitin proteasome system enhance long-term memory formation upon olfactory conditioning in the honeybee (Apis mellifera).

Felsenberg J, Dyck Y, Kloß A, Dahlmann B, Kloetzel PM, Eisenhardt D.

J Exp Biol. 2014 Oct 1;217(Pt 19):3441-6. doi: 10.1242/jeb.108142. Epub 2014 Jul 25.

31.

Modelling proteasome and proteasome regulator activities.

Liepe J, Holzhütter HG, Kloetzel PM, Stumpf MP, Mishto M.

Biomolecules. 2014 Jun 20;4(2):585-99. doi: 10.3390/biom4020585. Review.

32.

Adult human liver contains intermediate-type proteasomes with different enzymatic properties.

Gohlke S, Kloss A, Tsokos M, Textoris-Taube K, Keller C, Kloetzel PM, Dahlmann B.

Ann Hepatol. 2014 Jul-Aug;13(4):429-38.

33.

Trypanosoma cruzi infection down-modulates the immunoproteasome biosynthesis and the MHC class I cell surface expression in HeLa cells.

Camargo R, Faria LO, Kloss A, Favali CB, Kuckelkorn U, Kloetzel PM, de Sá CM, Lima BD.

PLoS One. 2014 Apr 21;9(4):e95977. doi: 10.1371/journal.pone.0095977. eCollection 2014.

34.

Cross-presentation of synthetic long peptides by human dendritic cells: a process dependent on ERAD component p97/VCP but Not sec61 and/or Derlin-1.

Ménager J, Ebstein F, Oger R, Hulin P, Nedellec S, Duverger E, Lehmann A, Kloetzel PM, Jotereau F, Guilloux Y.

PLoS One. 2014 Feb 27;9(2):e89897. doi: 10.1371/journal.pone.0089897. eCollection 2014.

35.

T lymphocytes export proteasomes by way of microparticles: a possible mechanism for generation of extracellular proteasomes.

Bochmann I, Ebstein F, Lehmann A, Wohlschlaeger J, Sixt SU, Kloetzel PM, Dahlmann B.

J Cell Mol Med. 2014 Jan;18(1):59-68. doi: 10.1111/jcmm.12160. Epub 2013 Oct 31.

36.

Molecular alterations in proteasomes of rat liver during aging result in altered proteolytic activities.

Gohlke S, Mishto M, Textoris-Taube K, Keller C, Giannini C, Vasuri F, Capizzi E, D'Errico-Grigioni A, Kloetzel PM, Dahlmann B.

Age (Dordr). 2014 Feb;36(1):57-72. doi: 10.1007/s11357-013-9543-x. Epub 2013 May 22.

37.

Poly-Ub-substrate-degradative activity of 26S proteasome is not impaired in the aging rat brain.

Giannini C, Kloß A, Gohlke S, Mishto M, Nicholson TP, Sheppard PW, Kloetzel PM, Dahlmann B.

PLoS One. 2013 May 7;8(5):e64042. doi: 10.1371/journal.pone.0064042. Print 2013.

38.

Cytokine-induced oxidative stress in cardiac inflammation and heart failure-how the ubiquitin proteasome system targets this vicious cycle.

Voigt A, Rahnefeld A, Kloetzel PM, Krüger E.

Front Physiol. 2013 Mar 6;4:42. doi: 10.3389/fphys.2013.00042. eCollection 2013.

39.

Gene expression of catalytic proteasome subunits and resistance toward proteasome inhibition of B lymphocytes from patients with primary sjogren syndrome.

Martinez-Gamboa L, Lesemann K, Kuckelkorn U, Scheffler S, Ghannam K, Hahne M, Gaber-Elsner T, Egerer K, Naumann L, Buttgereit F, Dörner T, Kloetzel PM, Burmester GR, Faustman DL, Feist E.

J Rheumatol. 2013 May;40(5):663-73. doi: 10.3899/jrheum.120680. Epub 2013 Mar 15.

PMID:
23504381
40.

Immunoproteasomes are important for proteostasis in immune responses.

Ebstein F, Voigt A, Lange N, Warnatsch A, Schröter F, Prozorovski T, Kuckelkorn U, Aktas O, Seifert U, Kloetzel PM, Krüger E.

Cell. 2013 Feb 28;152(5):935-7. doi: 10.1016/j.cell.2013.02.018. No abstract available.

41.

Analysis of proteasome generated antigenic peptides by mass spectrometry.

Textoris-Taube K, Keller C, Kuckelkorn U, Kloetzel PM.

Methods Mol Biol. 2013;960:15-29. doi: 10.1007/978-1-62703-218-6_2.

PMID:
23329475
42.

Driving forces of proteasome-catalyzed peptide splicing in yeast and humans.

Mishto M, Goede A, Taube KT, Keller C, Janek K, Henklein P, Niewienda A, Kloss A, Gohlke S, Dahlmann B, Enenkel C, Kloetzel PM.

Mol Cell Proteomics. 2012 Oct;11(10):1008-23. Epub 2012 Jul 20.

43.

Mapping of O-GlcNAc sites of 20 S proteasome subunits and Hsp90 by a novel biotin-cystamine tag.

Overath T, Kuckelkorn U, Henklein P, Strehl B, Bonar D, Kloss A, Siele D, Kloetzel PM, Janek K.

Mol Cell Proteomics. 2012 Aug;11(8):467-77. doi: 10.1074/mcp.M111.015966. Epub 2012 May 3.

44.

Emerging roles of immunoproteasomes beyond MHC class I antigen processing.

Ebstein F, Kloetzel PM, Krüger E, Seifert U.

Cell Mol Life Sci. 2012 Aug;69(15):2543-58. doi: 10.1007/s00018-012-0938-0. Epub 2012 Mar 2. Review.

PMID:
22382925
45.

The FAT10- and ubiquitin-dependent degradation machineries exhibit common and distinct requirements for MHC class I antigen presentation.

Ebstein F, Lehmann A, Kloetzel PM.

Cell Mol Life Sci. 2012 Jul;69(14):2443-54. doi: 10.1007/s00018-012-0933-5. Epub 2012 Feb 19.

46.

Immunoproteasomes at the interface of innate and adaptive immune responses: two faces of one enzyme.

Krüger E, Kloetzel PM.

Curr Opin Immunol. 2012 Feb;24(1):77-83. doi: 10.1016/j.coi.2012.01.005. Epub 2012 Jan 31. Review.

PMID:
22296715
47.

Impairment of immunoproteasome function by β5i/LMP7 subunit deficiency results in severe enterovirus myocarditis.

Opitz E, Koch A, Klingel K, Schmidt F, Prokop S, Rahnefeld A, Sauter M, Heppner FL, Völker U, Kandolf R, Kuckelkorn U, Stangl K, Krüger E, Kloetzel PM, Voigt A.

PLoS Pathog. 2011 Sep;7(9):e1002233. doi: 10.1371/journal.ppat.1002233. Epub 2011 Sep 1.

48.

Antigen-presentation capacity of dendritic cells is impaired in ongoing enterovirus myocarditis.

Rahnefeld A, Ebstein F, Albrecht N, Opitz E, Kuckelkorn U, Stangl K, Rehm A, Kloetzel PM, Voigt A.

Eur J Immunol. 2011 Sep;41(9):2774-81. doi: 10.1002/eji.201041039. Epub 2011 Jul 29.

49.

The only proposed T-cell epitope derived from the TEL-AML1 translocation is not naturally processed.

Popovic J, Li LP, Kloetzel PM, Leisegang M, Uckert W, Blankenstein T.

Blood. 2011 Jul 28;118(4):946-54. doi: 10.1182/blood-2010-12-325035. Epub 2011 May 25.

PMID:
21613253
50.

CTL escape mediated by proteasomal destruction of an HIV-1 cryptic epitope.

Cardinaud S, Consiglieri G, Bouziat R, Urrutia A, Graff-Dubois S, Fourati S, Malet I, Guergnon J, Guihot A, Katlama C, Autran B, van Endert P, Lemonnier FA, Appay V, Schwartz O, Kloetzel PM, Moris A.

PLoS Pathog. 2011 May;7(5):e1002049. doi: 10.1371/journal.ppat.1002049. Epub 2011 May 12.

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