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Items: 16

1.

Small-Molecule Dual PLK1 and BRD4 Inhibitors are Active Against Preclinical Models of Pediatric Solid Tumors.

Timme N, Han Y, Liu S, Yosief HO, García HD, Bei Y, Klironomos F, MacArthur IC, Szymansky A, von Stebut J, Bardinet V, Dohna C, Künkele A, Rolff J, Hundsdörfer P, Lissat A, Seifert G, Eggert A, Schulte JH, Zhang W, Henssen AG.

Transl Oncol. 2019 Dec 20;13(2):221-232. doi: 10.1016/j.tranon.2019.09.013. [Epub ahead of print]

2.

Extrachromosomal circular DNA drives oncogenic genome remodeling in neuroblastoma.

Koche RP, Rodriguez-Fos E, Helmsauer K, Burkert M, MacArthur IC, Maag J, Chamorro R, Munoz-Perez N, Puiggròs M, Dorado Garcia H, Bei Y, Röefzaad C, Bardinet V, Szymansky A, Winkler A, Thole T, Timme N, Kasack K, Fuchs S, Klironomos F, Thiessen N, Blanc E, Schmelz K, Künkele A, Hundsdörfer P, Rosswog C, Theissen J, Beule D, Deubzer H, Sauer S, Toedling J, Fischer M, Hertwig F, Schwarz RF, Eggert A, Torrents D, Schulte JH, Henssen AG.

Nat Genet. 2020 Jan;52(1):29-34. doi: 10.1038/s41588-019-0547-z. Epub 2019 Dec 16.

PMID:
31844324
3.

Context-specific regulation of cell survival by a miRNA-controlled BIM rheostat.

Labi V, Peng S, Klironomos F, Munschauer M, Kastelic N, Chakraborty T, Schoeler K, Derudder E, Martella M, Mastrobuoni G, Hernandez-Miranda LR, Lahmann I, Kocks C, Birchmeier C, Kempa S, Quintanilla-Martinez de Fend L, Landthaler M, Rajewsky N, Rajewsky K.

Genes Dev. 2019 Dec 1;33(23-24):1673-1687. doi: 10.1101/gad.330134.119. Epub 2019 Nov 7.

PMID:
31699777
4.

Prohibitin promotes de-differentiation and is a potential therapeutic target in neuroblastoma.

MacArthur IC, Bei Y, Garcia HD, Ortiz MV, Toedling J, Klironomos F, Rolff J, Eggert A, Schulte JH, Kentsis A, Henssen AG.

JCI Insight. 2019 Apr 18;5. pii: 127130. doi: 10.1172/jci.insight.127130.

5.

Spatiotemporal m(i)RNA Architecture and 3' UTR Regulation in the C. elegans Germline.

Diag A, Schilling M, Klironomos F, Ayoub S, Rajewsky N.

Dev Cell. 2018 Dec 17;47(6):785-800.e8. doi: 10.1016/j.devcel.2018.10.005. Epub 2018 Nov 8.

6.

Characterization of Transcription Termination-Associated RNAs: New Insights into their Biogenesis, Tailing, and Expression in Primary Tumors.

Laudadio I, Formichetti S, Gioiosa S, Klironomos F, Rajewsky N, Macino G, Carissimi C, Fulci V.

Int J Genomics. 2018 Apr 26;2018:1243858. doi: 10.1155/2018/1243858. eCollection 2018.

7.

Loss of a mammalian circular RNA locus causes miRNA deregulation and affects brain function.

Piwecka M, Glažar P, Hernandez-Miranda LR, Memczak S, Wolf SA, Rybak-Wolf A, Filipchyk A, Klironomos F, Cerda Jara CA, Fenske P, Trimbuch T, Zywitza V, Plass M, Schreyer L, Ayoub S, Kocks C, Kühn R, Rosenmund C, Birchmeier C, Rajewsky N.

Science. 2017 Sep 22;357(6357). pii: eaam8526. doi: 10.1126/science.aam8526. Epub 2017 Aug 10.

PMID:
28798046
8.

Epigenomic Profiling of Human CD4+ T Cells Supports a Linear Differentiation Model and Highlights Molecular Regulators of Memory Development.

Durek P, Nordström K, Gasparoni G, Salhab A, Kressler C, de Almeida M, Bassler K, Ulas T, Schmidt F, Xiong J, Glažar P, Klironomos F, Sinha A, Kinkley S, Yang X, Arrigoni L, Amirabad AD, Ardakani FB, Feuerbach L, Gorka O, Ebert P, Müller F, Li N, Frischbutter S, Schlickeiser S, Cendon C, Fröhler S, Felder B, Gasparoni N, Imbusch CD, Hutter B, Zipprich G, Tauchmann Y, Reinke S, Wassilew G, Hoffmann U, Richter AS, Sieverling L; DEEP Consortium, Chang HD, Syrbe U, Kalus U, Eils J, Brors B, Manke T, Ruland J, Lengauer T, Rajewsky N, Chen W, Dong J, Sawitzki B, Chung HR, Rosenstiel P, Schulz MH, Schultze JL, Radbruch A, Walter J, Hamann A, Polansky JK.

Immunity. 2016 Nov 15;45(5):1148-1161. doi: 10.1016/j.immuni.2016.10.022.

9.

Epigenetic dynamics of monocyte-to-macrophage differentiation.

Wallner S, Schröder C, Leitão E, Berulava T, Haak C, Beißer D, Rahmann S, Richter AS, Manke T, Bönisch U, Arrigoni L, Fröhler S, Klironomos F, Chen W, Rajewsky N, Müller F, Ebert P, Lengauer T, Barann M, Rosenstiel P, Gasparoni G, Nordström K, Walter J, Brors B, Zipprich G, Felder B, Klein-Hitpass L, Attenberger C, Schmitz G, Horsthemke B.

Epigenetics Chromatin. 2016 Jul 29;9:33. doi: 10.1186/s13072-016-0079-z. eCollection 2016.

10.

The Lupus Autoantigen La Prevents Mis-channeling of tRNA Fragments into the Human MicroRNA Pathway.

Hasler D, Lehmann G, Murakawa Y, Klironomos F, Jakob L, Grässer FA, Rajewsky N, Landthaler M, Meister G.

Mol Cell. 2016 Jul 7;63(1):110-24. doi: 10.1016/j.molcel.2016.05.026. Epub 2016 Jun 23.

11.

Unambiguous identification of miRNA:target site interactions by different types of ligation reactions.

Grosswendt S, Filipchyk A, Manzano M, Klironomos F, Schilling M, Herzog M, Gottwein E, Rajewsky N.

Mol Cell. 2014 Jun 19;54(6):1042-1054. doi: 10.1016/j.molcel.2014.03.049. Epub 2014 May 22.

12.

Can we always sweep the details of RNA-processing under the carpet?

Klironomos FD, de Meaux J, Berg J.

Phys Biol. 2013 Oct;10(5):056007. doi: 10.1088/1478-3975/10/5/056007. Epub 2013 Oct 3.

PMID:
24091933
13.

How epigenetic mutations can affect genetic evolution: model and mechanism.

Klironomos FD, Berg J, Collins S.

Bioessays. 2013 Jun;35(6):571-8. doi: 10.1002/bies.201200169. Epub 2013 Apr 12.

PMID:
23580343
14.
15.

Pairing and density-wave phases in boson-fermion mixtures at fixed filling.

Klironomos FD, Tsai SW.

Phys Rev Lett. 2007 Sep 7;99(10):100401. Epub 2007 Sep 7.

PMID:
17930377
16.

Anisotropic states of two-dimensional electrons in high magnetic fields.

Ettouhami AM, Doiron CB, Klironomos FD, Côté R, Dorsey AT.

Phys Rev Lett. 2006 May 19;96(19):196802. Epub 2006 May 16.

PMID:
16803124

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