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Increased inflammation, oxidative stress and a reduction in antioxidant defense enzymes in perivascular adipose tissue contribute to vascular dysfunction in type 2 diabetes.

Azul L, Leandro A, Boroumand P, Klip A, Seiça R, Sena CM.

Free Radic Biol Med. 2020 Jan;146:264-274. doi: 10.1016/j.freeradbiomed.2019.11.002. Epub 2019 Nov 5.


Palmitoylation of NOD1 and NOD2 is required for bacterial sensing.

Lu Y, Zheng Y, Coyaud É, Zhang C, Selvabaskaran A, Yu Y, Xu Z, Weng X, Chen JS, Meng Y, Warner N, Cheng X, Liu Y, Yao B, Hu H, Xia Z, Muise AM, Klip A, Brumell JH, Girardin SE, Ying S, Fairn GD, Raught B, Sun Q, Neculai D.

Science. 2019 Oct 25;366(6464):460-467. doi: 10.1126/science.aau6391. Epub 2019 Oct 24.


Deficiency of the autophagy gene ATG16L1 induces insulin resistance through KLHL9/KLHL13/CUL3-mediated IRS1 degradation.

Frendo-Cumbo S, Jaldin-Fincati JR, Coyaud E, Laurent EMN, Townsend LK, Tan JMJ, Xavier RJ, Pillon NJ, Raught B, Wright DC, Brumell JH, Klip A.

J Biol Chem. 2019 Nov 1;294(44):16172-16185. doi: 10.1074/jbc.RA119.009110. Epub 2019 Sep 12.


Thirty sweet years of GLUT4.

Klip A, McGraw TE, James DE.

J Biol Chem. 2019 Jul 26;294(30):11369-11381. doi: 10.1074/jbc.REV119.008351. Epub 2019 Jun 7. Review.


Rho GTPases-Emerging Regulators of Glucose Homeostasis and Metabolic Health.

Møller LLV, Klip A, Sylow L.

Cells. 2019 May 9;8(5). pii: E434. doi: 10.3390/cells8050434. Review.


Endothelial cell barriers: Transport of molecules between blood and tissues.

Yazdani S, Jaldin-Fincati JR, Pereira RVS, Klip A.

Traffic. 2019 Jun;20(6):390-403. doi: 10.1111/tra.12645. Epub 2019 Apr 24. Review.


NOD1: An Interface Between Innate Immunity and Insulin Resistance.

Rivers SL, Klip A, Giacca A.

Endocrinology. 2019 May 1;160(5):1021-1030. doi: 10.1210/en.2018-01061. Review.


Sphingolipid changes do not underlie fatty acid-evoked GLUT4 insulin resistance nor inflammation signals in muscle cells.

Pillon NJ, Frendo-Cumbo S, Jacobson MR, Liu Z, Milligan PL, Hoang Bui H, Zierath JR, Bilan PJ, Brozinick JT, Klip A.

J Lipid Res. 2018 Jul;59(7):1148-1163. doi: 10.1194/jlr.M080788. Epub 2018 May 23.


The cell biology of systemic insulin function.

Tokarz VL, MacDonald PE, Klip A.

J Cell Biol. 2018 Jul 2;217(7):2273-2289. doi: 10.1083/jcb.201802095. Epub 2018 Apr 5. Review.


Male Mice Lacking NLRX1 Are Partially Protected From High-Fat Diet-Induced Hyperglycemia.

Costford SR, Tattoli I, Duan FT, Volchuk A, Klip A, Philpott DJ, Woo M, Girardin SE.

J Endocr Soc. 2018 Feb 21;2(4):336-347. doi: 10.1210/js.2017-00360. eCollection 2018 Apr 1.


Insulin uptake and action in microvascular endothelial cells of lymphatic and blood origin.

Jaldin-Fincati JR, Pereira RVS, Bilan PJ, Klip A.

Am J Physiol Endocrinol Metab. 2018 Aug 1;315(2):E204-E217. doi: 10.1152/ajpendo.00008.2018. Epub 2018 Mar 6.


Herpud1 impacts insulin-dependent glucose uptake in skeletal muscle cells by controlling the Ca2+-calcineurin-Akt axis.

Navarro-Marquez M, Torrealba N, Troncoso R, Vásquez-Trincado C, Rodriguez M, Morales PE, Villalobos E, Eura Y, Garcia L, Chiong M, Klip A, Jaimovich E, Kokame K, Lavandero S.

Biochim Biophys Acta Mol Basis Dis. 2018 May;1864(5 Pt A):1653-1662. doi: 10.1016/j.bbadis.2018.02.018. Epub 2018 Feb 24.


GLUT4 Translocation in Single Muscle Cells in Culture: Epitope Detection by Immunofluorescence.

Jaldin-Fincati JR, Bilan PJ, Klip A.

Methods Mol Biol. 2018;1713:175-192. doi: 10.1007/978-1-4939-7507-5_14.


Electrical pulse stimulation induces GLUT4 translocation in C2C12 myotubes that depends on Rab8A, Rab13, and Rab14.

Li Z, Yue Y, Hu F, Zhang C, Ma X, Li N, Qiu L, Fu M, Chen L, Yao Z, Bilan PJ, Klip A, Niu W.

Am J Physiol Endocrinol Metab. 2018 May 1;314(5):E478-E493. doi: 10.1152/ajpendo.00103.2017. Epub 2017 Oct 31.


Intermittent fasting promotes adipose thermogenesis and metabolic homeostasis via VEGF-mediated alternative activation of macrophage.

Kim KH, Kim YH, Son JE, Lee JH, Kim S, Choe MS, Moon JH, Zhong J, Fu K, Lenglin F, Yoo JA, Bilan PJ, Klip A, Nagy A, Kim JR, Park JG, Hussein SM, Doh KO, Hui CC, Sung HK.

Cell Res. 2017 Nov;27(11):1309-1326. doi: 10.1038/cr.2017.126. Epub 2017 Oct 17.


Supportive data on the regulation of GLUT4 activity by 3-O-methyl-D-glucose.

Shamni O, Cohen G, Gruzman A, Zaid H, Klip A, Cerasi E, Sasson S.

Data Brief. 2017 Jul 28;14:329-336. doi: 10.1016/j.dib.2017.07.069. eCollection 2017 Oct.


Regulation of GLUT4 activity in myotubes by 3-O-methyl-d-glucose.

Shamni O, Cohen G, Gruzman A, Zaid H, Klip A, Cerasi E, Sasson S.

Biochim Biophys Acta Biomembr. 2017 Oct;1859(10):1900-1910. doi: 10.1016/j.bbamem.2017.06.013. Epub 2017 Jun 23.


Update on GLUT4 Vesicle Traffic: A Cornerstone of Insulin Action.

Jaldin-Fincati JR, Pavarotti M, Frendo-Cumbo S, Bilan PJ, Klip A.

Trends Endocrinol Metab. 2017 Aug;28(8):597-611. doi: 10.1016/j.tem.2017.05.002. Epub 2017 Jun 8. Review.


Circulating NOD1 Activators and Hematopoietic NOD1 Contribute to Metabolic Inflammation and Insulin Resistance.

Chan KL, Tam TH, Boroumand P, Prescott D, Costford SR, Escalante NK, Fine N, Tu Y, Robertson SJ, Prabaharan D, Liu Z, Bilan PJ, Salter MW, Glogauer M, Girardin SE, Philpott DJ, Klip A.

Cell Rep. 2017 Mar 7;18(10):2415-2426. doi: 10.1016/j.celrep.2017.02.027.


Deconstructing metabolic inflammation using cellular systems.

Chan KL, Boroumand P, Milanski M, Pillon NJ, Bilan PJ, Klip A.

Am J Physiol Endocrinol Metab. 2017 Apr 1;312(4):E339-E347. doi: 10.1152/ajpendo.00039.2017. Epub 2017 Feb 14. Review.


Saturated fatty acids activate caspase-4/5 in human monocytes, triggering IL-1β and IL-18 release.

Pillon NJ, Chan KL, Zhang S, Mejdani M, Jacobson MR, Ducos A, Bilan PJ, Niu W, Klip A.

Am J Physiol Endocrinol Metab. 2016 Nov 1;311(5):E825-E835. doi: 10.1152/ajpendo.00296.2016. Epub 2016 Sep 13.


Endothelial Transcytosis of Insulin: Does It Contribute to Insulin Resistance?

Lee WL, Klip A.

Physiology (Bethesda). 2016 Sep;31(5):336-45. doi: 10.1152/physiol.00010.2016. Review.


Homeostasis - the Walter B. Cannon's Legacy - Applied to the Metabolic Syndrome and the Scientific Enterprise.

Klip A.

Physiology (Bethesda). 2016 Jul;31(4):246-7. doi: 10.1152/physiol.00011.2016. No abstract available.


Rac1 governs exercise-stimulated glucose uptake in skeletal muscle through regulation of GLUT4 translocation in mice.

Sylow L, Nielsen IL, Kleinert M, Møller LL, Ploug T, Schjerling P, Bilan PJ, Klip A, Jensen TE, Richter EA.

J Physiol. 2016 Sep 1;594(17):4997-5008. doi: 10.1113/JP272039. Epub 2016 Jun 16.


Contracting C2C12 myotubes release CCL2 in an NF-κB-dependent manner to induce monocyte chemoattraction.

Miyatake S, Bilan PJ, Pillon NJ, Klip A.

Am J Physiol Endocrinol Metab. 2016 Jan 15;310(2):E160-70. doi: 10.1152/ajpendo.00325.2015. Epub 2015 Nov 10.


A complex of Rab13 with MICAL-L2 and α-actinin-4 is essential for insulin-dependent GLUT4 exocytosis.

Sun Y, Jaldin-Fincati J, Liu Z, Bilan PJ, Klip A.

Mol Biol Cell. 2016 Jan 1;27(1):75-89. doi: 10.1091/mbc.E15-05-0319. Epub 2015 Nov 4.


The Rho-guanine nucleotide exchange factor PDZ-RhoGEF governs susceptibility to diet-induced obesity and type 2 diabetes.

Chang YJ, Pownall S, Jensen TE, Mouaaz S, Foltz W, Zhou L, Liadis N, Woo M, Hao Z, Dutt P, Bilan PJ, Klip A, Mak T, Stambolic V.

Elife. 2015 Oct 29;4. pii: e06011. doi: 10.7554/eLife.06011.


NOD2 activation induces oxidative stress contributing to mitochondrial dysfunction and insulin resistance in skeletal muscle cells.

Maurya CK, Arha D, Rai AK, Kumar SK, Pandey J, Avisetti DR, Kalivendi SV, Klip A, Tamrakar AK.

Free Radic Biol Med. 2015 Dec;89:158-69. doi: 10.1016/j.freeradbiomed.2015.07.154. Epub 2015 Sep 21.


Dissecting signalling by individual Akt/PKB isoforms, three steps at once.

Osorio-Fuentealba C, Klip A.

Biochem J. 2015 Sep 1;470(2):e13-6. doi: 10.1042/BJ20150750.


Different immune cells mediate mechanical pain hypersensitivity in male and female mice.

Sorge RE, Mapplebeck JC, Rosen S, Beggs S, Taves S, Alexander JK, Martin LJ, Austin JS, Sotocinal SG, Chen D, Yang M, Shi XQ, Huang H, Pillon NJ, Bilan PJ, Tu Y, Klip A, Ji RR, Zhang J, Salter MW, Mogil JS.

Nat Neurosci. 2015 Aug;18(8):1081-3. doi: 10.1038/nn.4053. Epub 2015 Jun 29.


Palmitoleate Reverses High Fat-induced Proinflammatory Macrophage Polarization via AMP-activated Protein Kinase (AMPK).

Chan KL, Pillon NJ, Sivaloganathan DM, Costford SR, Liu Z, Théret M, Chazaud B, Klip A.

J Biol Chem. 2015 Jul 3;290(27):16979-88. doi: 10.1074/jbc.M115.646992. Epub 2015 May 18.


Palmitate-induced inflammatory pathways in human adipose microvascular endothelial cells promote monocyte adhesion and impair insulin transcytosis.

Pillon NJ, Azizi PM, Li YE, Liu J, Wang C, Chan KL, Hopperton KE, Bazinet RP, Heit B, Bilan PJ, Lee WL, Klip A.

Am J Physiol Endocrinol Metab. 2015 Jul 1;309(1):E35-44. doi: 10.1152/ajpendo.00611.2014. Epub 2015 May 5.


Clathrin-dependent entry and vesicle-mediated exocytosis define insulin transcytosis across microvascular endothelial cells.

Azizi PM, Zyla RE, Guan S, Wang C, Liu J, Bolz SS, Heit B, Klip A, Lee WL.

Mol Biol Cell. 2015 Feb 15;26(4):740-50. doi: 10.1091/mbc.E14-08-1307. Epub 2014 Dec 24.


Calcium signaling in insulin action on striated muscle.

Contreras-Ferrat A, Lavandero S, Jaimovich E, Klip A.

Cell Calcium. 2014 Nov;56(5):390-6. doi: 10.1016/j.ceca.2014.08.012. Epub 2014 Sep 6. Review.


Signaling of the p21-activated kinase (PAK1) coordinates insulin-stimulated actin remodeling and glucose uptake in skeletal muscle cells.

Tunduguru R, Chiu TT, Ramalingam L, Elmendorf JS, Klip A, Thurmond DC.

Biochem Pharmacol. 2014 Nov 15;92(2):380-8. doi: 10.1016/j.bcp.2014.08.033. Epub 2014 Sep 6.


Reciprocal regulation of endocytosis and metabolism.

Antonescu CN, McGraw TE, Klip A.

Cold Spring Harb Perspect Biol. 2014 Jul 1;6(7):a016964. doi: 10.1101/cshperspect.a016964. Review.


Nucleotides released from palmitate-challenged muscle cells through pannexin-3 attract monocytes.

Pillon NJ, Li YE, Fink LN, Brozinick JT, Nikolayev A, Kuo MS, Bilan PJ, Klip A.

Diabetes. 2014 Nov;63(11):3815-26. doi: 10.2337/db14-0150. Epub 2014 Jun 10.


Ca²⁺ signals promote GLUT4 exocytosis and reduce its endocytosis in muscle cells.

Li Q, Zhu X, Ishikura S, Zhang D, Gao J, Sun Y, Contreras-Ferrat A, Foley KP, Lavandero S, Yao Z, Bilan PJ, Klip A, Niu W.

Am J Physiol Endocrinol Metab. 2014 Jul 15;307(2):E209-24. doi: 10.1152/ajpendo.00045.2014. Epub 2014 Jun 3.


Mice lacking NOX2 are hyperphagic and store fat preferentially in the liver.

Costford SR, Castro-Alves J, Chan KL, Bailey LJ, Woo M, Belsham DD, Brumell JH, Klip A.

Am J Physiol Endocrinol Metab. 2014 Jun 15;306(12):E1341-53. doi: 10.1152/ajpendo.00089.2014. Epub 2014 Apr 22.


Signal transduction meets vesicle traffic: the software and hardware of GLUT4 translocation.

Klip A, Sun Y, Chiu TT, Foley KP.

Am J Physiol Cell Physiol. 2014 May 15;306(10):C879-86. doi: 10.1152/ajpcell.00069.2014. Epub 2014 Mar 5. Review.


Insulin elicits a ROS-activated and an IP₃-dependent Ca²⁺ release, which both impinge on GLUT4 translocation.

Contreras-Ferrat A, Llanos P, Vásquez C, Espinosa A, Osorio-Fuentealba C, Arias-Calderon M, Lavandero S, Klip A, Hidalgo C, Jaimovich E.

J Cell Sci. 2014 May 1;127(Pt 9):1911-23. doi: 10.1242/jcs.138982. Epub 2014 Feb 25.


Myosin Va mediates Rab8A-regulated GLUT4 vesicle exocytosis in insulin-stimulated muscle cells.

Sun Y, Chiu TT, Foley KP, Bilan PJ, Klip A.

Mol Biol Cell. 2014 Apr;25(7):1159-70. doi: 10.1091/mbc.E13-08-0493. Epub 2014 Jan 29.


Akt and Rac1 signaling are jointly required for insulin-stimulated glucose uptake in skeletal muscle and downregulated in insulin resistance.

Sylow L, Kleinert M, Pehmøller C, Prats C, Chiu TT, Klip A, Richter EA, Jensen TE.

Cell Signal. 2014 Feb;26(2):323-31. doi: 10.1016/j.cellsig.2013.11.007. Epub 2013 Nov 9.


Pro-inflammatory macrophages increase in skeletal muscle of high fat-fed mice and correlate with metabolic risk markers in humans.

Fink LN, Costford SR, Lee YS, Jensen TE, Bilan PJ, Oberbach A, Blüher M, Olefsky JM, Sams A, Klip A.

Obesity (Silver Spring). 2014 Mar;22(3):747-57. doi: 10.1002/oby.20615. Epub 2013 Oct 16.


Insulin stimulates mitochondrial fusion and function in cardiomyocytes via the Akt-mTOR-NFκB-Opa-1 signaling pathway.

Parra V, Verdejo HE, Iglewski M, Del Campo A, Troncoso R, Jones D, Zhu Y, Kuzmicic J, Pennanen C, Lopez-Crisosto C, Jaña F, Ferreira J, Noguera E, Chiong M, Bernlohr DA, Klip A, Hill JA, Rothermel BA, Abel ED, Zorzano A, Lavandero S.

Diabetes. 2014 Jan;63(1):75-88. doi: 10.2337/db13-0340. Epub 2013 Sep 5.


Putting Rac1 on the path to glucose uptake.

Rudich A, Klip A.

Diabetes. 2013 Jun;62(6):1831-2. doi: 10.2337/db13-0381. No abstract available.


Expression of anti-inflammatory macrophage genes within skeletal muscle correlates with insulin sensitivity in human obesity and type 2 diabetes.

Fink LN, Oberbach A, Costford SR, Chan KL, Sams A, Blüher M, Klip A.

Diabetologia. 2013 Jul;56(7):1623-8. doi: 10.1007/s00125-013-2897-x. Epub 2013 Apr 18.


Cross-talk between skeletal muscle and immune cells: muscle-derived mediators and metabolic implications.

Pillon NJ, Bilan PJ, Fink LN, Klip A.

Am J Physiol Endocrinol Metab. 2013 Mar 1;304(5):E453-65. doi: 10.1152/ajpendo.00553.2012. Epub 2012 Dec 31. Review.

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