Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 7

1.

Rational Engineering Defines a Molecular Switch That Is Essential for Activity of Spider-Venom Peptides against the Analgesics Target NaV1.7.

Klint JK, Chin YK, Mobli M.

Mol Pharmacol. 2015 Dec;88(6):1002-10. doi: 10.1124/mol.115.100784. Epub 2015 Oct 1.

PMID:
26429937
2.

Seven novel modulators of the analgesic target NaV 1.7 uncovered using a high-throughput venom-based discovery approach.

Klint JK, Smith JJ, Vetter I, Rupasinghe DB, Er SY, Senff S, Herzig V, Mobli M, Lewis RJ, Bosmans F, King GF.

Br J Pharmacol. 2015 May;172(10):2445-58. doi: 10.1111/bph.13081. Epub 2015 Mar 4.

3.

From foe to friend: using animal toxins to investigate ion channel function.

Kalia J, Milescu M, Salvatierra J, Wagner J, Klint JK, King GF, Olivera BM, Bosmans F.

J Mol Biol. 2015 Jan 16;427(1):158-175. doi: 10.1016/j.jmb.2014.07.027. Epub 2014 Aug 1. Review.

4.

Isolation, synthesis and characterization of ω-TRTX-Cc1a, a novel tarantula venom peptide that selectively targets L-type Cav channels.

Klint JK, Berecki G, Durek T, Mobli M, Knapp O, King GF, Adams DJ, Alewood PF, Rash LD.

Biochem Pharmacol. 2014 May 15;89(2):276-86. doi: 10.1016/j.bcp.2014.02.008. Epub 2014 Feb 19.

PMID:
24561180
5.

Discovery of a selective NaV1.7 inhibitor from centipede venom with analgesic efficacy exceeding morphine in rodent pain models.

Yang S, Xiao Y, Kang D, Liu J, Li Y, Undheim EA, Klint JK, Rong M, Lai R, King GF.

Proc Natl Acad Sci U S A. 2013 Oct 22;110(43):17534-9. doi: 10.1073/pnas.1306285110. Epub 2013 Sep 30.

6.

Production of recombinant disulfide-rich venom peptides for structural and functional analysis via expression in the periplasm of E. coli.

Klint JK, Senff S, Saez NJ, Seshadri R, Lau HY, Bende NS, Undheim EA, Rash LD, Mobli M, King GF.

PLoS One. 2013 May 7;8(5):e63865. doi: 10.1371/journal.pone.0063865. Print 2013.

7.

Spider-venom peptides that target voltage-gated sodium channels: pharmacological tools and potential therapeutic leads.

Klint JK, Senff S, Rupasinghe DB, Er SY, Herzig V, Nicholson GM, King GF.

Toxicon. 2012 Sep 15;60(4):478-91. doi: 10.1016/j.toxicon.2012.04.337. Epub 2012 Apr 20. Review.

PMID:
22543187

Supplemental Content

Loading ...
Support Center