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Items: 13


Inhibiting the stringent response blocks Mycobacterium tuberculosis entry into quiescence and reduces persistence.

Dutta NK, Klinkenberg LG, Vazquez MJ, Segura-Carro D, Colmenarejo G, Ramon F, Rodriguez-Miquel B, Mata-Cantero L, Porras-De Francisco E, Chuang YM, Rubin H, Lee JJ, Eoh H, Bader JS, Perez-Herran E, Mendoza-Losana A, Karakousis PC.

Sci Adv. 2019 Mar 20;5(3):eaav2104. doi: 10.1126/sciadv.aav2104. eCollection 2019 Mar.


TLR2-Modulating Lipoproteins of the Mycobacterium tuberculosis Complex Enhance the HIV Infectivity of CD4+ T Cells.

Skerry C, Klinkenberg LG, Page KR, Karakousis PC.

PLoS One. 2016 Jan 25;11(1):e0147192. doi: 10.1371/journal.pone.0147192. eCollection 2016.


Rv1894c is a novel hypoxia-induced nitronate monooxygenase required for Mycobacterium tuberculosis virulence.

Klinkenberg LG, Karakousis PC.

J Infect Dis. 2013 May 15;207(10):1525-34. doi: 10.1093/infdis/jit049. Epub 2013 Feb 13.


Strain-dependent CNS dissemination in guinea pigs after Mycobacterium tuberculosis aerosol challenge.

Be NA, Klinkenberg LG, Bishai WR, Karakousis PC, Jain SK.

Tuberculosis (Edinb). 2011 Sep;91(5):386-9. doi: 10.1016/ Epub 2011 Aug 9.


The stringent response is required for full virulence of Mycobacterium tuberculosis in guinea pigs.

Klinkenberg LG, Lee JH, Bishai WR, Karakousis PC.

J Infect Dis. 2010 Nov 1;202(9):1397-404. doi: 10.1086/656524.


The impact of mouse passaging of Mycobacterium tuberculosis strains prior to virulence testing in the mouse and guinea pig aerosol models.

Converse PJ, Eisenach KD, Theus SA, Nuermberger EL, Tyagi S, Ly LH, Geiman DE, Guo H, Nolan ST, Akar NC, Klinkenberg LG, Gupta R, Lun S, Karakousis PC, Lamichhane G, McMurray DN, Grosset JH, Bishai WR.

PLoS One. 2010 Apr 21;5(4):e10289. doi: 10.1371/journal.pone.0010289.


Biphasic kill curve of isoniazid reveals the presence of drug-tolerant, not drug-resistant, Mycobacterium tuberculosis in the guinea pig.

Ahmad Z, Klinkenberg LG, Pinn ML, Fraig MM, Peloquin CA, Bishai WR, Nuermberger EL, Grosset JH, Karakousis PC.

J Infect Dis. 2009 Oct 1;200(7):1136-43. doi: 10.1086/605605.


Role of the dosR-dosS two-component regulatory system in Mycobacterium tuberculosis virulence in three animal models.

Converse PJ, Karakousis PC, Klinkenberg LG, Kesavan AK, Ly LH, Allen SS, Grosset JH, Jain SK, Lamichhane G, Manabe YC, McMurray DN, Nuermberger EL, Bishai WR.

Infect Immun. 2009 Mar;77(3):1230-7. doi: 10.1128/IAI.01117-08. Epub 2008 Dec 22.


Metronidazole lacks activity against Mycobacterium tuberculosis in an in vivo hypoxic granuloma model of latency.

Klinkenberg LG, Sutherland LA, Bishai WR, Karakousis PC.

J Infect Dis. 2008 Jul 15;198(2):275-83. doi: 10.1086/589515.


Accelerated detection of Mycobacterium tuberculosis genes essential for bacterial survival in guinea pigs, compared with mice.

Jain SK, Hernandez-Abanto SM, Cheng QJ, Singh P, Ly LH, Klinkenberg LG, Morrison NE, Converse PJ, Nuermberger E, Grosset J, McMurray DN, Karakousis PC, Lamichhane G, Bishai WR.

J Infect Dis. 2007 Jun 1;195(11):1634-42. Epub 2007 Apr 23.


Combinatorial repression of the hypoxic genes of Saccharomyces cerevisiae by DNA binding proteins Rox1 and Mot3.

Klinkenberg LG, Mennella TA, Luetkenhaus K, Zitomer RS.

Eukaryot Cell. 2005 Apr;4(4):649-60.


Recruitment of Tup1-Ssn6 by yeast hypoxic genes and chromatin-independent exclusion of TATA binding protein.

Mennella TA, Klinkenberg LG, Zitomer RS.

Eukaryot Cell. 2003 Dec;2(6):1288-303.

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