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Items: 43


Structure of the Human ACP-ISD11 Heterodimer.

Herrera MG, Noguera ME, Sewell KE, Agudelo Suárez WA, Capece L, Klinke S, Santos J.

Biochemistry. 2019 Nov 19;58(46):4596-4609. doi: 10.1021/acs.biochem.9b00539. Epub 2019 Nov 8.


An All-Inclusive and Straightway Laboratory Activity to Solve the Three-Dimensional Crystal Structure of a Protein.

Klinke S, Rinaldi J, Goldbaum FA, Suarez S, Otero LH.

Biochem Mol Biol Educ. 2019 Nov;47(6):700-707. doi: 10.1002/bmb.21296. Epub 2019 Aug 24.


Structural Insights into the Inhibition of the Extended-Spectrum β-Lactamase PER-2 by Avibactam.

Ruggiero M, Papp-Wallace KM, Brunetti F, Barnes MD, Bonomo RA, Gutkind G, Klinke S, Power P.

Antimicrob Agents Chemother. 2019 Aug 23;63(9). pii: e00487-19. doi: 10.1128/AAC.00487-19. Print 2019 Sep.


Deciphering the number and location of active sites in the monomeric glyoxalase I of Zea mays.

González JM, Agostini RB, Alvarez CE, Klinke S, Andreo CS, Campos-Bermudez VA.

FEBS J. 2019 Aug;286(16):3255-3271. doi: 10.1111/febs.14855. Epub 2019 Apr 29.


A high-throughput screening for inhibitors of riboflavin synthase identifies novel antimicrobial compounds to treat brucellosis.

Serer MI, Carrica MDC, Trappe J, López Romero S, Bonomi HR, Klinke S, Cerutti ML, Goldbaum FA.

FEBS J. 2019 Jul;286(13):2522-2535. doi: 10.1111/febs.14829. Epub 2019 Apr 10.


The Reaction Mechanism of Metallo-β-Lactamases Is Tuned by the Conformation of an Active-Site Mobile Loop.

Palacios AR, Mojica MF, Giannini E, Taracila MA, Bethel CR, Alzari PM, Otero LH, Klinke S, Llarrull LI, Bonomo RA, Vila AJ.

Antimicrob Agents Chemother. 2018 Dec 21;63(1). pii: e01754-18. doi: 10.1128/AAC.01754-18. Print 2019 Jan.


Engineering a bifunctional copper site in the cupredoxin fold by loop-directed mutagenesis.

Espinoza-Cara A, Zitare U, Alvarez-Paggi D, Klinke S, Otero LH, Murgida DH, Vila AJ.

Chem Sci. 2018 Jun 28;9(32):6692-6702. doi: 10.1039/c8sc01444b. eCollection 2018 Aug 28.


Crystallization and initial X-ray diffraction analysis of the multi-domain Brucella blue light-activated histidine kinase LOV-HK in its illuminated state.

Rinaldi J, Fernández I, Poth LM, Shepard WE, Savko M, Goldbaum FA, Klinke S.

Biochem Biophys Rep. 2018 Sep 26;16:39-43. doi: 10.1016/j.bbrep.2018.09.005. eCollection 2018 Dec.


Draft Genome Sequence of Methylobacterium sp. Strain V23, Isolated from Accretion Ice of the Antarctic Subglacial Lake Vostok.

Sapp A, Huguet-Tapia JC, Sánchez-Lamas M, Antelo GT, Primo ED, Rinaldi J, Klinke S, Goldbaum FA, Bonomi HR, Christner BC, Otero LH.

Genome Announc. 2018 Mar 8;6(10). pii: e00145-18. doi: 10.1128/genomeA.00145-18.


The disruptive effect of lysozyme on the bacterial cell wall explored by an in-silico structural outlook.

Primo ED, Otero LH, Ruiz F, Klinke S, Giordano W.

Biochem Mol Biol Educ. 2018 Jan;46(1):83-90. doi: 10.1002/bmb.21092. Epub 2017 Nov 13.


Structural and mutational analyses of the Leptospira interrogans virulence-related heme oxygenase provide insights into its catalytic mechanism.

Soldano A, Klinke S, Otero LH, Rivera M, Catalano-Dupuy DL, Ceccarelli EA.

PLoS One. 2017 Aug 3;12(8):e0182535. doi: 10.1371/journal.pone.0182535. eCollection 2017.


Structural and functional characterization of a cold adapted TPM-domain with ATPase/ADPase activity.

Cerutti ML, Otero LH, Smal C, Pellizza L, Goldbaum FA, Klinke S, Aran M.

J Struct Biol. 2017 Mar;197(3):201-209. doi: 10.1016/j.jsb.2016.10.010. Epub 2016 Nov 1.


Structure of the Full-Length Bacteriophytochrome from the Plant Pathogen Xanthomonas campestris Provides Clues to its Long-Range Signaling Mechanism.

Otero LH, Klinke S, Rinaldi J, Velázquez-Escobar F, Mroginski MA, Fernández López M, Malamud F, Vojnov AA, Hildebrandt P, Goldbaum FA, Bonomi HR.

J Mol Biol. 2016 Sep 25;428(19):3702-20. doi: 10.1016/j.jmb.2016.04.012. Epub 2016 Apr 20.


Structural Insights into the HWE Histidine Kinase Family: The Brucella Blue Light-Activated Histidine Kinase Domain.

Rinaldi J, Arrar M, Sycz G, Cerutti ML, Berguer PM, Paris G, Estrín DA, Martí MA, Klinke S, Goldbaum FA.

J Mol Biol. 2016 Mar 27;428(6):1165-1179. doi: 10.1016/j.jmb.2016.01.026. Epub 2016 Feb 2.


A bacterial protease inhibitor protects antigens delivered in oral vaccines from digestion while triggering specific mucosal immune responses.

Ibañez AE, Coria LM, Carabajal MV, Delpino MV, Risso GS, Cobiello PG, Rinaldi J, Barrionuevo P, Bruno L, Frank F, Klinke S, Goldbaum FA, Briones G, Giambartolomei GH, Pasquevich KA, Cassataro J.

J Control Release. 2015 Dec 28;220(Pt A):18-28. doi: 10.1016/j.jconrel.2015.10.011. Epub 2015 Oct 9.


Aggressive systemic mastocytosis of the liver with cholangitis.

Waldburger N, Rupp C, Klinke S, Wieczorek K, Gotthardt D, Kirchner T, Schirmacher P, Straub BK.

Hepat Oncol. 2015 Oct;2(4):343-347. doi: 10.2217/hep.15.33. Epub 2015 Nov 6.


S-SAD phasing of monoclinic histidine kinase from Brucella abortus combining data from multiple crystals and orientations: an example of data-collection strategy and a posteriori analysis of different data combinations.

Klinke S, Foos N, Rinaldi JJ, Paris G, Goldbaum FA, Legrand P, Guimarães BG, Thompson A.

Acta Crystallogr D Biol Crystallogr. 2015 Jul;71(Pt 7):1433-43. doi: 10.1107/S1399004715007622. Epub 2015 Jun 30.


Snapshots of Conformational Changes Shed Light into the NtrX Receiver Domain Signal Transduction Mechanism.

Fernández I, Otero LH, Klinke S, Carrica MDC, Goldbaum FA.

J Mol Biol. 2015 Oct 9;427(20):3258-3272. doi: 10.1016/j.jmb.2015.06.010. Epub 2015 Jun 23.


Crystal Structure of the Peroxo-diiron(III) Intermediate of Deoxyhypusine Hydroxylase, an Oxygenase Involved in Hypusination.

Han Z, Sakai N, Böttger LH, Klinke S, Hauber J, Trautwein AX, Hilgenfeld R.

Structure. 2015 May 5;23(5):882-892. doi: 10.1016/j.str.2015.03.002. Epub 2015 Apr 9.


Crystallization and preliminary X-ray characterization of the full-length bacteriophytochrome from the plant pathogen Xanthomonas campestris pv. campestris.

Klinke S, Otero LH, Rinaldi J, Sosa S, Guimarães BG, Shepard WE, Goldbaum FA, Bonomi HR.

Acta Crystallogr F Struct Biol Commun. 2014 Dec 1;70(Pt 12):1636-9. doi: 10.1107/S2053230X14023243. Epub 2014 Nov 14.


Solution and crystal structure of BA42, a protein from the Antarctic bacterium Bizionia argentinensis comprised of a stand-alone TPM domain.

Aran M, Smal C, Pellizza L, Gallo M, Otero LH, Klinke S, Goldbaum FA, Ithurralde ER, Bercovich A, Mac Cormack WP, Turjanski AG, Cicero DO.

Proteins. 2014 Nov;82(11):3062-78. doi: 10.1002/prot.24667. Epub 2014 Sep 3.


Crystallographic and kinetic study of riboflavin synthase from Brucella abortus, a chemotherapeutic target with an enhanced intrinsic flexibility.

Serer MI, Bonomi HR, Guimarães BG, Rossi RC, Goldbaum FA, Klinke S.

Acta Crystallogr D Biol Crystallogr. 2014 May;70(Pt 5):1419-34. doi: 10.1107/S1399004714005161. Epub 2014 Apr 30.


The crystal structure of sterol carrier protein 2 from Yarrowia lipolytica and the evolutionary conservation of a large, non-specific lipid-binding cavity.

De Berti FP, Capaldi S, Ferreyra R, Burgardt N, Acierno JP, Klinke S, Monaco HL, Ermácora MR.

J Struct Funct Genomics. 2013 Dec;14(4):145-53. doi: 10.1007/s10969-013-9166-6. Epub 2013 Nov 17.


The β-scaffold of the LOV domain of the Brucella light-activated histidine kinase is a key element for signal transduction.

Rinaldi J, Gallo M, Klinke S, Paris G, Bonomi HR, Bogomolni RA, Cicero DO, Goldbaum FA.

J Mol Biol. 2012 Jun 29;420(1-2):112-27. doi: 10.1016/j.jmb.2012.04.006. Epub 2012 Apr 11.


An atypical riboflavin pathway is essential for Brucella abortus virulence.

Bonomi HR, Marchesini MI, Klinke S, Ugalde JE, Zylberman V, Ugalde RA, Comerci DJ, Goldbaum FA.

PLoS One. 2010 Feb 25;5(2):e9435. doi: 10.1371/journal.pone.0009435.


Structure of the mature ectodomain of the human receptor-type protein-tyrosine phosphatase IA-2.

Primo ME, Klinke S, Sica MP, Goldbaum FA, Jakoncic J, Poskus E, Ermácora MR.

J Biol Chem. 2008 Feb 22;283(8):4674-81. Epub 2007 Nov 29.


Affinity maturation increases the stability and plasticity of the Fv domain of anti-protein antibodies.

Acierno JP, Braden BC, Klinke S, Goldbaum FA, Cauerhff A.

J Mol Biol. 2007 Nov 16;374(1):130-46. Epub 2007 Sep 11.


Structural and kinetic properties of lumazine synthase isoenzymes in the order Rhizobiales.

Klinke S, Zylberman V, Bonomi HR, Haase I, Guimarães BG, Braden BC, Bacher A, Fischer M, Goldbaum FA.

J Mol Biol. 2007 Oct 26;373(3):664-80. Epub 2007 Aug 21.


Evolution of vitamin B2 biosynthesis: 6,7-dimethyl-8-ribityllumazine synthases of Brucella.

Zylberman V, Klinke S, Haase I, Bacher A, Fischer M, Goldbaum FA.

J Bacteriol. 2006 Sep;188(17):6135-42.


Crystallographic studies on decameric Brucella spp. Lumazine synthase: a novel quaternary arrangement evolved for a new function?

Klinke S, Zylberman V, Vega DR, Guimarães BG, Braden BC, Goldbaum FA.

J Mol Biol. 2005 Oct 14;353(1):124-37.


High order quaternary arrangement confers increased structural stability to Brucella sp. lumazine synthase.

Zylberman V, Craig PO, Klinke S, Braden BC, Cauerhff A, Goldbaum FA.

J Biol Chem. 2004 Feb 27;279(9):8093-101. Epub 2003 Dec 1.


Redundant mitochondrial targeting signals in yeast adenylate kinase.

Schricker R, Angermayr M, Strobel G, Klinke S, Korber D, Bandlow W.

J Biol Chem. 2002 Aug 9;277(32):28757-64. Epub 2002 Jun 3.


Translocation of Yersinia entrocolitica across reconstituted intestinal epithelial monolayers is triggered by Yersinia invasin binding to beta1 integrins apically expressed on M-like cells.

Schulte R, Kerneis S, Klinke S, Bartels H, Preger S, Kraehenbuhl JP, Pringault E, Autenrieth IB.

Cell Microbiol. 2000 Apr;2(2):173-85.


Role of phaD in accumulation of medium-chain-length Poly(3-hydroxyalkanoates) in Pseudomonas oleovorans.

Klinke S, de Roo G, Witholt B, Kessler B.

Appl Environ Microbiol. 2000 Sep;66(9):3705-10.


Inactivation of isocitrate lyase leads to increased production of medium-chain-length poly(3-hydroxyalkanoates) in Pseudomonas putida.

Klinke S, Dauner M, Scott G, Kessler B, Witholt B.

Appl Environ Microbiol. 2000 Mar;66(3):909-13.


[Activated protein C resistance and venous thrombophilia: molecular genetic prevalence study in the German population].

Ehrenforth S, Klinke S, von Depka Prondzinski M, Kreuz W, Ganser A, Scharrer I.

Dtsch Med Wochenschr. 1999 Jun 25;124(25-26):783-7. German.


Production of medium-chain-length poly(3-hydroxyalkanoates) from gluconate by recombinant Escherichia coli.

Klinke S, Ren Q, Witholt B, Kessler B.

Appl Environ Microbiol. 1999 Feb;65(2):540-8.


The prothrombin 20210 A allele is frequently coinherited in young carriers of the factor V Arg 506 to Gln mutation with venous thrombophilia.

Ehrenforth S, Ludwig G, Klinke S, Krause M, Scharrer I, Nowak-Gottl U.

Blood. 1998 Mar 15;91(6):2209-10. No abstract available.


Oral anticoagulants and fetal loss.

Rintelen C, Mannhalter C, Pabinger I, Scharrer I, Klinke S.

Lancet. 1996 Dec 21-28;348(9043):1735. No abstract available.


["Blood gas analysis" by W. Bomke, M. O. Krebs and R. Rossaint in number 3/96].

Langenstein H, Klinke S.

Anaesthesist. 1996 Oct;45(10):993-4. Review. German. No abstract available.


[Strategies in screening for chromosome number aberrations in women younger than 35 years of age].

Klinke S, Paccaud F, Pescia G, Gutzwiller F.

Ther Umsch. 1988 Oct;45(10):682-7. French. No abstract available.


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