Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 105

1.

Cancer cell specific inhibition of Wnt/β-catenin signaling by forced intracellular acidification.

Melnik S, Dvornikov D, Müller-Decker K, Depner S, Stannek P, Meister M, Warth A, Thomas M, Muley T, Risch A, Plass C, Klingmüller U, Niehrs C, Glinka A.

Cell Discov. 2018 Jul 3;4:37. doi: 10.1038/s41421-018-0033-2. eCollection 2018.

2.

Expression ratio of the TGFβ-inducible gene MYO10 is prognostic for overall survival of squamous cell lung cancer patients and predicts chemotherapy response.

Dvornikov D, Schneider MA, Ohse S, Szczygieł M, Titkova I, Rosenblatt M, Muley T, Warth A, Herth FJ, Dienemann H, Thomas M, Timmer J, Schilling M, Busch H, Boerries M, Meister M, Klingmüller U.

Sci Rep. 2018 Jun 22;8(1):9517. doi: 10.1038/s41598-018-27912-1.

3.

Model-based identification of TNFα-induced IKKβ-mediated and IκBα-mediated regulation of NFκB signal transduction as a tool to quantify the impact of drug-induced liver injury compounds.

Oppelt A, Kaschek D, Huppelschoten S, Sison-Young R, Zhang F, Buck-Wiese M, Herrmann F, Malkusch S, Krüger CL, Meub M, Merkt B, Zimmermann L, Schofield A, Jones RP, Malik H, Schilling M, Heilemann M, van de Water B, Goldring CE, Park BK, Timmer J, Klingmüller U.

NPJ Syst Biol Appl. 2018 Jun 11;4:23. doi: 10.1038/s41540-018-0058-z. eCollection 2018.

4.

Whither systems medicine?

Apweiler R, Beissbarth T, Berthold MR, Blüthgen N, Burmeister Y, Dammann O, Deutsch A, Feuerhake F, Franke A, Hasenauer J, Hoffmann S, Höfer T, Jansen PL, Kaderali L, Klingmüller U, Koch I, Kohlbacher O, Kuepfer L, Lammert F, Maier D, Pfeifer N, Radde N, Rehm M, Roeder I, Saez-Rodriguez J, Sax U, Schmeck B, Schuppert A, Seilheimer B, Theis FJ, Vera J, Wolkenhauer O.

Exp Mol Med. 2018 Mar 2;50(3):e453. doi: 10.1038/emm.2017.290. Review.

5.

Resolving the Combinatorial Complexity of Smad Protein Complex Formation and Its Link to Gene Expression.

Lucarelli P, Schilling M, Kreutz C, Vlasov A, Boehm ME, Iwamoto N, Steiert B, Lattermann S, Wäsch M, Stepath M, Matter MS, Heikenwälder M, Hoffmann K, Deharde D, Damm G, Seehofer D, Muciek M, Gretz N, Lehmann WD, Timmer J, Klingmüller U.

Cell Syst. 2018 Jan 24;6(1):75-89.e11. doi: 10.1016/j.cels.2017.11.010. Epub 2017 Dec 13.

6.

Model Based Targeting of IL-6-Induced Inflammatory Responses in Cultured Primary Hepatocytes to Improve Application of the JAK Inhibitor Ruxolitinib.

Sobotta S, Raue A, Huang X, Vanlier J, Jünger A, Bohl S, Albrecht U, Hahnel MJ, Wolf S, Mueller NS, D'Alessandro LA, Mueller-Bohl S, Boehm ME, Lucarelli P, Bonefas S, Damm G, Seehofer D, Lehmann WD, Rose-John S, van der Hoeven F, Gretz N, Theis FJ, Ehlting C, Bode JG, Timmer J, Schilling M, Klingmüller U.

Front Physiol. 2017 Oct 9;8:775. doi: 10.3389/fphys.2017.00775. eCollection 2017.

7.

Correlated receptor transport processes buffer single-cell heterogeneity.

Kallenberger SM, Unger AL, Legewie S, Lymperopoulos K, Klingmüller U, Eils R, Herten DP.

PLoS Comput Biol. 2017 Sep 25;13(9):e1005779. doi: 10.1371/journal.pcbi.1005779. eCollection 2017 Sep. Erratum in: PLoS Comput Biol. 2018 Mar 1;14 (3):e1006037.

8.

An individual-based model for collective cancer cell migration explains speed dynamics and phenotype variability in response to growth factors.

Stichel D, Middleton AM, Müller BF, Depner S, Klingmüller U, Breuhahn K, Matthäus F.

NPJ Syst Biol Appl. 2017 Mar 3;3:5. doi: 10.1038/s41540-017-0006-3. eCollection 2017.

9.

BMP-9 interferes with liver regeneration and promotes liver fibrosis.

Breitkopf-Heinlein K, Meyer C, König C, Gaitantzi H, Addante A, Thomas M, Wiercinska E, Cai C, Li Q, Wan F, Hellerbrand C, Valous NA, Hahnel M, Ehlting C, Bode JG, Müller-Bohl S, Klingmüller U, Altenöder J, Ilkavets I, Goumans MJ, Hawinkels LJ, Lee SJ, Wieland M, Mogler C, Ebert MP, Herrera B, Augustin H, Sánchez A, Dooley S, Ten Dijke P.

Gut. 2017 May;66(5):939-954. doi: 10.1136/gutjnl-2016-313314. Epub 2017 Mar 23.

PMID:
28336518
10.

IL-1β-induced and p38MAPK-dependent activation of the mitogen-activated protein kinase-activated protein kinase 2 (MK2) in hepatocytes: Signal transduction with robust and concentration-independent signal amplification.

Kulawik A, Engesser R, Ehlting C, Raue A, Albrecht U, Hahn B, Lehmann WD, Gaestel M, Klingmüller U, Häussinger D, Timmer J, Bode JG.

J Biol Chem. 2017 Apr 14;292(15):6291-6302. doi: 10.1074/jbc.M117.775023. Epub 2017 Feb 21.

11.

Protein abundance of AKT and ERK pathway components governs cell type-specific regulation of proliferation.

Adlung L, Kar S, Wagner MC, She B, Chakraborty S, Bao J, Lattermann S, Boerries M, Busch H, Wuchter P, Ho AD, Timmer J, Schilling M, Höfer T, Klingmüller U.

Mol Syst Biol. 2017 Jan 24;13(1):904. doi: 10.15252/msb.20167258.

12.

TTCA: an R package for the identification of differentially expressed genes in time course microarray data.

Albrecht M, Stichel D, Müller B, Merkle R, Sticht C, Gretz N, Klingmüller U, Breuhahn K, Matthäus F.

BMC Bioinformatics. 2017 Jan 14;18(1):33. doi: 10.1186/s12859-016-1440-8.

13.

High-Content Imaging Platform for Profiling Intracellular Signaling Network Activity in Living Cells.

Kuchenov D, Laketa V, Stein F, Salopiata F, Klingmüller U, Schultz C.

Cell Chem Biol. 2016 Dec 22;23(12):1550-1559. doi: 10.1016/j.chembiol.2016.11.008. Epub 2016 Dec 8.

14.

A Thymic Epithelial Stem Cell Pool Persists throughout Ontogeny and Is Modulated by TGF-β.

Ucar O, Li K, Dvornikov D, Kreutz C, Timmer J, Matt S, Brenner L, Smedley C, Travis MA, Hofmann TG, Klingmüller U, Kyewski B.

Cell Rep. 2016 Oct 4;17(2):448-457. doi: 10.1016/j.celrep.2016.09.027.

15.

Identification of Cell Type-Specific Differences in Erythropoietin Receptor Signaling in Primary Erythroid and Lung Cancer Cells.

Merkle R, Steiert B, Salopiata F, Depner S, Raue A, Iwamoto N, Schelker M, Hass H, Wäsch M, Böhm ME, Mücke O, Lipka DB, Plass C, Lehmann WD, Kreutz C, Timmer J, Schilling M, Klingmüller U.

PLoS Comput Biol. 2016 Aug 5;12(8):e1005049. doi: 10.1371/journal.pcbi.1005049. eCollection 2016 Aug.

16.

Downregulation of the TGFβ Pseudoreceptor BAMBI in Non-Small Cell Lung Cancer Enhances TGFβ Signaling and Invasion.

Marwitz S, Depner S, Dvornikov D, Merkle R, Szczygieł M, Müller-Decker K, Lucarelli P, Wäsch M, Mairbäurl H, Rabe KF, Kugler C, Vollmer E, Reck M, Scheufele S, Kröger M, Ammerpohl O, Siebert R, Goldmann T, Klingmüller U.

Cancer Res. 2016 Jul 1;76(13):3785-801. doi: 10.1158/0008-5472.CAN-15-1326. Epub 2016 May 17.

17.

Context-specific flow through the MEK/ERK module produces cell- and ligand-specific patterns of ERK single and double phosphorylation.

Iwamoto N, D'Alessandro LA, Depner S, Hahn B, Kramer BA, Lucarelli P, Vlasov A, Stepath M, Böhm ME, Deharde D, Damm G, Seehofer D, Lehmann WD, Klingmüller U, Schilling M.

Sci Signal. 2016 Feb 2;9(413):ra13. doi: 10.1126/scisignal.aab1967.

PMID:
26838549
18.

Cytokinesis failure in RhoA-deficient mouse erythroblasts involves actomyosin and midbody dysregulation and triggers p53 activation.

Konstantinidis DG, Giger KM, Risinger M, Pushkaran S, Zhou P, Dexheimer P, Yerneni S, Andreassen P, Klingmüller U, Palis J, Zheng Y, Kalfa TA.

Blood. 2015 Sep 17;126(12):1473-82. doi: 10.1182/blood-2014-12-616169. Epub 2015 Jul 30.

19.

T160‐phosphorylated CDK2 defines threshold for HGF dependent proliferation in primary hepatocytes.

Mueller S, Huard J, Waldow K, Huang X, D'Alessandro LA, Bohl S, Börner K, Grimm D, Klamt S, Klingmüller U, Schilling M.

Mol Syst Biol. 2015 Mar;11(3):795.

20.

Data2Dynamics: a modeling environment tailored to parameter estimation in dynamical systems.

Raue A, Steiert B, Schelker M, Kreutz C, Maiwald T, Hass H, Vanlier J, Tönsing C, Adlung L, Engesser R, Mader W, Heinemann T, Hasenauer J, Schilling M, Höfer T, Klipp E, Theis F, Klingmüller U, Schöberl B, Timmer J.

Bioinformatics. 2015 Nov 1;31(21):3558-60. doi: 10.1093/bioinformatics/btv405. Epub 2015 Jul 3.

PMID:
26142188
21.

Erythropoietin improves the accumulation and therapeutic effects of carboplatin by enhancing tumor vascularization and perfusion.

Doleschel D, Rix A, Arns S, Palmowski K, Gremse F, Merkle R, Salopiata F, Klingmüller U, Jarsch M, Kiessling F, Lederle W.

Theranostics. 2015 May 1;5(8):905-18. doi: 10.7150/thno.11304. eCollection 2015.

22.

Disentangling the Complexity of HGF Signaling by Combining Qualitative and Quantitative Modeling.

D'Alessandro LA, Samaga R, Maiwald T, Rho SH, Bonefas S, Raue A, Iwamoto N, Kienast A, Waldow K, Meyer R, Schilling M, Timmer J, Klamt S, Klingmüller U.

PLoS Comput Biol. 2015 Apr 23;11(4):e1004192. doi: 10.1371/journal.pcbi.1004192. eCollection 2015 Apr.

23.

Unraveling liver complexity from molecular to organ level: challenges and perspectives.

D'Alessandro LA, Hoehme S, Henney A, Drasdo D, Klingmüller U.

Prog Biophys Mol Biol. 2015 Jan;117(1):78-86. doi: 10.1016/j.pbiomolbio.2014.11.005. Epub 2014 Nov 26. Review.

PMID:
25433231
24.

Identification of isoform-specific dynamics in phosphorylation-dependent STAT5 dimerization by quantitative mass spectrometry and mathematical modeling.

Boehm ME, Adlung L, Schilling M, Roth S, Klingmüller U, Lehmann WD.

J Proteome Res. 2014 Dec 5;13(12):5685-94. doi: 10.1021/pr5006923. Epub 2014 Nov 7.

PMID:
25333863
25.

The virtual liver: state of the art and future perspectives.

Drasdo D, Bode J, Dahmen U, Dirsch O, Dooley S, Gebhardt R, Ghallab A, Godoy P, Häussinger D, Hammad S, Hoehme S, Holzhütter HG, Klingmüller U, Kuepfer L, Timmer J, Zerial M, Hengstler JG.

Arch Toxicol. 2014 Dec;88(12):2071-5. doi: 10.1007/s00204-014-1384-6. No abstract available.

PMID:
25331938
26.

Leukemogenic Ptpn11 allele causes defective erythropoiesis in mice.

Usenko T, Chan G, Torlakovic E, Klingmüller U, Neel BG.

PLoS One. 2014 Oct 7;9(10):e109682. doi: 10.1371/journal.pone.0109682. eCollection 2014.

27.

A rapidly reversible chemical dimerizer system to study lipid signaling in living cells.

Feng S, Laketa V, Stein F, Rutkowska A, MacNamara A, Depner S, Klingmüller U, Saez-Rodriguez J, Schultz C.

Angew Chem Int Ed Engl. 2014 Jun 23;53(26):6720-3. doi: 10.1002/anie.201402294. Epub 2014 May 19.

PMID:
24841150
28.

Unbiased RNAi screen for hepcidin regulators links hepcidin suppression to proliferative Ras/RAF and nutrient-dependent mTOR signaling.

Mleczko-Sanecka K, Roche F, da Silva AR, Call D, D'Alessio F, Ragab A, Lapinski PE, Ummanni R, Korf U, Oakes C, Damm G, D'Alessandro LA, Klingmüller U, King PD, Boutros M, Hentze MW, Muckenthaler MU.

Blood. 2014 Mar 6;123(10):1574-85. doi: 10.1182/blood-2013-07-515957. Epub 2014 Jan 2.

29.

Lessons learned from quantitative dynamical modeling in systems biology.

Raue A, Schilling M, Bachmann J, Matteson A, Schelker M, Kaschek D, Hug S, Kreutz C, Harms BD, Theis FJ, Klingmüller U, Timmer J.

PLoS One. 2013 Sep 30;8(9):e74335. doi: 10.1371/journal.pone.0074335. eCollection 2013. Erratum in: PLoS One. 2013;8(12). doi:10.1371/annotation/ea0193d8-1f7f-492a-b0b7-d877629fdcee. Schelke, Max [corrected to Schelker, Max].

30.

High-dimensional Bayesian parameter estimation: case study for a model of JAK2/STAT5 signaling.

Hug S, Raue A, Hasenauer J, Bachmann J, Klingmüller U, Timmer J, Theis FJ.

Math Biosci. 2013 Dec;246(2):293-304. doi: 10.1016/j.mbs.2013.04.002. Epub 2013 Apr 16.

PMID:
23602931
31.

Excemplify: a flexible template based solution, parsing and managing data in spreadsheets for experimentalists.

Shi L, Jong L, Wittig U, Lucarelli P, Stepath M, Mueller S, D'Alessandro LA, Klingmüller U, Müller W.

J Integr Bioinform. 2013 Apr 3;10(2):220. doi: 10.2390/biecoll-jib-2013-220.

PMID:
23549603
32.

Hepatocellular carcinoma: a systems biology perspective.

D'Alessandro LA, Meyer R, Klingmüller U.

Front Physiol. 2013 Feb 25;4:28. doi: 10.3389/fphys.2013.00028. eCollection 2013.

33.

The microtubule affinity regulating kinase MARK4 promotes axoneme extension during early ciliogenesis.

Kuhns S, Schmidt KN, Reymann J, Gilbert DF, Neuner A, Hub B, Carvalho R, Wiedemann P, Zentgraf H, Erfle H, Klingmüller U, Boutros M, Pereira G.

J Cell Biol. 2013 Feb 18;200(4):505-22. doi: 10.1083/jcb.201206013. Epub 2013 Feb 11.

34.

Erythropoiesis and globin switching in compound Klf1::Bcl11a mutant mice.

Esteghamat F, Gillemans N, Bilic I, van den Akker E, Cantù I, van Gent T, Klingmüller U, van Lom K, von Lindern M, Grosveld F, Bryn van Dijk T, Busslinger M, Philipsen S.

Blood. 2013 Mar 28;121(13):2553-62. doi: 10.1182/blood-2012-06-434530. Epub 2013 Jan 29.

35.

A Systems Biology Study on NFκB Signaling in Primary Mouse Hepatocytes.

Pinna F, Sahle S, Beuke K, Bissinger M, Tuncay S, D'Alessandro LA, Gauges R, Raue A, Timmer J, Klingmüller U, Schirmacher P, Kummer U, Breuhahn K.

Front Physiol. 2012 Dec 31;3:466. doi: 10.3389/fphys.2012.00466. eCollection 2012.

36.

Hepatocyte-specific S100a8 and S100a9 transgene expression in mice causes Cxcl1 induction and systemic neutrophil enrichment.

Wiechert L, Németh J, Pusterla T, Bauer C, De Ponti A, Manthey S, Marhenke S, Vogel A, Klingmüller U, Hess J, Angel P.

Cell Commun Signal. 2012 Dec 15;10(1):40. doi: 10.1186/1478-811X-10-40.

37.

Heterogeneous kinetics of AKT signaling in individual cells are accounted for by variable protein concentration.

Meyer R, D'Alessandro LA, Kar S, Kramer B, She B, Kaschek D, Hahn B, Wrangborg D, Karlsson J, Kvarnström M, Jirstrand M, Lehmann WD, Timmer J, Höfer T, Klingmüller U.

Front Physiol. 2012 Nov 28;3:451. doi: 10.3389/fphys.2012.00451. eCollection 2012.

38.

Cellular ERK phospho-form profiles with conserved preference for a switch-like pattern.

Hahn B, D'Alessandro LA, Depner S, Waldow K, Boehm ME, Bachmann J, Schilling M, Klingmüller U, Lehmann WD.

J Proteome Res. 2013 Feb 1;12(2):637-46. doi: 10.1021/pr3007232. Epub 2012 Dec 26.

PMID:
23210697
39.

Spatial aspects in the SMAD signaling pathway.

Claus J, Friedmann E, Klingmüller U, Rannacher R, Szekeres T.

J Math Biol. 2013 Nov;67(5):1171-97. doi: 10.1007/s00285-012-0574-1. Epub 2012 Sep 18.

PMID:
22986890
41.

An integrative model links multiple inputs and signaling pathways to the onset of DNA synthesis in hepatocytes.

Huard J, Mueller S, Gilles ED, Klingmüller U, Klamt S.

FEBS J. 2012 Sep;279(18):3290-313. doi: 10.1111/j.1742-4658.2012.08572.x. Epub 2012 Apr 10.

42.

In silico labeling reveals the time-dependent label half-life and transit-time in dynamical systems.

Maiwald T, Blumberg J, Raue A, Hengl S, Schilling M, Sy SK, Becker V, Klingmüller U, Timmer J.

BMC Syst Biol. 2012 Feb 27;6:13. doi: 10.1186/1752-0509-6-13.

43.

Dynamics and feedback loops in the transforming growth factor β signaling pathway.

Wegner K, Bachmann A, Schad JU, Lucarelli P, Sahle S, Nickel P, Meyer C, Klingmüller U, Dooley S, Kummer U.

Biophys Chem. 2012 Mar;162:22-34. doi: 10.1016/j.bpc.2011.12.003. Epub 2012 Jan 5.

PMID:
22284904
44.

Targeted near-infrared imaging of the erythropoietin receptor in human lung cancer xenografts.

Doleschel D, Mundigl O, Wessner A, Gremse F, Bachmann J, Rodriguez A, Klingmüller U, Jarsch M, Kiessling F, Lederle W.

J Nucl Med. 2012 Feb;53(2):304-11. doi: 10.2967/jnumed.111.091124. Epub 2012 Jan 6.

45.

Mathematical modeling of hematological malignancies.

Schilling M, Klingmuller U.

Front Biosci (Elite Ed). 2012 Jan 1;4:1648-53.

PMID:
22201981
46.

Receptor dynamics in signaling.

Becker V, Timmer J, Klingmüller U.

Adv Exp Med Biol. 2012;736:313-23. doi: 10.1007/978-1-4419-7210-1_18. Review.

PMID:
22161337
47.

Predictive mathematical models of cancer signalling pathways.

Bachmann J, Raue A, Schilling M, Becker V, Timmer J, Klingmüller U.

J Intern Med. 2012 Feb;271(2):155-65. doi: 10.1111/j.1365-2796.2011.02492.x. Review.

48.

Centrosomal targeting of tyrosine kinase activity does not enhance oncogenicity in chronic myeloproliferative disorders.

Bochtler T, Kirsch M, Maier B, Bachmann J, Klingmüller U, Anderhub S, Ho AD, Krämer A.

Leukemia. 2012 Apr;26(4):728-35. doi: 10.1038/leu.2011.283. Epub 2011 Oct 21.

PMID:
22015771
49.

Prognostic significance of erythropoietin in pancreatic adenocarcinoma.

Welsch T, Zschäbitz S, Becker V, Giese T, Bergmann F, Hinz U, Keleg S, Heller A, Sipos B, Klingmüller U, Büchler MW, Werner J, Giese NA.

PLoS One. 2011;6(8):e23151. doi: 10.1371/journal.pone.0023151. Epub 2011 Aug 1.

50.

Division of labor by dual feedback regulators controls JAK2/STAT5 signaling over broad ligand range.

Bachmann J, Raue A, Schilling M, Böhm ME, Kreutz C, Kaschek D, Busch H, Gretz N, Lehmann WD, Timmer J, Klingmüller U.

Mol Syst Biol. 2011 Jul 19;7:516. doi: 10.1038/msb.2011.50.

Supplemental Content

Loading ...
Support Center