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Items: 1 to 50 of 53

1.

Identification of Trypanosoma brucei AdoMetDC Inhibitors Using a High-Throughput Mass Spectrometry-Based Assay.

Volkov OA, Cosner CC, Brockway AJ, Kramer M, Booker M, Zhong S, Ketcherside A, Wei S, Longgood J, McCoy M, Richardson TE, Wring SA, Peel M, Klinger JD, Posner BA, De Brabander JK, Phillips MA.

ACS Infect Dis. 2017 Jul 14;3(7):512-526. doi: 10.1021/acsinfecdis.7b00022. Epub 2017 Apr 7.

2.

Aminoindoles, a novel scaffold with potent activity against Plasmodium falciparum.

Barker RH Jr, Urgaonkar S, Mazitschek R, Celatka C, Skerlj R, Cortese JF, Tyndall E, Liu H, Cromwell M, Sidhu AB, Guerrero-Bravo JE, Crespo-Llado KN, Serrano AE, Lin JW, Janse CJ, Khan SM, Duraisingh M, Coleman BI, Angulo-Barturen I, Jiménez-Díaz MB, Magán N, Gomez V, Ferrer S, Martínez MS, Wittlin S, Papastogiannidis P, O'Shea T, Klinger JD, Bree M, Lee E, Levine M, Wiegand RC, Munoz B, Wirth DF, Clardy J, Bathurst I, Sybertz E.

Antimicrob Agents Chemother. 2011 Jun;55(6):2612-22. doi: 10.1128/AAC.01714-10. Epub 2011 Mar 21.

3.

Novel inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase with anti-malarial activity in the mouse model.

Booker ML, Bastos CM, Kramer ML, Barker RH Jr, Skerlj R, Sidhu AB, Deng X, Celatka C, Cortese JF, Guerrero Bravo JE, Crespo Llado KN, Serrano AE, Angulo-Barturen I, Jiménez-Díaz MB, Viera S, Garuti H, Wittlin S, Papastogiannidis P, Lin JW, Janse CJ, Khan SM, Duraisingh M, Coleman B, Goldsmith EJ, Phillips MA, Munoz B, Wirth DF, Klinger JD, Wiegand R, Sybertz E.

J Biol Chem. 2010 Oct 22;285(43):33054-64. doi: 10.1074/jbc.M110.162081. Epub 2010 Aug 11.

4.

Discovery of new S-adenosylmethionine decarboxylase inhibitors for the treatment of Human African Trypanosomiasis (HAT).

Hirth B, Barker RH Jr, Celatka CA, Klinger JD, Liu H, Nare B, Nijjar A, Phillips MA, Sybertz E, Willert EK, Xiang Y.

Bioorg Med Chem Lett. 2009 Jun 1;19(11):2916-9. doi: 10.1016/j.bmcl.2009.04.096. Epub 2009 Apr 24.

PMID:
19419862
5.

Novel S-adenosylmethionine decarboxylase inhibitors for the treatment of human African trypanosomiasis.

Barker RH Jr, Liu H, Hirth B, Celatka CA, Fitzpatrick R, Xiang Y, Willert EK, Phillips MA, Kaiser M, Bacchi CJ, Rodriguez A, Yarlett N, Klinger JD, Sybertz E.

Antimicrob Agents Chemother. 2009 May;53(5):2052-8. doi: 10.1128/AAC.01674-08. Epub 2009 Mar 16.

6.

Tolevamer, an anionic polymer, neutralizes toxins produced by the BI/027 strains of Clostridium difficile.

Hinkson PL, Dinardo C, DeCiero D, Klinger JD, Barker RH Jr.

Antimicrob Agents Chemother. 2008 Jun;52(6):2190-5. doi: 10.1128/AAC.00041-08. Epub 2008 Apr 7.

7.

Toxin binding of tolevamer, a polyanionic drug that protects against antibiotic-associated diarrhea.

Braunlin W, Xu Q, Hook P, Fitzpatrick R, Klinger JD, Burrier R, Kurtz CB.

Biophys J. 2004 Jul;87(1):534-9.

8.

GT160-246, a toxin binding polymer for treatment of Clostridium difficile colitis.

Kurtz CB, Cannon EP, Brezzani A, Pitruzzello M, Dinardo C, Rinard E, Acheson DW, Fitzpatrick R, Kelly P, Shackett K, Papoulis AT, Goddard PJ, Barker RH Jr, Palace GP, Klinger JD.

Antimicrob Agents Chemother. 2001 Aug;45(8):2340-7.

9.

Performance of an automated Q-beta replicase amplification assay for Mycobacterium tuberculosis in a clinical trial.

Smith JH, Radcliffe G, Rigby S, Mahan D, Lane DJ, Klinger JD.

J Clin Microbiol. 1997 Jun;35(6):1484-91.

10.

Detection of Mycobacterium tuberculosis directly from sputum by using a prototype automated Q-beta replicase assay.

Smith JH, Buxton D, Cahill P, Fiandaca M, Goldston L, Marselle L, Rigby S, Olive DM, Hendricks A, Shimei T, Klinger JD, Lane DJ, Mahan DE.

J Clin Microbiol. 1997 Jun;35(6):1477-83.

11.

Identification of Salmonella enteritidis from experimentally infected hens using a colorimetric DNA hybridization method.

Cotter PF, Murphy JE, Klinger JD, Taylor RL Jr.

Avian Dis. 1995 Oct-Dec;39(4):873-8.

PMID:
8719223
12.

Q-beta replicase-amplified assay for detection of Mycobacterium tuberculosis directly from clinical specimens.

Shah JS, Liu J, Buxton D, Hendricks A, Robinson L, Radcliffe G, King W, Lane D, Olive DM, Klinger JD.

J Clin Microbiol. 1995 Jun;33(6):1435-41.

13.

Detection of Mycobacterium tuberculosis directly from spiked human sputum by Q-beta replicase-amplified assay.

Shah JS, Liu J, Buxton D, Stone B, Nietupski R, Olive DM, King W, Klinger JD.

J Clin Microbiol. 1995 Feb;33(2):322-8.

14.

Infection with a plasmid-free variant Chlamydia related to Chlamydia trachomatis identified by using multiple assays for nucleic acid detection.

An Q, Radcliffe G, Vassallo R, Buxton D, O'Brien WJ, Pelletier DA, Weisburg WG, Klinger JD, Olive DM.

J Clin Microbiol. 1992 Nov;30(11):2814-21.

15.

Cystic fibrosis. Infection and immunity to Pseudomonas.

Sorensen RU, Waller RL, Klinger JD.

Clin Rev Allergy. 1991 Spring-Summer;9(1-2):47-74. Review.

PMID:
1884328
16.

Granulocyte transfusions in septic adult and newborn rats: distribution of granulocytes and effect on peripheral blood and bone marrow.

Baley JE, Bruce M, Stork EK, Klinger JD, Medvik K, Shurin S.

J Lab Clin Med. 1990 Mar;115(3):283-91.

PMID:
2313160
17.

A new colorimetric nucleic acid hybridization assay for Listeria in foods.

King W, Raposa S, Warshaw J, Johnson A, Halbert D, Klinger JD.

Int J Food Microbiol. 1989 Jun;8(3):225-32.

PMID:
2484438
18.

Purification and characterization of an extracellular protease from Pseudomonas cepacia.

McKevitt AI, Bajaksouzian S, Klinger JD, Woods DE.

Infect Immun. 1989 Mar;57(3):771-8.

19.

Comparative studies of nucleic acid hybridization assay for Listeria in foods.

Klinger JD, Johnson A, Croan D, Flynn P, Whippie K, Kimball M, Lawrie J, Curiale M.

J Assoc Off Anal Chem. 1988 May-Jun;71(3):669-73.

PMID:
2455706
20.

Isolation of Listeria: a review of procedures and future prospects.

Klinger JD.

Infection. 1988;16 Suppl 2:S98-105. Review.

PMID:
3047068
21.

Colonization of the respiratory tract with Pseudomonas cepacia in cystic fibrosis. Risk factors and outcomes.

Tablan OC, Martone WJ, Doershuk CF, Stern RC, Thomassen MJ, Klinger JD, White JW, Carson LA, Jarvis WR.

Chest. 1987 Apr;91(4):527-32.

PMID:
3829745
22.

Therapeutic evaluation of piperacillin for acute pulmonary exacerbations in cystic fibrosis.

Reed MD, Stern RC, Myers CM, Klinger JD, Yamashita TS, Blumer JL.

Pediatr Pulmonol. 1987 Mar-Apr;3(2):101-9.

PMID:
3588053
23.

Biological effects of Pseudomonas aeruginosa phenazine pigments.

Sorensen RU, Klinger JD.

Antibiot Chemother (1971). 1987;39:113-24. Review. No abstract available.

PMID:
3118778
24.

Pseudomonas cepacia: decrease in colonization in patients with cystic fibrosis.

Thomassen MJ, Demko CA, Doershuk CF, Stern RC, Klinger JD.

Am Rev Respir Dis. 1986 Oct;134(4):669-71.

PMID:
3767122
25.

Pseudomonas cepacia: biology, mechanisms of virulence, epidemiology.

Goldmann DA, Klinger JD.

J Pediatr. 1986 May;108(5 Pt 2):806-12. Review.

PMID:
3517271
27.

Biochemical and pathologic evidence for proteolytic destruction of lung connective tissue in cystic fibrosis.

Bruce MC, Poncz L, Klinger JD, Stern RC, Tomashefski JF Jr, Dearborn DG.

Am Rev Respir Dis. 1985 Sep;132(3):529-35.

PMID:
3898942
28.

Ceftazidime therapy in patients with cystic fibrosis and multiply-drug-resistant pseudomonas.

Blumer JL, Stern RC, Klinger JD, Yamashita TS, Meyers CM, Blum A, Reed MD.

Am J Med. 1985 Aug 9;79(2A):37-46.

PMID:
3895917
29.

Some visual effects caused by the beverage kava.

Garner LF, Klinger JD.

J Ethnopharmacol. 1985 Jul;13(3):307-11.

PMID:
4058033
30.

Use of an automatic refraction device in a Third World country.

Garner LF, Kinnear RF, Klinger JD, Jones J.

J Am Optom Assoc. 1985 Jul;56(7):538-41.

PMID:
3874895
31.

Prevalence of myopia in school children in Vanuatu.

Garner LF, Kinnear RF, Klinger JD, McKellar MJ.

Acta Ophthalmol (Copenh). 1985 Jun;63(3):323-6.

PMID:
3875961
34.

Pseudomonas cepacia colonization among patients with cystic fibrosis. A new opportunist.

Thomassen MJ, Demko CA, Klinger JD, Stern RC.

Am Rev Respir Dis. 1985 May;131(5):791-6.

PMID:
3923882
35.

Occurrence and antimicrobial susceptibility of gram-negative nonfermentative bacilli in cystic fibrosis patients.

Klinger JD, Thomassen MJ.

Diagn Microbiol Infect Dis. 1985 Mar;3(2):149-58.

PMID:
3979021
36.

Pharmacokinetics and cerebrospinal fluid penetration of ceftazidime in children with meningitis.

Blumer JL, Aronoff SC, Myers CM, O'Brien CA, Klinger JD, Reed MD.

Dev Pharmacol Ther. 1985;8(4):219-31.

PMID:
3896704
37.

Proteinases of Pseudomonas aeruginosa evoke mucin release by tracheal epithelium.

Klinger JD, Tandler B, Liedtke CM, Boat TF.

J Clin Invest. 1984 Nov;74(5):1669-78.

38.

Pulmonary cellular response to chronic irritation and chronic Pseudomonas aeruginosa pneumonia in cats.

Thomassen MJ, Klinger JD, Winnie GB, Wood RE, Burtner C, Tomashefski JF, Horowitz JG, Tandler B.

Infect Immun. 1984 Sep;45(3):741-7.

39.

Ceftazidime as initial therapy for suspected bacterial infections in hospitalized pediatric patients.

Reed MD, O'Brien CA, Aronoff SC, Klinger JD, Blumer JL.

Antimicrob Agents Chemother. 1984 Sep;26(3):318-21.

40.

A double-blinded comparative study of sultamicillin and potassium penicillin V in the treatment of childhood streptococcal pharyngitis.

Aronoff SC, Klinger JD, O'Brien CA, Jaffe AC, Blumer JL.

J Antimicrob Chemother. 1984 Sep;14(3):261-5.

PMID:
6092317
41.

An in-hospital evaluation of the sonic mist ultrasonic room humidifier.

Chatburn RL, Lough MD, Klinger JD.

Respir Care. 1984 Sep;29(9):893-9.

PMID:
10315606
42.

Cultures of thoracotomy specimens confirm usefulness of sputum cultures in cystic fibrosis.

Thomassen MJ, Klinger JD, Badger SJ, van Heeckeren DW, Stern RC.

J Pediatr. 1984 Mar;104(3):352-6.

PMID:
6423790
44.

Proteinases release mucin from airways goblet cells.

Boat TF, Cheng PI, Klinger JD, Liedtke CM, Tandler B.

Ciba Found Symp. 1984;109:72-88. Review.

PMID:
6394245
45.

Efficacy and safety of ceftriaxone in serious pediatric infections.

Aronoff SC, Murdell D, O'Brien CA, Klinger JD, Reed MD, Blumer JL.

Antimicrob Agents Chemother. 1983 Nov;24(5):663-6.

46.

In vitro inhibition of lymphocyte proliferation by Pseudomonas aeruginosa phenazine pigments.

Sorensen RU, Klinger JD, Cash HA, Chase PA, Dearborn DG.

Infect Immun. 1983 Jul;41(1):321-30.

47.

Once-daily vs. continuous aminoglycoside dosing: efficacy and toxicity in animal and clinical studies of gentamicin, netilmicin, and tobramycin.

Powell SH, Thompson WL, Luthe MA, Stern RC, Grossniklaus DA, Bloxham DD, Groden DL, Jacobs MR, DiScenna AO, Cash HA, Klinger JD.

J Infect Dis. 1983 May;147(5):918-32.

PMID:
6860416
48.

Protective immunization against chronic Pseudomonas aeruginosa pulmonary infection in rats.

Klinger JD, Cash HA, Wood RE, Miler JJ.

Infect Immun. 1983 Mar;39(3):1377-84.

49.

Suppression of in vitro lymphocyte DNA synthesis by killed Pseudomonas aeruginosa.

Rubin HR, Sorensen RU, Chase PA, Klinger JD.

Infect Immun. 1983 Feb;39(2):630-7.

50.

Induction of phagocytic inhibitory activity in cats with chronic Pseudomonas aeruginosa pulmonary infection.

Winnie GB, Klinger JD, Sherman JM, Thomassen MJ.

Infect Immun. 1982 Dec;38(3):1088-93.

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