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Items: 42

1.

Dose intensification of TRAIL-inducing ONC201 inhibits metastasis and promotes intratumoral NK cell recruitment.

Wagner J, Kline CL, Zhou L, Campbell KS, MacFarlane AW, Olszanski AJ, Cai KQ, Hensley HH, Ross EA, Ralff MD, Zloza A, Chesson CB, Newman JH, Kaufman H, Bertino J, Stein M, El-Deiry WS.

J Clin Invest. 2018 Jun 1;128(6):2325-2338. doi: 10.1172/JCI96711. Epub 2018 Apr 30.

2.
3.

Role of Dopamine Receptors in the Anticancer Activity of ONC201.

Kline CLB, Ralff MD, Lulla AR, Wagner JM, Abbosh PH, Dicker DT, Allen JE, El-Deiry WS.

Neoplasia. 2018 Jan;20(1):80-91. doi: 10.1016/j.neo.2017.10.002. Epub 2017 Dec 5.

4.

Single agent and synergistic combinatorial efficacy of first-in-class small molecule imipridone ONC201 in hematological malignancies.

Prabhu VV, Talekar MK, Lulla AR, Kline CLB, Zhou L, Hall J, Van den Heuvel APJ, Dicker DT, Babar J, Grupp SA, Garnett MJ, McDermott U, Benes CH, Pu JJ, Claxton DF, Khan N, Oster W, Allen JE, El-Deiry WS.

Cell Cycle. 2018;17(4):468-478. doi: 10.1080/15384101.2017.1403689. Epub 2018 Feb 19. Update in: Cell Cycle. 2018;17(16):1947-1948.

PMID:
29157092
5.

Cancer stem cell-related gene expression as a potential biomarker of response for first-in-class imipridone ONC201 in solid tumors.

Prabhu VV, Lulla AR, Madhukar NS, Ralff MD, Zhao D, Kline CLB, Van den Heuvel APJ, Lev A, Garnett MJ, McDermott U, Benes CH, Batchelor TT, Chi AS, Elemento O, Allen JE, El-Deiry WS.

PLoS One. 2017 Aug 2;12(8):e0180541. doi: 10.1371/journal.pone.0180541. eCollection 2017.

6.

Preclinical evaluation of the imipridone family, analogs of clinical stage anti-cancer small molecule ONC201, reveals potent anti-cancer effects of ONC212.

Wagner J, Kline CL, Ralff MD, Lev A, Lulla A, Zhou L, Olson GL, Nallaganchu BR, Benes CH, Allen JE, Prabhu VV, Stogniew M, Oster W, El-Deiry WS.

Cell Cycle. 2017 Oct 2;16(19):1790-1799. doi: 10.1080/15384101.2017.1325046. Epub 2017 May 10.

7.

ONC201 Demonstrates Antitumor Effects in Both Triple-Negative and Non-Triple-Negative Breast Cancers through TRAIL-Dependent and TRAIL-Independent Mechanisms.

Ralff MD, Kline CLB, Küçükkase OC, Wagner J, Lim B, Dicker DT, Prabhu VV, Oster W, El-Deiry WS.

Mol Cancer Ther. 2017 Jul;16(7):1290-1298. doi: 10.1158/1535-7163.MCT-17-0121. Epub 2017 Apr 19.

8.

Discovery and clinical introduction of first-in-class imipridone ONC201.

Allen JE, Kline CL, Prabhu VV, Wagner J, Ishizawa J, Madhukar N, Lev A, Baumeister M, Zhou L, Lulla A, Stogniew M, Schalop L, Benes C, Kaufman HL, Pottorf RS, Nallaganchu BR, Olson GL, Al-Mulla F, Duvic M, Wu GS, Dicker DT, Talekar MK, Lim B, Elemento O, Oster W, Bertino J, Flaherty K, Wang ML, Borthakur G, Andreeff M, Stein M, El-Deiry WS.

Oncotarget. 2016 Nov 8;7(45):74380-74392. doi: 10.18632/oncotarget.11814. Review.

9.

ONC201 kills solid tumor cells by triggering an integrated stress response dependent on ATF4 activation by specific eIF2α kinases.

Kline CL, Van den Heuvel AP, Allen JE, Prabhu VV, Dicker DT, El-Deiry WS.

Sci Signal. 2016 Feb 16;9(415):ra18. doi: 10.1126/scisignal.aac4374.

10.

Comparing the mechanical properties of the porcine knee meniscus when hydrated in saline versus synovial fluid.

Lakes EH, Kline CL, McFetridge PS, Allen KD.

J Biomech. 2015 Dec 16;48(16):4333-8. doi: 10.1016/j.jbiomech.2015.10.046. Epub 2015 Nov 7.

PMID:
26592438
11.

Small-Molecule NSC59984 Restores p53 Pathway Signaling and Antitumor Effects against Colorectal Cancer via p73 Activation and Degradation of Mutant p53.

Zhang S, Zhou L, Hong B, van den Heuvel AP, Prabhu VV, Warfel NA, Kline CL, Dicker DT, Kopelovich L, El-Deiry WS.

Cancer Res. 2015 Sep 15;75(18):3842-52. doi: 10.1158/0008-5472.CAN-13-1079. Epub 2015 Aug 20.

12.

The angular structure of ONC201, a TRAIL pathway-inducing compound, determines its potent anti-cancer activity.

Wagner J, Kline CL, Pottorf RS, Nallaganchu BR, Olson GL, Dicker DT, Allen JE, El-Deiry WS.

Oncotarget. 2014 Dec 30;5(24):12728-37.

13.

Personalized dosing via pharmacokinetic monitoring of 5-fluorouracil might reduce toxicity in early- or late-stage colorectal cancer patients treated with infusional 5-fluorouracil-based chemotherapy regimens.

Kline CL, Schiccitano A, Zhu J, Beachler C, Sheikh H, Harvey HA, Mackley HB, McKenna K, Staveley-O'Carroll K, Poritz L, Messaris E, Stewart D, Sivik J, El-Deiry WS.

Clin Colorectal Cancer. 2014 Jun;13(2):119-26. doi: 10.1016/j.clcc.2013.11.001. Epub 2013 Nov 20.

PMID:
24461492
14.

Personalizing colon cancer therapeutics: targeting old and new mechanisms of action.

Kline CL, El-Deiry WS.

Pharmaceuticals (Basel). 2013 Aug 21;6(8):988-1038. doi: 10.3390/ph6080988.

15.

Par-4 as a potential target for cancer therapy.

Irby RB, Kline CL.

Expert Opin Ther Targets. 2013 Jan;17(1):77-87. doi: 10.1517/14728222.2013.731047. Epub 2012 Oct 15. Review.

PMID:
23062118
16.

Preliminary observations indicate variable patterns of plasma 5-fluorouracil (5-FU) levels during dose optimization of infusional 5-FU in colorectal cancer patients.

Kline CL, Sheikh HS, Scicchitano A, Gingrich R, Beachler C, Finnberg NK, Liao J, Sivik J, El-Deiry WS.

Cancer Biol Ther. 2011 Oct 1;12(7):557-68. Epub 2011 Oct 1.

PMID:
21931273
17.
18.

The Akt inhibitor ISC-4 activates prostate apoptosis response protein-4 and reduces colon tumor growth in a nude mouse model.

Sharma AK, Kline CL, Berg A, Amin S, Irby RB.

Clin Cancer Res. 2011 Jul 1;17(13):4474-83. doi: 10.1158/1078-0432.CCR-10-2370. Epub 2011 May 9.

19.

Prostate apoptosis response protein 4 sensitizes human colon cancer cells to chemotherapeutic 5-FU through mediation of an NF kappaB and microRNA network.

Wang BD, Kline CL, Pastor DM, Olson TL, Frank B, Luu T, Sharma AK, Robertson G, Weirauch MT, Patierno SR, Stuart JM, Irby RB, Lee NH.

Mol Cancer. 2010 Apr 30;9:98. doi: 10.1186/1476-4598-9-98.

20.

Primary cell lines: false representation or model system? a comparison of four human colorectal tumors and their coordinately established cell lines.

Pastor DM, Poritz LS, Olson TL, Kline CL, Harris LR, Koltun WA, Chinchilli VM, Irby RB.

Int J Clin Exp Med. 2010 Feb 22;3(1):69-83.

21.

Delivery of PAR-4 plasmid in vivo via nanoliposomes sensitizes colon tumor cells subcutaneously implanted into nude mice to 5-FU.

Kline CL, Shanmugavelandy SS, Kester M, Irby RB.

Cancer Biol Ther. 2009 Oct;8(19):1831-7.

PMID:
19729995
22.

Src activity alters alpha3 integrin expression in colon tumor cells.

Kline CL, Olson TL, Irby RB.

Clin Exp Metastasis. 2009;26(2):77-87. doi: 10.1007/s10585-008-9215-x. Epub 2008 Oct 7.

PMID:
18839319
23.

Src kinase induces tumor formation in the c-SRC C57BL/6 mouse.

Kline CL, Jackson R, Engelman R, Pledger WJ, Yeatman TJ, Irby RB.

Int J Cancer. 2008 Jun 15;122(12):2665-73. doi: 10.1002/ijc.23445.

24.

Glucosamine-induced phosphorylation of the alpha-subunit of eukaryotic initiation factor 2 is mediated by the protein kinase R-like endoplasmic-reticulum associated kinase.

Kline CL, Schrufer TL, Jefferson LS, Kimball SR.

Int J Biochem Cell Biol. 2006;38(5-6):1004-14. Epub 2005 Nov 16.

PMID:
16324875
25.

Real-world scenarios help improve selection of radiology employees.

Kline CL, Groff K, Phillips M.

Radiol Manage. 1998 Nov-Dec;20(6):30-3.

PMID:
10338852
26.

Expectancies and functional impairment in chronic low back pain.

Council JR, Ahern DK, Follick MJ, Kline CL.

Pain. 1988 Jun;33(3):323-31.

PMID:
2971153
27.

The dyslexia-emotional dyad: implications for diagnosis and treatment.

Kline CL.

Can J Psychiatry. 1986 Aug;31(6):517-20.

PMID:
3756753
28.
29.

Anorexia nervosa: death from complications of ruptured gastric ulcer.

Kline CL.

Can J Psychiatry. 1979 Mar;24(2):153-6.

PMID:
427702
30.

Cognition conflict.

Kline CL.

Am J Orthopsychiatry. 1973 Apr;43(3):495-6. No abstract available.

PMID:
4711091
31.

An immigrant to Canada replies.

Kline CL.

Can Psychiatr Assoc J. 1972 Dec;17(6):476-7. No abstract available.

PMID:
4656666
32.

Children in child welfare agencies: a model for more effective delivery of medical and psychiatric services.

Shah CP, Kline CL.

Can J Public Health. 1972 Nov-Dec;63(6):517-22. No abstract available.

PMID:
4644520
33.

The young American expatriates in Canada: alienated or self-defined?

Kline CL, Rider K, Berry K, Elrod JM.

Am J Orthopsychiatry. 1971 Jan;41(1):74-84. No abstract available.

PMID:
5539496
34.

How can you help parents and children? I. Mental hygiene and our children.

KLINE CL.

Wis Med J. 1962 Nov;61:555. No abstract available.

PMID:
14033520
35.

Emotional illness associated with childbirth; a study of 52 patients and the literature.

KLINE CL.

Am J Obstet Gynecol. 1955 Apr;69(4):748-57. No abstract available.

PMID:
14361492
36.

Recognizing emotional problems in adolescent girls.

KLINE CL.

Wis Med J. 1953 Sep;52(9):482-6. No abstract available.

PMID:
13103107
37.

Some psychiatric implications of gynecologic surgery.

KLINE CL.

Wis Med J. 1951 Dec;50(12):1178-82. No abstract available.

PMID:
14893831
38.

Suicide; implications for the general medical man.

KLINE CL.

Wis Med J. 1950 Dec;49(12):1111-3. No abstract available.

PMID:
14798875
39.

Should the general hospital provide psychiatric services?

KLINE CL.

Wis Med J. 1950 Oct;49(10):901-3. No abstract available.

PMID:
14782496
40.

Toxic psychosis resulting from penicillin.

KLINE CL, HIGHSMITH LS.

Ann Intern Med. 1948 May;28(5):1057. No abstract available.

PMID:
18858406
41.

Recurrent mumps versus recurrent parotitis; case reports.

KLINE CL, HIGHSMITH LS.

Mo Med. 1948 Mar;45(3):200-2. No abstract available.

PMID:
18858679
42.

Sub-shock insulin therapy in anxiety states and anxiety depressions.

HOHMAN LB, KLINE CL.

Dis Nerv Syst. 1946 Oct;7:293-8. No abstract available.

PMID:
20999122

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