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Items: 27

1.

Ankyrin-B dysfunction predisposes to arrhythmogenic cardiomyopathy and is amenable to therapy.

Roberts JD, Murphy NP, Hamilton RM, Lubbers ER, James CA, Kline CF, Gollob MH, Krahn AD, Sturm AC, Musa H, El-Refaey M, Koenig S, Aneq MÅ, Hoorntje ET, Graw SL, Davies RW, Rafiq MA, Koopmann TT, Aafaqi S, Fatah M, Chiasson DA, Taylor MR, Simmons SL, Han M, van Opbergen CJ, Wold LE, Sinagra G, Mittal K, Tichnell C, Murray B, Codima A, Nazer B, Nguyen DT, Marcus FI, Sobriera N, Lodder EM, van den Berg MP, Spears DA, Robinson JF, Ursell PC, Green AK, Skanes AC, Tang AS, Gardner MJ, Hegele RA, van Veen TA, Wilde AA, Healey JS, Janssen PM, Mestroni L, van Tintelen JP, Calkins H, Judge DP, Hund TJ, Scheinman MM, Mohler PJ.

J Clin Invest. 2019 Jul 2;129(8):3171-3184. doi: 10.1172/JCI125538. eCollection 2019 Jul 2.

2.

Defining the molecular signatures of human right heart failure.

Williams JL, Cavus O, Loccoh EC, Adelman S, Daugherty JC, Smith SA, Canan B, Janssen PML, Koenig S, Kline CF, Mohler PJ, Bradley EA.

Life Sci. 2018 Mar 1;196:118-126. doi: 10.1016/j.lfs.2018.01.021. Epub 2018 Jan 31.

3.

Novel Variant in the ANK2 Membrane-Binding Domain Is Associated With Ankyrin-B Syndrome and Structural Heart Disease in a First Nations Population With a High Rate of Long QT Syndrome.

Swayne LA, Murphy NP, Asuri S, Chen L, Xu X, McIntosh S, Wang C, Lancione PJ, Roberts JD, Kerr C, Sanatani S, Sherwin E, Kline CF, Zhang M, Mohler PJ, Arbour LT.

Circ Cardiovasc Genet. 2017 Jan;10(1). pii: e001537. doi: 10.1161/CIRCGENETICS.116.001537.

4.

A Novel Mechanism for Human Cardiac Ankyrin-B Syndrome due to Reciprocal Chromosomal Translocation.

Huq AJ, Pertile MD, Davis AM, Landon H, James PA, Kline CF, Vohra J, Mohler PJ, Delatycki MB.

Heart Lung Circ. 2017 Jun;26(6):612-618. doi: 10.1016/j.hlc.2016.09.013. Epub 2016 Nov 16.

5.

Common human ANK2 variant confers in vivo arrhythmia phenotypes.

Musa H, Murphy NP, Curran J, Higgins JD, Webb TR, Makara MA, Wright P, Lancione PJ, Lubbers ER, Healy JA, Smith SA, Bennett V, Hund TJ, Kline CF, Mohler PJ.

Heart Rhythm. 2016 Sep;13(9):1932-40. doi: 10.1016/j.hrthm.2016.06.012. Epub 2016 Jun 11.

PMID:
27298202
6.

Dysfunction of the β2-spectrin-based pathway in human heart failure.

Smith SA, Hughes LD, Kline CF, Kempton AN, Dorn LE, Curran J, Makara M, Webb TR, Wright P, Voigt N, Binkley PF, Janssen PM, Kilic A, Carnes CA, Dobrev D, Rasband MN, Hund TJ, Mohler PJ.

Am J Physiol Heart Circ Physiol. 2016 Jun 1;310(11):H1583-91. doi: 10.1152/ajpheart.00875.2015. Epub 2016 Apr 22.

7.

Expression and function of the Scn5a-encoded voltage-gated sodium channel NaV 1.5 in the rat jejunum.

Beyder A, Gibbons SJ, Mazzone A, Strege PR, Saravanaperumal SA, Sha L, Higgins S, Eisenman ST, Bernard CE, Geurts A, Kline CF, Mohler PJ, Farrugia G.

Neurogastroenterol Motil. 2016 Jan;28(1):64-73. doi: 10.1111/nmo.12697. Epub 2015 Oct 13.

8.

SCN5A variant that blocks fibroblast growth factor homologous factor regulation causes human arrhythmia.

Musa H, Kline CF, Sturm AC, Murphy N, Adelman S, Wang C, Yan H, Johnson BL, Csepe TA, Kilic A, Higgins RS, Janssen PM, Fedorov VV, Weiss R, Salazar C, Hund TJ, Pitt GS, Mohler PJ.

Proc Natl Acad Sci U S A. 2015 Oct 6;112(40):12528-33. doi: 10.1073/pnas.1516430112. Epub 2015 Sep 21.

9.

Protein phosphatase 2A regulatory subunit B56α limits phosphatase activity in the heart.

Little SC, Curran J, Makara MA, Kline CF, Ho HT, Xu Z, Wu X, Polina I, Musa H, Meadows AM, Carnes CA, Biesiadecki BJ, Davis JP, Weisleder N, Györke S, Wehrens XH, Hund TJ, Mohler PJ.

Sci Signal. 2015 Jul 21;8(386):ra72. doi: 10.1126/scisignal.aaa5876.

10.

Ranolazine inhibits voltage-gated mechanosensitive sodium channels in human colon circular smooth muscle cells.

Neshatian L, Strege PR, Rhee PL, Kraichely RE, Mazzone A, Bernard CE, Cima RR, Larson DW, Dozois EJ, Kline CF, Mohler PJ, Beyder A, Farrugia G.

Am J Physiol Gastrointest Liver Physiol. 2015 Sep 15;309(6):G506-12. doi: 10.1152/ajpgi.00051.2015. Epub 2015 Jul 16.

11.

Use of whole exome sequencing for the identification of Ito-based arrhythmia mechanism and therapy.

Sturm AC, Kline CF, Glynn P, Johnson BL, Curran J, Kilic A, Higgins RS, Binkley PF, Janssen PM, Weiss R, Raman SV, Fowler SJ, Priori SG, Hund TJ, Carnes CA, Mohler PJ.

J Am Heart Assoc. 2015 May 26;4(5). pii: e001762. doi: 10.1161/JAHA.114.001762.

12.

Eps15 Homology Domain-containing Protein 3 Regulates Cardiac T-type Ca2+ Channel Targeting and Function in the Atria.

Curran J, Musa H, Kline CF, Makara MA, Little SC, Higgins JD, Hund TJ, Band H, Mohler PJ.

J Biol Chem. 2015 May 8;290(19):12210-21. doi: 10.1074/jbc.M115.646893. Epub 2015 Mar 30.

13.

Dysfunction in the βII spectrin-dependent cytoskeleton underlies human arrhythmia.

Smith SA, Sturm AC, Curran J, Kline CF, Little SC, Bonilla IM, Long VP, Makara M, Polina I, Hughes LD, Webb TR, Wei Z, Wright P, Voigt N, Bhakta D, Spoonamore KG, Zhang C, Weiss R, Binkley PF, Janssen PM, Kilic A, Higgins RS, Sun M, Ma J, Dobrev D, Zhang M, Carnes CA, Vatta M, Rasband MN, Hund TJ, Mohler PJ.

Circulation. 2015 Feb 24;131(8):695-708. doi: 10.1161/CIRCULATIONAHA.114.013708. Epub 2015 Jan 28.

14.

Ankyrin-B regulates Cav2.1 and Cav2.2 channel expression and targeting.

Kline CF, Scott J, Curran J, Hund TJ, Mohler PJ.

J Biol Chem. 2014 Feb 21;289(8):5285-95. doi: 10.1074/jbc.M113.523639. Epub 2014 Jan 6.

15.

Evolving form to fit function: cardiomyocyte intercalated disc and transverse-tubule membranes.

Kline CF, Mohler PJ.

Curr Top Membr. 2013;72:121-58. doi: 10.1016/B978-0-12-417027-8.00004-0. Review.

PMID:
24210429
16.

βIV-Spectrin and CaMKII facilitate Kir6.2 regulation in pancreatic beta cells.

Kline CF, Wright PJ, Koval OM, Zmuda EJ, Johnson BL, Anderson ME, Hai T, Hund TJ, Mohler PJ.

Proc Natl Acad Sci U S A. 2013 Oct 22;110(43):17576-81. doi: 10.1073/pnas.1314195110. Epub 2013 Oct 7.

17.

Defective interactions of protein partner with ion channels and transporters as alternative mechanisms of membrane channelopathies.

Kline CF, Mohler PJ.

Biochim Biophys Acta. 2014 Feb;1838(2):723-30. doi: 10.1016/j.bbamem.2013.05.024. Epub 2013 May 31. Review.

18.

Regulation of cardiac ATP-sensitive potassium channel surface expression by calcium/calmodulin-dependent protein kinase II.

Sierra A, Zhu Z, Sapay N, Sharotri V, Kline CF, Luczak ED, Subbotina E, Sivaprasadarao A, Snyder PM, Mohler PJ, Anderson ME, Vivaudou M, Zingman LV, Hodgson-Zingman DM.

J Biol Chem. 2013 Jan 18;288(3):1568-81. doi: 10.1074/jbc.M112.429548. Epub 2012 Dec 6.

19.

A β(IV)-spectrin/CaMKII signaling complex is essential for membrane excitability in mice.

Hund TJ, Koval OM, Li J, Wright PJ, Qian L, Snyder JS, Gudmundsson H, Kline CF, Davidson NP, Cardona N, Rasband MN, Anderson ME, Mohler PJ.

J Clin Invest. 2010 Oct;120(10):3508-19. doi: 10.1172/JCI43621. Epub 2010 Sep 27.

20.

From Fifth Business to Protagonist: the complex roles of ion channel anchors in cardiac arrhythmia.

Kline CF, Mohler PJ.

Drug Discov Today Dis Models. 2009 Sep 1;6(3):63-69.

21.

Ankyrin-B regulates Kir6.2 membrane expression and function in heart.

Li J, Kline CF, Hund TJ, Anderson ME, Mohler PJ.

J Biol Chem. 2010 Sep 10;285(37):28723-30. doi: 10.1074/jbc.M110.147868. Epub 2010 Jul 7.

22.

EH domain proteins regulate cardiac membrane protein targeting.

Gudmundsson H, Hund TJ, Wright PJ, Kline CF, Snyder JS, Qian L, Koval OM, Cunha SR, George M, Rainey MA, Kashef FE, Dun W, Boyden PA, Anderson ME, Band H, Mohler PJ.

Circ Res. 2010 Jul 9;107(1):84-95. doi: 10.1161/CIRCRESAHA.110.216713. Epub 2010 May 20.

23.

Ankyrin regulates KATP channel membrane trafficking and gating in excitable cells.

Kline CF, Hund TJ, Mohler PJ.

Channels (Austin). 2010 Jan-Feb;4(1):55-7. Epub 2010 Jan 16.

24.

Dual role of K ATP channel C-terminal motif in membrane targeting and metabolic regulation.

Kline CF, Kurata HT, Hund TJ, Cunha SR, Koval OM, Wright PJ, Christensen M, Anderson ME, Nichols CG, Mohler PJ.

Proc Natl Acad Sci U S A. 2009 Sep 29;106(39):16669-74. doi: 10.1073/pnas.0907138106. Epub 2009 Sep 15.

25.

Revisiting ankyrin-InsP3 receptor interactions: ankyrin-B associates with the cytoplasmic N-terminus of the InsP3 receptor.

Kline CF, Cunha SR, Lowe JS, Hund TJ, Mohler PJ.

J Cell Biochem. 2008 Jul 1;104(4):1244-53. doi: 10.1002/jcb.21704.

26.

Ankyrin-B syndrome: enhanced cardiac function balanced by risk of cardiac death and premature senescence.

Mohler PJ, Healy JA, Xue H, Puca AA, Kline CF, Allingham RR, Kranias EG, Rockman HA, Bennett V.

PLoS One. 2007 Oct 17;2(10):e1051.

27.

Weighing in on molecular anchors: the role of ankyrin polypeptides in human arrhythmia.

Kline CF, Mohler PJ.

Expert Rev Cardiovasc Ther. 2006 Jul;4(4):477-85. Review.

PMID:
16918266

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